Low dose lower. Medical search. Frequent questions

Shares in Roche and Genentech have slipped after late-stage data from a trial of their oncology agent Avastin showed that both the standard dose and a lower dose of the drug, in combination with chemotherapy, improved progression-free survival in patients with non-small-cell lung cancer. (pharmatimes.com)
In the Phase III AVAiL trial, more than 1,000 patients with previously untreated advanced non-squamous NSCLC received either the standard 15mg/kg dose of Avastin (bevacizumab) or a 7.5mg/kg dose in addition to chemotherapy, or chemotherapy alone. (pharmatimes.com)
The data revealed that both doses of the drug, plus chemotherapy, significantly prolonged progression-free survival, compared to chemotherapy alone and the companies noted that while the study was not designed to compare the two Avastin treatment doses, a similar treatment effect in progression-free survival was observed. (pharmatimes.com)
Purpose: Low-dose metronomic chemotherapy is an emergent treatment schedule in which low doses of cytotoxic agents are given orally continuously, with no or short drug-free intervals. (scirp.org)
The following data were collected: age, hormone and epidermal growth factor receptor 2 (HER-2) status, number of lines of chemotherapy prior to and after low-dose metronomic treatment, duration of metronomic treatment, toxicity reason for treatment discontinuation. (scirp.org)
Duration of low-dose metronomic chemotherapy was also correlated with the variables analyzed and treatment outcomes. (scirp.org)
In 2000, two articles reporting the first rationale of chemotherapy in low doses were published. (scirp.org)
This report did lead to an additional study, which used chemotherapy and lower doses of CSI to treat standard risk medulloblastoma (Packer et al, JCO 17(7), 2127, 1999). (oncolink.org)
These results were very positive, and chemotherapy with reduced dose (23.4 Gy) CSI has become the accepted standard of care in standard risk medulloblastoma. (oncolink.org)

A new study suggests that taking low-dose aspirin daily may reduce the risk of developing type 2 diabetes in adults 65 and older. (healthnews.com)

On the basis of results from the National Lung Screening Trial (NLST), national guidelines now recommend using low-dose computed tomography (LDCT) to screen high-risk smokers for lung cancer. (cdc.gov)
The National Lung Screening Trial (NLST) showed that lung cancer screening with low-dose computed tomography (LDCT) significantly reduced lung cancer deaths among heavy smokers compared with screening with chest x-ray (1). (cdc.gov)
LDCT (low-dose computed tomography) works much like an x-ray exam to produce pictures of your chest and lungs. (fryemedctr.com)

Methods: We retrospectively analyzed 40 patients with metastatic breast cancer treated with low doses of Cyclophosphamide and/or Methotrexate and/or Capecitabine in a single center from June 2009 to April 2014. (scirp.org)
However, cyclophosphamide is still used either as a single agent or as adjuvant therapy to treat lymphomas, and breast and ovarian cancers at much lower doses. (monash.edu)
The efficacy of low dose cyclophosphamide is primarily due to its ability to promote anti-tumour immunity, by selectively depleting regulatory T cells and enhancing effector T cell function. (monash.edu)
In this review, we highlight the potential for improving the efficacy of low dose cyclophosphamide by combining insights on the mechanisms of cyclophosphamide-mediated cytotoxicity, and how these cytotoxic effects of cyclophosphamide influence T cell function, thereby contributing to anti-tumour immunity. (monash.edu)

The researchers at Monash University, Australia, examined how low doses of aspirin affect the incidence of diabetes and fasting plasma glucose (FPG) levels in older adults. (healthnews.com)

These two trials are part of a series of five trials evaluating the safety and efficacy of Stellarex .035″ low-dose [1] DCB to restore and maintain blood flow in the superficial femoral artery and popliteal arteries of patients with peripheral arterial disease. (philips.com)
In this study, we evaluated the immunogenicity and protective efficacy of reduced doses of Ad26.COV2.S. 30 rhesus macaques were immunized once with 1×10 11 , 5×10 10 , 1.125×10 10 , or 2×10 9 vp Ad26.COV2.S or sham and were challenged with SARS-CoV-2 by the intranasal and intratracheal routes. (nih.gov)
This study compares treatment with standard dose craniospinal irradiation (CSI) with reduced dose CSI, in the attempt to maintain efficacy but reduce toxicity of treatment. (oncolink.org)

A low-dose (400 microg/d) rather than a high-dose of folic acid supplementation may be sufficient to reduce plasma homocysteine concentration in hyperhomocysteinemic patients with CAD. (nutraingredients-usa.com)
Women who took other nonsteroidal anti-inflammatory medications such as ibuprofen did not see as much of a difference, nor did those taking a regular high-dose aspirin. (wcpo.com)
Previous studies have showed mixed results in breast cancer impact among women who took a regular high-dose aspirin. (wcpo.com)

Suggested daily doses of supplemental lithium range from about 0.3 mg to 5 mg - similar to, or slightly above, the amounts of lithium obtained per day from what we normally eat and drink (see Dosage ). (consumerlab.com)
Be aware that many supplements on the market provide more lithium than you want, but it is possible to use partial dosing (see Dosage ). (consumerlab.com)

Significantly fewer patients in the low-dose group reported vomiting and abdominal pain than the standard regimen group. (who.int)
Hypoglycaemia, preterm labour and recrudescence were slightly but not significantly higher in patients in the standard group than low-dose group. (who.int)
The researchers report that, while the low-dose folic acid supplements had no significant effect on homocysteine concentrations in the general study population, levels did significantly decrease in hyperhomocysteinemic subjects by 1.8 micromoles per litre. (nutraingredients-usa.com)
"The significant result of this study was that a low dose of folic acid supplementation (400 microg/d) could significantly decrease plasma homocysteine concentration in hyperhomocysteinemic patients with CAD but not in normohomocysteinemia patients," wrote the researchers. (nutraingredients-usa.com)
Current treatments can only temporarily slow the decline, but new evidence suggests that tiny doses of lithium can significantly delay the onset of dementia. (thecarlatreport.com)

Data should soon be available on three to seven years of supplementation with B vitamins on cognitive function on about 20,000 of the 50,000 participants with previous cardiovascular or renal disease in the 12 large homocysteine-lowering trials for the prevention of cardiovascular events. (nutraingredients-usa.com)
In that study, "it is possible that the lack of effect is due to the alternate day low dose we used, but data from other randomized trials generally do not support an effect on breast cancer," she said in an emailed statement, so the current study's result is different. (wcpo.com)
Case-control studies, cohort studies, and randomized clinical trials (RCTs) were included from MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov if they analyzed the odds or risk of cutaneous melanoma in individuals who were exposed to low-dose methotrexate and compared with individuals who were unexposed. (hcplive.com)

Choose the Best Low-Dose Lithium Supplement. (consumerlab.com)
CL Tests Reveal Which Low-Dose Lithium Supplements Offer the Best Quality and Value. (consumerlab.com)
Lithium is a mineral used in large doses (hundreds of milligrams) as prescription medicine to treat bipolar disease but at much lower doses (fractions of a milligram to a few milligrams) as a dietary supplement. (consumerlab.com)
However, some observational studies and small clinical studies suggest that low-dose lithium may improve mood, reduce the risk of suicide and reduce the risk and/or progression of dementia (see What It Does ). (consumerlab.com)
Make sure you're choosing the best low-dose lithium supplements approved in our tests! (consumerlab.com)
Low-Dose Lithium to Delay Dementia? (thecarlatreport.com)
He comes to your office after reading an online article about low-dose lithium for dementia prevention and asks if you can prescribe it. (thecarlatreport.com)
Several studies have found that patients with mood disorders who took lithium had a lower incidence of dementia than similar patients who were not prescribed lithium. (thecarlatreport.com)
In the one negative study, average lithium exposures were unusually low. (thecarlatreport.com)
To sum up, the existing empirical evidence is suggestive of an antidementia effect with low-dose lithium, but we need more studies before drawing definitive conclusions. (thecarlatreport.com)
A larger randomized trial using full-dose lithium (serum levels of 0.6-0.8 mEq/L) is scheduled for completion in 2023 (the LATTICE trial). (thecarlatreport.com)
What are the potential risks of low-dose lithium? (thecarlatreport.com)
Lithium at low serum levels presents no significant renal risk if creatinine is monitored, as suggested by a two-year controlled trial that found no changes in renal function with low-dose lithium in the elderly (Aprahamian I et al, J Clin Psychiatry 2014 Jul;75(7):e672-678). (thecarlatreport.com)
On the other hand, thyroid suppression by therapeutic doses of lithium is very common, affecting roughly 10% of patients who start standard doses of lithium (Kirov G et al, J Affect Disord 2005;87(2-3):313-317). (thecarlatreport.com)
Two sources of data suggest that even tiny doses of lithium can lower thyroid hormone. (thecarlatreport.com)
Second, in a small primary care study, 12% of patients given low-dose lithium (average level 0.43 mEq/L) had a TSH increase >4.2 mIU/L during follow-up. (thecarlatreport.com)
Thus it appears that low lithium doses, perhaps even less than 1 mg/day, may suppress thyroid function. (thecarlatreport.com)
It is available in health food stores and via the internet, in doses closer to the lithium concentrations found in drinking water in some regions. (thecarlatreport.com)

This expected side-effects of quinine (tinnitus, dose has been reduced effectively in chil- vomiting and abdominal pain). (who.int)
These data demonstrate that a single immunization with a relatively low dose of Ad26.COV2.S effectively protected against SARS-CoV-2 challenge in rhesus macaques. (nih.gov)
In order for any low-dose birth control to work effectively, you must take each dose daily at the same time to prevent pregnancy. (greatist.com)
Studies show that lung CT scans using low doses of radiation can effectively detect lung cancer in its earliest stages and most importantly, lower your risk of dying from lung cancer. (fryemedctr.com)

Other studies have shown that large doses of broad-spectrum antibiotics in adult animals can affect behaviour. (sciencedaily.com)
The vials of these lower-dose vaccine - a third of the dose of the adult vaccine - has already gotten shipped out to lots of places around the country. (wvtf.org)

In a landmark study, researchers at St. Joseph's Healthcare Hamilton and McMaster University have found that providing clinical (low) doses of penicillin to pregnant mice and their offspring results in long-term behavioural changes. (sciencedaily.com)
Since then, researchers have found you don't need big doses of hormones to prevent pregnancy, leading to today's version of the pill. (greatist.com)
In the 23% of women who reported using low-dose aspirin regularly, researchers saw a 20% reduction in the risk of developing HR-positive/HER2 negative breast cancer, some of the most common forms of the disease. (wcpo.com)

The shares in the two firms have fallen because analysts have picked up on the fact that the success of the low dose arm of the study will lead doctors to use the lower, and therefore less expensive, dose in the majority of lung cancer patients. (pharmatimes.com)

These changes include elevated levels of aggression and lower levels of anxiety, accompanied by characteristic neurochemical changes in the brain and an imbalance in their gut microbes. (sciencedaily.com)

RÉSUMÉ Des femmes enceintes soudanaises atteintes de paludisme à falciparum chloroquino-résistant qui ont consulté dans un hôpital du Soudan oriental ont été réparties de manière aléatoire entre les deux schémas thérapeutiques de quinine suivants : faible dose, 10 mg/kg 2 fois/jour (18 patientes), ou standard, 10 mg/kg 3 fois/jour (24 patientes). (who.int)

The main problem is that, as a consequence of Poisson statistics, the required illumination dose is inversely proportional to the square of the spatial resolution 7 , and thus improving spatial resolution means quadratically higher doses. (nature.com)
The risk was inversely associated with taking a low-dose aspirin three or more times a week, compared with those women who had no regular low-dose aspirin use. (wcpo.com)

Comprehensively defining the risk of melanoma associated with low-dose methotrexate is important for clinicians across several medical disciplines. (hcplive.com)
A systematic review and meta-analysis indicated that low-dose methotrexate, a commonly used treatment for a variety of inflammatory disorders, exposure was associated with a small increased risk of developing melanoma. (hcplive.com)
Despite decades of clinical use, some studies suggest that low-dose methotrexate may be associated with an increased risk of skin cancer. (hcplive.com)
While methotrexate was associated with a 15% increased risk of melanoma, the absolute risk increase was low to minimal. (hcplive.com)
Association Between Low-Dose Methotrexate Exposure and Melanoma A Systematic Review and Meta-analysis. (hcplive.com)

Renal impairment is rare and is mainly a risk in patients on relatively high lifelong cumulative doses , especially when there are spikes above 0.8 mEq/L (Clos S et al, Lancet Psychiatry 2015;2(12):1075-1083). (thecarlatreport.com)

Combination low-dose birth control has small amounts of synthetic estrogen and progesterone. (greatist.com)

People with the so-called TT homozygote genotype with low folate status are reported to have higher homocysteine concentrations than the other genotypes, putting this subset at increased risk of CAD and cognitive decline. (nutraingredients-usa.com)
People who started using glucose-lowering medication or had an FBP level of 7.0 mmol/L or higher at annual follow-up visits were considered as having diabetes. (healthnews.com)
Moreover, our findings show that a higher vaccine dose may be required for protection in the upper respiratory tract compared with the lower respiratory tract. (nih.gov)
Some people get gnarly side effects, especially when the hormones are at higher doses. (greatist.com)
Side effects associated with low dose (7.5 mg/day or less) daily prednisone are less severe than those seen with higher doses (greater than 30mg/day) and can usually be managed with precautions. (sjogrens.org)
Serious side effects associated with higher doses and long-term use (greater than 1 month) are impaired wound healing, decreased growth (in children), decreased muscle production, fat deposits, stomach ulcers or bleeding, vision problems, higher risk for infection, and in rare cases life-threatening allergic reactions. (sjogrens.org)
This attempt to reduce CSI dose was unsuccessful, as it resulted in a higher rate of failure, which is obviously a very serious result of inadequate treatment. (oncolink.org)

Moreover, using low-dose aspirin did not appear to reduce the incidence of cardiovascular disease. (healthnews.com)

The U.S. Preventive Services Task Force recommends against initiating low-dose aspirin use to prevent cardiovascular disease in people 60 years or older. (healthnews.com)
US Preventive Services Task Force guidelines recommend that certain people take low-dose aspirin regularly to reduce the risk of cardiovascular disease and colorectal cancer. (wcpo.com)

As with all medications, corticosteroids have some adverse side effects related to the dose and the duration in which the medication is taken. (sjogrens.org)

A low-dose daily supplement of folic acid improved levels homocysteine in people with high levels of the amino acid and could reduce the risk of coronary artery disease, suggests a small study from Taiwan. (nutraingredients-usa.com)

ABSTRACT Pregnant Sudanese women who presented at a hospital in eastern Sudan with chloroquine- resistant falciparum malaria were randomly allocated to one of two quinine regimens: low-dose (10 mg/kg 2 times/day) (18 patients) or standard (10 mg/kg 3 times/day) (24 patients). (who.int)
The standard dose of quinine is 10 mg/ up, all patients were asked daily about the kg, 3 times per day for 7 days [ 12 ]. (who.int)
However, folic acid supplements do not seem to lower plasma homocysteine in patients with CAD with normal plasma homocysteine level. (nutraingredients-usa.com)
It is well known that all these low-dose schedules have a favorable safety profile and may provide an adequate tumor control in patients with metastatic breast cancer. (scirp.org)
Regardless of your results, annual screenings are recommended, as yearly low-dose CT scans have been shown to decrease mortality in patients who had increased risk due to smoking. (fryemedctr.com)
Medicare now covers the cost of low-dose CT screening for high risk patients. (fryemedctr.com)
The outcome evaluation measured how the program affected purchases of fruits and vegetables among low-income patients and patient satisfaction with the program. (cdc.gov)
Prescriptions were distributed to eligible low-income patients in clinics and community settings. (cdc.gov)
Fruit and vegetable prescriptions are an effective way to increase affordability of healthy foods for low-income patients. (cdc.gov)

9, 2022 Preterm and low birth weight babies are routinely given antibiotics to prevent, not just treat, infections, which they have a high risk of developing. (sciencedaily.com)

Although the list of side effects may make you wonder whether you should take this medication or not, please be reassured that many people take daily low dose prednisone with minor or no side effects. (sjogrens.org)
Your doctor can instruct you on how to slowly decrease your dose if you need to stop taking this medication for any reason. (sjogrens.org)

Misra says the company's advanced dose reduction technology, AIDR 3D, is available in all its scanners, even the entry level machines, something unique among manufacturers. (dotmed.com)
Toshiba also built in dose reduction technologies and started the upgrade process very early on, Misra says. (dotmed.com)
Low-dose folic acid supplementation for eight weeks for the TT genotype people led to a significant 2.1 micromoles per litre reduction in homocysteine levels, and 1.4 micromoles per litre for people who carry the T-allele either hetero- or homozygously. (nutraingredients-usa.com)
Compared with conventional atomic-resolution STEM imaging techniques, the mixed-state ptychographic approach simultaneously provides a four-times-faster acquisition, with double the information limit at the same dose, or up to a fifty-fold reduction in dose at the same resolution. (nature.com)
Nancy Cook, a professor in the Department of Epidemiology at Harvard University who also researches aspirin's impact on cancer, published a study in 2013 that found a reduction in colorectal cancer after 10 years of low-dose aspirin use but found no association with reduction in breast cancer. (wcpo.com)

The U.S. Preventive Services Task Force has recommended that taking a low-dose asprin daily can help prevent both heart disease and colorectal cancer in adults ages 50 to 69. (wcpo.com)

Then came a 2019 continuation of the positive low-dose study by Forlenza and colleagues. (thecarlatreport.com)

Vaccine doses as low as 2×10 9 vp provided robust protection in bronchoalveolar lavage, whereas doses of 1.125×10 10 vp were required for protection in nasal swabs. (nih.gov)
At suboptimal vaccine doses, viral breakthrough was observed but did not show evidence of virologic, immunologic, histopathologic, or clinical enhancement of disease compared with sham controls. (nih.gov)
That's after CDC Director Rochelle Walensky officially recommended Pfizer's lower-dose vaccine for 5- to 11-year-olds. (wvtf.org)

This has led to the hypothesis that by lowering circulating levels of homocysteine by B vitamin supplements, the risk and occurrence of dementia could be reduced. (nutraingredients-usa.com)

Simulations have suggested the possibility of extremely low-dose imaging by electron ptychography, in principle beyond that of all other electron imaging approaches to date including high-resolution TEM imaging widely used in Cryo-EM community-a potential outcome of considerable importance for the study of electron radiation-sensitive materials including biological macromolecules. (nature.com)
The new low dose 3-D system from Hologic requires less compression time and reduces radiation exposure. (azbigmedia.com)

Here, we demonstrate low-dose, sub-angstrom resolution imaging with picometer precision using mixed-state electron ptychography. (nature.com)

She also cautioned that before adding a low-dose daily aspirin to your morning routine, remember that the current study is merely observational. (wcpo.com)
For those experiencing swelling and/or elevated blood pressure, a healthy low sodium diet, regular exercise, and stress management can help to keep your blood pressure under control while taking daily low dose prednisone. (sjogrens.org)

Folic acid is known to lower plasma homocysteine levels, and high levels of the amino acid, hyperhomocysteinemia, are a marker for heart disease and thought to be a risk factor for atherosclerotic disease, which contributes to heart attacks. (nutraingredients-usa.com)
While more research is needed on whether low-dose aspirin can reduce the risk of diabetes in older adults, following a healthy diet , being physically active, and quitting smoking can help to maintain healthy glucose levels. (healthnews.com)
Study shows that low-dose aspirin associated with a 15% lower risk of developing diabetes in people aged over 65 years. (healthnews.com)
More potential good news for people who regularly take a low-dose aspirin: Women who took one had a lower risk of breast cancer, according to a study published in the journal Breast Cancer Research on Monday. (wcpo.com)
The new study did not look at why there might be an association between lower cancer risk and aspirin, but author Leslie Bernstein, a professor in the Division of Cancer Etiology in the Department of Population Sciences at the Beckman Research Institute of the City of Hope Comprehensive Cancer Center, said one reason may be because aspirin can lower inflammation. (wcpo.com)
When Bernstein read about the potential inhibitor impact of aspirin, she wondered whether there would be a connection to lowering breast cancer risk. (wcpo.com)

If you are eligible, your primary care provider will schedule your low-dose lung CT scan. (fryemedctr.com)

The new study, published in the journal Nutrition Research (Vol. 26, pp. 460-466), reports that even a low-dose folic acid supplement (400 micrograms) could lead to significant reductions in hyperhomocysteinemic elderly people. (nutraingredients-usa.com)

Stellarex is the only low-dose drug-coated balloon with a proven treatment effect at three years compared to the existing standard-of-care in the U.S. and Europe. (philips.com)
Historically, most cytotoxic treatment regimens have been developed to be used at its maximum tolerated dose (MTD), in order to achieve better tumor control. (scirp.org)
A low-dose lung screening is capable of detecting very small but potentially cancerous cells at the earliest stages, which may allow for the least invasive treatment options. (fryemedctr.com)

Never stop or decrease your dose unless instructed by your doctor. (sjogrens.org)

Low-dose penicillin taken late in pregnancy and in early life of mice offspring, changes behavior and the balance of microbes in the gut. (sciencedaily.com)
In this paper, we report that low-dose penicillin taken late in pregnancy and in early life of mice offspring, changes behaviour and the balance of microbes in the gut. (sciencedaily.com)
A previous study in 2014 raised similar concerns after finding that giving clinical doses of penicillin to mice in late pregnancy and early life led to a state of vulnerability to dietary induction of obesity. (sciencedaily.com)

Public health officials are very aware that uptake might be low. (wvtf.org)
John C. Lincoln's Breast Health and Research Center in North Phoenix is now Arizona's first site to offer low dose 3-D mammography, the latest innovation in breast cancer screening. (azbigmedia.com)
The new, low dose 3-D mammograms are now available at the same cost as conventional 2-D mammography at John C. Lincoln's Breast Health and Research Center, 19646 N. 27th Ave., #205. (azbigmedia.com)
Being first to offer low dose 3-D mammography is typical for John C. Lincoln's Breast Health Center, which has a history of being at the forefront of breast cancer screening. (azbigmedia.com)
3 See http://www.who.int/nmh/events/2015/bloomberg-data-for-health/en/ (accessed 10 October 2016). (who.int)

When the door of the room opened and Long Hao slowly appeared in low dose hypertension medicine the. (jewishledger.com)

Your chance of serious side effects is low, because of the low dose of hormones. (greatist.com)
What are the side effects of low dose prednisone? (sjogrens.org)
Ask the Expert: What are the side effects of taking a low dose prednisone every day? (sjogrens.org)

But since we're focusing on low-dose birth control here, let's zero in on the two main types: combination and the "minipill. (greatist.com)

If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. (doctorsolve.com)

Un nombre significative- ment moindre de patientes dans le groupe du traitement à faible dose a signalé des vomissements et des douleurs abdominales par rapport aux patientes recevant le traitement standard. (who.int)
L'hypoglycémie, le travail prématuré et la recrudescence étaient légèrement, mais non significativement, plus élevés chez les pa- tientes du groupe du traitement standard que dans le groupe du traitement à faible dose. (who.int)

Lower dose 3-D mammography is an important evolution in breast cancer screening," Dr. Greer says. (azbigmedia.com)
No matter how you look at it," Dr. Greer said, "lower dose 3-D breast cancer screening provides a better patient experience. (azbigmedia.com)

http://www.un.org/en/ga/search/view_doc.asp?symbol=A/RES/68/300 (accessed 10 October 2016). (who.int)

However, low doses might not translate to low tissue levels. (thecarlatreport.com)

1 See paragraphs 16-18 of document A69/10, based on data included in the Noncommunicable diseases progress monitor 2015, availab le at http://www.who.int/nmh/publications/ncd-progress-monitor-2015/en/ (accessed 10 October 2016). (who.int)

But there haven't been previous studies that have tested the effects of clinical doses of a commonly-used, narrow-spectrum antibiotic such as penicillin on gut bacteria and behaviour. (sciencedaily.com)

Food insecurity - the limited or uncertain availability of nutritionally adequate and safe foods (6) - disproportionately affects people with low incomes, people of color, and rural residents (7). (cdc.gov)

The widely adopted atomic-resolution imaging methods in scanning transmission electron microscopy (STEM), such as annular dark-field (ADF) or coherent bright-field (cBF) imaging, are intrinsically dose inefficient as they use only a small fraction of the scattered electrons, being constructed via a simple integration of a limited portion of phase space. (nature.com)

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