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  • ovary
  • For survivors under 1500 meters significant differences are seen between the numbers of observed cancers of the lung, stomach, uterus and ovary and the expected cases calculated from the age-specific rates of the non-exposed portion of the Hiroshima population. (osti.gov)
  • spindle cell
  • Some types of cancer are named for the size and shape of the cells under a microscope, such as giant cell carcinoma, spindle cell carcinoma, and small-cell carcinoma. (wikipedia.org)
  • commonly
  • The risk of cancer increases significantly with age and many cancers occur more commonly in developed countries. (wikipedia.org)
  • In the few cases described in the literature to date, the male-to-female ratio is approximately unity, and right lung lesions occurred twice as commonly as left lung lesions. (wikipedia.org)
  • It often has a paraneoplastic syndrome causing ectopic production of parathyroid hormone-related protein (PTHrP), resulting in hypercalcemia, however paraneoplastic syndrome is more commonly associated with small cell lung cancer. (wikipedia.org)
  • It is a gene commonly associated with hereditary nonpolyposis colorectal cancer. (wikipedia.org)
  • diseases
  • No significant trends with exposure were observed for the cancers of interest, but for circulatory diseases and IHD, there was a statistically significant trend for increasing HR with mean and maximum BLLs. (bmj.com)
  • It is well known that cancer is a generic term relating to a large group of diseases that can affect any part of the body. (freepatentsonline.com)
  • According to the World Health Organization (WHO) chronic diseases include cerebrovasuclar, cardiovascular, and renovascular disorders, neoplasms, respiratory diseases and diabetes mellitus, because these diseases require continuous care and efforts from a set of equipment, public policies and people in general. (scielo.br)
  • The data registry and biospecimen bank will provide core support services for future IRB approved multidisciplinary research on cancer and other chronic diseases carried out by members of the Fred and Pamela Buffett Cancer Center as well as internal and external research collaborators from different participating institutions/centers. (clinicaltrials.gov)
  • Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. (wikipedia.org)
  • Many cancers can be prevented by not smoking, maintaining a healthy weight, not drinking too much alcohol, eating plenty of vegetables, fruits and whole grains, vaccination against certain infectious diseases, not eating too much processed and red meat, and avoiding too much sunlight exposure. (wikipedia.org)
  • Cancers are a large family of diseases that involve abnormal cell growth with the potential to invade or spread to other parts of the body. (wikipedia.org)
  • Somatic evolution is important in the process of aging as well as the development of some diseases, including cancer. (wikipedia.org)
  • Cyclophosphamide is used to treat cancers and autoimmune diseases. (wikipedia.org)
  • citation needed
  • medical citation needed] The initial work-up of a cancer of unknown primary includes a CT scan of the chest, abdomen, and pelvis, with IV contrast. (wikipedia.org)
  • citation needed] Top1 is a validated target for the treatment of human cancers. (wikipedia.org)
  • citation needed] To circumvent these limitations, Dr. Mark Cushman at Purdue University and Dr. Yves Pommier at the National Cancer Institute developed the non-camptothecin family of indenoisoquinoline inhibitors of Top1. (wikipedia.org)
  • The preclinical and IND package filed with the US Food and Drug Administration along with complete GMP production supporting the lead molecule are components of the published and non-published information covered by the license agreement with Purdue Research Foundation the National Cancer Center and Linus Oncology, Inc.[citation needed] Linus Oncology has licensed the intellectual property that covers the development of these and related indenoisoquinoline derivatives. (wikipedia.org)
  • melanoma
  • About 14.1 million new cases occur a year (not including skin cancer other than melanoma). (wikipedia.org)
  • If skin cancer other than melanoma were included in total new cancers each year, it would account for around 40% of cases. (wikipedia.org)
  • Confusingly, some types of cancer use the -noma suffix, examples including melanoma and seminoma. (wikipedia.org)
  • Combining radiation therapy with immunotherapy is an active area of investigation and has shown some promise for melanoma and other cancers. (wikipedia.org)
  • Among 20 cancers evaluated, microsatellite instable (MSI) colon cancer (mismatch repair deficient) had the second highest frequency of mutations (after melanoma). (wikipedia.org)
  • incidence
  • This study was conducted to describe the cancer incidence associated with employment in small-sized Korean iron foundries and to compare those findings to the Korean population. (cdc.gov)
  • Cancer morbidity in 208 Korean foundries was analyzed using the Standardized Incidence Ratio (SIR) and Standardized Rate Ratio (SRR). (cdc.gov)
  • The 1957-1958 incidence of neoplasms among the survivors of the Hiroshima A-bomb, varies directly with radiation dose insofar as it may be inferred from distance from the hypocenter at exposure. (osti.gov)
  • Young adults are diagnosed with cancer at more advanced stages, indicating that health professionals should be aware of cancer incidence in this age group. (scielo.br)
  • Armitage and Doll explained the cancer incidence data, as a function of age, as a process of the sequential accumulation of somatic mutations (or other rate limiting steps). (wikipedia.org)
  • breast
  • Breast cancer showed a moderate but steady increase. (aacrjournals.org)
  • The benefits of screening in breast cancer are controversial. (wikipedia.org)
  • The development of therapies with specific molecular or genetic targets, which inhibit growth-promoting signals from classic endocrine hormones (primarily estrogens for breast cancer and androgens for prostate cancer) are now called hormonal therapies. (wikipedia.org)
  • Gene
  • Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. (nih.gov)
  • Although silencing of some genes in cancers occurs by mutation, a large proportion of carcinogenic gene silencing is a result of altered DNA methylation (see DNA methylation in cancer). (wikipedia.org)
  • Using gene set enrichment analysis, 569 out of 938 gene sets were hypermethylated and 369 were hypomethylated in cancers. (wikipedia.org)
  • Loss of imprinting of insulin-like growth factor gene (IGF2) increases risk of colorectal cancer and is associated with Beckwith-Wiedemann syndrome which significantly increases the risk of cancer for newborns. (wikipedia.org)
  • MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) is a protein that in humans is encoded by the MLH1 gene located on Chromosome 3. (wikipedia.org)
  • This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). (wikipedia.org)
  • Only a minority of sporadic cancers with a DNA repair deficiency have a mutation in a DNA repair gene. (wikipedia.org)
  • However, a majority of sporadic cancers with a DNA repair deficiency do have one or more epigenetic alterations that reduce or silence DNA repair gene expression. (wikipedia.org)
  • sporadic
  • In 1971, Knudson published the 2-hit hypothesis for mutation and cancer based on statistical analysis of inherited and sporadic cases of retinoblastoma. (wikipedia.org)
  • nearly
  • At least 10 of those genes had hypermethylated promoters in nearly 100% of colon cancers. (wikipedia.org)
  • In the developing world nearly 20% of cancers are due to infections such as hepatitis B, hepatitis C and human papillomavirus infection. (wikipedia.org)
  • Epidemiology
  • Thank you for sharing this Cancer Epidemiology, Biomarkers & Prevention article. (aacrjournals.org)
  • Message Body (Your Name) thought you would be interested in this article in Cancer Epidemiology, Biomarkers & Prevention. (aacrjournals.org)
  • The iCaRe2 serves as a collaboration platform for studies (including clinical trials) performed in centers with expertise in cancer biology, pathology, epidemiology, genetics, early detection, and patient care. (clinicaltrials.gov)
  • significantly higher
  • Overall cancer morbidity in foundry workers (SIR=1.11, 95% confidence interval [CI]=1.01-1.21) was significantly higher than that of Korean general population. (cdc.gov)
  • The majority of epithelial cancers are only moderately radiosensitive, and require a significantly higher dose of radiation (60-70 Gy) to achieve a radical cure. (wikipedia.org)
  • population
  • Lung cancer (SIR=1.45, 95%CI=1.11-1.87) and lymphohematopoietic cancer (SIR=1.58, 95%CI=1.00-2.37) in production workers were significantly high compared to Korean general population. (cdc.gov)
  • In this study, statistically significant excess lung cancer was observed in production workers comparing to Korean general population and office workers. (cdc.gov)
  • Also, cancer morbidity of overall cancer, lung cancer and stomach cancer was significantly increased with duration of employment at ten and more years comparing to Korean general population. (cdc.gov)
  • While the relative risk of developing a non-AIDS-defining neoplasm in HIV-infected persons on the average is 2-3 times, the risk for developing HL in HIV-infected cases impressively ranges between 5 and 25 times when compared to the general population. (sun.ac.za)
  • There are three necessary and sufficient conditions for natural selection, all of which are met in a neoplasm: There must be variation in the population. (wikipedia.org)
  • In this way, a population of mutant cells, called a clone, can expand in the neoplasm. (wikipedia.org)
  • Hypomethylation
  • In cancer cells "global hypomethylation" due to disruption in DNA methyltransferases (DNMTs) may promote mitotic recombination and chromosome rearrangement, ultimately resulting in aneuploidy when the chromosomes fail to separate properly during mitosis. (wikipedia.org)