GengrafMedicationCalcineurin inhibitorMedicationsAnti-ThymocytAutoimmune conditionsMycophenolate mofetilDoseInhibitsRestasisDrugsAtorvastatinSimvastatinTacrolimusOrgan transplant rejectionDosageTransplantsSevereDropsHumansSteroidsMonotherapyDosesKeratitisSulfasalazineInhibitorsTreatmentsChronicImmune systemStatinsDosagesCapsulesPeripheralSymptomaticBindsLymphocytesRheumatoid arthritisPatientsAllergicConcentrationsTreatmentLiverTransplantSubstancesKidney functionAplasticDrugIncreased levelsPreventSymptomsBoneKidneysDecreaseCholesterolInjectionAdverse
Gengraf1
- tell your doctor and pharmacist if you are allergic to cyclosporine (Gengraf, Neoral, Sandimmune), any other medications, or Cremophor EL. (medlineplus.gov)
Medication12
- Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. (wikipedia.org)
- Cyclosporine is a medication that suppresses immune system function. (medicalnewstoday.com)
- Cyclosporine is a prescription medication that doctors often use to treat autoimmune conditions such as RA and psoriasis. (medicalnewstoday.com)
- Cyclosporine is available in original or modified forms that improve how well the body absorbs the medication. (medicalnewstoday.com)
- Cyclosporine is an immunosuppressant medication. (indiamart.com)
- Chronic low-grade bacterial infection, autoimmunity, and some types of medication (eg, cyclosporine, diphenylhydantoin, carbamazepine) have also been implicated in the pathogenesis in some patients. (medscape.com)
- The medication cyclosporine causes kidney damage. (newsx.com)
- In those with abnormal cholesterol levels induced by HIV/AIDS medication, taking fish oil supplements by mouth lowers triglyceride levels. (newsx.com)
- Some studies show that peppermint may lower your blood sugar and blood pressure as well, so it's not recommended for people taking medication for diabetes or blood pressure issues. (webmd.com)
- Atopica's active ingredient Cyclosporine is an immunosuppressive medication that can prevent organ rejection in organ transplants, treat rheumatoid arthritis, psoriasis. (petcarerx.com)
- The medication is often started at low doses when treating RA to prevent side effects, typically 1 to 2 tablets a day. (rheumatology.org)
- Sulfasalazine can lower sperm counts but this effect is reversible when the medication is discontinued. (rheumatology.org)
Calcineurin inhibitor1
- Cyclosporine is a calcineurin inhibitor. (medscape.com)
Medications8
- Cyclosporine injection must be given under the supervision of a doctor who is experienced in treating transplant patients and prescribing medications that decrease the activity of the immune system. (medlineplus.gov)
- This risk may be higher if you receive cyclosporine injection with other medications that decrease the activity of the immune system such as azathioprine (Imuran), cancer chemotherapy, methotrexate (Rheumatrex), sirolimus (Rapamune), and tacrolimus (Prograf). (medlineplus.gov)
- Cyclosporine injection is used with other medications to prevent transplant rejection (attack of the transplanted organ by the immune system of the person receiving the organ) in people who have received kidney, liver, and heart transplants. (medlineplus.gov)
- Cyclosporine is in a class of medications called immunosuppressants. (medlineplus.gov)
- The initial dosage of cyclosporine for an organ transplant depends on the organ and any other medications a person is taking. (medicalnewstoday.com)
- WEDNESDAY, May 9 (HealthDay News) -- The widely used class of cholesterol-lowering medications known as statins may help elderly patients with high blood pressure avoid developing atrial fibrillation, a heart rhythm abnormality tied to stroke. (comprar-medicina.com)
- Sulfasalazine may interfere with warfarin (Coumadin), cyclosporine or digoxin, so dose adjustments may be needed if these medications are taken together. (rheumatology.org)
- Sulfasalazine increases the risk for liver injury if given with the drug isoniazid (INH), a drug for tuberculosis and may increase the risk for low blood sugar in patients taking certain medications for diabetes such as glimepiride (Amaryl), glyburide (Diabeta, Micronase, Glynase) and glipizide (Glucotrol). (rheumatology.org)
Anti-Thymocyt1
- This information leaflet is for patients who have been prescribed ciclosporin as part of immuno-suppressive treatment (IST) that is given with Anti-Thymocyte Globulin(ATG). (theaat.org.uk)
Autoimmune conditions1
- Cyclosporine is an alternative treatment for autoimmune conditions such as rheumatoid arthritis (RA) and psoriasis . (medicalnewstoday.com)
Mycophenolate mofetil1
- Cyclosporine and mycophenolate mofetil were administered as posttransplant immunosuppression. (aacrjournals.org)
Dose10
- it is thus recommended that the lowest effective dose for people requiring long-term treatment be used. (wikipedia.org)
- Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. (ox.ac.uk)
- Adding low-dose cyclosporin A to parenteral gold therapy in rheumatoid arthritis: a double-blind placebo-controlled study. (rheuma-online.de)
- Combination therapy in recent onset rheumatoid arthritis: a randomized double blind trial of the addition of low dose cyclosporine to patients treated with low dose chloroquine. (rheuma-online.de)
- To determine the concentration of ciclosporin in your blood in order to establish a dose regime, maintain therapeutic levels, and detect toxic levels. (labtestsonline.org.uk)
- As soon as ciclosporin therapy begins, usually daily or 2-3 times a week, and periodically after that as dose is adjusted or maintained. (labtestsonline.org.uk)
- There is not a close relationship, between the dose of ciclosporin given and level of drug in the blood. (labtestsonline.org.uk)
- Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
- These may improve with time and are often avoided by slowly increasing from a low starting dose. (rheumatology.org)
- Treatment should be started with a low dose of Amiloride, i.e. 5mg (1 tablet), plus a low dosage of the other diuretic agent. (janusinfo.se)
Inhibits2
- This cyclosporin-cyclophilin complex inhibits calcineurin, which is normally responsible for activating the transcription of interleukin 2. (wikipedia.org)
- Cyclosporine inhibits immune system function. (medicalnewstoday.com)
Restasis1
- An aqueous suspension of 0.05% cyclosporine (Restasis®) was developed by Allergan Pharmaceuticals for treatment of KCS in human patients. (wedgewoodpharmacy.com)
Drugs3
- Cyclosporine, also called cyclosporin A (CsA), was the first discovered and is the only commercially available drug in the cyclosporin category of immunosuppressive drugs. (wedgewoodpharmacy.com)
- The FDA has authorised several fish oil products as prescription drugs for lowering triglyceride levels. (newsx.com)
- Some drugs (cyclosporine or Prograf) can increase the potassium level in your blood. (columbiasurgery.org)
Atorvastatin1
- Patients who require greater than 45% low-density lipoprotein (LDL) reduction may be started on atorvastatin 40 mg orally once a day. (drugs.com)
Simvastatin1
- ZOCOR (simvastatin) is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus. (globalrph.com)
Tacrolimus2
- The aim of this study was the evaluation of the first commercially available in-vitro diagnostic (IVD)- mass spectrometric immunosuppressant assay from Chromsystems (MassTox Immunosuppressants ONEMINUTE Test) and the comparison to a routinely used online solid phase extraction liquid chromatography-tandem mass spectrometric assay method for the measurement of cyclosporine A, everolimus, sirolimus, and tacrolimus in patient whole blood samples. (nih.gov)
- The limit of quantification for the commercial assay was 0.5 ng/mL for everolimus, sirolimus, and tacrolimus and 5 ng/mL for cyclosporine A. The coefficient of variation for all immunosuppressants was lower than 7% (within day) and 12% (between days) for all 5 concentration levels. (nih.gov)
Organ transplant rejection1
- One animal study found worrisome evidence that baicalin might markedly reduce the absorption of drug cyclosporine , used to prevent organ transplant rejection. (epnet.com)
Dosage1
- Doctors may adjust the dosage for people with medical conditions that affect how well the body absorbs cyclosporine. (medicalnewstoday.com)
Transplants3
- Ciclosporin is indicated to treat and prevent graft-versus-host disease in bone marrow transplantation and to prevent rejection of kidney, heart, and liver transplants. (wikipedia.org)
- Cyclosporine injection is also sometimes used to treat Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever) and to prevent rejection in patients who have received pancreas or cornea transplants. (medlineplus.gov)
- Cyclosporin (Cyclosporine) is an immunosuppressive agent used to prevent rejection of organ or bone marrow transplants. (comprar-medicina.com)
Severe7
- In addition to these indications, ciclosporin is also used in severe atopic dermatitis, Kimura disease, pyoderma gangrenosum, chronic hives, acute systemic mastocytosis, and posterior or intermediate uveitis with noninfective cause. (wikipedia.org)
- citation needed] Ciclosporin has also been used in people with acute severe ulcerative colitis and hives that do not respond to treatment with steroids. (wikipedia.org)
- In a recent randomized, cross-over trial we showed that cyclosporin, an inhibitor of T-lymphocyte activation, improved lung function in patients with chronic severe asthma. (ersjournals.com)
- These data demonstrate that in patients with chronic severe asthma, cyclosporin therapy which results in clinical improvement is associated with a decrease in serum concentrations of sIL-2R. (ersjournals.com)
- Infliximab treatment in combination with cyclosporin A in patients with severe refractory rheumatoid arthritis. (rheuma-online.de)
- Ciclosporin eye drops may be prescribed in severe keratitis (inflammation of the cornea). (labtestsonline.org.uk)
- When the symptoms in these cases are judged to be severe, extensive, and disabling, ciclosporin may be prescribed. (labtestsonline.org.uk)
Drops1
- Compounded ophthalmic cyclosporine drops have been used commonly in 1.0-2.0% concentrations in corn oil when Optimmune® was either commercially unavailable or owners were physically unable to apply an ointment. (wedgewoodpharmacy.com)
Humans2
- medical citation needed] Ciclosporin is listed as an IARC Group 1 carcinogen (i.e. there is sufficient evidence of carcinogenicity in humans), specifically leading to squamous cell skin cancer and non-Hodgkin lymphoma. (wikipedia.org)
- Evidence suggesting that some flavonoids or flavonoid-rich foods may enhance cognitive function is currently limited, and it is not yet known whether their consumption could lower the risk of cognitive impairments and dementia in humans. (oregonstate.edu)
Steroids1
Monotherapy1
- Although the incidence of drug-induced skeletal muscle toxicity is very low (0.1-0.2%) with monotherapy, it may increase following concomitant drug therapy with the immunosuppressant, cyclosporine A (CsA), and possibly with certain other hypolipidemic agents. (aspetjournals.org)
Doses1
- When I got back home, I was on prednisone and large doses of cyclosporin. (aamds.org)
Keratitis1
- In treating chronic superficial keratitis (pannus), nictitans plasmacytic conjunctivitis and pigmentary keratitis, topical cyclosporine is effective whether used with topical corticosteroids or in place of corticosteroids. (wedgewoodpharmacy.com)
Sulfasalazine1
- Cyclosporin and sulfasalazine combination in the treatment of early rheumatoid arthritis. (rheuma-online.de)
Inhibitors1
- cyclosporine , plasmapheresis or IV immune globulin, early corticosteroid therapy, and tumor necrosis factor-alpha inhibitors have been used. (msdmanuals.com)
Treatments1
- Reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia (HoFH) as an adjunct to other lipid-lowering treatments (e.g. (globalrph.com)
Chronic4
- Since T-cells orchestrate most chronic immune responses, cyclosporine has broad anti-inflammatory effects. (wedgewoodpharmacy.com)
- Cyclosporine does not activate collagenase, hence it is much safer for chronic use than corticosteroids, particularly in exophthalmic breeds susceptible to ocular injury. (wedgewoodpharmacy.com)
- Healthcare professionals deem neutropenia to be chronic if a person has a low neutrophil level on at least three occasions over 3 months . (medicalnewstoday.com)
- The principal symptoms are inflammatory chronic back pain, peripheral arthritis (typically asymmetric monoarthritis or oligoarthritis predominantly affecting the joints of the lower extremities), dactylitis, and enthesitis [ 1 ]. (hindawi.com)
Immune system2
- Receiving cyclosporine injection may increase the risk that you will develop an infection or cancer, especially lymphoma (cancer of a part of the immune system) or skin cancer. (medlineplus.gov)
- Ciclosporin affects the ability of certain white blood cells in the immune system to respond to this foreign tissue . (labtestsonline.org.uk)
Statins1
- Statins are a class of prescription medicines that have been used for decades to lower low-density lipoprotein (LDL-C or "bad") cholesterol in the blood. (safemedication.com)
Dosages2
- Cyclosporine comes in various forms and dosages. (medicalnewstoday.com)
- Those with existing conditions that affect their kidneys or liver can take smaller dosages of cyclosporine. (medicalnewstoday.com)
Capsules3
- People can take cyclosporine capsules (modified) or cyclosporine oral solution (modified) daily to help treat RA and psoriasis. (medicalnewstoday.com)
- We are a leading Wholesale Trader of Cyclosporine Capsules Ip 50 Mg, Cyclosporine Capsules Ip 25mg, Methotrexate Tablets IP 7.5mg, Ursodeoxycholic Acid Sustained Release 600 mg Tablets, Imatinib 400 Mg Tablets and Trihexyphenidyl Trifluoperazine Tablets from New Delhi, India. (indiamart.com)
- The cyclosporin capsules were the biggest capsules that I had ever seen. (aamds.org)
Peripheral1
- Peripheral venous blood was obtained from 22 patients during the last 4 weeks of both the cyclosporin and placebo treatment periods and serum stored at -80 degrees C pending measurement of sIL-2R concentration by enzyme immunoassay. (ersjournals.com)
Symptomatic1
- The optimal age at which to initiate lipid-lowering therapy to decrease the risk of symptomatic adulthood CAD has not been determined. (globalrph.com)
Binds2
- Ciclosporin binds to the cytosolic protein cyclophilin (immunophilin) of lymphocytes, especially of T cells. (wikipedia.org)
- medical citation needed] Ciclosporin also binds to the cyclophilin D protein that constitutes part of the mitochondrial permeability transition pore (MPTP), thus preventing MPTP opening. (wikipedia.org)
Lymphocytes1
- Ciclosporin is believed to work by decreasing the function of lymphocytes. (wikipedia.org)
Rheumatoid arthritis2
- Combination therapy of cyclosporine A with methotrexate or hydroxychloroquine in refractory rheumatoid arthritis. (rheuma-online.de)
- Combination therapy of cyclosporine with methotrexate and gold in rheumatoid arthritis (2 pilot studies). (rheuma-online.de)
Patients8
- Topical cyclosporine has several beneficial effects in dry-eye patients. (wedgewoodpharmacy.com)
- To investigate whether changes in serum sIL-2R concentration could be related to clinical response we prospectively compared serum sIL-2R concentrations in patients during cyclosporin and placebo treatment. (ersjournals.com)
- The decreases in serum sIL-2R concentrations associated with cyclosporin therapy in these patients correlated with the percentage increases in their morning peak expiratory flow rate (PEFR) measurements on cyclosporin as compared with placebo. (ersjournals.com)
- Reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia (Fredrickson type IIa, heterozygous familial and nonfamilial) or mixed dyslipidemia (Fredrickson type IIb). (globalrph.com)
- It should not be taken with cyclosporine, a drug taken by organ transplant patients. (webmd.com)
- Nearly half (47%) the patients stated they would refuse generic substitution of ciclosporin when it became available if this was just to save the health authority money. (who.int)
- RÉSUMÉ La présente étude a examiné les connaissances et la compréhension actuelles des patients en matière de substitution par des génériques. (who.int)
- À notre avis, la substitution par des génériques ne doit pas être mise en oeuvre de manière aléatoire en raison de l'incertitude et des faibles connaissances des patients. (who.int)
Allergic1
- A doctor or nurse will watch you closely while you are receiving cyclosporine injection so that you can be treated quickly if you have a serious allergic reaction. (medlineplus.gov)
Concentrations2
- Mean serum concentrations of sIL-2R were significantly lower on cyclosporin therapy (560 U.ml-1) as compared with placebo (676 U.ml-1). (ersjournals.com)
- The test for ciclosporin is requested to measure the amount of drug in the blood to determine whether drug concentrations have reached therapeutic levels and are not in a toxic range. (labtestsonline.org.uk)
Treatment3
- The fact sheet explains what treatment involving ciclosporin is, how it works and any potential side effects or complications. (theaat.org.uk)
- After treatment all my counts were very low. (aamds.org)
- Mortality can be as high as 7.5% in children and 20 to 25% in adults but tends to be lower with early treatment. (msdmanuals.com)
Liver1
- Ciclosporin is used routinely in the transplantation of kidney, heart, liver, and other organs. (labtestsonline.org.uk)
Transplant2
- Doctors also use cyclosporine to help prevent the body from rejecting an organ after a solid organ transplant. (medicalnewstoday.com)
- People tend to continue taking cyclosporine for several weeks after the transplant. (medicalnewstoday.com)
Substances1
- Pravastatin is also used to reduce the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. (safemedication.com)
Kidney function2
- Ciclosporin is used with caution in these cases and needs to be carefully monitored with regular blood tests to detect changes in kidney function . (labtestsonline.org.uk)
- In persons who have recently rejected a donated kidney and are receiving cyclosporine, fish oil appears to enhance kidney function. (newsx.com)
Aplastic1
- Ciclosporin is an immuno-suppressant medicine which has been used for many years to treat aplastic anaemia. (theaat.org.uk)
Drug2
- Ciclosporin is an immunosuppressive drug used to dampen the body's natural defences. (labtestsonline.org.uk)
- Testing ciclosporin levels in the blood can help ensure that drug levels are in a range that will be therapeutic for you. (labtestsonline.org.uk)
Increased levels1
- Ciclosporin use after a kidney transplantation is associated with increased levels of uric acid in the blood and, in some cases, gout. (wikipedia.org)
Prevent1
- Lowering your blood level of cholesterol and fats with pravastatin has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks. (safemedication.com)
Symptoms5
- A person may not show symptoms if they have a low white blood cell count. (medicalnewstoday.com)
- A person with leukopenia may have other symptoms that relate to the cause of their low white blood cell count. (medicalnewstoday.com)
- The immunosuppressive qualities of ciclosporin have also been found to be useful in treating symptoms of some autoimmune disease and other disorders. (labtestsonline.org.uk)
- Ciclosporin helps to control the immune response in these cases, decreasing the severity of symptoms. (labtestsonline.org.uk)
- If the level is too low, the body may reject the organ (in the case of transplantation) or symptoms may reappear (autoimmune cases). (labtestsonline.org.uk)
Bone4
- Cyclosporine A impairs bone repair in critical defects filled with different osteoconductive bone substitutes. (bvsalud.org)
- The CSDs not filled with biomaterials demonstrated lower bone formation in the CCP group. (bvsalud.org)
- At 15 days, less bone formation was observed in the CSDs filled with DBB, a smaller volume of mineralized tissue was observed in the CSDs filled with HA/TCP, and the expression levels of BMP2 and osteocalcin were lower in the CCP group compared to the CTR group. (bvsalud.org)
- The use of cyclosporine impaired bone repair in CSD, and this effect can be partially explained by the suppression of BMP2 and osteocalcin expression. (bvsalud.org)
Kidneys1
- Ciclosporin causes hypertension by inducing vasoconstriction in the kidneys and increasing sodium reabsorption. (wikipedia.org)
Decrease1
- It may decrease the proliferation of immune cells, resulting in low autoimmune activity. (medscape.com)
Cholesterol1
- These conditions can include low cholesterol or low magnesium levels. (medicalnewstoday.com)
Injection3
- Talk to your doctor about the risks of receiving cyclosporine injection. (medlineplus.gov)
- Cyclosporine injection should only be used to treat people who are unable to take cyclosporine by mouth. (medlineplus.gov)
- Cyclosporine injection comes as a solution (liquid) to be injected over 2 to 6 hours into a vein, usually by a doctor or nurse in a hospital or medical facility. (medlineplus.gov)
Adverse1
- This is because taking too much cyclosporine can result in adverse side effects. (medicalnewstoday.com)