• They report that cigarette smoke preferentially depreses the function of immune cells in lymph nodes that lie within the lung tissue, and that only prolonged smoke exposure induces changes in immune cells stored in other parts of the body. (thefreelibrary.com)
  • Shopp warns that non-immune-related factors--such as the breakdown of lung tissue or emphysema -- also could contribute to smokers' increased susceptibility to respiratory infections. (thefreelibrary.com)
  • Different disorders are caused depending on the different parts of the lungs that are affected, like the airways (the tubes that carry oxygen and other gases through the lungs), the lung tissue, or the blood vessels in the lung. (feinsteininstitute.org)
  • Asthma for instance affects the airways, pulmonary fibrosis affects the lung tissue, and pulmonary hypertension affects the blood vessels in the lung. (feinsteininstitute.org)
  • A high resolution histology image of lung tissue (background), and the tree-like respiratory system. (pnnl.gov)
  • One, led by staff scientists Geremy Clair and Paul Piehowski, used a novel platform for ultrasensitive analysis to characterize, for the first time, the ontogeny of protein changes during normal lung development in minute microdissected alveolar tissue. (pnnl.gov)
  • While the paper by Dautel and Kyle examined whole-lung samples, the paper by Clair and Piehowski focused on analysis at a much finer resolution by looking at microdissected alveolar tissue. (pnnl.gov)
  • From time-points roughly equivalent to early lung development in humans (in-utero mice at gestational day 16.5 and mice at postnatal days 7 and 28) they examined minute microdissected alveolar tissue representing only 4,000 lung cells. (pnnl.gov)
  • Impressively, their ultra-small scale analysis allowed characterization of more than 3,400 proteins, providing the first in-depth global characterization of the ontogeny of protein changes in microdissected alveolar tissue during normal lung development. (pnnl.gov)
  • The mammalian lung consists of a complex, tree-like structure, wherein branched airways terminate in alveoli that exchange gases with the blood. (aiche.org)
  • In the avian lung, airways that begin terminally branched during development eventually come together and fuse, creating a closed circuit of airways that interweave with vasculature to exchange gases. (aiche.org)
  • These new branches are similar in morphology to the branches observed in the early mouse lung, with a similar pattern of smooth muscle coverage, suggesting a role for smooth muscle in shaping the airways and facilitating fusion. (aiche.org)
  • People with chronic lung conditions like asthma, chronic obstructive pulmonary disease (COPD), or bronchitis experience inflamed airways that make it difficult for air to circulate the lungs. (dherbs.com)
  • Coughing is the body's attempt to get rid of mucus, but coughing that is out of your control can make things worse because your airways close, trapping mucus in the lungs. (dherbs.com)
  • Mucous membranes in the nose and mouth moisten and warm the air, but they also trap foreign particles, pathogens, and external threats from entering the trachea (windpipe) and lungs. (dherbs.com)
  • To raise public awareness about the importance of lung health, a number of health-related organizations including the American Association of Respiratory Care (AARC), the American Thoracic Society, and the American College of Chest Physicians have come together to designate 2010 "The Year of the Lung. (qualityhealth.com)
  • Chest percussion works to loosen the mucus in your lungs . (dherbs.com)
  • Alveoli represent the fundamental unit for gas exchange - that is, breathing - and play additional critical roles, such as the production of pulmonary surfactant, a fluid that decreases surface tension and prevents lung collapse,' said Clair. (pnnl.gov)
  • Six hours after infection, the researchers saw an increased bacterial load in the lungs and bronchial fluid of the mice, compared to mice of the same age whose mothers were not given antibiotics. (nutraingredients.com)
  • You body needs oxygen to function and oxygen is obtained through gas exchange that takes place in the lungs. (healthstatus.com)
  • The greater the lung capacity the easier it is to provide your body and its organs with the vital oxygen it needs to live a happier, healthier life. (healthstatus.com)
  • All terrestrial vertebrates rely on lungs to extract oxygen from the air and expel carbon dioxide generated in body tissues, but the structure of these lungs is not the same across the animal kingdom. (aiche.org)
  • Lungs allow us to breathe - to take in oxygen and release carbon dioxide. (pnnl.gov)
  • The lungs work nonstop to deliver oxygen to the bloodstream and expel carbon dioxide from the body. (dherbs.com)
  • Every cell in the body draws oxygen from the blood, so impaired lung function, which can result from any number of respiratory conditions or poor diet, means that the lungs cannot efficiently supply the body with the necessary amount of oxygen. (dherbs.com)
  • The efficiency of lung function and lung capacity determine how well they can deliver oxygen to the body and how quickly they can get rid of carbon dioxide. (dherbs.com)
  • When stale air becomes trapped in the lungs, it makes it difficult for them to absorb new oxygen. (dherbs.com)
  • They found that cigarette exposure for 21 weeks or more significantly depressed B-cell function in the lung-associated lymph nodes, while exposure for more than 35 weeks affected immune cells in other lymphoid tissues such as the spleen. (thefreelibrary.com)
  • It's very important to note that lung capacity can be improved, but lung function cannot. (dherbs.com)
  • We recently found that patterned differentiation of airway smooth muscle drives branching morphogenesis of the epithelium in the mouse lung, but to date this mechanism is unexplored in other systems. (aiche.org)
  • Yet despite an existential importance, the development of the lungs and the rules governing the process that enables respiration are still not well understood at the molecular level. (pnnl.gov)
  • The diaphragm tightens and flattens, allowing you to suck air into your lungs. (dherbs.com)
  • Any activity that engages the abdominal muscles, especially the diaphragm, is beneficial for the lungs. (dherbs.com)
  • Singing is all about using the diaphragm to project sound, so sing in the shower, car, or in the garden to increase lung capacity. (dherbs.com)
  • If you want to improve lung health then you need to improve lung capacity, and you'll find that the following exercises can help you do just that. (dherbs.com)
  • We aim to use these insights to manipulate smooth muscle differentiation in the developing lung in order to direct epithelial morphogenesis, ultimately gaining precise mechanical control over these developing tissues. (aiche.org)
  • We found that smooth muscle is present in a mesh-like pattern around the lung epithelium and regulated by the same molecular signaling pathways as in the murine lung. (aiche.org)
  • It helps to fill the lungs with air when it moves down, and it pushes air out of the lungs as it moves back up. (dherbs.com)
  • To fill these knowledge gaps, a cohort of PNNL scientists is using advanced mass spectrometry tools to perform a systematic characterization of normal lung development in mice and humans as part of the LungMAP Consortium funded by the National Heart Lung and Blood Institute. (pnnl.gov)
  • Previous animal studies have shown cigarette-induced immune dysfunction, but these did not focus on lung-associated lymph nodes and did not reveal what types of immune cells were primarily affected. (thefreelibrary.com)
  • Human studies have yielded inconsistent results, probably because these studies haven't looked at the lung-associated lymph nodes, says George M. Shopp, also at lovelace. (thefreelibrary.com)