###### cardiac

- An automated, closed-loop 1D-0D modelling framework was developed, and we demonstrate its efficacy in (1) reproducing measured multi-variate cardiovascular variables (pulse pressure, total peripheral resistance and cardiac output) and (2) providing automated estimates of variables that have not been measured (uterine arterial and venous blood flow, pulse wave velocity, pulsatility index). (springer.com)
- Using this model as a framework, results were analyzed for the four distinct phases of the cardiac cycle - diastole, isovolumic contraction, ejection and isovolumic relaxation. (biomedcentral.com)
- Unique parameter identification for cardiac diagnosis in critical care using minimal data sets. (ac.be)
- The simplified models can also act as a bridge to identifying more sophisticated cardiac models, by providing an initial set of patient specific parameters that can reveal trends and interactions in the data over time. (ac.be)
- Cardiac contraction is modeled using the varying-elastance concept. (physiology.org)
- In summary, the combined protocol strategy can be readily applied for quantitative TATS network studies during physiological myocyte adaptation or disease changes, comparison of different cardiac or skeletal muscle cell types, phenotyping of transgenic models, and pharmacological or therapeutic interventions. (jove.com)
- The displacement field during the cardiac cycle is described by three time-dependent parameters, using a family of volume-preserving mappings based on prolate spheroidal coordinates. (deepdyve.com)
- Stress equilibrium is imposed in weak form and the resulting force balance equations are coupled to a lumped-parameter model of the circulation, leading to a system of differential-algebraic equations, whose numerical solution yields predictions of LV pressure and volume, together with spatial distributions of stresses and strains throughout the cardiac cycle. (deepdyve.com)
- This approach allows simulations of LV dynamics that run faster than real time, and could be used to determine patient-specific parameters of LV performance on-line from clinically available measurements, with the eventual goal of real-time, patient-specific analysis of cardiac parameters. (deepdyve.com)
- This is a lumped parameter model for cardiac activation based on the work of Heldt et al. (cellml.org)

###### Mathematical Models

- Mathematical models based on one-dimensional flow equations are usually used to study the hemodynamic mechanism for the effects of vascular stenoses on cardiovascular system. (hindawi.com)
- elements of the lymphatic system such as the nodes, which act as pumps and reservoirs, have not been addressed by mathematical models. (royalsocietypublishing.org)
- The lack of mathematical models developed for the study of its function presents a wealth of opportunities for researchers. (royalsocietypublishing.org)
- Section 4 deals with the mathematical models developed thus far and discusses their key assumptions and limitations. (royalsocietypublishing.org)
- We will then introduce mathematical models of different degree of complexity: from zero-dimensional (0-D) lumped parameter models of the whole circulation, to one-dimensional (1-D) models of pulse wave propagation in vessel networks, to three-dimensional (3-D) fluid-structure interaction formulations. (sjtu.edu.cn)
- We then used that data to develop mathematical models of the patient's response over time, using those equations to develop controller functions. (rpi.edu)
- These patient outputs were measured in response to certain drugs (Nitroprusside, and Dopamine), and mathematical models were calculated to represent the responses. (rpi.edu)

###### physiologically based

- We then review some of (i) the key data resources available for use in model development and (ii) the potential areas where advances made within the physiome modelling community could contribute to physiologically based pharmacokinetic and physiologically based pharmacokinetic/pharmacodynamic modelling in support of personalized drug development. (royalsocietypublishing.org)
- 2002. This CellMl model represents a structurally complete model of a lumped parameter, physiologically-based circulatory system. (cellml.org)

###### response to orthostatic stress

- Existing models approximate certain aspects of the circulation and its response to orthostatic stress, but the transients seen on passive head-up tilt (HUT) have proven difficult to capture. (physiology.org)

###### hemodynamics

- Simulators incorporating mammalian responses such as the regulation of vascular resistance, heart rate and stroke volume are a requisite for testing of devices that interfere directly with the hemodynamics of the cardiovascular system. (forschung3r.ch)

###### systemic

- This lumped pulsatile cardiovascular model consists of eight compartments of the body that include pumping heart, the systemic circulation, and the pulmonary circulation. (koreascience.or.kr)
- This paper presents a new concept of parameter identification, applied to a 2 chamber model of the left ventricle systemic system. (canterbury.ac.nz)
- The model comprises three main parts: the heart, the systemic loop, and the displacement pump VAD, as illustrated in Fig. 1. (cellml.org)
- We developed a baroreflex model combined with a lumped-parameter model of the circulation, including viscoelastic stress-relaxation of the systemic veins. (physiology.org)
- This model captures many key features of wave propagation in the systemic network and, in particular, pulse pressure amplification (PPA), which is a mechanical biomarker of cardiovascular risk. (hindawi.com)
- On the one hand, lumped parameter or 0D models [ 5 - 7 ] are particularly relevant when modeling interactions between the systemic network and other major systems (nervous, respiratory, and digestive) but are unable to describe pulse wave propagation. (hindawi.com)

###### dynamics

- Methods We developed a unique computational fluid dynamics and lumped parameter modeling framework based on patient-specific hemodynamic input parameters and validated it against patient-specific clinical outcomes (before and after intervention). (onlinejacc.org)
- Modern numerical methods are employed for the one-dimensional model (PDEs), for the EFMC model and valve dynamics (ODEs). (springer.com)
- The goal is to apply the simplified models to retrospective data on groups of patients to help characterize population trends or un-modelled dynamics within known bounds. (ac.be)
- However, there are highly non-linear valve dynamics inherent in these models which makes parameter identification difficult. (canterbury.ac.nz)
- This model describes the human cardiovascular dynamics under a displacement pump type ventricular assist device (VAD) support using lumped-parameter modelling, based on the concept of hydraulic-electric analogue. (cellml.org)
- A concentrated parameter model for the human cardiovascular system including heart valve dynamics and atrioventricular interaction, Korakianitis T, Shi Y, 2006. (cellml.org)
- Numerical simulation of cardiovascular dynamics with different types of VAD assistance, Shi Y, Korakianitis T, Bowles C, 2007. (cellml.org)
- These lectures will show how to apply concepts of fluid dynamics to model blood flow in vessel networks of the cardiovascular system. (sjtu.edu.cn)
- The course offers a detailed introduction to hybrid systems, which are dynamical systems combining continuous dynamics (modeled by differential equations) with discrete dynamics (modeled by automata). (bu.edu)
- The use of these techniques will help to develop mechanistic insight into signaling pathways that regulate cellular excitability, Ca 2+ dynamics and contractility and provide a much more physiologically relevant characterization of cardiovascular disease. (jove.com)
- Synthetic models can be fabricated with systematic changes to geometry and material properties, allowing for the study of healthy and unhealthy human phonatory aerodynamics, structural dynamics, and acoustics. (jove.com)
- Toward this goal, a low-order theoretical model is presented, in which LV shape is represented using a small number of parameters, allowing rapid computational simulations of LV dynamics. (deepdyve.com)

###### system

- The one-dimensional model for a deformable lymphatic vessel is a nonlinear system of hyperbolic Partial Differential Equations (PDEs). (springer.com)
- In this paper, we describe a mathematical model of the cardiovascular system in human pregnancy. (springer.com)
- The human cardiovascular system undergoes significant physiological and structural adaptations during healthy pregnancy. (springer.com)
- The maternal cardiovascular system also undergoes several major physical adaptations. (springer.com)
- As a first step towards this final goal, a computational model of the gastrointestinal system has been developed and used to simulate realistic blood flow during normal conditions. (biomedcentral.com)
- An anatomically and physiologically realistic computational model of the major mesenteric arteries has been developed for the gastrointestinal system. (biomedcentral.com)
- The purpose of our current research is to develop an extensible anatomically and biophysically based computational model of the mesenteric arterial system, which is the main blood supply to the human intestine, and to use this model to carefully examine intestinal blood flow. (biomedcentral.com)
- Lumped parameter approaches for modelling the cardiovascular system typically have many parameters of which a significant percentage are often not identifiable from limited data sets. (ac.be)
- This separates sub-structures of more complex cardiovascular system models to create uniquely identifiable simplified models that are one to one with the measurements. (ac.be)
- In addition, a new concept of parameter identification is presented where the changes in the parameters are treated as an actuation force into a feed back control system, and the reference output is taken to be steady state values of measured volume and pressure. (ac.be)
- The first simulator was based on lumped-parameter modeling of the cardiovascular system, whereby properties of the circulation that are normally geometrically distributed throughout the body are lumped in one discrete component. (forschung3r.ch)
- This model is characterized by great flexibility because the tanks can simulate any part of the cardiovascular system that is implemented in the software: ventricles, atria, pulmonary artery, veins, etc. (forschung3r.ch)
- Lumped parameter differential equation models are a common approach to modeling the cardiovascular system. (canterbury.ac.nz)
- Pulsatile mock loop systems are largely used to investigate the cardiovascular system in vitro. (asme.org)
- Bioengineering principles applied to the cardiovascular system. (stanford.edu)
- Anatomy of human cardiovascular system, comparative anatomy and allometric scaling principles. (stanford.edu)
- Physical mechanisms of mechanochemical coupling in biological molecular motors, using F1 ATPase as the principal model system. (stanford.edu)
- Transient response of the cardiovascular system to active standing and passive HUT has been the focus of various studies ( 3 , 34 , 45 , 47 , 51 , 59 ). (physiology.org)
- Nevertheless, there is a notable disparity in terms of research effort expended in relation to the treatment of lymphatic diseases in contrast to the cardiovascular system. (royalsocietypublishing.org)
- While similarities to the cardiovascular system exist, there are considerable differences in their anatomy and physiology. (royalsocietypublishing.org)
- The study of the lymphatic system is still in its infancy, the vast majority of the models presented in the literature to date having been developed since 2003. (royalsocietypublishing.org)
- The present review attempts to summarize the current knowledge on the lymphatic system with an emphasis on the modelling of its biomechanical behaviour. (royalsocietypublishing.org)
- In this study, we combined a three-dimensional finite element electromechanical model of ventricles, which is based on human ventricular morphology captured by magnetic resonance imaging (MRI) with a lumped model of the circulatory system and continuous flow LVAD function in order to construct an integrated model of an LVAD implanted-cardiovascular system. (biomedcentral.com)
- Embodiments include a system for determining cardiovascular information for a patient. (patents.com)
- The at least one computer system may also be configured to create a three-dimensional model representing the portion of the anatomical structure based on the patient-specific data, create a physics-based model relating to a blood flow characteristic within the portion of the anatomical structure, and determine a fractional flow reserve within the portion of the anatomical structure based on the three-dimensional model and the physics-based model. (patents.com)
- The quantitative analysis of pulsatile pressure-flow relationships provides insight into the structure and regulation of the cardiovascular system. (ahajournals.org)
- For this purpose, the 3D electromechanical model of the failing ventricles used in previous studies was coupled with a lumped parameter model of valvular regurgitation and the IABP-treated vascular system. (springer.com)
- In this study, IABP function was incorporated into the electromechanical model of a ventricle with mitral and aortic valve regurgitation with a lumped model of the circulatory system. (springer.com)
- The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. (patentsencyclopedia.com)
- The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. (patentsencyclopedia.com)
- 186. The system of claim 185, wherein the at least one computer system is configured to determine multiple fractional flow reserves, wherein each of the multiple fractional flow reserves corresponds to one of the coronary arteries, and wherein the at least one computer system is configured to provide the three-dimensional model and the multiple fractional flow reserves for display together on the display device. (patentsencyclopedia.com)
- 187. The system of claim 186, wherein the at least one computer system is configured to provide the three-dimensional model and the fractional flow reserves such that each fractional flow reserve is positioned, on the display device, overlying the coronary artery to which it corresponds. (patentsencyclopedia.com)
- 189. The system of claim 185, wherein the at least one computer system is configured to provide additional patient-specific data via the display device, wherein the additional patient-specific data, the three-dimensional model and the fractional flow reserve are displayed together on the display device. (patentsencyclopedia.com)
- 191. The system of claim 189, wherein the at least one computer system is configured to provide at least one alternate view of the three-dimensional model on the display device in a small window near the three-dimensional model. (patentsencyclopedia.com)
- 192. The system of claim 185, wherein the at least one computer system is configured to provide the three-dimensional model with each of the coronary arteries color coded to indicate the fractional flow reserve determined by the computer system along a length of that coronary artery. (patentsencyclopedia.com)
- Effects of system modeling errors and simplifications (i.e., modal truncation) are studied. (bu.edu)
- Mouse models provide the possibility of utilizing different genetic models including gene-targeted mice and tissue specific gene-targeted mice (cre-flox system). (jove.com)
- ABSTRACT: The objective of this study is to develop a model of the cardiovascular system capable of simulating the short-term (less than or equal to 5 min) transient and steady-state hemodynamic responses to head-up tilt and lower body negative pressure. (cellml.org)

###### numerical

- 4 ] and Singh and Shah [ 5 ] analyzed the decreases of instantaneous maximal transvalvular pressure in aortic stenosis using numerical models. (hindawi.com)
- An analytical solution has been developed to model blood flow in tapering vessels and when compared with the numerical solution, showed excellent agreement. (biomedcentral.com)
- To this end, numerical simulations were performed using acquired central pressure signals from different subject groups (young, adults, and hypertensive) as input and then comparing the output of the model with measured radial artery pressure waveforms. (hindawi.com)
- Pathological conditions were modeled as changes in arterial elasticity ( E ). Numerical results showed that the model was able to propagate acquired pressure waveforms and to reproduce PPA variations as a consequence of elastic changes. (hindawi.com)
- We also present a practical biomedical application of the developed numerical model to the problem of blood flow variability in cerebral circulation due to anatomical features of the vascular network in the presence of the atherosclerosis disease. (springer.com)

###### circulation

- A new mathematical model of pumping heart coupled to lumped compartments of blood circulation is presented. (koreascience.or.kr)
- We extend the developed lumped model of circulation in normal case into a specific model for arrhythmia. (koreascience.or.kr)
- It is also the first model capable of capturing wave propagation phenomena in the utero-ovarian circulation, which are important for the accurate estimation of arterial stiffness in contemporary obstetric practice. (springer.com)
- Derived from workspace Cardiovascular Circulation DVad at changeset 13fe14bd8114 . (cellml.org)
- a modeling approach to the study of the blood circulation and its response to postural changes can provide insight into the underlying physiology. (physiology.org)
- The simulated BP response of a recent model, including a detailed circulation and reflex model ( 21 ), shows a major BP dip in the first 10-20 s after HUT ( 20 ). (physiology.org)
- It uses the Heldt et al activation function and extends the lumped parameter circulation model such that the circulation through organs is represented. (cellml.org)
- The model consists of a closed-loop lumped-parameter representation of the circulation connected to set-point models of the arterial and cardiopulmonary baroreflexes. (cellml.org)
- Schematic diagram of full body circulation model. (cellml.org)
- Kholodov, A.S.: Some dynamic models of external breathing and blood circulation with consideration for their coherence and mass transfer. (springer.com)

###### physiologic

- Supervised learning on coarse mesh solutions can augment traditional physics-based modelling of complex physiologic phenomena. (royalsocietypublishing.org)

###### vascular

- For the purpose of a better understanding of the correlation between vascular stenoses and ABI, a computational model for simulating blood pressure and flow propagation in various arterial stenosis circumstances was developed with a detailed compartmental description of the heart and main arteries. (hindawi.com)
- The model will provide a basis for future studies aiming to elucidate the physiological mechanisms underlying the dynamic properties (changing shapes) of vascular flow waveforms that are observed with advancing gestation. (springer.com)
- We believe that such a model could have clinical applications particularly with relation to mesenteric ischemia, a complex vascular problem that arises due to a narrowing or blockage of blood vessels that supply oxygenated blood to the small and large intestines, for which accurate diagnosis is often delayed. (biomedcentral.com)
- It consists of a simplified fluid circuit with lumped parameter elements implemented in hardware (compliance chamber, vascular resistor, and venous reservoir). (forschung3r.ch)
- The calculation and modeling of vascular input impedance are based on the assumption that pressure and flow are linearly related in the frequency domain. (ahajournals.org)
- The calculation of vascular impedance by Fourier methods and Windkessel-type lumped parameter models is based on the assumption that pressure and flow are linearly related in the frequency domain. (ahajournals.org)
- Both of these noninvasive measures of vascular dysfunction are independent predictors of future cardiovascular events in patients with and without kidney disease. (jove.com)

###### physiological

- The quantitative physiological aspects of the respiratory and cardiovascular systems are studied. (bu.edu)
- The topics covered will include sampling theory, continuous and discrete Fourier transforms and series, Laplace transforms, Linear systems theory, signal filtering, models of biological and physiological systems, and analysis of dynamic and feedback systems. (iit.edu)
- The course expands upon the systems and signal processing concepts introduced in BME 330 to develop the tools to model physiological processes and the feedback control of these processes. (iit.edu)
- Yet, the physiological influences on the IVIM perfusion parameters ("pseudo-diffusion" coefficient D*, perfusion fraction f, and flow related parameter fD*) remain insufficiently characterized. (jove.com)
- 1997) have developed a simulator to relate the infusion of certain drugs to changes in physiological parameters. (rpi.edu)
- It has 1) a nonlinear, pulsatile-flow cardiovascular model, 2) a physiological regulatory model of the baroreceptors, 3) a pharmacokinetics model, and 4) pharmacodynamic models of the drugs. (rpi.edu)

###### Physiology

- Integrative cardiovascular physiology, blood fluid mechanics and transport in the microcirculation. (stanford.edu)
- In this paper, we roadmap the efforts required for the physiome community to improve interoperability of data and models, from distinct physiology domains and scales, to effectively predict multiscale drug handling and action in support of personalized medicine. (royalsocietypublishing.org)
- I will discuss how mathematical modeling techniques can be used to address a host of previously unanswered questions in renal physiology and pathophysiology: When deprived of water, how does a mammal produce a highly concentrated urine? (sjtu.edu.cn)
- We will start with a brief introduction to cardiovascular anatomy and physiology, focusing on concepts that are relevant to blood flow modelling. (sjtu.edu.cn)

###### CellML

- Construction of lumped-parameter cardiovascular models using the CellML language. (nih.gov)
- The current CellML model implementation runs in OpenCell. (cellml.org)
- This CellML model runs in both COR and PCEnv. (cellml.org)

###### arterial

- 1 - 3 ] developed finite element models including nonlinearities arising from geometry and material properties to analyze the characteristics of blood flow and pressure decrease caused by an arterial stenosis. (hindawi.com)
- ABI, defined as the ratio of systolic pressure in the ankle arteries (the posterior tibial artery in this model) and systolic pressure in the brachial artery (Figure 1 ), was an important noninvasive measurement for the detection of arterial obstructive disease, especially for the lower extremity arterial stenosis [ 8 - 10 ]. (hindawi.com)
- Transgenic and toxic models of pulmonary arterial hypertension (PAH) are widely used to study the pathophysiology of PAH and to investigate potential therapies. (jove.com)
- Arterial pressure waves have been described in one dimension using several approaches, such as lumped (Windkessel) or distributed (using Navier-Stokes equations) models. (hindawi.com)
- We considered two models simulating drug delivery to the arterial wall: (i) two-dimensional drug-coated balloons and (ii) three-dimensional drug-eluting stents. (royalsocietypublishing.org)

###### framework

- We obtain the posterior distribution of the model parameters in a Bayesian framework. (jove.com)
- By obtaining efficient solutions at a fraction of the computational cost, this framework has the potential to transform how modelling approaches can be applied in the evaluation of medical technologies and their real-time administration in an increasingly personalized fashion. (royalsocietypublishing.org)

###### Approach

- Biofliud Mechanics in Cardiovascular Systems is one of the first books to take an interdisciplinary approach to the subject. (indigo.ca)
- Computational modeling is an alternative approach to overcome this limitation. (springer.com)
- An alternative approach consists of modeling blood pressure waves using a Korteweg-de Vries (KdV) equation and representing pressure waves as combinations of solitons. (hindawi.com)

###### simulate

- An anatomically and biophysically based model of the major mesenteric arteries has been developed to be used to simulate normal blood flows. (biomedcentral.com)
- Extensive computer models are developed to simulate the behavior of these systems in the frequency and time domains. (bu.edu)
- Several published models have been designed to simulate the cardiovascular response to passive tilt or active standing ( 1 , 21 , 22 , 28 , 29 , 32 , 44 ). (physiology.org)
- This, in fact, resembles active standing, rather than passive HUT, although the model was designed to simulate passive tilt and does not include any effect of the active part of the maneuver on peripheral resistance. (physiology.org)
- On the basis of experimental evidence, we adjusted some model parameters to simulate experimental data. (cellml.org)

###### complex cardiovascular

- These simulators contribute to the 3R-principles in several respects: (i) they have been used to execute complex cardiovascular research studies without having to sacrifice animals. (forschung3r.ch)

###### simulations

- This lecture series are designed to introduce the basic mathematical modeling, analysis and simulations for chemical reaction kinetics (CKS). (sjtu.edu.cn)
- The cross-validated, supervised learner-based predictions improved fidelity as compared with computational simulations performed at coarse level meshes-a result consistent across all outputs and computational models considered. (royalsocietypublishing.org)

###### Pulmonary Embolism

- The method is validated in both simulation and on a porcine model of pulmonary embolism. (canterbury.ac.nz)

###### hemodynamic

- Models used in those studies were mostly applied to the analysis of hemodynamic effects of stenoses on blood pressure decreases or flow characteristics. (hindawi.com)
- Although it is important to analyze the hemodynamic factors related to the right ventricle (RV) after left ventricular assist device (LVAD) implantation, previous studies have focused only on the alteration of the ventricular shape and lack quantitative analysis of the various hemodynamic parameters. (biomedcentral.com)
- Therefore, we quantitatively analyzed various hemodynamic parameters related to the RV under normal, heart failure (HF), and HF incorporated with continuous flow LVAD therapy by using a computational model. (biomedcentral.com)
- Simulation studies, on the other hand, can overcome those limitations and provide data on a variety of hemodynamic parameters in a noninvasive manner. (biomedcentral.com)
- Model verification was performed by comparing the simulation output under baseline conditions and at different levels of orthostatic stress to sets of population-averaged hemodynamic data reported in the literature. (cellml.org)

###### Windkessel

- We determined the impedance spectra at several cycle lengths for each embryo and a reference curve from a three-element Windkessel model with the use of nonlinear curve fitting. (ahajournals.org)

###### afterload

- They consist of a pump, which replicates the heart, coupled with a lumped-parameter hydraulic afterload, which simulates vasculature. (asme.org)

###### fluid

- We propose a one-dimensional model for collecting lymphatics coupled with a novel Electro-Fluid-Mechanical Contraction (EFMC) model for dynamical contractions, based on a modified FitzHugh-Nagumo model for action potentials. (springer.com)
- The EFMC model combines the electrical activity of lymphangions (action potentials) with fluid-mechanical feedback (circumferential stretch of the lymphatic wall and wall shear stress) and lymphatic vessel wall contractions. (springer.com)

###### Imaging

- Conclusions: This new method offers a robust and time saving procedure to quantify myocardial tissue and blood with displacement, velocity and deformation parameters on regular sequences of CMR imaging. (jove.com)

###### differential

- The EFMC model is governed by four Ordinary Differential Equations (ODEs) and phenomenologically relies on: (1) environmental calcium influx, (2) stretch-activated calcium influx, and (3) contraction inhibitions induced by wall shear stresses. (springer.com)
- Models that use Partial Differential Equations. (physiome.org)

###### dynamical

- In this work, we present a dynamical one-dimensional network model of haemodynamics. (springer.com)

###### simulation

- The goal of developing therapies and dosage regimes for characterized subgroups of the general population can be facilitated by the use of simulation models able to incorporate information about inter-individual variability in drug disposition (pharmacokinetics), toxicity and response effect (pharmacodynamics). (royalsocietypublishing.org)

###### ventricular

- It causes and aggravates pre-existing AR while performing well in the event of mitral regurgitation (MR). Indirect parameters, such as the mean systolic pressure, product of heart rate and peak systolic pressure, and pressure-volume are used to quantify the effect of IABP on ventricular workload. (springer.com)
- The goal of this study is to examine the effect of IABP therapy on ventricular mechanics under valvular insufficiency by using a computational model of the heart. (springer.com)
- Indirect parameters such as the mean systolic pressure, product of heart rate and peak systolic pressure, and pressure-volume are used to quantify the effect of IABP on ventricular workload. (springer.com)
- The goal of this study involves examining the effect of IABP therapy on ventricular mechanics under the valvular insufficiency condition, which includes the AR and MR conditions in the failing ventricle, by using a computational model of the heart. (springer.com)
- To test this hypothesis, we used a computational model to explore the effects of heart rate (HR) and aortic rigidity on left ventricular (LV) power requirement. (jove.com)
- Echocardiography is the mainstay of the noninvasive assessment of right ventricular function in rodent models and has the advantage of clear translation to humans in whom the same tool is used. (jove.com)
- Left ventricular mass (LVM) is known to be related to overall and cardiovascular mortality in end stage kidney disease (ESKD) patients. (jove.com)

###### elasticity

- In each segment, individual components are modelled by representations of the local resistance to blood flow, vessel elasticity and the inertia of the blood. (cellml.org)

###### time-dependent

- The pumping heart is modeled by the time-dependent linear curves of compliances in the heart. (koreascience.or.kr)
- In the current study, a large strain time-dependent constitutive model of human vocal fold tissue is used to investigate effects of phonatory posturing cyclic strain in the range of 1 Hz to 10 Hz. (jove.com)

###### finite element models

- Enhanced finite element models in biomechanics. (stanford.edu)

###### Methods

- Using the methods of grounded theory, our findings were synthesized into a theoretical model depicting the structure and process of formal family meetings within this setting. (jove.com)
- Standard methods for parameter identification rely on gradient descent, which can often converge to wrong solutions, particularly as the number of parameters increases. (canterbury.ac.nz)
- Overview of congenital and adult cardiovascular disease, diagnostic methods and treatment strategies. (stanford.edu)
- Existing methods for studying voice production include in vivo experimentation using human and animal subjects, in vitro experimentation using excised larynges and synthetic models, and computational modeling. (jove.com)

###### elastance

- The heart is modelled as a two-chambered pump with variable elastance and two heart valves to control the direction of blood flow. (cellml.org)

###### wave propagation

- Classical models of these systems are considered including lumped element models, branching tree structures, and distributed parameter models to predict wave propagation in compliant walled tubes filled with compressible or incompressible fluids. (bu.edu)

###### simulator

- Hence, this simulator is valuable for a broad array of cardiovascular devices. (forschung3r.ch)
- Segers P, Dubois F, De Wachter D, Verdonck P. Role and relevancy of a cardiovascular simulator. (forschung3r.ch)
- The closed-loop cardiovascular drug delivery simulator models multiple factors. (rpi.edu)

###### diseases

- These models provide valuable tools in examining and understanding cardiovascular diseases. (koreascience.or.kr)
- The partial occlusion of arteries due to stenotic obstruction is one of the most frequent cardiovascular diseases in human beings. (hindawi.com)

###### Computational Models

- Statistical Atlases and Computational Models of the Heart. (springer.com)
- Yet resource limitations force one to compromise with reduced order computational models and idealized assumptions that yield either qualitative descriptions or approximate, quantitative solutions to problems of interest. (royalsocietypublishing.org)

###### biological

- This review outlines some of the challenges and opportunities for those engaged in modelling biological systems. (royalsocietypublishing.org)
- From a control design perspective, the important issues from the PD model are the large variability in the observed responses, typical of biological systems, and the significant delay between the HR response and the infusion administration. (rpi.edu)

###### biochemical

- Computational modelling of physical and biochemical processes has emerged as a means of evaluating medical devices, offering new insights that explain current performance, inform future designs and even enable personalized use. (royalsocietypublishing.org)

###### murine models

- Published echocardiography protocols in murine models of PAH are lacking. (jove.com)
- The use of primary cardiomyocytes (CMs) in culture has provided a powerful complement to murine models of heart disease in advancing our understanding of heart disease. (jove.com)
- To elucidate mechanisms of renal injury due to ischemia and possible therapeutic strategies murine models are intensively required 7-13 . (jove.com)

###### Flow

- This is the first model capable of estimating volumetric blood flow to the uterus via the utero-ovarian communicating arteries. (springer.com)
- Using this model, blood flow has been simulated which show physiologically realistic flow profiles. (biomedcentral.com)
- and provide the three-dimensional model and the fractional flow reserve to a user via a display device, wherein the three-dimensional model and the fractional flow reserve are displayed together on the display device. (patentsencyclopedia.com)

###### dysfunction

- Purpose: An accurate and practical method to measure parameters like strain in myocardial tissue is of great clinical value, since it has been shown, that strain is a more sensitive and earlier marker for contractile dysfunction than the frequently used parameter EF. (jove.com)

###### Characterization

- Characterization of small fiber pathology in a mouse model of Fabry disease. (nih.gov)

###### vitro

- The approval of new cardiovascular devices for clinical use depends upon data that are gleaned from in vitro and in vivo . (forschung3r.ch)

###### human

- Through its efforts to standardize annotation with consequent increase in data usability, the human physiome project has a vital role in improving productivity in model development and, thus, the development of personalized therapy regimes. (royalsocietypublishing.org)
- D*(t), and demonstrate in the healthy human brain that both parameters D* and fD* are significantly larger during systole than diastole, while the diffusion coefficient D and f do not vary significantly. (jove.com)
- Consequently, one- and two-layer synthetic vocal fold models have exhibited disadvantages 3,6,8 such as higher onset pressures than what are typical for human phonation (onset pressure is the minimum lung pressure required to initiate vibration), unnaturally large inferior-superior motion, and lack of a "mucosal wave" (a vertically-traveling wave that is characteristic of healthy human vocal fold vibration). (jove.com)
- Ethanol administration to pregnant rodents has been used to model human exposure during the first and second trimesters of pregnancy. (jove.com)

###### clinical

- Emerging applications in clinical medicine and medical device design are just beginning to embrace the potential of computational modelling [ 1 , 2 ]. (royalsocietypublishing.org)

###### objective

- Objective: Our purpose was to rigorously examine the nature of family meetings as conducted in an inpatient hospice care unit in order to generate an inductive theoretical model. (jove.com)
- The objective is to use this modeled information to design a control device to read several patient outputs, and to adjust the dosage of several drugs accordingly. (rpi.edu)