AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth CareGeographicals
AdenocarcinomaLung NeoplasmsCarcinoma, Non-Small-Cell LungLungAdenocarcinoma, MucinousPrognosisNeoplasm StagingCarcinoma, Small CellTumor Markers, BiologicalAdenocarcinoma, Clear CellOvarian NeoplasmsImmunohistochemistryCarcinoma, Squamous CellStomach NeoplasmsGene Expression Regulation, NeoplasticAdenocarcinoma, Bronchiolo-AlveolarCarcinoma, EndometrioidSurvival AnalysisSurvival RateCell Line, TumorPancreatic NeoplasmsLung DiseasesRetrospective StudiesEsophageal NeoplasmsSmokingNeoplasm InvasivenessEndometrial NeoplasmsAntineoplastic AgentsNeoplasm MetastasisAntineoplastic Combined Chemotherapy ProtocolsRisk FactorsSmall Cell Lung CarcinomaCystadenocarcinoma, SerousColonic NeoplasmsNeoplasm ProteinsDNA, NeoplasmBreast NeoplasmsCase-Control StudiesDisease-Free SurvivalTreatment OutcomeEarly Detection of CancerReverse Transcriptase Polymerase Chain ReactionGene Expression ProfilingMutationTissue Array AnalysisAdenocarcinoma, PapillaryCarcinomaCarcinoma, Pancreatic DuctalRNA, MessengerFollow-Up StudiesKidney NeoplasmsProstatic NeoplasmsKaplan-Meier EstimateDisease ProgressionTumor Cells, CulturedSarcomaNeoplasm Recurrence, LocalMice, NudeCarcinoma, Large CellReceptor, Epidermal Growth FactorCisplatinBarrett EsophagusGenetic Predisposition to DiseaseLymphoma, Non-HodgkinCombined Modality TherapyImmunoenzyme TechniquesMesotheliomaProspective StudiesIncidenceLiposarcomaCarcinoma, AdenosquamousNeoplasmsCell ProliferationLung InjuryTumor Suppressor Protein p53Drug Resistance, NeoplasmOligonucleotide Array Sequence AnalysisRiskPneumonectomyMultivariate AnalysisAntigens, NeoplasmOdds RatioPolymerase Chain ReactionPleural NeoplasmsGenotypeAge FactorsTumor BurdenTomography, X-Ray ComputedDNA MethylationNeoplasm GradingSensitivity and SpecificityTime FactorsSEER ProgramCardiaQuinazolinesCarcinoma, VerrucousUterine Cervical NeoplasmsNeoplasms, Glandular and EpithelialUnited StatesCohort Studies
NSCLCTumorsTumorCarcinomaLUADHistologic SubtypesIncidenceDifferent histological subtypesMortalityColorectalInternational Multidisciplinary Classification of Lung AdenocarcinomaBiomarkersDiagnosisMalignanciesMethodsHistologyPrognosticOncologyEpidemiologicalMinimally invasive lungTissuesCarcinomasNeoplasmsPathologyInvasiveRecurrenceChemotherapyCharacteristicsMetastasisPathologicalPancreatic cancer2023MucinousEarly-stage adenocarcinomaPredominantPatients with lung adenocarcinoma2021MetastasesPulmonaryComputed tomography2020TissueCommonFrequentLesionsHuman lungPleuralClassificationBiliary tractTranscriptomeOncogenicSurvivalEndometrialEpidemiology2016Surgically resectedCause of lung cancerArchetypesEpithelialClinicopathologicalSurgical resectionGeneDeathsGastric
NSCLC27
  • BACKGROUND: Non-small cell lung cancer (NSCLC) is heterogeneous. (bvsalud.org)
  • Molecular subtyping based on the gene expression profiles is an effective technique for diagnosing and determining the prognosis of NSCLC patients. (bvsalud.org)
  • METHODS: Here, we downloaded the NSCLC expression profiles from The Cancer Genome Atlas and the Gene Expression Omnibus databases. (bvsalud.org)
  • Furthermore, we identified two NSCLC molecular subtypes yielding a significantly distinctive prognosis. (bvsalud.org)
  • Lobectomy remains the standard treatment for early-stage non-small cell lung cancer (NSCLC).In practice, however, sublobar resection has been selectively offered for patients with clinical Stage IA NSCLC as curative treatment. (iaslc.org)
  • To seek optimal surgical procedure for early stage lung cancer, we carried out retrospective analyses of 2122 patients who had undergone limited resection for c-T1N0M0 NSCLC from 26 institutions of Japanese association for chest surgery. (iaslc.org)
  • It has been seen that ALDH1 expression in non-small cell lung cancer (NSCLC) and the presence of marker was linked to a more tumorigenic potential in the in vivo assessment and shorter disease-free survival in NSCLC patients with platinum treatment. (ijpmonline.org)
  • Screening in high-risk smokers results in a reduction in lung cancer mortality, however, screening efforts are primarily focused on non-small cell lung cancer (NSCLC). (frontiersin.org)
  • Lung cancers are histologically classified as Small Cell Lung Cancer (SCLC) or Non-Small Cell Lung Cancer (NSCLC). (frontiersin.org)
  • Background: Non-small cell lung cancer (NSCLC) comprises the majority (~85%) of all lung tumors, with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being the most frequently diagnosed histological subtypes. (houstonmethodist.org)
  • Functional studies in non-small cell lung cancer (NSCLC) patients revealed that hyperactivation of the NF-E2-related factor 2 (Nrf2) pathway facilitates tumor growth. (oncotarget.com)
  • Non-small cell lung cancer (NSCLC) accounts for 85% to 90% of total pulmonary malignancies [ 1 ], and it is the most lethal cancer worldwide [ 2 ]. (oncotarget.com)
  • Cigarette smoking is a strong risk factor for developing non-small cell lung cancer (NSCLC). (biomedcentral.com)
  • The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these biomarkers in primary tumor tissue from NSCLC patients. (uit.no)
  • Non-small cell lung cancer (NSCLC) accounts for 70%-80% in lung cancer, and among them, lung adenocarcinoma (LAD) accounting for almost half of lung cancers, was one of the most common histologic subtype. (biomedcentral.com)
  • Non-small cell lung cancer (NSCLC) is currently the leading cause of cancer-related deaths worldwide and represents an incredibly challenging problem for clinicians. (amegroups.org)
  • This retrospective study evaluated patients with stage I-III NSCLC selected from the LACE-Bio database composed of 4 large cohorts-this includes the International Adjuvant Lung Cancer Trial ( 13 ), JBR.10 ( 14 ), Adjuvant Navelbine International Trialist Association ( 15 ), and Cancer and Leukemia Group B/Alliance for Clinical Trials in Oncology ( 16 ). (amegroups.org)
  • To profile genomic and epigenomic of a naïve Chinese non-small cell lung cancer (NSCLC) cohort and investigate the association between tumor mutation burden (TMB) and DNA methylation (DNAm) to explore potential alternative/complimentary biomarkers for NSCLC immunotherapies. (biomedcentral.com)
  • Approximately 85% of lung cancer cases are non-small cell lung cancer (NSCLC) [ 2 ]. (biomedcentral.com)
  • More oddly enough, in lung adenocarcinoma, a histological subtype of NSCLC, high HDAC1 appearance continues to be correlated with poor prognosis, a lesser differentiation quality, and decreased five-year disease-free success price15C18. (iassist2012.org)
  • In recent years, there has been a major paradigm shift in the management of non-small cell lung cancer (NSCLC). (amegroups.org)
  • In this review, we will examine the major subtypes of oncogenic drivers behind NSCLC as well as the development of targeted agents available to treat them both now and in the foreseeable future. (amegroups.org)
  • Over the last decade, molecular translational research advances have heralded major breakthroughs in the understanding, diagnosis and management of lung cancer, particularly for the more common (~80%) non-small cell lung cancer (NSCLC). (amegroups.org)
  • This distinction alone allows for a more tailored selection of cytotoxic chemotherapy in advanced NSCLC without a driver mutation, as seen with enhanced efficacy with pemetrexed in adenocarcinoma ( 14 , 15 ) or the toxicity concerns of bevacizumab in patients with squamous histology ( 16 ). (amegroups.org)
  • In this review, we will examine the major subtypes of driver mutations that have been identified in NSCLC and relevant targeted therapies available both now, and in the foreseeable future. (amegroups.org)
  • The traditional and now over-simplified histological distinctions within NSCLC include adenocarcinoma, SCC and large cell carcinoma ( Figure 1 ). (amegroups.org)
  • In comparison ligand-dependent autocrine and paracrine signaling offers a mechanism that's unbiased of somatic mutation and continues to be confirmed by our group in both non-small cell lung cancers (NSCLC) and HNSCC (35 36 Herein we demonstrate that FGFR1 is normally co-expressed with FGF2 within a subset of MPM cell lines. (cancerrealitycheck.com)
Tumors15
  • Lung adenocarcinoma (LUAD) is one of the malignant lung tumors. (hindawi.com)
  • Lung cancer is one of the malignant tumors for which no effective cure has been found so far. (hindawi.com)
  • We collected 76 surgically resected primary tumors of invasive lung adenocarcinoma, including 51 IMA and 25 non-mucinous adenocarcinomas (non-IMA). (figshare.com)
  • Methods: We integrated transcriptomics and metabolomics to analyze 30 human lung tumors and adjacent noncancerous tissues. (houstonmethodist.org)
  • Expression levels of S100A4 and ephrin-A1 were significantly higher in adenocarcinomas compared to other histological subtypes, and S100A4-positive tumors were smaller and more differentiated than tumors without expression. (uit.no)
  • Is the Subject Area "Lung and intrathoracic tumors" applicable to this article? (plos.org)
  • Solid predominant tumors are associated with higher incidence of early recurrence at distant sites in addition to having worse prognosis among stage I lung ADC patients ( 10 ). (amegroups.org)
  • Finally, the cell line with the paradigmatic SMARCA4-dUT markers was engrafted into immunocompromised mice to assess the histological morphology of the formed tumors and compare them with those formed by a bona fide LUAD cancer cell line. (ugr.es)
  • The upsurge in FGFR1 gene duplicate number is particularly highly relevant to lung cancers and acts as the main element biomarker for affected individual recruitment to two open up studies of FGFR-specific TKIs in solid tumors (NCT01004224 and NCT00979134). (cancerrealitycheck.com)
  • Due to the heterogeneous nature of tumors, molecular profiling is crucial to our understanding of how genomics plays a role in the cause or development of an individual cancer. (biomedcentral.com)
  • Tumors or cancer of the MOUTH. (lookformedical.com)
  • Tumors or cancer of the SKIN . (lookformedical.com)
  • Tumors or cancer of the LUNG. (lookformedical.com)
  • Tumors or cancer of the LIVER. (lookformedical.com)
  • Tumors or cancer of the UTERINE CERVIX. (lookformedical.com)
Tumor34
  • Mesothelioma that affects the pleura can cause these signs and symptoms: Chest wall pain Pleural effusion, or fluid surrounding the lung Shortness of breath - which could be due to a collapsed lung or the pleural effusion Fatigue or anemia Wheezing, hoarseness, or a cough Blood in the sputum (fluid) coughed up (hemoptysis) In severe cases, the person may have many tumor masses. (wikipedia.org)
  • Our observations indicate that induction of NY-ESO-I autoantibodies depends on the histological subtype within a given tumor entity. (nih.gov)
  • MDSC and TGFβ are required for facilitation of tumor growth in the lungs of mice exposed to carbon nanotube s. (cdc.gov)
  • This suggests the emergence of new etiological factors and mechanisms including those defining the lung microenvironment, promoting tumor growth. (cdc.gov)
  • Assuming that the lung is the main portal of entry for broadly used nanomaterial s and their established proinflammatory propensities, we hypothesized that nanomaterial s may contribute to changes facilitating tumor growth. (cdc.gov)
  • Here, we report that an acute exposure to single-walled carbon nanotube s (SWCNT) induces recruitment and accumulation of lung-associated myeloid-derived suppressor cells (MDSC) and MDSC-derived production of TGFβ, resulting in upregulated tumor burden in the lung. (cdc.gov)
  • Enrollment required patients with a tumor ≤ 2 cm in diameter, diagnosed or suspected as a clinical T1N0M0 carcinoma in the lung periphery based on a CT scan. (iaslc.org)
  • DM: maximum tumor diameter on mediastinal settings, DL: maximum tumor diameter on lung settings). (iaslc.org)
  • There was no clear correlation between tumor size, TDR, and Noguchi subtype. (iaslc.org)
  • Sequence alterations are abundant in cancer genomes but the proportion of fragments in cell-free DNA (cfDNA) that harbor tumor-specific (somatic) mutations is often low 8 , 9 , making it difficult to detect bona fide variants amidst background noise from sequence changes introduced in library construction and sequencing. (nature.com)
  • In principle, if mutations could be identified in cfDNA without knowledge of alterations in the tumor, then they could be useful for early cancer detection. (nature.com)
  • In India, lung carcinoma is the fifth-most common tumor and second-most common tumor in the males as per the Indian Council of Medical Research registry of 2002. (ijpmonline.org)
  • Since tumor metastasis is the main obstacle for long-term survival after surgical resection, identification of molecular markers related to metastasis may better predict the prognosis in patients with lung adenocarcinoma. (biomedcentral.com)
  • These vesicles are constitutively secreted by all cell types and EVs released from cancer cells can functionally alter recipient cells by reprogramming them to become active contributors to tumor growth, metastasis, and immunosuppression ( 10 ). (frontiersin.org)
  • Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
  • Primary tumor tissues of lung adenocarcinoma (ADC) ( n = 26) and squamous cell carcinoma (SQCC) ( n = 18) obtained from surgery were assigned to subgroups according to the patient's smoking status. (biomedcentral.com)
  • The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma. (cdc.gov)
  • Despite recent progress and development of surgical techniques and minimally invasive approaches, approximately 40% of lung ADC patients experience tumor recurrence and death following complete resection ( 3 , 4 ). (amegroups.org)
  • The World Health Organization's tumor classification guidelines are frequently updated and renewed as knowledge of cancer biology advances. (ugr.es)
  • For instance, in 2021, a novel lung tumor subtype named SMARCA4-deficient, undifferentiated tumor (SMARCA4-dUT, code 8044/3) was included. (ugr.es)
  • As this tumor type was recently described, it is feasible that some cell models formerly classified as lung adenocarcinoma (LUAD) could now be better classified as SMARCA4-dUT. (ugr.es)
  • However, so far, not all lung cancer patients give an effective clinical response to ICI therapy even the positive PD-L1 expression in tumor tissue [ 14 ]. (biomedcentral.com)
  • Considering that HDAC1 overexpression and EGFR activity are related to tumor development and cancers cell success highly, HDAC1 tyrosine phosphorylation may present a feasible target to control HDAC1 protein amounts in potential potential cancers treatment strategies. (iassist2012.org)
  • Carcinogen Metabolism Pathway and Tumor Suppressor Gene Polymorphisms and Gallbladder Cancer Risk in North Indians: A Hospital-Based Case-Control Study. (omicsdi.org)
  • BACKGROUND:Carcinogen metabolism pathway and tumor suppressor gene polymorphisms have been reported to be associated with increased gallbladder cancer risk. (omicsdi.org)
  • We examined whether genetic polymorphisms of metabolic enzymes cytochrome P450 1A1 and glutathione S-transferase and tumor suppressor gene p53 (TP53) are associated with an increased risk of gallbladder cancer in North Indians. (omicsdi.org)
  • Chromosomal translocations in FGFR genes are also observed in several malignancies (29 30 Amplification of FGFR2 is often observed in gastric malignancies and FGFR1 in breasts cancer tumor squamous cell lung malignancies and HNSCC (FGFR1) (31-34). (cancerrealitycheck.com)
  • Such tumor profiles can subsequently be applied to exclusively tailor cancer therapies to directly target a causative mutation for a malignancy, ultimately achieving a personalized and precise approach to cancer treatment. (biomedcentral.com)
  • It focuses on how precision oncology has shaped advances in the impact of non-coding RNAs in epigenetics and cancer, immunotherapy and tumor biology, and the clinical significance of various therapies in a range of cancers. (biomedcentral.com)
  • HRCT signs of lung adenocarcinoma are closely related to the pathological subtype and differentiation degree and have great value in helping predict tumor types and devise clinical treatment plans. (ijrr.com)
  • Comprehensive analysis of tumor mutation burden and immune microenvironment in prostate cancer. (cdc.gov)
  • To identify operable lung cancer patients with risk for metastatic relapse we search for new prognostic biomarkers based on analysis of genome-wide gene expression data and conventional protein marker validation based on analysis of primary tumor tissue. (lu.se)
  • By analysis of patient specific alterations in circulating tumor DNA in blood samples we aim to establish blood-based assays for early detection of lung cancer, treatment monitoring, and early detection of relapse in the primary and advanced setting. (lu.se)
  • Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival. (cancercentrum.se)
Carcinoma22
LUAD5
  • Despite the availability of various therapies including surgery, radiation, and targeted therapies, unfortunately, there are significant barriers to effective treatment of LUAD and an overall survival of less than five years in patients with lung adenocarcinoma [ 3 ]. (hindawi.com)
  • The current study aims to construct a robust ferroptosis-related lncRNAs signature to increase the predicted value of lung adenocarcinoma (LUAD) by bioinformatics analysis. (researchsquare.com)
  • Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer and accounts for approximately 40% of all lung cancer cases. (aging-us.com)
  • Lung adenocarcinoma (LUAD) is the most common histological type of lung cancer and has the highest cancer mortality rate worldwide [ 1 ]. (aging-us.com)
  • Recently, next-generation sequencing, especially single-cell RNA sequencing is a possible option for the analysis of detailed cell population subtypes of LUAD from bulk tissue samples at single cell level [ 10 , 11 ]. (aging-us.com)
Histologic Subtypes3
  • The majority of invasive ADCs are heterogenous with several histologic subtypes presenting simultaneously ( 7 ). (amegroups.org)
  • Although it has been shown that histologic subtypes can be used to stratify surgically resected patients into prognostic groups, its value in determining the survival benefit of chemotherapy has yet to be established. (amegroups.org)
  • Other histologic subtypes include adenosquamous, clear cell, and papillary serous carcinomas. (medscape.com)
Incidence15
  • Rationale Exposure to ambient air pollutants has been associated with increased lung cancer incidence and mortality, but due to the high case fatality rate, little is known about the impacts of air pollution exposures on survival after diagnosis. (bmj.com)
  • SS had significant causal relationships with lymphomas, prostate cancer, and endometrial cancer, and suggestive evidence of association was found in liver and bile duct cancer and cancer of urinary tract, indicating that SS may play a vital role in the incidence of these malignancies. (biomedcentral.com)
  • To address these challenges, we developed an approach, called GEnome-wide Mutational Incidence for Non-Invasive detection of cancer (GEMINI), that can identify a much larger number of somatic alterations in cfDNA (Fig. 1 ). (nature.com)
  • The lung cancer has an increased incidence and is associated with the highest death by cancer worldwide. (umbalk.org)
  • The incidence of lung cancer is increasing, especially in centers without screening programs. (umbalk.org)
  • Moreover, there is now a convergence between lung cancer incidence in the youngest birth cohorts, reflecting the convergence in cigarette use in males and females.6 In Europe, about 70% of lung cancer cases in females are attributed to an active smoking habit versus 85% in males, 7 whereas in Asia very few lung cancer cases in females are attributable to tobacco smoking. (touchoncology.com)
  • Even if the incidence of lung cancer in male non-smokers is consistently higher than in female non-smokers,8 the proportion of non-smokers in females with lung cancer is rather significant compared with males in all studies. (touchoncology.com)
  • A new study - a collaboration between IARC - International Agency for Research on Cancer / World Health Organization and Guangdong Medical College (China) - quantifies for the first time the global burden of lung cancer incidence for the four main histological subtypes, documenting the substantial variations across world regions and their constituent countries. (oncodaily.com)
  • Epidemiological studies have shown a clear link between breathing high concentrations of radon and incidence of lung cancer . (knowpia.com)
  • In low-income countries, it is one of the most common causes of cancer death with an incidence rate of 47.3 per 100,000 women. (wikipedia.org)
  • As the forecasted occurrence of MPM (2 0 to 3 0 situations each year) may possess peaked in america incidence is normally expected to continue steadily to boost worldwide because of variable asbestos legislation (1 3 Three histological subtypes of MPM have already been described VTX-2337 epithelioid sarcomatoid and biphasic (blended). (cancerrealitycheck.com)
  • After doubling in the early 1970s, the incidence of uterine cancer has remained fairly constant. (medscape.com)
  • Background: In some settings, lung cancer incidence appears higher among disadvantaged groups. (who.int)
  • We analyzed the harmonized database of the Lung Cancer Cohort Consortium (LC3) to assess the relationship between socioeconomic status and lung cancer incidence across different world regions. (who.int)
  • Among current/former smoking participants, higher educational level was associated with decreased lung cancer incidence in nearly all cohorts. (who.int)
Different histological subtypes2
  • During last decades, changes have been observed in the frequency of different histological subtypes of lung cancer, one of the most common causes of morbidity and mortality, with a declining proportion of squamous cell carcinomas and an increasing proportion of adenocarcinomas, particularly in developed countries. (cdc.gov)
  • The aim of this study is to detect the expression of Notch-1 and analyze its clinicopathological or prognostic significance in different histological subtypes of Lung Adenocarcinomas (LADs). (biomedcentral.com)
Mortality10
  • Due to the fact that most lung cancers are diagnosed as advanced after regional or distant spread of the malignancy, this disease has a high mortality rate worldwide [ 2 ]. (hindawi.com)
  • Lung cancer is currently the most frequently diagnosed major cancer and is the leading cause of cancer-related mortality in both men and women worldwide [1]. (who.int)
  • Most human mortality associated with cancer is a consequence of diagnosis at late stages, when therapies are less effective 1 . (nature.com)
  • Despite a number of factors like the increasing numbers of new cases (171,600) per year, the large numbers of current and ex-smokers at risk in the United States (50 million each), position of lung cancer as a predominant cause of death among Americans (6%), and a constant 72% mortality rate among lung cancer patients, there is almost no strategy or research funding for this epidemic even in the developed world. (ijpmonline.org)
  • Low-dose computed tomography (LDCT) screening among high-risk populations remains an effective strategy for curbing mortality, with an observed 20% reduction in lung cancer-associated mortality ( 3 ). (frontiersin.org)
  • 2 In females, mortality due to lung cancer has been greater than mortality due to breast cancer since 1987. (touchoncology.com)
  • While stabilisation or even a decrease in the number of lung cancers in males is emerging in most European countries, mortality due to lung cancer in females is increasing. (touchoncology.com)
  • Multiple distant metastases are the major cause of mortality in lung cancer. (aging-us.com)
  • Expected scenarios for the reduction of mortality due to cervical cancer worldwide (and specially in low-income countries) have been reviewed, given assumptions with respect to the achievement of recommended prevention targets using triple-intervention strategies defined by WHO. (wikipedia.org)
  • Lung cancer remains by far the single most common cause of cancer-related mortality with nearly 1.6 million deaths worldwide in 2012 or nearly 20% of cancer mortality as a whole ( 1 ). (amegroups.org)
Colorectal12
  • Investigators wanted to analyze the diagnostic performance of methylation-sensitive restriction enzyme digestion followed by sequencing using cell-free DNA and explore the cancer signal origin of the cancer using DNN analyses for colorectal and lung cancers. (ajmc.com)
  • Methylation-sensitive restriction enzyme digestion followed by sequencing (MRE-Seq) was found to be an advantageous method for identifying global hypomethylation patterns in liquid biopsy samples and precisely diagnosing colorectal and lung cancers , as well as determining the cancer signal origin (CSO) of the cancer using deep neural network (DNN) analysis, according to Scientific Reports . (ajmc.com)
  • The aim of this study was to analyze the diagnostic performance of MRE-Seq using cfDNA and explore the cancer signal origin (CSO) of the cancer using DNN analyses on liquid biopsy of colorectal and lung cancers. (ajmc.com)
  • A total of 191 patients with stage I-IV cancers (95 lung cancers and 96 colorectal cancers) and 126 participants who did not have cancer were enrolled in this study. (ajmc.com)
  • The CSO model's true-positive rates were 94.4% for colorectal cancers and 89.9% for lung cancers. (ajmc.com)
  • The general accuracy of the liquid biopsy method was observed to be lower for lung vs colorectal cancer, probably because of the greater diversity of histological subtypes and larger differences in DNA methylation patterns in lung cancer compared with colorectal cancer. (ajmc.com)
  • Targeted next-generation sequencing (NGS) technology detects specific mutations that can provide treatment opportunities for colorectal cancer (CRC) patients. (preprints.org)
  • Molecular heterogeneity is one of the most important concerns in colorectal cancer (CRC), which results in a wide range of therapy responses and patient prognosis. (biomedcentral.com)
  • It is the fourth most common cancer, accounting for 7% of female cancers, following breast, lung, and colorectal cancer. (medscape.com)
  • Another group of women at increased risk of premenopausal endometrial cancer are those with Lynch II syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). (medscape.com)
  • BACKGROUND: Colorectal cancer (CRC) is the fourth most common cancer in Nigeria, and it affects mostly persons in their middle age. (bvsalud.org)
  • OBJECTIVES: To evaluate the expression of COX-2 and HER2 and determine their correlation with clinicopathologic parameters in surgically resected histologically diagnosed cases of colorectal cancer. (bvsalud.org)
International Multidisciplinary Classification of Lung Adenocarcinoma2
  • According to the International Multidisciplinary Classification of Lung Adenocarcinoma (LAD) by International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) in 2011, the diagnosis of LAD is changing from simple morphology into a comprehensive multidisciplinary classification. (biomedcentral.com)
  • 2011) International association for the study of lung cancer/American thoracic society/European respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary. (ijrr.com)
Biomarkers9
  • Despite previous genomic studies on lung IMA, the genetic characteristics and the prognosis-related biomarkers in Chinese surgically resected lung IMA remain unclear. (figshare.com)
  • Advancements in technology such as proteomics, genomics have led to the concept of personalized medicine wherein the integration of biomarkers into clinic directs cancer therapeutics. (scirp.org)
  • In this review, we will look at the biomarkers that prove to be valuable tools for the personalization of cancer therapeutics among lung and breast cancer patients. (scirp.org)
  • HER2 positive breast tumours now carry a much better survival owing to the identification of the biomarker signifying the pivotal nature of biomarkers in cancer therapeutics. (scirp.org)
  • Consequently, novel objective biomarkers that reflect postoperative risk in lung cancer patients who smoke must be identified. (biomedcentral.com)
  • From our data, we propose three PC isomers, PC (14:0_18:2), PC (16:1_16:1), and PC (16:0_16:2), and a lipid peak of m/z 736.5276 as novel candidate biomarkers for postoperative recurrence risk in lung ADC and SQCC patients who are smokers. (biomedcentral.com)
  • With the recent advancements in mass spectrometry technology, lipidomics has been utilized as a new field for exploring cancer biomarkers [ 12 ]. (biomedcentral.com)
  • Specific lipids in cancer tissues have been reported as potential biomarkers reflecting patient prognosis and the risk of postoperative recurrence. (biomedcentral.com)
  • 2015) Variation in the expression levels of predictive chemotherapy biomarkers in histological subtypes of lung adenocarcinoma: an immunohistochemical study of tissue samples. (ijrr.com)
Diagnosis17
  • The diagnosis may be suspected based on chest X-ray and CT scan findings, and is confirmed by either examining fluid produced by the cancer or by a tissue biopsy of the cancer. (wikipedia.org)
  • In recent years, gene expression profiling chips have been widely used in the research fields of various diseases to reveal the association between diseases and genes and provide valuable clues for the pathogenesis of diseases to determine the diagnosis and prognosis of cancer [ 5 ]. (hindawi.com)
  • Conclusions These epidemiological findings support the hypothesis that air pollution exposures after lung cancer diagnosis shorten survival. (bmj.com)
  • Does exposure to ambient air pollution after diagnosis of lung cancer affect survival? (bmj.com)
  • Patients with lung cancer, with higher average ambient NO 2 , PM 2.5 and PM 10 exposures since diagnosis, had shorter survival, with the largest differences in survival for patients with early-stage non-small cell cancers (particularly adenocarcinomas). (bmj.com)
  • This is the first study to link individual-level estimates of air pollution exposures after lung cancer diagnosis to survival, and the study population was the population-based sample of 352 053 patients with newly diagnosed lung cancer during 1988-2009 in California, as ascertained by the California Cancer Registry. (bmj.com)
  • Liquid biopsy has shown potential for early cancer detection and diagnosis. (ajmc.com)
  • Additionally, it may be possible to create more accurate and specific liquid biopsy methods for cancer diagnosis by analyzing the methylation patterns of cancer and benign disease samples. (ajmc.com)
  • The study highlights the potential of liquid biopsy methods for improving cancer diagnosis and detection, suggesting that further development and validation of these methods could have important implications for improving cancer survival and quality of life," concluded the study authors. (ajmc.com)
  • Somatic mutations are a hallmark of tumorigenesis and may be useful for non-invasive diagnosis of cancer. (nature.com)
  • Immunohistochemistry and electron microscopy are invaluable techniques for diagnosis and subclassification, but our intention was to render the classification simple and practical to every surgical laboratory, so that most lung tumours could be classified by light microscopic criteria. (ersjournals.com)
  • Small cell lung cancer (SCLC) is characterized by poor prognosis and challenging diagnosis. (frontiersin.org)
  • Notch-1 could be used as a predictable biomarker to be detected in different pathological and histological subtypes in LAD for diagnosis or prognosis. (biomedcentral.com)
  • Despite the development of diagnosis, surgery, and chemotherapy during the last decade, GBC remains an aggressive cancer with an overall dismal outcome [ 2 ]. (medsci.org)
  • While endometrial cancer affects reproductive age as well as postmenopausal women, 75% of endometrial cancers occur in postmenopausal women, with the mean age of diagnosis at 61 years. (medscape.com)
  • Methods We estimated costs (personnel, location, consumables and indirect) and time involved in breast cancer diagnosis at the Butaro Cancer Centre of Excellence, Rwanda, using time-driven activity-based costing. (bvsalud.org)
  • Findings We estimated that breast cancer diagnosis in Rwanda costs 138.29 United States dollars (US$) per patient when conducting biomarker analysis by immunohistochemistry. (bvsalud.org)
Malignancies5
  • The cancer-associated antigen NY-ESO-1 is expressed in a number of malignancies of different histological type. (nih.gov)
  • Liquid biopsies may overcome these challenges and provide an attractive approach for the non-invasive detection of lung cancer and other malignancies. (nature.com)
  • The most common category of nonmesotheliomatous cancer to involve the pleura is represented by extrapleural primary malignancies that secondarily involve the pleura via metastatic spread. (medscape.com)
  • Activating mutations take place in FGFR2 and FGFR3 resulting in constitutive dimerization in bladder endometrial and squamous cell lung malignancies (26-28). (cancerrealitycheck.com)
  • The most common of these malignancies is uterine cancer. (medscape.com)
Methods4
  • The bioinformatics methods are widely used to study lung adenocarcinoma, and MCODE [ 6 ] is used to build clustering in the vast network of gene function modules. (hindawi.com)
  • Methods Participants were 352 053 patients with newly diagnosed lung cancer during 1988-2009 in California, ascertained by the California Cancer Registry. (bmj.com)
  • METHODS:This hospital-based case-control study was conducted in 96 gallbladder cancer patients with gallstones (cases) and 93 cholelithiasis patients (controls) at the Sanjay Gandhi Postgraduate Institute of Medical Sciences in Lucknow, India from July 2014 through May 2017. (omicsdi.org)
  • There are many methods to treat cancer. (biomedcentral.com)
Histology2
  • Histology of each case was reviewed according to the IASLC/ATS/ERS classification and stratified based on predominant histologic subtype. (amegroups.org)
  • By characterization of the genomic, transcriptional, and DNA methylation landscape in lung cancer subgroups defined by histology and other clinicopathological factors in both own and public cohorts we search for new molecular subgroups of potential clinical relevance, additional targets for synergistic treatment, and a deepened understanding of the molecular pathogenesis. (lu.se)
Prognostic3
  • The number of EMT-related proteins' alteration is a significant prognostic marker to predict overall survival in patients with lung adenocarcinoma. (biomedcentral.com)
  • Prognostic value of each subtype was investigated by comparing outcomes between the adjuvant chemotherapy arm and the no-chemotherapy arm. (amegroups.org)
  • 2013) Prognostic significance of the IASLC/ATS/ERS classification in Chinese patients-a single institution retrospective study of 292 lung adenocarcinoma. (ijrr.com)
Oncology4
  • Precision oncology has made progress in leaps and bounds in recent years and is currently at the heart of revolutionizing cancer research. (biomedcentral.com)
  • As this research continues to develop and evolve, the enhanced use of precision oncology in cancer treatment ultimately aims to improve prognosis and outcomes for patients. (biomedcentral.com)
  • Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2019 8 14 (11): 2003-2008. (cdc.gov)
  • 1993). The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. (cancercentrum.se)
Epidemiological4
  • This study documents for the first time the clinical and epidemiological characteristics of lung cancer cases in Qatar from 1998 to 2005. (who.int)
  • The aim of the present study was to document the clinical and epidemiological characteristics of lung cancer cases in Qatar. (who.int)
  • It has been 17 years since the World Health Organization (WHO) classification was updated in 1981 1 , and since this time considerable progress has been made in understanding the epidemiological histogenetic and molecular biology of lung cancer. (ersjournals.com)
  • In addition to changes in smoking prevalence and cigarette composition causing a transition in the epidemiological profile of lung cancer, there is accumulating evidence of causal mechanisms linking air pollution to risk of adenocarcinoma. (who.int)
Minimally invasive lung2
  • The objective of this study is to confirm limited resection efficacy as radical surgery in patients with minimally invasive lung cancer as indicated by high-resolution (HR) computed tomography (CT), and to confirm intraoperative cytology as a negative margin indicator and reliable margin non-recurrence predictor. (iaslc.org)
  • 2018) CT-texture analysis of subsolid nodules for differentiating invasive from in-situ and minimally invasive lung adenocarcinoma subtypes. (ijrr.com)
Tissues5
  • The expression of EMT-related proteins including cytokeratin, E-cadherin, TTF-1, β-catenin, vimentin, Snail, Twist, CD44 was evaluated by immunohistochemistry using a tissue array method in the lung adenocarcinoma tissues of 95 patients. (biomedcentral.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Because cigarette smoking and oncogenesis alter lipid metabolism in lung tissue, we hypothesized that the lipid profiles in lung cancer tissues are influenced by cigarette smoking and can reflect the postoperative recurrence risk in smoking lung cancer patients. (biomedcentral.com)
  • More interestingly, the expression of Notch-1 protein was often observed to be negative in solid predominant adenocarcinoma (SPA) tissues, but highly expressed in papillary predominant adenocarcinoma (PPA) and micropapillary predominant adenocarcinoma (MPA) tissues. (biomedcentral.com)
  • The simulation results manifested a significant contribution of DMAA-TMC in the adsorption and release of cancer chemotherapy drugs in normal and neoplastic tissues. (biomedcentral.com)
Carcinomas3
  • About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. (wikipedia.org)
  • Approximately eighty percent of endometrial carcinomas are endometrioid adenocarcinomas. (medscape.com)
  • Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)
Neoplasms3
  • Nonmesotheliomatous cancers of the pleura include an assortment of malignant neoplasms that primarily or secondarily involve pleura. (medscape.com)
  • Invasive neoplasms of the female pelvic organs account for almost 15% of all cancers in women. (medscape.com)
  • These data have been combined with previously published LNET data to perform integrative analysis using multi-omics factor analysis (MOFA), resulting in a molecular map of lung neuroendocrine neoplasms for exploration. (who.int)
Pathology1
  • In 1994, the WHO adopted the International Association for the Study of Lung Cancer (IASLC) pathology panel to comprise the core membership of the WHO committee, to develop a new revised classification of lung and pleural tumours. (ersjournals.com)
Invasive7
  • So far, however, HRCT scans appear to predict non- or minimally invasive sub-solid lung cancers with high reliability, warranting limited resection as curative surgery in this cohort. (iaslc.org)
  • This approach lays the groundwork for non-invasive cancer detection using genome-wide mutation features that may facilitate cancer screening and monitoring. (nature.com)
  • Invasive mucinous adenocarcinoma (IMA) of the lung is a distinct histological subtype with unique clinical and pathological features. (figshare.com)
  • In 2011, the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society (IASLC/ATS/ERS) recommended a new classification system to characterize invasive lung ADC based on predominant histologic subtype [lepidic (LEP), acinar (ACN), papillary (PAP), solid (SOL), and micropapillary (MIP)] with presence of each histologic subtype reported in 5% increments ( 6 ). (amegroups.org)
  • We retrospectively reviewed HRCT images of 394 lung adenocarcinoma cases and compared the diversity of images among preinvasive lesions (PILs), minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) and the differentiation degrees of IAC by Kruskal-Wallis and χ 2 tests. (ijrr.com)
  • Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes. (cdc.gov)
  • Uterine cancer is defined as any invasive neoplasm of the uterine corpus. (medscape.com)
Recurrence3
  • We have repeatedly warned that delayed cut-end recurrence is possible following limited resection even for small sub-solid lung cancers. (iaslc.org)
  • The risk of postoperative recurrence is higher in lung cancer patients who smoke than non-smokers. (biomedcentral.com)
  • Presence of MIP subtype is an independent risk factor for local recurrence only for patients who have undergone limited resection, regardless of predominant histologic subtype ( 11 ). (amegroups.org)
Chemotherapy7
  • LEP rs7799039, LEPR rs1137101, and ADIPOQ rs2241766 and 1501299 Polymorphisms Are Associated With Obesity and Chemotherapy Response in Mexican Women With Breast Cancer. (cdc.gov)
  • While meta-analysis has confirmed survival benefits for patients with pathologic stage II or IIIA lung ADC who have undergone adjuvant chemotherapy following surgical resection ( 5 ), there is still controversy over the role of chemotherapy in pathologic stage I patients. (amegroups.org)
  • investigated the implications of the new lung ADC classification system on clinical outcomes following adjuvant chemotherapy ( 12 ). (amegroups.org)
  • Conversely, treatment for small cell lung cancer remains chemotherapy-based and whilst there are promising results with novel cytotoxics, its platinum-etoposide backbone holds strong ( 2 ). (amegroups.org)
  • In the current work, the penetration, co-loading, and co-release of Doxorubicin (DOX) and Paclitaxel (PAX), as two cancer chemotherapy agents, were investigated using a novel modified copolymer with functionalized SWCNT. (biomedcentral.com)
  • Smart drug delivery carrier can be a valuable nanohybrid for loading, transporting, and releasing of cancer chemotherapy drugs. (biomedcentral.com)
  • among them, Paclitaxel (PAX) and Doxorubicin (DOX) are conventional cancer chemotherapy drugs. (biomedcentral.com)
Characteristics1
  • Most of this classification is based on the histological characteristics of tumours seen in surgical or needle biopsy, and is primarily based on light microscopy, although immunohistochemistry and electron microscopy findings are provided when necessary. (ersjournals.com)
Metastasis5
  • EMT is known to be involved in the progression and metastasis of various cancers. (biomedcentral.com)
  • According to the American Joint Committee on Cancer (AJCC) staging system, distant metastasis (M1) with any T or any N stage is defined as Stage IV [ 5 ]. (medsci.org)
  • Leptin Receptor (LEPR) has been suggested to have several roles in cancer metastasis. (biomedcentral.com)
  • 2015) CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma. (ijrr.com)
  • Johnsson A, Kiani NA, Gernaat SAM, Wilking U, Shabo I, Hedayati E. Planning for return to work during the first year after breast cancer metastasis: A Swedish cohort study. (cancercentrum.se)
Pathological1
  • To study the relationship between high-resolution computed tomography (HRCT) signs and the pathological subtypes and differentiation degree of lung adenocarcinoma. (ijrr.com)
Pancreatic cancer1
  • Methylated DNA immunoprecipitation coupled with high-throughput sequencing was used as an affinity purification-based method, with AUCs of 0.978, 0.918, and 0.971 for acute myeloid leukemia, pancreatic cancer, and lung cancer, respectively. (ajmc.com)
20231
Mucinous2
Early-stage adenocarcinoma3
Predominant3
  • Unlike other Gulf countries, adenocarcinoma was the predominant type in both Qatari nationals and expatriates (43.9% of lung cancer types). (who.int)
  • It has been shown that predominant subtypes are associated with survival outcomes in patients with early-stage lung ADC ( 8 , 9 ). (amegroups.org)
  • 0.01) compared with other subtype predominant groups. (amegroups.org)
Patients with lung adenocarcinoma1
20212
  • Clinical cancer research : an official journal of the American Association for Cancer Research 2021 5 27 (14): 4066-4076. (cdc.gov)
  • Journal of the National Cancer Institute 2021 3 113 (9): 1194-1202. (cdc.gov)
Metastases2
  • Although SCLC constitutes the minority of lung cancer cases, it represents an aggressive form of cancer characterized by a high growth fraction, early development of metastases, and extremely poor prognosis, with less than 7% 5-year survival rate ( 2 ). (frontiersin.org)
  • Endometrial cancer is one of the (less common) causes of cannonball metastases to the lung. (radiopaedia.org)
Pulmonary1
  • It was a Pilot study where biopsies from 55 fresh previously untreated lung cancer patients visiting the Pulmonary Medicine Department of Era's Lucknow Medical College and Hospital Lucknow and King George's Medical University were taken for 18 months November 2014-April 2016, after taking proper informed consent from them. (ijpmonline.org)
Computed tomography2
  • For example, screening for lung cancer using low-dose computed tomography (LDCT) is recommended in the United States for adults aged 50-80 years who have smoked at least 20 pack years and currently smoke or have quit smoking within the last 15 years 3 . (nature.com)
  • 2018) A competing round-robin prediction model for histologic subtype prediction of lung adenocarcinomas based on thoracic computed tomography. (ijrr.com)
20204
  • Globally, there were an estimated 2 206 771 new cases of lung cancer in 2020: 1 435 943 in males and 770 828 in females. (oncodaily.com)
  • Senga, S. and Arakelyan, J. (2020) Biomarker Driven Cancer Therapeutics: Existing Tools and Remaining Gaps. (scirp.org)
  • Key topics at the first virtual European Respiratory Society (ERS) International Congress (2020) included novel diagnostic and therapeutic approaches in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, lung cancer, interstitial lung disease, obstructive airway disorders and infectious diseases. (ersjournals.com)
  • Asian Pacific journal of cancer prevention : APJCP 2020 9 21 (9): 2783-2791. (cdc.gov)
Tissue3
  • Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the internal organs (known as the mesothelium). (wikipedia.org)
  • We analyzed whole-genome sequencing data from 2,511 individuals in the Pan-Cancer Analysis of Whole Genomes (PCAWG) study as well as 489 individuals from four prospective cohorts and found distinct regional mutation type-specific frequencies in tissue and cell-free DNA from patients with cancer that were associated with replication timing and other chromatin features. (nature.com)
  • In non-tumoral lung tissue, transversion and DNA adducts were more frequent in females even though tobacco exposure was less than in males. (touchoncology.com)
Common18
  • Adenocarcinoma is the most common histological subtype, accounting for about half of all lung cancers [ 1 ]. (hindawi.com)
  • Lung cancer has been the most common cancer for decades. (bmj.com)
  • Among non-small cell lung cancer variants, adenocarcinoma is the most common histological subtype. (biomedcentral.com)
  • Lung cancer is the most common cancer in the world and, by 2002, there were 1.35 million new cases, representing 12.4% of all new cancers. (touchoncology.com)
  • Cancer cells exhibit a common phenotype of uncontrolled proliferation, and their lipid metabolism is altered to generate energy and biomass components efficiently [ 13 , 14 ]. (biomedcentral.com)
  • Worldwide, cervical cancer is both the fourth-most common type of cancer and the fourth-most common cause of death from cancer in women. (wikipedia.org)
  • Bleeding after douching or after a pelvic exam is a common symptom of cervical cancer. (wikipedia.org)
  • Having multiple strains at the same time is common, including those that can cause cervical cancer along with those that cause warts. (wikipedia.org)
  • The most common histologic subtype is adenocarcinoma (ADC), which accounts for approximately 50% of NSCLCs ( 3 , 4 ). (amegroups.org)
  • Gallbladder cancer (GBC) is the most common malignancy of the biliary system. (medsci.org)
  • Gallbladder cancer (GBC) is the most common malignancy of the biliary system, representing 80-95% of all biliary tract cancers worldwide [ 1 ]. (medsci.org)
  • Co-treatment of PAX and DOX is a common and useful regime in cancer therapy researchs. (biomedcentral.com)
  • Endometrial adenocarcinoma is the most common gynecologic malignancy in the United States. (medscape.com)
  • Cancer of the uterine corpus is the most common pelvic gynecologic malignancy in the United States and in most developed countries with access to sufficient health care. (medscape.com)
  • 4] The most common low-grade endometrioid endometrial cancers have been associated with obesity, nulliparity, anovulatory menstrual cycles, diabetes, and hypertension. (medscape.com)
  • Uterine sarcomas, regardless of the histologic subtype, are more common in black women. (medscape.com)
  • Breast cancer is the most common malignancy in women and a heterogeneous disease at the molecular level. (lu.se)
  • IgG4 is the least common of the 4 subtypes of IgG. (msdmanuals.com)
Frequent6
  • 1 It is also the most frequent cause of death by cancer, with 1.18 million deaths. (touchoncology.com)
  • 3 In Europe, lung cancer is the most frequent cause of death by cancer in males. (touchoncology.com)
  • pendent of those associated with cretory ducts, columnar epithelia the KRAS gene is more frequent- other key mechanistic characteris- lining the gastrointestinal tract and ly mutated in human cancer, which tics of IARC Group 1 carcinogens. (who.int)
  • According to the United States Environmental Protection Agency (EPA), radon is the second most frequent cause of lung cancer, after cigarette smoking, causing 21,000 lung cancer deaths per year in the United States. (knowpia.com)
  • While radon is the second most frequent cause of lung cancer, it is the number one cause among non-smokers, according to EPA policy-oriented estimates. (knowpia.com)
  • Frequent COPD exacerbations lead to a more rapid decline in lung function. (ersjournals.com)
Lesions1
  • 2018) New technique of percutaneous CT fluoroscopy-guided marking before video-assisted thoracoscopic surgery for small lung lesions: feasibility of using a 25-gauge needle without local anaesthesia. (ijrr.com)
Human lung1
Pleural5
  • Whereas pleural mesothelioma is highly associated with asbestos exposure , nonmesotheliomatous cancers have generally not been proven to result from exposure to airborne asbestos. (medscape.com)
  • [ 5 ] An earlier report, in 1956, by Babolini and Blasi, described the same clinicopathological entity using the nomenclature, "The pleural form of primary cancer of the lung. (medscape.com)
  • Overlapping lung and pleural involvement in individual cases has given rise to the more inclusive term "pleuropulmonary" synovial sarcoma. (medscape.com)
  • Malignant pleural mesothelioma (MPM) is normally connected with asbestos exposure VTX-2337 and it is a cancer which VTX-2337 has not been significantly influenced by little molecule-based targeted therapeutics. (cancerrealitycheck.com)
  • Launch Malignant pleural mesothelioma (MPM) comes from the mesothelial cells coating the pleural cavity encircling the lungs and much less frequently in the peritoneum (1). (cancerrealitycheck.com)
Classification3
  • Our proposed MRE-seq performance is comparable to the previous bisulfite sequencing method in accuracy of the cancer detection and classification of CSO with use of [a] relatively smaller amount of blood from a single tube collection and [requires] lower sequencing depth coverage compared to the whole genome bisulfite sequencing analysis," said the researchers. (ajmc.com)
  • There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)
  • List of the cancer sites available in the CI5plus database and their corresponding International Classification of Disease (ICD, 10th revision) codes. (who.int)
Biliary tract1
  • Gemcitabine combined with oxaliplatin (GEMOX) in advanced biliary tract adenocarcinoma: a GERCOR study. (cancercentrum.se)
Transcriptome1
  • The transcriptome data were abstracted from The Cancer Genome Atlas (TCGA). (researchsquare.com)
Oncogenic2
  • Up to 60% of lung adenocarcinoma and up to 50-80% of SCC have a known oncogenic driver mutation ( Figure 1 ) ( 18 , 19 ). (amegroups.org)
  • Comprehensive investigation of oncogenic driver mutations in Chinese non-small cell lung cancer patients. (cdc.gov)
Survival3
  • This study aimed to determine whether ambient air pollutant exposures are associated with the survival of patients with lung cancer. (bmj.com)
  • Although progress has been made in each area, lung cancer survival remains stubbornly poor, suggesting that novel approaches are needed. (bmj.com)
  • R, Flisberg P, Hedlund L, Östlund I, Bergkvist L. Impact of general anaesthesia on breast cancer survival: a 5-year follow up of a pragmatic, randomised, controlled trial, the CAN-study, comparing propofol and sevoflurane. (cancercentrum.se)
Endometrial8
  • After correcting the heterogeneity and horizontal pleiotropy, the results indicated that patients with SS were significantly associated with an increased risk of lymphomas (odds ratio [OR] = 1.0010, 95% confidence interval [CI]: 1.0005-1.0015, P = 0.0002) and reduced risks of prostate cancer (OR = 0.9972, 95% CI: 0.9960-0.9985, P = 2.45 × 10 −5 ) and endometrial cancer (OR = 0.9414, 95% CI: 0.9158-0.9676, P = 1.65 × 10 −5 ). (biomedcentral.com)
  • Association of Single Nucleotide Polymorphism -2548 G/A (rs12112075) of leptin gene with endometrial cancer and uterine leiomyomas. (cdc.gov)
  • No evidence suggests that routine endometrial sampling or transvaginal sonography to evaluate the endometrial stripe in asymptomatic women has a role in early detection of uterine cancer, even in women who take tamoxifen after breast cancer or has a cancer syndrome. (medscape.com)
  • This article discusses endometrial cancer and uterine sarcomas. (medscape.com)
  • This is an autosomally dominant germline mutation in DNA mismatch repair (MMR) genes (MSH1, MSH2, MSH6) and accounts for 9% of patients younger than 50 years with endometrial cancer. (medscape.com)
  • These mutations lead to microsatellite instability in 90% of colon cancers and 75% of endometrial cancers. (medscape.com)
  • Besides colon cancer, women affected have a 40-60% risk of endometrial cancer by age 70 years, compared to a baseline population risk of 1.5% at the same age. (medscape.com)
  • Fifty-one percent of women had endometrial or ovarian cancer diagnosed first as the sentinel cancer. (medscape.com)
Epidemiology1
  • We used the two-sample Mendelian randomization (MR) approach to circumvent these limitations of observational epidemiology by constructing a genetic instrument for BMI, based on results from the GIANT consortium, which was evaluated in relation to lung cancer risk using GWAS results on 16,572 lung cancer cases and 21,480 controls. (liverpool.ac.uk)
20162
  • MONOGRAPH ON LUNG CANCERLung Cancer Registry Data of 2000-2008Copyright 2016 Lung Center of the PhilippinesAll Rights Reserved. (dokumen.tips)
  • 2016) Lung adenocarcinoma: Correlation of quantitative CT findings with pathologic findings. (ijrr.com)
Surgically resected1
  • Our study provided genomic insights into Chinese surgically resected lung IMA. (figshare.com)
Cause of lung cancer2
  • Cigarette smoke is the number one cause of lung cancer. (who.int)
  • Smoking habits vary within the different countries in Europe, with a significant decrease in tobacco consumption in the UK, Sweden and Finland between 1970 and 1994 and a significant increase in Portugal (+64.2%).5 Even if active tobacco smoking is the main cause of lung cancer in females, the attributable risk is inferior to that noted in males. (touchoncology.com)
Archetypes4
  • As a reference, I've been using the existing archetypes "Microscopic findings - [Type] cancer," for example, "Breast" as seen in this archetype Clinical Knowledge Manager . (openehr.org)
  • From my observations, it appears that these archetypes do not include the histological subtype. (openehr.org)
  • I am contemplating the creation of cluster archetypes named "Histological cancer subtype. (openehr.org)
  • To these data we applied the evolutionary theory of task specialisation (ParetoTI) to identify and characterise distinct archetypes, i.e. molecular subtypes, of LNETs. (who.int)
Epithelial1
Clinicopathological2
Surgical resection1
  • From January 2007 to December 2009, 95 patients undergoing surgical resection for lung adenocarcinoma at Nanjing Drum Tower Hospital were enrolled in this study. (biomedcentral.com)
Gene6
  • Differentially expressed genes were obtained by comparing gene expression between lung adenocarcinoma samples and normal samples. (hindawi.com)
  • The analyzed gene datasets were downloaded from the Gene Expression Omnibus and The Cancer Genome Atlas (TCGA) database. (cancerindex.org)
  • Association of two obesity-related gene polymorphisms LEPG2548A rs7799039 and LEPRQ223R rs1137101 with the risk of breast cancer. (cdc.gov)
  • Study of the association between polymorphism of persistent obesity, human leptin gene/leptin receptor gene and molecular subtypes of breast cancer]. (cdc.gov)
  • Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer. (cdc.gov)
  • However, lack of both and induces apoptosis in mouse oocytes13 as well as the SW579 thyroid cancers cell series14, whereas the lack of each gene provides Levomilnacipran HCl little impact likely because of settlement in the other individually. (iassist2012.org)
Deaths6
  • Worldwide, lung cancer causes nearly one in five cancer deaths, about 1.59 million deaths annually ( http://globocan.iarc.fr ). (bmj.com)
  • Of late as per WHO Lung cancer deaths are declining in men, and the death rate in women has plateaued secondary to decreases in smoking. (ijpmonline.org)
  • [1] However, 9.3% of cancer-related deaths in both the sexes is still attributed to lung cancer. (ijpmonline.org)
  • This is about 8% of the total cases and total deaths from cancer. (wikipedia.org)
  • About 70% of cervical cancers and 90% of deaths occur in developing countries. (wikipedia.org)
  • However, it has a favorable prognosis because the majority of patients present at an early stage, resulting in only 4% of cancer deaths in women. (medscape.com)
Gastric1
  • Decrease HDAC1 expression due to the decreased appearance of Rhotekin (RTKN) in gastric cancers cells is normally proposed to result in higher p53 acetylation amounts, that allows for the increased expression of its target genes involved with promoting cell cycle apoptosis11 and arrest. (iassist2012.org)