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  • tumor
  • When the lung is biopsied, the histological analysis will reveal a tumor arising from the bronchial glands. (statpearls.com)
  • The reports showed that every transformed SCLC tumor sample retained its original EGFR -activating mutation [ 6 - 11 ], supporting the idea that these were not independent second-primary cancers [ 2 ]. (jpatholtm.org)
  • Aberrant activation of the Hedgehog (Hh) signaling pathway, a crucial developmental pathway, drives the tumor growth of Gorlin-type cancers. (aacrjournals.org)
  • However, recent data suggest that paracrine activation of the pathway is tumor suppressive rather than oncogenic in sporadic epithelial cancers. (aacrjournals.org)
  • Thus, we explored the role of stromal Hh pathway activation in growth of lung tumor epithelia. (aacrjournals.org)
  • Co-culture of high SHH expressing tumor epithelial cells and Shh-Light2 reporter cell lines demonstrated that SHH activated the fibroblast reporter in a paracrine manner, rather than an autocrine effect on cancer cells. (aacrjournals.org)
  • Treatment with the SMO inhibitor, KAAD-cyclopamine, also inhibited the growth of tumor epithelial cells in co-culture with NIH-3T3 fibroblast cells but the effect was decreased when co-cultured with lung fibroblasts. (aacrjournals.org)
  • Furthermore, mutant Kras lung cancers express high levels of IHH that dominates the tumor suppressive effect of our mouse models. (aacrjournals.org)
  • Mutations in TP53 tumor suppressor gene have been found in approximately 50% of lung adenocarcinoma cases, but the presence of a TP53 mutation does not always associate with increased mortality. (aacrjournals.org)
  • plural adenocarcinomas or adenocarcinomata /ˌædɪnoʊkɑːrsɪˈnoʊmɪtə/) is a type of cancerous tumor that can occur in several parts of the body. (wikipedia.org)
  • By staining the cells from a biopsy, a pathologist can determine whether the tumor is an adenocarcinoma or some other type of cancer. (wikipedia.org)
  • Reduced tumour blood flow inhibits tumor cell proliferation and migration hence slowing the growth and spread of the cancer. (wikipedia.org)
  • It is used in anatomic pathology as a marker to determine if a tumor arises from the lung or thyroid. (wikipedia.org)
  • FA is a rare tumor, with a relative incidence estimated to be no more than 0.5% of all lung cancers. (wikipedia.org)
  • Other presenting symptoms described have included: flu-like syndrome with cough and fever, FA is an epithelial tumor whose cells and architecture resemble that of fetal lung tissues in the pseudoglandular stage of development (which occurs at about 10-16 weeks gestation in the human), with complex glandular structures and morules with cell nuclei that appear clear due to the accumulation of biotin. (wikipedia.org)
  • A case of combined small cell lung carcinoma featuring components of FA and cells resembling those from carcinoid tumor has been reported, illustrating the unique complexity and heterogeneity of divergent histogenesis and cell differentiation in lung cancer. (wikipedia.org)
  • KRAS
  • Mutations of the proto-oncogene KRAS have been identified by some groups as being a valid prognostic indicator for adenocarcinoma of the lung. (aacrjournals.org)
  • Based on this study of 181 patients from two major medical centers located in different cities, we conclude that KRAS mutation status is not a satisfactory predictor of prognosis in lung adenocarcinoma, but the substitution of a polar or charged amino acid for the wild-type glycine residue may be a negative prognostic indicator. (aacrjournals.org)
  • The in vivo role of paracrine SHH was tested using autochthonous lung cancer models with conditional KRAS G12D activation, p53 loss,, and SHH loss compared to wild-type SHH. (aacrjournals.org)
  • clinical
  • Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. (springer.com)
  • Differential protein stability and clinical responses of EML4-ALK fusion variants to various ALK inhibitors in advanced ALK-rearranged non-small cell lung cancer. (springer.com)
  • The Symposium is sponsored by the American Society of Clinical Oncology (ASCO), the American Society for Radiation Oncology (ASTRO), the International Association for the Study of Lung Cancer (IASLC) and The University of Chicago Medicine. (marketwired.com)
  • Molecular testing should be performed on all individuals with lung adenocarcinomas irrespective of clinical characteristics. (aacrjournals.org)
  • In recent years, cancer gene panels using next-generation sequencing techniques have become cheaper and more commonly used in the clinical setting in hopes of discovering a targetable gene alteration or qualifying patients to enroll into clinical trials ( 4 ). (aacrjournals.org)
  • It is in phase II clinical trials for adenocarcinoma, non-small cell lung cancer, and renal cell carcinoma. (wikipedia.org)
  • The clinical development of Lipoplatin in adenocarcinomas establishes this drug as the most active platinum drug with significantly lower side effects. (wikipedia.org)
  • TTF1 is more than merely a clinical marker of lung adenocarcinoma. (wikipedia.org)
  • Immunohistochemistry
  • In one study studying the role of Cdc42 in cervical cancer, immunohistochemistry was used to detect Cdc42 expression in three types of tissues: normal cervical tissues, cervical intraepithelial neoplasia (CIN) I or below, CIN II or above, and cervical cancer tissues. (wikipedia.org)
  • cervical cancer
  • Cdc42 overexpression significantly improved the ability of cervical cancer cells to migrate, possibly due to improved pseudopodia formation. (wikipedia.org)
  • survival
  • The study looked for a significant difference in progression-free survival - the time before the cancers began growing again, after an initial response or stable disease. (cancergrace.org)
  • In human lung adenocarcinoma patients, higher expression of SHH mRNA in lung adenocarcinoma correlated with poor overall and progression free survival. (aacrjournals.org)
  • Furthermore, we found that S100A4 overexpression is associated with the presence of lymphovascular invasion (P = 0.0189) and with decreased overall survival (Hazard ratio 2.14, 95% confidence interval 1.08-4.22, P = 0.0243) among patients with lung adenocarcinoma. (aacrjournals.org)
  • Furthermore, the score was able to predict recurrence-free survival in patients with stage I adenocarcinoma, and was also associated with smoking status. (aacrjournals.org)
  • There was evidence that Cdc42 inhibition by AZA197 treatment suppresses proliferative and pro-survival signaling pathways via PAK1-ERK signaling and reduces colon cancer cell migration and invasion. (wikipedia.org)
  • smokers
  • Lung adenocarcinoma accounts for 60 percent of all non-small cell lung cancers and is the most common form of lung cancer in both smokers and non-smokers and patients younger than 45 years old. (marketwired.com)
  • These mutations are more commonly seen in Asians, women, and non-smokers (who also tend to more often have adenocarcinoma). (wikipedia.org)
  • In the 1970s epidemiologic evidence relative to tobacco-related cancers and data for coronary heart disease indicated a reduced risk among filter smokers for these diseases. (wikipedia.org)
  • Between 1970 and 1980 some studies showed a 20-50% reduction in risk of lung cancer for long-term smokers of filtered cigarettes as compared to smokers of non-filtered cigarettes (IARC, 1986) but later studies indicated a similar risk for lung cancer in smokers of filtered and non-filtered cigarettes. (wikipedia.org)
  • epithelia
  • JSRV acutely transforms the lung epithelia into cancerous cells, with type-2 pneumocytes and club cells being the likely target for JSRV transformation. (wikipedia.org)
  • tumours
  • citation needed] Angiogenesis is a process that is essential for the growth and spread of all solid tumours, blocking it prevents the tumour from growing and may result in tumour shrinkage as well as a reduction in the spread of the cancer to other parts of the body. (wikipedia.org)
  • amplification
  • On the basis of genomic and functional analyses, we identify NKX2-1 (NK2 homeobox 1, also called TITF1), which lies in the minimal 14q13.3 amplification interval and encodes a lineage-specific transcription factor, as a novel candidate proto-oncogene involved in a significant fraction of lung adenocarcinomas. (broadinstitute.org)
  • oncogenic
  • Oncogenic fusion genes consisting of echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) can be detected in 5-7% of lung adenocarcinoma cases. (springer.com)
  • Disease
  • Biocare Medical offers an expanding portfolio of integrated products to address the rapidly growing cancer and infectious disease diagnostic and research markets using tissue immunostaining and in situ hybridization methods. (biocare.net)
  • Lung disease called chronic obstructive pulmonary disease (COPD). (webmd.com)
  • When disease presents with low-grade histologic features the cancer rarely spreads through the lymphatic system or through the bloodstream. (wikipedia.org)
  • The term mucinous adenocarcinoma is used in different contexts depending on the reference material used by the pathologist for disease classification. (wikipedia.org)
  • Factors that increase the risk of prostate cancer include: older age, a family history of the disease, and race. (wikipedia.org)
  • Most people with prostate cancer do not end up dying from the disease. (wikipedia.org)
  • Activating mutations of the Ras protein and upstream elements of the Ras protein may play a role in more than two thirds of all human cancers, including most metastatic disease, which suggests that Reolysin may be an effective therapeutic for many Ras-activated tumor types and potentially for some cell proliferative disorders. (wikipedia.org)
  • mucin
  • Highly differentiated adenocarcinomas form SRCCs via a loss of adherens and tight junctions that typically separate MUC4, a mucin protein, and ErbB2, an oncogenic receptor. (wikipedia.org)
  • Pseudomyxoma peritonei (PMP) is a clinical condition caused by cancerous cells (mucinous adenocarcinoma) that produce abundant mucin or gelatinous ascites. (wikipedia.org)
  • tissues
  • By doing so at the site of cancerous tissues in the body, L-DOS47 is believed to modify the microenvironmental conditions of lung cancer cells in a manner that leads to their death. (drugs.com)
  • In addition, the local production of ammonia at the site of cancerous tissues is thought to readily diffuse into the cancer cells to exert a potent cytotoxic effect by interfering with their critical metabolic functions. (drugs.com)
  • Pasireotide works by binding to a protein called somatostatin receptor, which is expressed in many tissues throughout the body including thyroid cancer cells. (clinicaltrials.gov)
  • It is expressed in all over the body, but its expression in the lung, liver and kidney was higher than other tissues [ 4 , 5 ]. (biomedres.info)
  • The gene is expressed at low levels in almost all human tissues, but higher levels have been seen in certain cancer tissues. (wikipedia.org)
  • liver
  • Oncology, Gastroenterology and Hepatology Reports (OGH Reports) [ISSN:Print -2278-8921, Online - 2348-aims to explore the areas of Cancer research and gastrointestinal tract including the liver. (oghreports.org)
  • breast
  • my aunt was suffering from breast cancer. (unews.top)
  • One study suggests that when signet-ring cells are found in a breast tumor, the presence of gastric cancer should also be considered. (wikipedia.org)
  • It has received regulatory approval for use as a treatment for non-small cell lung cancer, although there is emerging evidence to support its use in other cancers such as breast cancer. (wikipedia.org)
  • Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers. (wikipedia.org)
  • verification needed] Phase II results for breast cancer that over-expresses the protein human epidermal growth factor receptor 2 (Her2-positive breast cancer) were described as promising by the authors, with 19 of 41 patients achieving benefit from afatinib. (wikipedia.org)
  • Her2-negative breast cancers showed limited or no response to the drug. (wikipedia.org)
  • Breast Cancer Research and Treatment. (wikipedia.org)
  • As part of REOLYSIN's registration pathway, Oncolytics, in partnership with CCTG, is conducting a phase 2 clinical trial in metastatic breast cancer patients receiving standard weekly paclitaxel therapy. (wikipedia.org)
  • Several studies have outlined the importance of autocrine IL-6 signaling in lung and breast cancers. (wikipedia.org)
  • Both mouse and human in vivo models of HER2-overexpressing breast cancers relied critically on this HER2-IL-6-STAT3 signaling pathway. (wikipedia.org)
  • destroy
  • Dr. Chao will highlight previously announced laboratory and animal data that demonstrates the potential for L-DOS47 to bind to and debilitate and destroy human lung adenocarcinoma cells. (drugs.com)
  • As an antioxidant curcumin helps destroy lung cancer cells and also reverses drug resistance. (turmericforhealth.com)
  • and Adaptive immune response - antigen presenting cells (APCs) display tumor-associated antigens (TAA) and viral-associated antigens (VAA) to educate T-cells to recognize and destroy cancer cells. (wikipedia.org)
  • mutations
  • A study published in Biofactors, 2015 demonstrated that dietary curcumin can prevent lung cancer caused by Benzo[a]pyrene and prevents its mutagenic action (ability to cause mutations that cause cancer). (turmericforhealth.com)
  • Mutations resulting in deletion or reduction of function of the CDKN2A gene are associated with increased risk of a wide range of cancers and alterations of the gene are frequently seen in cancer cell lines. (wikipedia.org)
  • Germline mutations in CDKN2A are associated with an increased susceptibility to develop skin cancer. (wikipedia.org)
  • De-regulation of the autocrine Wnt signaling pathway via mutations in APC and Axin have been linked to activation of various types of human cancer. (wikipedia.org)
  • prevention
  • The Company is actively developing innovative products for the prevention and treatment of cancer based on its proprietary technologies. (drugs.com)
  • While 5α-reductase inhibitors appear to decrease low-grade cancer risk they do not affect high-grade cancer risk and thus are not recommended for prevention. (wikipedia.org)
  • Asian Pacific Journal of Cancer Prevention. (wikipedia.org)
  • colon cancer
  • The distribution of 25 TN combinations (left) and the distribution of colon cancer and rectum cancer (right) between the training set and testing set [online only]. (springermedizin.de)
  • NEDD9 is induced by Wnt signaling in colon cancer, based on binding to T-cell factor (TCF) factors in the promoter region. (wikipedia.org)
  • signet
  • A down-regulation of E-cadherin is essential for the initiation and progression a gastric signet ring cell cancer cells. (wikipedia.org)
  • For example, neoplasms characterized by high-grade features, invasive glands and or signet ring cells, are termed adenocarcinoma in pathology literature. (wikipedia.org)
  • human
  • Since its inception, Oncolytics Biotech Inc. has worked to take REOLYSIN, its proprietary formulation of human reovirus, through the development and regulatory requirements necessary to develop it as a potential cancer therapeutic. (wikipedia.org)
  • Thyroid Cancer
  • The purpose of this study is to determine the effectiveness of two anticancer drugs, everolimus and pasireotide, in patients with thyroid cancer when the cancer is no longer responding to treatment with radioiodine or where it is deemed unsafe for the patient to receive additional radioiodine treatment. (clinicaltrials.gov)
  • The investigators also want to establish the best manner of taking the two medications when used together to treat thyroid cancer. (clinicaltrials.gov)
  • Would this be good for thyroid cancer? (unews.top)
  • diagnosis
  • Anal sac adenocarcinomas are often suspected due to location (palpable masse in anal sac) and behavior, but a biopsy and histopathology is necessary for a definitive diagnosis. (wikipedia.org)
  • COPD
  • Some research shows that taking a specific whey protein supplement daily for 6 weeks can improve shortness of breath but not lung function or quality of life in people with COPD. (webmd.com)
  • Other research suggests that taking whey protein supplements does not improve lung function, muscle function, or exercise in people with COPD. (webmd.com)
  • positive correlation
  • RESULTS: Analysis of the MethylCap-seq data revealed a strong positive correlation between replicate experiments and between paired tumor/lung samples. (ox.ac.uk)
  • For example, one group found a positive correlation between persistently activated tyrosine-phosphorylated STAT3 (pSTAT3), found in 50% of lung adenocarcinomas, and IL-6. (wikipedia.org)