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  • diseases
  • Nevertheless, there is a notable disparity in terms of research effort expended in relation to the treatment of lymphatic diseases in contrast to the cardiovascular system. (royalsocietypublishing.org)
  • In particular, the ability to study ion homeostasis, ion channel function, cellular excitability and excitation-contraction coupling and their alterations in diseased conditions and by disease-causing mutations have led to significant insights into cardiac diseases. (jove.com)
  • To understand the role of RV in the pathogenesis of cardiac diseases, a reliable and noninvasive method to access the RV structurally and functionally is essential. (jove.com)
  • The partial occlusion of arteries due to stenotic obstruction is one of the most frequent cardiovascular diseases in human beings. (hindawi.com)
  • dysfunction
  • Both of these noninvasive measures of vascular dysfunction are independent predictors of future cardiovascular events in patients with and without kidney disease. (jove.com)
  • Those changes are likely to be responsible for the increased arrhythmogenic risk and the contractile alterations leading to systolic and diastolic dysfunction in cardiac patients. (jove.com)
  • Purpose: An accurate and practical method to measure parameters like strain in myocardial tissue is of great clinical value, since it has been shown, that strain is a more sensitive and earlier marker for contractile dysfunction than the frequently used parameter EF. (jove.com)
  • Emerging clinical data support the notion that RV dysfunction is critical to the pathogenesis of cardiovascular disease and heart failure 1-3 . (jove.com)
  • In addition, the RV is remarkably sensitive to cardiac pathologies, including left ventricular (LV) dysfunction, valvular disease or RV infarction 4 . (jove.com)
  • This method will enable a better understanding of the role of RV cardiac dysfunction. (jove.com)
  • These results demonstrated that without AMPK, CR triggers adverse effects that can lead to cardiac dysfunction, suggesting that AMPK signaling pathway is indispensible for energy homeostasis and myocardial adaptation to CR, a dietary intervention that normally produces beneficial cardiac effects. (jove.com)
  • interventions
  • In summary, the combined protocol strategy can be readily applied for quantitative TATS network studies during physiological myocyte adaptation or disease changes, comparison of different cardiac or skeletal muscle cell types, phenotyping of transgenic models, and pharmacological or therapeutic interventions. (jove.com)
  • hemodynamic
  • We provide a detailed description of animal preparation, image acquisition and hemodynamic calculation of stroke volume, cardiac output and an estimate of pulmonary artery pressure. (jove.com)
  • Models used in those studies were mostly applied to the analysis of hemodynamic effects of stenoses on blood pressure decreases or flow characteristics. (hindawi.com)
  • Correspondingly, AMPK?2 KO mice had markedly reduced cardiac function during CR as determined by echocardiography and hemodynamic measurements. (jove.com)
  • ABSTRACT: The objective of this study is to develop a model of the cardiovascular system capable of simulating the short-term (less than or equal to 5 min) transient and steady-state hemodynamic responses to head-up tilt and lower body negative pressure. (cellml.org)
  • Model verification was performed by comparing the simulation output under baseline conditions and at different levels of orthostatic stress to sets of population-averaged hemodynamic data reported in the literature. (cellml.org)
  • valvular
  • The goal of this study is to examine the effect of IABP therapy on ventricular mechanics under valvular insufficiency by using a computational model of the heart. (springer.com)
  • The goal of this study involves examining the effect of IABP therapy on ventricular mechanics under the valvular insufficiency condition, which includes the AR and MR conditions in the failing ventricle, by using a computational model of the heart. (springer.com)
  • Transgenic
  • Transgenic and toxic models of pulmonary arterial hypertension (PAH) are widely used to study the pathophysiology of PAH and to investigate potential therapies. (jove.com)
  • dynamics
  • The goal is to apply the simplified models to retrospective data on groups of patients to help characterize population trends or un-modelled dynamics within known bounds. (ac.be)
  • Synthetic models can be fabricated with systematic changes to geometry and material properties, allowing for the study of healthy and unhealthy human phonatory aerodynamics, structural dynamics, and acoustics. (jove.com)
  • The use of these techniques will help to develop mechanistic insight into signaling pathways that regulate cellular excitability, Ca 2+ dynamics and contractility and provide a much more physiologically relevant characterization of cardiovascular disease. (jove.com)
  • Toward this goal, a low-order theoretical model is presented, in which LV shape is represented using a small number of parameters, allowing rapid computational simulations of LV dynamics. (deepdyve.com)
  • responses
  • These trends can assist in improved prediction of patient responses to cardiac disturbance and therapy intervention with potentially smaller and less invasive data sets. (ac.be)
  • From a control design perspective, the important issues from the PD model are the large variability in the observed responses, typical of biological systems, and the significant delay between the HR response and the infusion administration. (rpi.edu)
  • However, it was disturbed by the AR and worsened the cardiovascular responses that followed the AR. (springer.com)
  • Cardiac responses such as cardiac output and blood pressure vary according to the type of valve that is affected and the severity of the regurgitation. (springer.com)
  • murine models
  • To elucidate mechanisms of renal injury due to ischemia and possible therapeutic strategies murine models are intensively required 7-13 . (jove.com)
  • The use of primary cardiomyocytes (CMs) in culture has provided a powerful complement to murine models of heart disease in advancing our understanding of heart disease. (jove.com)
  • clinical
  • Correction: cardiac mechanics and ventricular twist by three-dimensional strain analysis in relation to B-type natriuretic Peptide as a clinical prognosticator for heart failure patients. (jove.com)
  • We hypothesized that greater RV mass and RV end-diastolic volume (RVEDV), smaller RV stroke volume (RVSV), and lower RV ejection fraction (RVEF) measured by cardiac magnetic resonance imaging (MRI) in participants free of clinical cardiovascular disease at baseline would be associated with a greater risk of self-reported dyspnea. (jove.com)
  • systolic pressure
  • It causes and aggravates pre-existing AR while performing well in the event of mitral regurgitation (MR). Indirect parameters, such as the mean systolic pressure, product of heart rate and peak systolic pressure, and pressure-volume are used to quantify the effect of IABP on ventricular workload. (springer.com)
  • Indirect parameters such as the mean systolic pressure, product of heart rate and peak systolic pressure, and pressure-volume are used to quantify the effect of IABP on ventricular workload. (springer.com)
  • ABI, defined as the ratio of systolic pressure in the ankle arteries (the posterior tibial artery in this model) and systolic pressure in the brachial artery (Figure 1 ), was an important noninvasive measurement for the detection of arterial obstructive disease, especially for the lower extremity arterial stenosis [ 8 - 10 ]. (hindawi.com)
  • Imaging
  • Conclusions: This new method offers a robust and time saving procedure to quantify myocardial tissue and blood with displacement, velocity and deformation parameters on regular sequences of CMR imaging. (jove.com)
  • Transient
  • The image acquisition time (45 versus 68 min, p=0.002) and anaesthesia duration (100 versus 132 min, p=0.02) were shorter in the ferumoxytol group.CONCLUSION: Transient low blood pressure was common in children undergoing cardiac MRI with anaesthesia, but the incidence of hypotension did not differ between ferumoxytol and gadolinium groups. (stanford.edu)
  • consequently
  • This explanation of the immediate response to active and passive posture change implies that venous return and, consequently, cardiac output (CO) are not sufficiently reduced to induce a BP dip. (physiology.org)
  • Consequently, one- and two-layer synthetic vocal fold models have exhibited disadvantages 3,6,8 such as higher onset pressures than what are typical for human phonation (onset pressure is the minimum lung pressure required to initiate vibration), unnaturally large inferior-superior motion, and lack of a "mucosal wave" (a vertically-traveling wave that is characteristic of healthy human vocal fold vibration). (jove.com)
  • mice
  • We performed a systematic evaluation of a novel model for isolated renal artery occlusion in mice, which specifically avoids the use of clamping or suturing the renal pedicle 14 . (jove.com)
  • CR activated cardiac AMPK signaling in WT mice, but not in AMPK?2 KO mice. (jove.com)
  • In addition, CR accelerated cardiac autophagic flux in WT mice, but failed to do so in AMPK?2 KO mice. (jove.com)
  • contrast
  • We hypothesized that, in the cardiovascular response to passive HUT, where, in contrast to active standing, little BP dip is observed, features affecting the preload play a key role. (physiology.org)
  • BACKGROUND: Ferumoxytol, an "off-label" contrast agent, allows for better cardiac MRI quality as compared with gadolinium-based contrast agents. (stanford.edu)
  • determinants
  • The aims of the present study are 1) to determine whether LVM is associated with mortality and various cardiovascular events and 2) to identify determinants of LVM including biomarkers of inflammation and fibrosis. (jove.com)
  • blood
  • Blood pressure (MAP) and cardiac output (CO) from an intensive care "patient" were simulated using Simulink. (rpi.edu)
  • Lymphatic valves are modelled by extending an existing lumped-parameter model for blood vessels. (springer.com)
  • In this article, we hypothesize that D* and fD*, which depend on blood speed, should vary during the cardiac cycle. (jove.com)
  • 1 - 3 ] developed finite element models including nonlinearities arising from geometry and material properties to analyze the characteristics of blood flow and pressure decrease caused by an arterial stenosis. (hindawi.com)
  • displacement
  • The displacement field during the cardiac cycle is described by three time-dependent parameters, using a family of volume-preserving mappings based on prolate spheroidal coordinates. (deepdyve.com)
  • time-dependent
  • In the current study, a large strain time-dependent constitutive model of human vocal fold tissue is used to investigate effects of phonatory posturing cyclic strain in the range of 1 Hz to 10 Hz. (jove.com)
  • theoretical model
  • Objective: Our purpose was to rigorously examine the nature of family meetings as conducted in an inpatient hospice care unit in order to generate an inductive theoretical model. (jove.com)
  • Our findings provide a theoretical model that can inform the design of a family meeting to address family members' needs for meaningful and contextualized information, validation of their important contributions to care, and preparation for the patient's death. (jove.com)
  • numerical
  • 4 ] and Singh and Shah [ 5 ] analyzed the decreases of instantaneous maximal transvalvular pressure in aortic stenosis using numerical models. (hindawi.com)
  • lymphatic
  • The EFMC model combines the electrical activity of lymphangions (action potentials) with fluid-mechanical feedback (circumferential stretch of the lymphatic wall and wall shear stress) and lymphatic vessel wall contractions. (springer.com)
  • output
  • For any given aortic rigidity, there exists an optimum HR that minimizes the LV power requirement at a given cardiac output. (jove.com)
  • objective
  • The objective is to use this modeled information to design a control device to read several patient outputs, and to adjust the dosage of several drugs accordingly. (rpi.edu)
  • Markers
  • The compromised cardiac function was associated with increased markers of oxidative stress, endoplasmic reticulum stress and myocyte apoptosis. (jove.com)
  • significantly
  • Patients with chronic kidney disease (CKD) have significantly increased risk of cardiovascular disease (CVD) compared to the general population, and this is only partially explained by traditional CVD risk factors. (jove.com)
  • D*(t), and demonstrate in the healthy human brain that both parameters D* and fD* are significantly larger during systole than diastole, while the diffusion coefficient D and f do not vary significantly. (jove.com)
  • minimal
  • Superpositioned impedance spectra showed minimal scatter along the model impedance from 0 to 6 Hz. (ahajournals.org)
  • Unique parameter identification for cardiac diagnosis in critical care using minimal data sets. (ac.be)
  • We describe a vapor chamber paradigm that can be used to model exposure to ethanol, with minimal handling, during all three trimesters. (jove.com)
  • known
  • In homology modeling, an already known secondary structure is transferred to another ITS2 sequence, whose secondary structure was not able to fold correctly in a direct fold. (jove.com)
  • Left ventricular mass (LVM) is known to be related to overall and cardiovascular mortality in end stage kidney disease (ESKD) patients. (jove.com)