• Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. (medkoo.com)
  • Hycanthone, a new active metabolite of lucanthone. (nih.gov)
  • A comparison of oral and parenteral activity of hycanthone and lucanthone in experimental infections with Schistosoma mansoni. (nih.gov)
  • Schistosomicidal activity of lucanthone hydrochloride, hycanthone and their metabolites in mice and hamsters. (nih.gov)
  • 1970), Bogitsh (1975) and Clarkson and Erasmus (1984) have shown that either in vitro or in vivo administration of the drugs Astiban, Hycanthone, Lucanthone and Niridizole can precipitate morphological changes in the gastrodermis of schistosomes similar to changes resulting from starvation (Bogitsh, 1975). (scialert.net)
  • In Schistosoma mansoni infections in Saudi Arabia a cure was obtained in 6 out of 12 cases with lucanthone hydrochloride (Nilodin) in dosages of 55 to 75 mg./kg. (ajtmh.org)
  • of lucanthone hydrochloride and 4 out of 4 cases were cured with 20 to 24 mg./kg. (ajtmh.org)
  • The purpose of the study is to determine the effectiveness of an investigational drug called lucanthone, when combined with temozolomide (TMZ) and radiation in the treatment of Glioblastoma Multiforme (GBM). (clinicaltrials.gov)
  • Lucanthone is an orally available small molecule inhibitor of AP endonuclease. (aacrjournals.org)
  • Lucanthone is orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APEX1 or APE1), with anti-schistosomal and potential antineoplastic activity. (medkoo.com)
  • Inhibition of AP endonuclease by lucanthone leads to the accumulation of abasic sites in DNA that are converted to lethal double-strand breaks leading to sensitization of tumor cells to alkylating agents and to radiation. (aacrjournals.org)
  • Lucanthone is an orally administered small-molecule which inhibits Topoisomerase II and AP endonuclease. (medkoo.com)
  • More recent research shows that lucanthone sensitizes tumor cells to radiation and chemotherapy by inhibiting DNA repair (AP endonuclease). (medkoo.com)
  • Since some of the anti-metabolite agents such as pemetrexed are also known to produce abasic sites in DNA, we hypothesized that lucanthone could potentiate the anti-tumor activity of pemetrexed. (aacrjournals.org)
  • It is a metabolite of lucanthone. (wikipedia.org)
  • Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. (harvard.edu)
  • COMBINATION ANTI-CANCER AGENTS - The present disclosure relates to methods of treating cancer in mammals by administration of Lucanthone and at least one anti-metabolite. (patentsencyclopedia.com)
  • Pharmaceutical compositions and kits comprising Lucanthone and at least one anti-metabolite also are disclosed. (patentsencyclopedia.com)
  • This is an international, multicenter, randomized, double blind placebo controlled phase II study to evaluate the safety and efficacy of lucanthone administered as an adjunct to patients receiving primary treatment of GBM with temozolomide and radiation. (clinicaltrials.gov)
  • Lucanthone or Placebo will be given as an oral at 10-15 mg/kg/day for 6 weeks along with radiation and TMZ during the concomitant phase. (clinicaltrials.gov)
  • Therefore, lucanthone may sensitize tumor cells to radiation and chemotherapy. (medkoo.com)
  • According to Spectrum Pharmaceuticals's website, Lucanthone inhibits Topoisomerase II and interferes with the repair of DNA damage that is caused by radiation and chemotherapy. (medkoo.com)
  • This is a randomized, double blind placebo controlled study to evaluate safety and efficacy of lucanthone administered as an adjunct to patients receiving whole brain radiation therapy (WBRT) as primary treatment for brain metastases secondary to non-small cell lung cancer. (careacross.com)
  • Carew JS, Espitia CM, Esquivel JA 2nd, Mahalingam D, Kelly KR, Reddy G, Giles FJ, Nawrocki ST (2011b) Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. (springer.com)
  • Furthermore, lucanthone inhibits autophagy through the disruption of lysosomal function. (medkoo.com)
  • Both pemetrexed and lucanthone inhibited tumor growth relative to the vehicles during the 28 days of treatment. (aacrjournals.org)
  • During the 28-day period, the body weight changes excluding the tumor weights were -2.9%, -0.9%, -6.1% and -1.7% for vehicles, pemetrexed, lucanthone, and the combination of pemetrexed and lucanthone, respectively. (aacrjournals.org)
  • Lucanthone intercalates DNA and interferes with the activity of topoisomerases I and II during replication and transcription, thereby inhibiting the synthesis of macromolecules. (medkoo.com)
  • and malignancy models drug loading concentrations and graphene allotropes used in studies of doxorubicin camptothecin lucanthone Ritonavir and paclitaxel loaded onto graphene for malignancy Ritonavir therapy. (livingseas.org)
  • Treatments were administered 7 times at frequency of once every 4 days and included vehicles, pemetrexed given intraperitoneally at 200 mg/kg, lucanthone given orally at 80 mg/kg, and the combinations of pemetrexed and lucanthone at the same doses. (aacrjournals.org)
  • Lucanthone has structural and biochemical similarities to Actinomycin D but has no hematological or GI toxicity at clinically tolerated doses. (medkoo.com)
  • Comparing to the vehicle-treated group, these represented 19%, 33%, and 55% of growth inhibition for groups treated with pemetrexed, lucanthone, and the combination of pemetrexed and lucanthone, respectively. (aacrjournals.org)
  • Combination treatment of lucanthone and pemetrexed was well tolerated. (aacrjournals.org)
  • Lucanthone HCl (studied as a reference drug) had only feeble to moderate effect in mice or monkeys even though several rigorous oral regimens were tried. (ajtmh.org)
  • Mulholland K., Wu Ch., "Computational Study of Anticancer Drug Resistance Caused by 10 Topisomerase I Mutations, Including 7 Camptothecin Analogs and Lucanthone", J. Chem Inf. (mathnet.ru)
  • drug en dag. (medicoinvestor.com)
  • Lucanthone is currently in clinical development for the treatment of brain tumors. (medkoo.com)
  • Behavioural Sleep Disorders across the Developmental Age Span: An Overview of Causes, Consequences and Treatment Modalities - Descarga este documento en PDF. (duhnnae.com)
  • In the maintenance phase, lucanthone/placebo will be administered along with TMZ on days 1-5 of a 28-day cycle for 6 cycles. (clinicaltrials.gov)
  • Han lægger en del vægt på deres 3 guldproduker i phase II pipelinen, Orzarelix, Lucanthone og SPI-2012. (medicoinvestor.com)
  • In preclinical tests, lucanthone was shown to enhance the sensitivity of animals to an anticancer agent in a time dependent and reversible manner. (medkoo.com)