• Since tumor metastasis is the main obstacle for long-term survival after surgical resection, identification of molecular markers related to metastasis may better predict the prognosis in patients with lung adenocarcinoma. (biomedcentral.com)
  • Carcinogen Metabolism Pathway and Tumor Suppressor Gene Polymorphisms and Gallbladder Cancer Risk in North Indians: A Hospital-Based Case-Control Study. (omicsdi.org)
  • BACKGROUND:Carcinogen metabolism pathway and tumor suppressor gene polymorphisms have been reported to be associated with increased gallbladder cancer risk. (omicsdi.org)
  • We examined whether genetic polymorphisms of metabolic enzymes cytochrome P450 1A1 and glutathione S-transferase and tumor suppressor gene p53 (TP53) are associated with an increased risk of gallbladder cancer in North Indians. (omicsdi.org)
  • The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma. (cdc.gov)
  • EXO1 mutations also have been reported concerning different types of tumor and prognosis of cancers, such as breast, ovarian, pancreatic, and lung cancer [ 23 - 25 ]. (hindawi.com)
  • Such tumor profiles can subsequently be applied to exclusively tailor cancer therapies to directly target a causative mutation for a malignancy, ultimately achieving a personalized and precise approach to cancer treatment. (biomedcentral.com)
  • It focuses on how precision oncology has shaped advances in the impact of non-coding RNAs in epigenetics and cancer, immunotherapy and tumor biology, and the clinical significance of various therapies in a range of cancers. (biomedcentral.com)
  • RHAMM protein expression correlates with histological differentiation stages and extent of the primary tumor (T stages) in 156 patients with primary NSCLC. (biomedfrontiers.org)
  • Taken together, RHAMM, most likely RHAMMv3 (RHAMMB), can serve as a prognostic factor for lung adenocarcinomas and a potential therapeutic target in NSCLC to inhibit tumor migration. (biomedfrontiers.org)
  • To profile genomic and epigenomic of a naïve Chinese non-small cell lung cancer (NSCLC) cohort and investigate the association between tumor mutation burden (TMB) and DNA methylation (DNAm) to explore potential alternative/complimentary biomarkers for NSCLC immunotherapies. (biomedcentral.com)
  • However, so far, not all lung cancer patients give an effective clinical response to ICI therapy even the positive PD-L1 expression in tumor tissue [ 14 ]. (biomedcentral.com)
  • Thus, a holistic view of homeostatic mechanisms through the study of genomic and epigenetic aberrations is needed to understand the core of cancer biology and the pathophysiological features of cancer during oncogenesis and tumor progression. (molcells.org)
  • Importance: The protein p53 is an unequivocal tumor suppressor that is altered in half of all cancers. (stanford.edu)
  • Due to its heterogeneities, 90% of ovarian carcinoma are epithelial ovarian cancer (EOC), while the rest could be classified as non-EOC, including asexual cell tumor, ovarian yolk cystic tumor, granulosa cell tumor, metastatic OC, etc. (amegroups.org)
  • Overall, we demonstrate a lower alpha diversity in normal lung as compared to non-tumor adjacent or tumor tissue. (biomedcentral.com)
  • Background/Aim: Uterine mesonephric-like adenocarcinoma (MLA) is a rare malignant tumor of the female genital tract. (iiarjournals.org)
  • Mesonephric adenocarcinoma (MA) is a rare malignant tumor of the female genital tract. (iiarjournals.org)
  • The term mesonephric-like adenocarcinoma (MLA) has been suggested for a malignant tumor arising in the uterine corpus and the adnexa. (iiarjournals.org)
  • e.g., single nucleotide variants or indels) and somatic copy number alterations (SCNAs), are the underlying driving force for tumor growth. (biomedcentral.com)
  • An alternative metric to quantify ITH is mutant-allele tumor heterogeneity (MATH) [ 13 ], which is defined as 100×MAD/median, where median is the median of the variant allele frequencies (VAFs) of all somatic point mutations within a sample, and MAD is the median absolute deviation of the VAFs. (biomedcentral.com)
  • In India, lung carcinoma is the fifth-most common tumor and second-most common tumor in the males as per the Indian Council of Medical Research registry of 2002. (ijpmonline.org)
  • Considering the imbalance in the dataset, due to large difference in the number of cases for each tumor, two preprocessing strategies were considered: i) setting a percentage cut-off threshold to remove less represented cancer types, ii) dividing cancer types into different groups based on biological criteria and training a specific XGBoost model for each of them. (biomedcentral.com)
  • The Cancer Genome Atlas (TCGA) program started fifteen years ago, and more than 20,000 molecularly characterized primary tumors, and matched normal samples, spanning 33 cancer types are now available to the scientific community, providing an extraordinary resource for deepening and further shedding light on tumor complexity. (biomedcentral.com)
  • Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival. (cancercentrum.se)
  • Approximately eighty percent of endometrial carcinomas are endometrioid adenocarcinomas. (medscape.com)
  • Other histologic subtypes include adenosquamous, clear cell, and papillary serous carcinomas. (medscape.com)
  • The two largest subtypes of lung cancer are adenocarcinoma and squamous cell carcinoma, which together account for about 80% of non-small cell carcinomas (NSCLS). (biomedfrontiers.org)
  • To further confirm that RHAMM is upregulated in NSCLC, we looked at mRNA levels in 57 paired lung adenocarcinomas and 49 pair lung squamous cell carcinomas from The Cancer Genome Atlas (TCGA). (biomedfrontiers.org)
  • About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. (wikipedia.org)
  • Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma (EBV-GCLS) is a rare variant of early gastric carcinomas. (biomedcentral.com)
  • Background Microsatellite lack of stability (MSI) resulting from inactivation of the DNA mismatch fix program (MMR) characterizes a highly immunological subtype of colorectal carcinomas. (immune-source.com)
  • Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)
  • Adenocarcinoma ("adeno" = "gland", "carcinoma" = cancer of epithelium) is the most common type of lung cancer in the U.S., Japan, and most of Western Europe, although it is the second most common form in Eastern parts of Europe (after squamous cell carcinoma). (wikipedia.org)
  • Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
  • The large cell carcinoma class has been enriched with several variants, including the LCNEC and the basaloid carcinoma, both with a dismal prognosis. (ersjournals.com)
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
  • Risk of Colorectal Carcinoma May Predispose to the Genetic Variants of the GST, CYP450 , and TP53 Genes Among Nonsmokers in the Saudi Community. (omicsdi.org)
  • Currently, it consists of histological subtypes of small lung cancer (SCLC) and non-small lung carcinoma (NSCLC), including adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma [ 4 , 5 ]. (hindawi.com)
  • Mendelian randomization analyses demonstrate that reduced FEV 1 increases squamous cell carcinoma risk (odds ratio (OR) = 1.51, 95% confidence intervals: 1.21-1.88), while reduced FEV 1 /FVC increases the risk of adenocarcinoma (OR = 1.17, 1.01-1.35) and lung cancer in never smokers (OR = 1.56, 1.05-2.30). (nature.com)
  • Expression of the receptor for hyaluronic acid mediated motility (RHAMM) is associated with poor prognosis and metastasis in non-small cell lung carcinoma. (biomedfrontiers.org)
  • The receptor for hyaluronic acid-mediated motility (RHAMM) is upregulated in various cancers, but its role in primary and metastatic non-small cell lung carcinoma (NSCLC) remains to be determined. (biomedfrontiers.org)
  • In a publicly available database, The Cancer Genome Atlas (TCGA), RHAMM mRNA expression is 12- and 10-fold higher in lung adenocarcinoma and squamous lung carcinoma than in matched normal lung tissues, respectively. (biomedfrontiers.org)
  • We have selected a total of 89 treatment naïve lung adenocarcinoma (LUAD) or lung squamous cell carcinoma (LUSC) patients from the Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College who underwent definitive surgical resection before adjuvant therapy, including chemotherapy or radiotherapy. (biomedcentral.com)
  • Typical sites of metastasis of endometrial carcinoma are pelvic and para-aortic lymph nodes, vagina, peritoneum, and lungs [ 2 ]. (karger.com)
  • Endometrial carcinoma is divided into two subtypes - type I and type II. (radiopaedia.org)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • Other studies in oral cancer [23,24] reported that there is no relationship between the histopathological grade of oral epithelial dysplasia or oral squamous cell carcinoma and the ploidy status. (researchgate.net)
  • Additionally, surgical samples from seven patients diagnosed with EGFR -mutant primary lung squamous carcinoma (LUSC) were collected. (springernature.com)
  • Further, these taxa, including Acidovorax , exhibit higher abundance among the subset of squamous cell carcinoma cases with TP53 mutations, an association not seen in adenocarcinomas. (biomedcentral.com)
  • The results of this comprehensive study show both microbiome-gene and microbiome-exposure interactions in squamous cell carcinoma lung cancer tissue. (biomedcentral.com)
  • MLA had the lowest progression-free survival rate among different histological types of endometrial carcinoma. (iiarjournals.org)
  • Diverse growth patterns make it difficult to distinguish uterine MLA from more commonly encountered histological types of endometrial carcinoma, including endometrial endometrioid carcinoma (EC) ( 10 ), serous carcinoma (SC), and carcinosarcoma (CS). (iiarjournals.org)
  • Hence, our objective was to detect association of cancer stem cell (CSC) marker aldehyde dehydrogenase 1 (ALDH1) with clinicopathological profile in lung carcinoma patients. (ijpmonline.org)
  • Strong ALDH1 expression correlates with higher stage of lung carcinoma making it a prognostic marker needing in-depth study. (ijpmonline.org)
  • however, a worldwide increase has been seen since then in deaths caused by Lung carcinoma leading to increased age-adjusted death rates. (ijpmonline.org)
  • In 1985, Lung carcinoma became the leading cause of cancer deaths in women and now causes approximately twice as many deaths as breast cancer. (ijpmonline.org)
  • Leptin -2548 G/A polymorphisms are associated to clinical progression of oral cancer and sensitive to oral tumorization in nonsmoking population. (cdc.gov)
  • Besides clinical factors of age, sex, smoking stage, histology, and grade, many genetic polymorphisms also were considered correlation with prognosis in cancer patients. (hindawi.com)
  • Multi-omics approaches are novel frameworks that integrate multiple omics datasets generated from the same patients to better understand the molecular and clinical features of cancers. (molcells.org)
  • Multi-omics approaches have been applied to numerous clinical studies for better identification of clinical subtypes or drug resistance, prediction of effective combination therapies, and identification of predictive biomarkers to increase the response rate to targeted treatments. (molcells.org)
  • There are several variants of cutaneous melanocytic tumors, characterized by differing clinical and pathologic features. (atlasgeneticsoncology.org)
  • The results were validated both by gene expression analysis and immunohistochemistry study in an independent 55 clinical samples from Fudan University Shanghai Cancer Center. (cancerindex.org)
  • I am the General Secretary of the International Society of Breast Pathology, Breast Specialty Editor of Histopathology, a member of the National Coordinating Committee of Breast Pathology (BIG18), National Institute of Cancer Research (NICR) Breast Clinical Studies Group (CSG) and its Breast Translational Subgroup, Breast Cancer Screening Programme Research Advisory Committee, the Pathological Society of Great Britain and Ireland Management Committee, and the international Breast Pathology Group. (nottingham.ac.uk)
  • Impact of concurrent genomic alterations on clinical outcomes in patients with ALK-rearranged non-small cell lung cancer. (cdc.gov)
  • Clinical Impact of Genomic and Pathway Alterations in Stage I EGFR-Mutant Lung Adenocarcinoma. (cdc.gov)
  • Sarcoma remains an important clinical entity among primary breast cancers. (oap-bioscience.org)
  • Some authors excluded cystosarcoma phyllodes from their studies due to its epithelial components, but others do not distinguish between other subtypes of breast sarcoma and cystosarcoma because of similar survival and clinical course. (oap-bioscience.org)
  • Different subtypes of compound EGFR mutations displayed distinct clinical features and genetic architectures, and rare mutation-dominant compound EGFR mutations were associated with enriched kinase domain-resided VUSs and poor clinical outcomes. (biomedcentral.com)
  • found that EGFR 20ins had at least 80 different insertion patterns, and lung cancer patients with EGFR 20ins showed different clinical responses to various EGFR TKIs [ 13 ]. (biomedcentral.com)
  • Given the significant need for clinical diagnostic tools in lung cancer, this study may provide novel biomarkers for early detection. (biomedcentral.com)
  • In China, which has the largest number of smokers and lung cancer cases in the world, the acinar tissue architectural pattern is by far the most common histological subtype of adenocarcinoma, comprising about 40% of all adenocarcinomas, and its incidence has increased significantly in recent decades. (wikipedia.org)
  • Among non-small cell lung cancer variants, adenocarcinoma is the most common histological subtype. (biomedcentral.com)
  • 2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). (wikipedia.org)
  • In 1994, the WHO adopted the International Association for the Study of Lung Cancer (IASLC) pathology panel to comprise the core membership of the WHO committee, to develop a new revised classification of lung and pleural tumours. (ersjournals.com)
  • I am medically qualified and gained Master (MSc pathology) and MD degrees in Pathology (by examination) , PhD in Molecular Pathology (Breast Cancer) from UoN and obtained the Fellowship of the Royal College of Pathologists by examination. (nottingham.ac.uk)
  • As Vice Chair for Translational Research in the Department of Pathology, I am involved in numerous translational cancer research projects that rely on the study of human biological samples. (dukecancerinstitute.org)
  • I am the director of the Duke BioRepository & Precision Pathology Center (Duke BRPC), a shared resource of the School of Medicine and the Duke Cancer Institute. (dukecancerinstitute.org)
  • Between January 2006 and December 2018, 3039 gastric cancer patients were identified after a search of electronic pathology database for gastric cancer treated with gastrectomy and lymphadenectomy at the Changzhou Second People's Hospital, which is one of tertiary medical centers in gastric cancer endemic regions in China. (biomedcentral.com)
  • Disruption of the epithelium by tobacco smoke can be a primary cause of inflammatory pathology, which is seen in both COPD and lung cancer. (biomedcentral.com)
  • Study of the association between polymorphism of persistent obesity, human leptin gene/leptin receptor gene and molecular subtypes of breast cancer]. (cdc.gov)
  • The study encourages new investigations which could further increase the classifier's performance, for example by considering more features and dividing tumors into their main molecular subtypes. (biomedcentral.com)
  • To these data we applied the evolutionary theory of task specialisation (ParetoTI) to identify and characterise distinct archetypes, i.e. molecular subtypes, of LNETs. (who.int)
  • Of 4 RHAMM splice variants, RHAMMv3 (also known as RHAMMB) is the dominant variant in NSCLC. (biomedfrontiers.org)
  • Current therapies for NSCLC including chemotherapy regimens and drugs that target molecular changes in cancer cells have considerable downsides. (biomedfrontiers.org)
  • Developing biomarkers for NSCLC that can identify which cancers are likely to metastasize would help prevent metastases by enabling tailored treatment earlier in the disease, while also providing a target for therapies that more successfully treat metastatic lung cancer. (biomedfrontiers.org)
  • Approximately 85% of lung cancer cases are non-small cell lung cancer (NSCLC) [ 2 ]. (biomedcentral.com)
  • From the abstract: 'Neoadjuvant or adjuvant immunotherapy can improve outcomes in patients with resectable non-small-cell lung cancer (NSCLC). (cdc.gov)
  • Results of in-vivo nude mouse xenograft studies of SCLC and NSCLC, which showed that orally administered 2HF inhibited growth of both histological types of lung cancer, confirmed in-vitro study results. (oncotarget.com)
  • Compound epidermal growth factor receptor ( EGFR ) mutations are less responsive to tyrosine kinase inhibitors (TKIs) than single EGFR mutations in non-small cell lung cancer (NSCLC). (biomedcentral.com)
  • We retrospectively studied the next-generation sequencing (NGS) data of treatment-naïve tumors from 1025 NSCLC patients with compound EGFR mutations, which were sub-categorized into different combinations of common mutations (19-Del and EGFR exon 21 p.L858R), rare mutations, and variants of uncertain significance (VUSs). (biomedcentral.com)
  • It has been seen that ALDH1 expression in non-small cell lung cancer (NSCLC) and the presence of marker was linked to a more tumorigenic potential in the in vivo assessment and shorter disease-free survival in NSCLC patients with platinum treatment. (ijpmonline.org)
  • Due to the heterogeneous nature of tumors, molecular profiling is crucial to our understanding of how genomics plays a role in the cause or development of an individual cancer. (biomedcentral.com)
  • From the abstract: ' Cancer immunogenomics is an emerging field that bridges genomics and immunology. (cdc.gov)
  • Germline mutations resulted in lung cancer pathogenesis by the constitutive activation of proto-oncogenes, such as the members of the EGFR (ERBB), MYC, and RASfamilies, PIK3CA, NKX2-1, and ALK [ 11 , 14 ]. (hindawi.com)
  • Molecular therapies target mutations like those in epidermal growth factor receptor (EGFR) that only occur in about 20% of lung adenocarcinomas. (biomedfrontiers.org)
  • However, most lung adenocarcinomas either lack an identifiable driver oncogene, or harbour mutations in KRAS and are therefore still treated with conventional chemotherapy. (nature.com)
  • Targeted next-generation sequencing (NGS) technology detects specific mutations that can provide treatment opportunities for colorectal cancer (CRC) patients. (preprints.org)
  • These mutations lead to microsatellite instability in 90% of colon cancers and 75% of endometrial cancers. (medscape.com)
  • Fine-tuned responses at various degrees and scales within the human body are central to the homeostatic mechanism that copes with potentially harmful environmental perturbations, including pathogens, smoking, and drugs, and interacts with the genetic background arising from spontaneous somatic mutations and numerous germline variants. (molcells.org)
  • PJS is autosomal-dominant condition caused by mutations of STK11, characterized by gastrointestinal polyposis, mucocutaneous pigmentation, and predisposition to a range of epithelial cancers: including colorectal, gastric, pancreatic, breast, ovarian cancers and sex cord tumors with annular tubules). (cancerindex.org)
  • The possibility of mutations of RAS signaling genes and/or TP53 in combination as a negative prognostic impact on pathological stage I non-small cell lung cancer. (cdc.gov)
  • Impact of ramucirumab plus erlotinib on circulating cell-free DNA from patients with untreated metastatic non-small cell lung cancer with EGFR-activating mutations (RELAY phase 3 randomized study). (cdc.gov)
  • Clinico-genomic features and targetable mutations in non-small cell lung cancers harboring BRAF non-V600E mutations: A multi-institutional genomic screening study (LC-SCRUM-Asia). (cdc.gov)
  • Herein, we hypothesize that somatic mutations together with cigarette smoke generate a dysbiotic microbiota that is associated with lung carcinogenesis. (biomedcentral.com)
  • In a pan-cancer study of 14 cancer types, we studied the associations between survival time and ITH quantified by SMASH, together with other features of somatic mutations. (biomedcentral.com)
  • In breast cancer, we are waiting for the results of large basket trials to incorporate the detection of actionable mutations to select targeted treatments, in a similar way to the management of lung cancer. (ecancer.org)
  • The prognostic implication of histopathologic subtyping of pulmonary adenocarcinoma according to the classification of the World Health Organization. (wikipedia.org)
  • The number of EMT-related proteins' alteration is a significant prognostic marker to predict overall survival in patients with lung adenocarcinoma. (biomedcentral.com)
  • The establishment of large-scale genomic collaborative efforts along with the development of new single-cell transcriptomic techniques and multi-omics approaches have enabled characterization of the mutational and transcriptional profiles of many cancer types and helped to identify clinically actionable alterations as well as predictive and prognostic biomarkers. (cdc.gov)
  • This methodology enables the detection of alternative splicing events in complex biological samples, providing a powerful tool to identify novel diagnostic and prognostic biomarkers for cancer and other pathologies. (biomedcentral.com)
  • Advances in high-throughput technologies and their involvement in the 'omics' of cancer have made possible the identification of hundreds of biomarkers and the development of predictive and prognostic platforms that model the management of cancer from evidence-based medicine to precision medicine. (ecancer.org)
  • RHAMM mRNA expression correlates with stages of differentiation and inferior survival in more than 400 cases of lung adenocarcinoma in the Director's Challenge cohort. (biomedfrontiers.org)
  • The overall prognosis for patients with these cancers is poor-those diagnosed at stage IV have a 5-year survival rate of only 4%-because more than half of them are diagnosed after the cancer has metastasized. (biomedfrontiers.org)
  • Malignant pleural mesothelioma (MPM) is an aggressive inflammatory cancer with a poor survival rate. (frontiersin.org)
  • A wide range of emerging omics and multi-view clustering algorithms now provide unprecedented opportunities to further classify cancers into subtypes, improve the survival prediction and therapeutic outcome of these subtypes, and understand key pathophysiological processes through different molecular layers. (molcells.org)
  • In this cohort study of 94 patients with resected melanoma brain metastases that underwent targeted DNA sequencing, BRAF V600E variant lesions were associated with worse intracranial progression-free survival and overall survival. (cdc.gov)
  • Unfortunately, lung cancer survival remains poor and has shown minimal improvement over the past five decades, owing to diagnosis at advanced stage and resistance to standard chemotherapy [ 2 ]. (biomedcentral.com)
  • Our results show that ITH is associated with survival time in several cancer types and its effect can be modified by other covariates, such as mutation burden. (biomedcentral.com)
  • 12 ] was that only a small number of patients (3 to 11 patients across nine cancer types, median of six patients) were classified as having both high ITH and non-censored survival time. (biomedcentral.com)
  • R, Flisberg P, Hedlund L, Östlund I, Bergkvist L. Impact of general anaesthesia on breast cancer survival: a 5-year follow up of a pragmatic, randomised, controlled trial, the CAN-study, comparing propofol and sevoflurane. (cancercentrum.se)
  • Ovarian cancer (OC) is one of the most fatal gynecologic malignant tumors worldwide, the morbidity of OC is ranked at the eighth among the most common women malignancies ( 1 ). (amegroups.org)
  • This may contribute to the generation of active RON variants by alternative splicing, which is frequently observed in primary tumors. (spandidos-publications.com)
  • In primary tumors, such as colon and breast cancers, overexpression of RON exists in a large number of cases and is often accompanied by the generation of different splicing variants ( 12 - 14 ). (spandidos-publications.com)
  • Here, we developed a plain ML model aimed at distinguishing cancer types based on genetic lesions, providing an additional tool to improve cancer diagnosis, particularly for tumors of unknown origin. (biomedcentral.com)
  • On the other hand, the disturbances in the proper HO-1 level are associated with the pathogenesis of some age-dependent disorders, including neurodegeneration, cancer or macular degeneration. (springer.com)
  • These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis. (nature.com)
  • The aim of this study was to identify valuable biomarkers by searching the candidate molecules that contribute to lung adenocarcinoma pathogenesis, especially KC subtype. (cancerindex.org)
  • In three cases which initially were taken for pleomorphic adenomas by routine histological examination, aneuploid cell populations exposed by DNA flow cytometric analysis gave rise to a closer inspection of the suspect lesions. (researchgate.net)
  • The expression of EMT-related proteins including cytokeratin, E-cadherin, TTF-1, β-catenin, vimentin, Snail, Twist, CD44 was evaluated by immunohistochemistry using a tissue array method in the lung adenocarcinoma tissues of 95 patients. (biomedcentral.com)
  • The information generated will be valuable for the prognosis of patients with lung adenocarcinoma. (biomedcentral.com)
  • From January 2007 to December 2009, 95 patients undergoing surgical resection for lung adenocarcinoma at Nanjing Drum Tower Hospital were enrolled in this study. (biomedcentral.com)
  • Samples were obtained from 56(58.8%) male and 39 (41.2%) female patients, and there were 51 (53.7%, I-II stage) cases of early-stage adenocarcinoma and 44 (46.3%, III-IV stage) cases of advanced-stage adenocarcinoma. (biomedcentral.com)
  • METHODS: Non-interventional, retrospective, multicentre, comparative study was carried out to describe the outcome of ES-SCLC patients included in the Epidémiologie Stratégie Médico-Economique (ESME) data platform for advanced and metastatic lung cancer. (bvsalud.org)
  • Most patients with endometrial cancer present with abnormal vaginal bleeding. (medscape.com)
  • However, it has a favorable prognosis because the majority of patients present at an early stage, resulting in only 4% of cancer deaths in women. (medscape.com)
  • Several candidate genes and genetic variants have been associated with morbidity and mortality among patients with CRC. (omicsdi.org)
  • METHODS:This hospital-based case-control study was conducted in 96 gallbladder cancer patients with gallstones (cases) and 93 cholelithiasis patients (controls) at the Sanjay Gandhi Postgraduate Institute of Medical Sciences in Lucknow, India from July 2014 through May 2017. (omicsdi.org)
  • Leptin receptor Q223R polymorphism in Egyptian female patients with breast cancer. (cdc.gov)
  • In this study, we focus on evaluating association between DNA repair polymorphisms of EXO1, RPA1, and prognosis in lung cancer patients whom received platinum-based chemotherapy. (hindawi.com)
  • 593 lung cancer patients were recruited in this study. (hindawi.com)
  • Rs1776148, rs1047840, and rs5030740 may act as prognosis markers in lung cancer patients with platinum-based chemotherapy. (hindawi.com)
  • And platinum-based chemotherapy still acted as the first-line treatment for lung cancer patients. (hindawi.com)
  • Thus, considering poor prognosis of lung cancer patients, it is crucial to find prognosis markers to develop predictive therapeutic methods. (hindawi.com)
  • found that high expression level of the EXO1 is associated with poor OS in breast and prostate cancer patients [ 26 , 27 ]. (hindawi.com)
  • After correcting the heterogeneity and horizontal pleiotropy, the results indicated that patients with SS were significantly associated with an increased risk of lymphomas (odds ratio [OR] = 1.0010, 95% confidence interval [CI]: 1.0005-1.0015, P = 0.0002) and reduced risks of prostate cancer (OR = 0.9972, 95% CI: 0.9960-0.9985, P = 2.45 × 10 −5 ) and endometrial cancer (OR = 0.9414, 95% CI: 0.9158-0.9676, P = 1.65 × 10 −5 ). (biomedcentral.com)
  • Epidemically, patients with Sjögren's syndrome history seemed to be under higher risks for developing certain cancers. (biomedcentral.com)
  • Lung cancer and obstructive pulmonary disease share multiple etiological factors, such as cigarette smoking, occupational inhalation hazards, and air pollution, and 50-70% of lung cancer patients present with co-existing COPD or airflow obstruction 6 . (nature.com)
  • Furthermore, reverse causality remains a concern since pulmonary symptoms may be early manifestations of lung cancer or acquired lung diseases in patients whose immune system has already been compromised by undiagnosed cancer. (nature.com)
  • As this research continues to develop and evolve, the enhanced use of precision oncology in cancer treatment ultimately aims to improve prognosis and outcomes for patients. (biomedcentral.com)
  • We analysed tumour and matched normal material from 230 previously untreated lung adenocarcinoma patients who provided informed consent ( Supplementary Table 1 ). (nature.com)
  • This is an autosomally dominant germline mutation in DNA mismatch repair (MMR) genes (MSH1, MSH2, MSH6) and accounts for 9% of patients younger than 50 years with endometrial cancer. (medscape.com)
  • We also introduce recent advances in the development of multi-omics algorithms and integration methods for multiple-layered datasets from cancer patients. (molcells.org)
  • Recent research has classified lung adenocarcinoma patients with KRAS mutation into three subtypes by co-occurring genetic events in TP53 (KP subgroup), STK11/LKB1 (KL subgroup) and CDKN2A/B inactivation plus TTF-1 low expression (KC subgroup). (cancerindex.org)
  • immunotherapy was associated with improved outcomes for patients with BRAF wildtype but not BRAF V600E variant brain metastases. (cdc.gov)
  • Archived (formalin-fixed paraffin-embedded) FFPE samples from thirty-three patients diagnosed with primary lung ASC underwent surgical resection at Shanghai Chest Hospital between 2017 and 2019 were involved. (springernature.com)
  • To evaluate the efficacy of EGFR TKIs in EGFR- mutant lung cancer patients, we included 160 LUAD, 52 ASC, and 65 LUSC patients who were treated with any EGFR-TKI monotherapy or combination therapies in the clinic. (springernature.com)
  • Race-Associated Genomic Correlates of Therapeutic Response in African American Patients With Non-Small-Cell Lung Cancer. (cdc.gov)
  • Clinicopathological features of this variant remain obscure, especially in Chinese patients. (biomedcentral.com)
  • The immune system produces systemic p53 autoantibodies (p53 Abs) in many cancer patients. (stanford.edu)
  • Conclusions and Relevance: This is the first meta-analysis proving the diagnostic utility of p53-Abs for cancer patients in predicting poorer outcomes. (stanford.edu)
  • Among all the female reproductive cancers, OC patients suffer from the worst prognosis with the highest mortality ( 2 ). (amegroups.org)
  • It was a Pilot study where biopsies from 55 fresh previously untreated lung cancer patients visiting the Pulmonary Medicine Department of Era's Lucknow Medical College and Hospital Lucknow and King George's Medical University were taken for 18 months November 2014-April 2016, after taking proper informed consent from them. (ijpmonline.org)
  • Despite a number of factors like the increasing numbers of new cases (171,600) per year, the large numbers of current and ex-smokers at risk in the United States (50 million each), position of lung cancer as a predominant cause of death among Americans (6%), and a constant 72% mortality rate among lung cancer patients, there is almost no strategy or research funding for this epidemic even in the developed world. (ijpmonline.org)
  • Salivary Gland Polymorphous Adenocarcinoma: Clinicopathological Features and Gene Alterations in 36 Japanese Patients. (nagoya-u.ac.jp)
  • Loss of epithelial proteins and/or acquisition of the expression of mesenchymal proteins were observed in lung adenocarcinoma. (biomedcentral.com)
  • Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)
  • Exposure to cigarette smoke, the primary risk factor in lung cancer, reduces epithelial barrier integrity and increases susceptibility to infections. (biomedcentral.com)
  • SS had significant causal relationships with lymphomas, prostate cancer, and endometrial cancer, and suggestive evidence of association was found in liver and bile duct cancer and cancer of urinary tract, indicating that SS may play a vital role in the incidence of these malignancies. (biomedcentral.com)
  • After doubling in the early 1970s, the incidence of uterine cancer has remained fairly constant. (medscape.com)
  • In low-income countries, it is one of the most common causes of cancer death with an incidence rate of 47.3 per 100,000 women. (wikipedia.org)
  • In China, gastric cancer remains a major health risk, ranking the second in cancer incidence and mortality with very poor prognosis [ 1 ]. (biomedcentral.com)
  • Background: In some settings, lung cancer incidence appears higher among disadvantaged groups. (who.int)
  • We analyzed the harmonized database of the Lung Cancer Cohort Consortium (LC3) to assess the relationship between socioeconomic status and lung cancer incidence across different world regions. (who.int)
  • Among current/former smoking participants, higher educational level was associated with decreased lung cancer incidence in nearly all cohorts. (who.int)
  • Invasive neoplasms of the female pelvic organs account for almost 15% of all cancers in women. (medscape.com)
  • Nonmesotheliomatous cancers of the pleura include an assortment of malignant neoplasms that primarily or secondarily involve pleura. (medscape.com)
  • These data have been combined with previously published LNET data to perform integrative analysis using multi-omics factor analysis (MOFA), resulting in a molecular map of lung neuroendocrine neoplasms for exploration. (who.int)
  • Despite some variants having only a slight effect on UBC risk, the interaction effect of combined genetic biomarkers-or even the presence of one copy of a variant allele-is potentially much greater. (omicsdi.org)
  • Acinar adenocarcinoma is a histological subtype of gland-forming cancer that is diagnosed when cuboidal and/or columnar shaped malignant cells in the neoplastic tissue form acini and tubules. (wikipedia.org)
  • In this study we comprehensively assess the shared genetic basis of impaired lung function and lung cancer risk by conducting genome-wide association analyses in the UK Biobank cohort to identify genetic determinants of three pulmonary phenotypes, forced expiratory volume in 1s (FEV 1 ), forced vital capacity (FVC), and FEV 1 /FVC. (nature.com)
  • Previous large observational cohort studies showed higher blood pressure (BP) positively associated with cancer. (biomedcentral.com)
  • Using lung tissue from 33 controls and 143 cancer cases, we conduct 16S ribosomal RNA (rRNA) bacterial gene sequencing, with RNA-sequencing data from lung cancer cases in The Cancer Genome Atlas serving as the validation cohort. (biomedcentral.com)
  • Inflammatory Drugs and Risk of Breast Cancer: Evidence from a General Female Population and a Mammographic Screening Cohort in Sweden. (cancercentrum.se)
  • Johnsson A, Kiani NA, Gernaat SAM, Wilking U, Shabo I, Hedayati E. Planning for return to work during the first year after breast cancer metastasis: A Swedish cohort study. (cancercentrum.se)
  • Schiza A, Fredriksson I, Sund M, Valachis A. De novo metastatic breast cancer in men vs women: a Swedish population-based cohort study. (cancercentrum.se)
  • Immunohistochemistry and electron microscopy are invaluable techniques for diagnosis and subclassification, but our intention was to render the classification simple and practical to every surgical laboratory, so that most lung tumours could be classified by light microscopic criteria. (ersjournals.com)
  • Most of this classification is based on the histological characteristics of tumours seen in surgical or needle biopsy, and is primarily based on light microscopy, although immunohistochemistry and electron microscopy findings are provided when necessary. (ersjournals.com)
  • Western blot analysis showed that stromal cells of lung tumours were characterised by a statistically considerably lower phrase level of the p16 proteins as likened with that in regular lung stromal cells. (immune-source.com)
  • Our lab has been involved in screening for genes that appear to be implicated in cancer development and metastases. (biomedfrontiers.org)
  • Endometrial cancer is one of the (less common) causes of cannonball metastases to the lung. (radiopaedia.org)
  • Lung cancer is currently the most frequently diagnosed major cancer and the most common cause of cancer mortality in males worldwide. (ersjournals.com)
  • Lung cancer is one of the major causes of cancer-related mortality worldwide. (hindawi.com)
  • Lung cancer is one of the most common diseases and one of the leading causes of cancer-related mortality in the world [ 1 ]. (hindawi.com)
  • The statistics estimated that about 1.8 million deaths are due to lung cancer, which accounted for 18.4% of total cancer mortality in 2018 [ 2 ]. (hindawi.com)
  • Lung cancer is the most commonly diagnosed cancer worldwide and the leading cause of cancer mortality 1 . (nature.com)
  • Lung cancer is the most common cause of global cancer-related mortality, leading to over a million deaths each year and adenocarcinoma is its most common histological type. (nature.com)
  • Epidemiologic evidence indicates that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer and that vitamin D supplementation is associated with decreased cancer mortality. (mdpi.com)
  • Expected scenarios for the reduction of mortality due to cervical cancer worldwide (and specially in low-income countries) have been reviewed, given assumptions with respect to the achievement of recommended prevention targets using triple-intervention strategies defined by WHO. (wikipedia.org)
  • Lung cancer is the leading cancer diagnosis worldwide (1.8 million/year) and has a higher mortality than that of the next top three cancers combined (158,080 vs 115,760 deaths) [ 1 ]. (biomedcentral.com)
  • The poorest outcomes of breast cancer seen in the region contrast with the lower mortality reported in developed countries. (ecancer.org)
  • Fifty-one percent of women had endometrial or ovarian cancer diagnosed first as the sentinel cancer. (medscape.com)
  • We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. (mdpi.com)
  • Ovarian cancer (OC) is one of the most lethal malignancies of women around the world. (amegroups.org)
  • EMT is known to be involved in the progression and metastasis of various cancers. (biomedcentral.com)
  • Finally, we summarize the latest findings from large-scale multi-omics studies of various cancers and their implications for patient subtyping and drug development. (molcells.org)
  • However, the association of genetic variants and gallbladder cancer risk in Indians are not well studied. (omicsdi.org)
  • Germline genetic the study of rare genetic variants. (who.int)
  • to identify individuals who are at high focus on identification of uncommon enough risk that they are likely to benefit or rare genetic variants that may have With the start of the new IARC Medium- from potential screening strategies. (who.int)
  • BACKGROUND: Small cell lung cancer (SCLC) is a highly aggressive entity of lung cancer with tendency toward early recurrence after first-line treatment. (bvsalud.org)
  • In 2011, we showed that RHAMM promotes metastasis of pancreatic cancer in mice. (biomedfrontiers.org)
  • Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. (cancerindex.org)
  • This is about 8% of the total cases and total deaths from cancer. (wikipedia.org)
  • About 70% of cervical cancers and 90% of deaths occur in developing countries. (wikipedia.org)
  • According to the World Health Organization statistical data, gastric cancer is the fifth most common cancer and the third leading cause of cancer-related deaths in the world [ 1 ]. (biomedcentral.com)
  • Lung cancer is the leading cancer diagnosis worldwide and the number one cause of cancer deaths. (biomedcentral.com)
  • Of late as per WHO Lung cancer deaths are declining in men, and the death rate in women has plateaued secondary to decreases in smoking. (ijpmonline.org)
  • [1] However, 9.3% of cancer-related deaths in both the sexes is still attributed to lung cancer. (ijpmonline.org)
  • Cancer is the second cause of death worldwide after hearth disease, accounting for more than 9 million deaths in 2018 [ 1 ]. (biomedcentral.com)
  • Breast cancer is a highly prevalent malignancy causing ≈45,000 deaths every year in women in Latin America (LATAM) and the Caribbean [ 33 ]. (ecancer.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • These large-scale high-throughput analytical methods have been applied to the identification of differential splicing events in cancer tissues [ 8 ]. (biomedcentral.com)
  • Leptin Receptor (LEPR) has been suggested to have several roles in cancer metastasis. (biomedcentral.com)
  • Metastasis from endometrial cancer to small bowel is very rare [ 3 ]. (karger.com)
  • In this report, we highlight an unusual site of metastasis of an endometrial adenocarcinoma to the small intestine. (karger.com)
  • Park H, Imoto S , Miyano S. Comprehensive information-based differential gene regulatory networks analysis (CIdrgn): Application to gastric cancer and chemotherapy-responsive gene network identification. (google.com)
  • Highest ranked abstract, 5th European Breast Cancer conference, Nice, France, 2006Nominated for RCPath's Gold and Specialty Medial Awards 2009. (nottingham.ac.uk)
  • In Europe, acinar adenocarcinoma may comprise the dominant architectural pattern in as many as 50-60% of all adenocarcinomas. (wikipedia.org)
  • Acinar adenocarcinoma of the lung is a highly lethal disease. (wikipedia.org)
  • Some studies suggest that the oncogenes H-ras and fes are important drivers of oncogenesis in many acinar-type lung cancers. (wikipedia.org)
  • Acinar adenocarcinomas are the most common form of prostate gland malignancy. (wikipedia.org)
  • Overall signature of acquired KRAS gene changes in advanced non-small cell lung cancer patient with EGFR-TKI resistance. (cdc.gov)
  • Influence of PD-L1 expression on the efficacy of EGFR-TKIs in EGFR-mutant non-small cell lung cancer. (cdc.gov)
  • A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
  • For example, cancer-related aberrantly spliced variants have been shown to be actively involved in the initiation and/or progression of some types of cancer [ 4 ]. (biomedcentral.com)
  • Recent studies have indicated that altered RON expression contributes significantly to cancer progression and malignancy. (spandidos-publications.com)
  • These inflammatory associated events have been proposed to lead to an increased risk or progression of diseases, including lung cancer. (biomedcentral.com)
  • Our findings are basis of proposing 2HF as therapeutic or preventative drug for lung cancer. (oncotarget.com)
  • The aim was to evaluate that whether EMT-related proteins' alterations are associated with clinicopathological features and prognosis in lung adenocarcinoma. (biomedcentral.com)
  • Genomic alterations in DNA repair genes also play a substantial role in response to chemotherapeutics underlying the genetics of multiple cancers, including breast, colorectal, ovarian, and lung cancer [ 11 - 13 ]. (hindawi.com)
  • Machine learning (ML) represents a powerful tool to capture relationships between molecular alterations and cancer types and to extract biological information. (biomedcentral.com)
  • In combination with histopathological examinations, this approach could improve cancer diagnosis by using specific DNA alterations, processed by a replicable and easy-to-use automated technology. (biomedcentral.com)
  • This large collection of datasets (genomic, transcriptomic, epigenomic data), profiled on multiple technological platforms, strongly reinforces the opportunity not only to improve the molecular alterations' understanding in human cancers, but also to refine the ability to diagnose, treat and prevent cancer in the era of precision medicine [ 2 ]. (biomedcentral.com)
  • Endometrial adenocarcinoma is the most common gynecologic malignancy in the United States. (medscape.com)
  • Cancer of the uterine corpus is the most common pelvic gynecologic malignancy in the United States and in most developed countries with access to sufficient health care. (medscape.com)
  • Endometrial cancer is the fourth most common cancer in females and is the most prevalent gynecological malignancy. (karger.com)
  • Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. (nature.com)
  • Disentangling the role of pulmonary impairment in lung cancer development is important from an etiological perspective, for refining disease susceptibility mechanisms, and for informing precision prevention and risk stratification strategies. (nature.com)
  • The aim was to evaluate changes in EMT-related protein and to investigate their association with clinicopathological parameters and prognosis in lung adenocarcinoma. (biomedcentral.com)
  • [ 5 ] An earlier report, in 1956, by Babolini and Blasi, described the same clinicopathological entity using the nomenclature, "The pleural form of primary cancer of the lung. (medscape.com)
  • These findings support a causal role of pulmonary impairment in lung cancer etiology. (nature.com)
  • Integrative analyses reveal that pulmonary function instruments, including 73 novel variants, influence lung tissue gene expression and implicate immune-related pathways in mediating the observed effects on lung carcinogenesis. (nature.com)
  • We examine the genetic correlation between pulmonary function phenotypes and lung cancer, followed by Mendelian randomization (MR) using novel genetic instruments to formally test the causal relevance of impaired pulmonary function, using the largest available dataset of 29,266 lung cancer cases and 56,450 controls from the OncoArray lung cancer collaboration 16 . (nature.com)
  • Even the presence of one copy of a variant allele in the CYP1A1 gene can predispose CRC risk. (omicsdi.org)
  • Association of two obesity-related gene polymorphisms LEPG2548A rs7799039 and LEPRQ223R rs1137101 with the risk of breast cancer. (cdc.gov)
  • Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer. (cdc.gov)
  • Association of Single Nucleotide Polymorphism -2548 G/A (rs12112075) of leptin gene with endometrial cancer and uterine leiomyomas. (cdc.gov)
  • Although some of the observed variants, such as chondroid meningiomas, clear-cell meningiomas, papillary meningiomas, and rhabdoid meningiomas, are associated with unfavorable prognoses, the other histologic patterns are not indicators of unfavorable biologic behavior. (medscape.com)
  • Precision oncology has made progress in leaps and bounds in recent years and is currently at the heart of revolutionizing cancer research. (biomedcentral.com)
  • The Cancer Moonshot Immuno-Oncology Translational Network (IOTN) at age 5: Accelerating Cancer Immunotherapies. (cdc.gov)
  • More regional cancer genomic initiatives and public availability of this data are needed in order to develop more precise oncology in locally advanced breast cancer. (ecancer.org)
  • Mendelian randomization (MR) method was used to investigate the causality between SS and different types of cancers. (biomedcentral.com)
  • We conducted the two-sample Mendelian randomization with the public genome-wide association studies (GWASs) summary statistics in European population to evaluate the causality between SS and nine types of cancers. (biomedcentral.com)
  • However, the associations between SS and other types of cancers were controversial. (biomedcentral.com)
  • We summarize new insights by IOTN researchers, some of which are ripe for translation for several types of cancers. (cdc.gov)
  • Outcomes, however, depend very much on how early the cancer is detected. (wikipedia.org)
  • The IOTN is focused on accelerating translation of cancer immunology research from bench to bedside and improving immunotherapy outcomes across a wide array of cancers. (cdc.gov)
  • Whereas pleural mesothelioma is highly associated with asbestos exposure , nonmesotheliomatous cancers have generally not been proven to result from exposure to airborne asbestos. (medscape.com)
  • Overlapping lung and pleural involvement in individual cases has given rise to the more inclusive term "pleuropulmonary" synovial sarcoma. (medscape.com)
  • Our results show that 2HF induced apoptosis in both histological types of lung cancer and inhibited proliferation and growth through suppression of CDK4, CCNB1, PIK3CA, AKT and RPS6KB1 (P70S6K) signaling. (oncotarget.com)
  • There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)
  • It has been 17 years since the World Health Organization (WHO) classification was updated in 1981 1 , and since this time considerable progress has been made in understanding the epidemiological histogenetic and molecular biology of lung cancer. (ersjournals.com)
  • We explored whether allelic variants of the GSTM1, GSTT1, CYP450 (rs4646903 and rs1048943), and TP53 (rs1042522) genes predisposed nonsmoking Saudi individuals to increased risk for CRC. (omicsdi.org)
  • The GSTM1 and TP53 rs1042522 variants can increase the development of CRC in Saudi nonsmokers. (omicsdi.org)
  • However, abnormal expression or aberrant activation of these molecules may convert normal growth signals to undesirable signals inducing overgrowth, becoming an important contributor to a variety of human cancers. (medsci.org)