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  • KRAS
  • Mutations of the proto-oncogene KRAS have been identified by some groups as being a valid prognostic indicator for adenocarcinoma of the lung. (aacrjournals.org)
  • Based on this study of 181 patients from two major medical centers located in different cities, we conclude that KRAS mutation status is not a satisfactory predictor of prognosis in lung adenocarcinoma, but the substitution of a polar or charged amino acid for the wild-type glycine residue may be a negative prognostic indicator. (aacrjournals.org)
  • The in vivo role of paracrine SHH was tested using autochthonous lung cancer models with conditional KRAS G12D activation, p53 loss,, and SHH loss compared to wild-type SHH. (aacrjournals.org)
  • Furthermore, mutant Kras lung cancers express high levels of IHH that dominates the tumor suppressive effect of our mouse models. (aacrjournals.org)
  • The effect of CXCR2 expression on tumor cells was studied using stable knockdown clones derived from a murine KRAS/p53-mutant lung adenocarcinoma cell line with high metastatic potential and an orthotopic syngeneic mouse model and in vitro using a CXCR2 small molecule antagonist (SB225002). (aacrjournals.org)
  • The small molecular inhibitor AZA197 has been used to inhibit Cdc42 in the treatment of KRAS mutant colorectal cancers. (wikipedia.org)
  • pulmonary
  • The vast majority of patients will have a smoking history and may have other associated diseases such as chronic obstructive pulmonary disease (COPD) or a family history of lung cancer. (statpearls.com)
  • Nintedanib, marketed under the brand names Ofev and Vargatef, is a medication used for the treatment of idiopathic pulmonary fibrosis (IPF) and along with other medications for some types of non-small-cell lung cancer. (wikipedia.org)
  • Tobacco smoke, besides being an irritant and significant indoor air pollutant, is known to cause lung cancer, heart disease, chronic obstructive pulmonary disease (COPD), emphysema, and other serious diseases in smokers (and, according to some, in non-smokers as well). (wikipedia.org)
  • Ovine pulmonary adenocarcinoma (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious disease of the lungs of sheep and goats. (wikipedia.org)
  • amplification
  • On the basis of genomic and functional analyses, we identify NKX2-1 (NK2 homeobox 1, also called TITF1), which lies in the minimal 14q13.3 amplification interval and encodes a lineage-specific transcription factor, as a novel candidate proto-oncogene involved in a significant fraction of lung adenocarcinomas. (broadinstitute.org)
  • epithelia
  • Thus, we explored the role of stromal Hh pathway activation in growth of lung tumor epithelia. (aacrjournals.org)
  • JSRV acutely transforms the lung epithelia into cancerous cells, with type-2 pneumocytes and club cells being the likely target for JSRV transformation. (wikipedia.org)
  • cell
  • Co-culture of high SHH expressing cell lines with murine embryonic and lung fibroblasts were used to confirm and probe the role of paracrine SHH expression on the growth of lung cancer cells. (aacrjournals.org)
  • Using lung cancer cell lines, ANKRD52 knockdowns showed significantly increased cell mobility while forced expressed ANKRD52 decreased cell mobility. (aacrjournals.org)
  • Two lung adenocarcinoma cell lines (CL1-0 and CL1-5) with different metastatic ability and radiosensitivity were used. (aacrjournals.org)
  • We pursued this hypothesis in 12 lung adenocarcinoma cell lines expressing mutant K-ras and 8 lines with only wildtype K-ras. (aacrjournals.org)
  • In vivo studies with cell line- and patient-derived lung adenocarcinoma xenografts confirmed enhanced antitumor activity for BMS-906024 plus paclitaxel versus either drug alone via decreased cell proliferation and increased apoptosis. (aacrjournals.org)
  • We overexpressed Slug in a lung adenocarcinoma cell line with very low Slug levels and investigated the in vitro and in vivo effects of Slug expression. (aacrjournals.org)
  • While each gland may not be secreting the same substance, as long as there is an exocrine function to the cell, it is considered glandular and its malignant form is therefore named adenocarcinoma. (wikipedia.org)
  • Knocking down β1 integrin inhibited cancer cell migration, whereas overexpressing the integrin in Cdc42-deficient cells restored endothelial invasion. (wikipedia.org)
  • There was evidence that Cdc42 inhibition by AZA197 treatment suppresses proliferative and pro-survival signaling pathways via PAK1-ERK signaling and reduces colon cancer cell migration and invasion. (wikipedia.org)
  • Research on gefitinib-sensitive non-small cell lung cancers has shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways. (wikipedia.org)
  • Of the types of non-small cell lung cancer histologies, adenocarcinoma is the type that most often harbors these mutations. (wikipedia.org)
  • During a normal embryologic processes, or during cell injury (such as ischemia-reperfusion injury during heart attacks and strokes) or during developments and processes in cancer, an apoptotic cell undergoes structural changes including cell shrinkage, plasma membrane blebbing, nuclear condensation, and fragmentation of the DNA and nucleus. (wikipedia.org)
  • BAP1 somatic mutations were identified in a small number of breast and lung cancer cell lines, but BAP1 was first shown to act as a tumor suppressor in cultured cells, where its deubiquitinase (UCH) domain and Nuclear localization sequences were required for BAP1 to suppress cell growth. (wikipedia.org)
  • Nintedanib exerts its anti-cancer effect by binding to and blocking the activation of cell receptors involved in blood vessel formation and reshaping (i.e. (wikipedia.org)
  • Reduced tumour blood flow inhibits tumor cell proliferation and migration hence slowing the growth and spread of the cancer. (wikipedia.org)
  • That is, the percentage of lung cancers that are adenocarcinomas has increased, while the percentage of squamous cell cancers has decreased. (wikipedia.org)
  • However, in ER-positive breast cancer cell line MCF-7, estradiol caused a dose-dependent decrease in LKB1 transcript and protein expression leading to a significant decrease in the phosphorylation of the LKB1 target AMPK. (wikipedia.org)
  • significantly
  • Among airway profiles that were significantly modulated following NNK, we found that expression changes (n=22) occurring as early as two months following exposure were significantly associated with lung cancer status when examined in airways of human smokers. (aacrjournals.org)
  • patients
  • In order to apply more effective therapeutic treatment, molecular markers that are able to predict the recurrence risk of patients with adenocarcinoma are critically needed. (aacrjournals.org)
  • Furthermore, the score was able to predict recurrence-free survival in patients with stage I adenocarcinoma, and was also associated with smoking status. (aacrjournals.org)
  • Moreover, less than 1% of patients presenting with stage 4 lung cancer survive for more than 5 years. (healthguideinfo.com)
  • Among 196 patients, 86 patients (43.9%) were triple negative adenocarcinoma, 73 patients (37.2%) presented with activating EGFR mutation, 17 patients (8.7%) with ALK and 13 patients (6.6%) with K-ras mutation. (aacrjournals.org)
  • Twenty-three patients with lung cancer with progressive disease after EGFR-TKI treatment and 21 patients who had never been treated with EGFR-TKIs were studied. (aacrjournals.org)
  • Blood levels of GP73 are higher in patients with liver cancer than in healthy individuals. (wikipedia.org)
  • Patients who are at risk for non-metastatic, or primary, liver cancer typically have chronic liver disease such as cirrhosis. (wikipedia.org)
  • Genzyme, QIAGEN, Argenomics S.A. & other companies make tests to detect EGFR mutations, designed to help predict which lung cancer patients may respond best to some therapies, including gefitinib and erlotinib. (wikipedia.org)
  • mutation
  • For therapies using EGFR-TKIs (e.g., gefitinib and erlotinib), it is essential to determine the epidermal growth factor receptor mutation status of lung cancer lesions. (aacrjournals.org)
  • These studies suggest that germline mutation of BAP1 results in a Tumor Predisposition Syndrome linking BAP1 to many more cancers. (wikipedia.org)
  • invasive
  • When these glands undergo a number of changes at the genetic level, they proceed in a predictable manner as they move from benign to an invasive, malignant colon cancer. (wikipedia.org)
  • pathways
  • However, a better understanding of the genomics of lung cancer and the molecular pathways underlying oncogenesis has led to the development of therapies specifically targeting these molecular programs. (aacrjournals.org)
  • These results are consistent with the starting hypothesis and suggest that mutant K-ras may enhance ROS in lung adenocarcinoma cells through several pathways. (aacrjournals.org)
  • cells
  • In conclusion, the Hh signaling pathway acts upon lung stromal cells in a paracrine fashion. (aacrjournals.org)
  • Radiotherapy is often applied for treating lung cancer, but it often fails because of the relative non-susceptibility of lung cancer cells to radiation. (aacrjournals.org)
  • MicroRNAs (miRNAs) have been reported to modulate the radiosensitivity of lung cancer cells and have the potential to improve the efficacy of radiotherapy. (aacrjournals.org)
  • The purpose of this study was to identify a miRNA that can adjust radiosensitivity in lung adenocarcinoma cells. (aacrjournals.org)
  • In summary the data suggest that mutant K-ras could influence ROS levels and DNA damage in several ways in lung adenocarcinoma cells: by downregulation of MnSOD and of several PRX isoforms, and by increasing DNA-damaging superoxide. (aacrjournals.org)
  • The purpose of our study was to assess CYP24A1 as a prognostic marker and study its relevance to antiproliferative activity of 1,25-D3 in lung AC cells. (aacrjournals.org)
  • To be classified as adenocarcinoma, the cells do not necessarily need to be part of a gland, as long as they have secretory properties. (wikipedia.org)
  • By staining the cells from a biopsy, a pathologist can determine whether the tumor is an adenocarcinoma or some other type of cancer. (wikipedia.org)
  • A continually active form of the transcription factor was also capable of restoring endothelial insertion to cancer cells lacking Cdc42. (wikipedia.org)
  • Invading cancer cells send out protrusions that reach down between neighboring endothelial cells to contact the underlying basement membrane. (wikipedia.org)
  • The cancer cells then spread out on this extracellular matrix so that the endothelial cells retract, and allow the invaders to insert themselves between them. (wikipedia.org)
  • In the absence of Cdc42, cancer cells failed to spread out on the basement membrane, and Cdc42-deficient cells showed reduced adhesion to extracellular matrix-coated coverslips. (wikipedia.org)
  • Cdc42 therefore promotes the attachment of cancer cells to both endothelial cells and the underlying basement membrane during transendothelial migration. (wikipedia.org)
  • It plays an active role in sustaining lung cancer cells in view of the experimental observation that it is mutated in lung cancer. (wikipedia.org)
  • genes
  • More generally, our results indicate that many of the genes that are involved in lung adenocarcinoma remain to be discovered. (broadinstitute.org)
  • Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription of genes specific for the thyroid, lung, and diencephalon. (wikipedia.org)
  • smokers
  • Temporal airway profiles were identified by linear models and analyzed by comparative genomics in normal airways of human smokers with and without lung cancer. (aacrjournals.org)
  • We underscore evolutionarily conserved profiles in the normal-appearing airway that develop prior to lung oncogenesis and that comprise viable markers for early lung cancer detection in suspect smokers. (aacrjournals.org)
  • In the 1970s epidemiologic evidence relative to tobacco-related cancers and data for coronary heart disease indicated a reduced risk among filter smokers for these diseases. (wikipedia.org)
  • Between 1970 and 1980 some studies showed a 20-50% reduction in risk of lung cancer for long-term smokers of filtered cigarettes as compared to smokers of non-filtered cigarettes (IARC, 1986) but later studies indicated a similar risk for lung cancer in smokers of filtered and non-filtered cigarettes. (wikipedia.org)
  • Disease
  • Biocare Medical offers an expanding portfolio of integrated products to address the rapidly growing cancer and infectious disease diagnostic and research markets using tissue immunostaining and in situ hybridization methods. (biocare.net)
  • Lung disease called chronic obstructive pulmonary disease (COPD). (webmd.com)
  • When disease presents with low-grade histologic features the cancer rarely spreads through the lymphatic system or through the bloodstream. (wikipedia.org)
  • The term mucinous adenocarcinoma is used in different contexts depending on the reference material used by the pathologist for disease classification. (wikipedia.org)
  • Factors that increase the risk of prostate cancer include: older age, a family history of the disease, and race. (wikipedia.org)
  • Most people with prostate cancer do not end up dying from the disease. (wikipedia.org)
  • Activating mutations of the Ras protein and upstream elements of the Ras protein may play a role in more than two thirds of all human cancers, including most metastatic disease, which suggests that Reolysin may be an effective therapeutic for many Ras-activated tumor types and potentially for some cell proliferative disorders. (wikipedia.org)
  • mucin
  • Highly differentiated adenocarcinomas form SRCCs via a loss of adherens and tight junctions that typically separate MUC4, a mucin protein, and ErbB2, an oncogenic receptor. (wikipedia.org)
  • Pseudomyxoma peritonei (PMP) is a clinical condition caused by cancerous cells (mucinous adenocarcinoma) that produce abundant mucin or gelatinous ascites. (wikipedia.org)
  • tissues
  • By doing so at the site of cancerous tissues in the body, L-DOS47 is believed to modify the microenvironmental conditions of lung cancer cells in a manner that leads to their death. (drugs.com)
  • In addition, the local production of ammonia at the site of cancerous tissues is thought to readily diffuse into the cancer cells to exert a potent cytotoxic effect by interfering with their critical metabolic functions. (drugs.com)
  • Pasireotide works by binding to a protein called somatostatin receptor, which is expressed in many tissues throughout the body including thyroid cancer cells. (clinicaltrials.gov)
  • It is expressed in all over the body, but its expression in the lung, liver and kidney was higher than other tissues [ 4 , 5 ]. (biomedres.info)
  • The gene is expressed at low levels in almost all human tissues, but higher levels have been seen in certain cancer tissues. (wikipedia.org)
  • liver
  • Oncology, Gastroenterology and Hepatology Reports (OGH Reports) [ISSN:Print -2278-8921, Online - 2348-aims to explore the areas of Cancer research and gastrointestinal tract including the liver. (oghreports.org)
  • breast
  • my aunt was suffering from breast cancer. (unews.top)
  • One study suggests that when signet-ring cells are found in a breast tumor, the presence of gastric cancer should also be considered. (wikipedia.org)
  • It has received regulatory approval for use as a treatment for non-small cell lung cancer, although there is emerging evidence to support its use in other cancers such as breast cancer. (wikipedia.org)
  • Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers. (wikipedia.org)
  • verification needed] Phase II results for breast cancer that over-expresses the protein human epidermal growth factor receptor 2 (Her2-positive breast cancer) were described as promising by the authors, with 19 of 41 patients achieving benefit from afatinib. (wikipedia.org)
  • Her2-negative breast cancers showed limited or no response to the drug. (wikipedia.org)
  • Breast Cancer Research and Treatment. (wikipedia.org)
  • As part of REOLYSIN's registration pathway, Oncolytics, in partnership with CCTG, is conducting a phase 2 clinical trial in metastatic breast cancer patients receiving standard weekly paclitaxel therapy. (wikipedia.org)
  • Several studies have outlined the importance of autocrine IL-6 signaling in lung and breast cancers. (wikipedia.org)
  • Both mouse and human in vivo models of HER2-overexpressing breast cancers relied critically on this HER2-IL-6-STAT3 signaling pathway. (wikipedia.org)
  • destroy
  • Dr. Chao will highlight previously announced laboratory and animal data that demonstrates the potential for L-DOS47 to bind to and debilitate and destroy human lung adenocarcinoma cells. (drugs.com)
  • As an antioxidant curcumin helps destroy lung cancer cells and also reverses drug resistance. (turmericforhealth.com)
  • and Adaptive immune response - antigen presenting cells (APCs) display tumor-associated antigens (TAA) and viral-associated antigens (VAA) to educate T-cells to recognize and destroy cancer cells. (wikipedia.org)
  • mutations
  • A study published in Biofactors, 2015 demonstrated that dietary curcumin can prevent lung cancer caused by Benzo[a]pyrene and prevents its mutagenic action (ability to cause mutations that cause cancer). (turmericforhealth.com)
  • Mutations resulting in deletion or reduction of function of the CDKN2A gene are associated with increased risk of a wide range of cancers and alterations of the gene are frequently seen in cancer cell lines. (wikipedia.org)
  • Germline mutations in CDKN2A are associated with an increased susceptibility to develop skin cancer. (wikipedia.org)
  • De-regulation of the autocrine Wnt signaling pathway via mutations in APC and Axin have been linked to activation of various types of human cancer. (wikipedia.org)
  • prevention
  • The Company is actively developing innovative products for the prevention and treatment of cancer based on its proprietary technologies. (drugs.com)
  • While 5α-reductase inhibitors appear to decrease low-grade cancer risk they do not affect high-grade cancer risk and thus are not recommended for prevention. (wikipedia.org)
  • Asian Pacific Journal of Cancer Prevention. (wikipedia.org)
  • colon cancer
  • The distribution of 25 TN combinations (left) and the distribution of colon cancer and rectum cancer (right) between the training set and testing set [online only]. (springermedizin.de)
  • NEDD9 is induced by Wnt signaling in colon cancer, based on binding to T-cell factor (TCF) factors in the promoter region. (wikipedia.org)
  • signet
  • A down-regulation of E-cadherin is essential for the initiation and progression a gastric signet ring cell cancer cells. (wikipedia.org)
  • For example, neoplasms characterized by high-grade features, invasive glands and or signet ring cells, are termed adenocarcinoma in pathology literature. (wikipedia.org)
  • human
  • Since its inception, Oncolytics Biotech Inc. has worked to take REOLYSIN, its proprietary formulation of human reovirus, through the development and regulatory requirements necessary to develop it as a potential cancer therapeutic. (wikipedia.org)
  • Thyroid Cancer
  • The purpose of this study is to determine the effectiveness of two anticancer drugs, everolimus and pasireotide, in patients with thyroid cancer when the cancer is no longer responding to treatment with radioiodine or where it is deemed unsafe for the patient to receive additional radioiodine treatment. (clinicaltrials.gov)
  • The investigators also want to establish the best manner of taking the two medications when used together to treat thyroid cancer. (clinicaltrials.gov)
  • Would this be good for thyroid cancer? (unews.top)
  • diagnosis
  • Anal sac adenocarcinomas are often suspected due to location (palpable masse in anal sac) and behavior, but a biopsy and histopathology is necessary for a definitive diagnosis. (wikipedia.org)
  • COPD
  • Some research shows that taking a specific whey protein supplement daily for 6 weeks can improve shortness of breath but not lung function or quality of life in people with COPD. (webmd.com)
  • Other research suggests that taking whey protein supplements does not improve lung function, muscle function, or exercise in people with COPD. (webmd.com)
  • positive correlation
  • RESULTS: Analysis of the MethylCap-seq data revealed a strong positive correlation between replicate experiments and between paired tumor/lung samples. (ox.ac.uk)
  • For example, one group found a positive correlation between persistently activated tyrosine-phosphorylated STAT3 (pSTAT3), found in 50% of lung adenocarcinomas, and IL-6. (wikipedia.org)