• Simvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. (nih.gov)
  • Up to 5% of patients taking simvastatin chronically may experience minor elevations in serum ALT levels during therapy, but confirmed elevations to above three times the upper limit of normal (ULN) occur in only 1% to 2% of patients. (nih.gov)
  • Isolated cases of an autoimmune hepatitis-like syndrome associated with simvastatin therapy have been reported, some of which did not reverse completely with discontinuation, resulting in a chronic hepatitis requiring long term immunosuppressive therapy. (nih.gov)
  • Using the search terms atorvastatin, simvastatin,pravastatin, rosuvastatin, fluvastatin, lovastatin, prospective trial, and randomized trial, the MEDLINE/EMBASE and the Cochrane Collaboration databases were reviewed for prospective randomized primary and secondary prevention trials of statin monotherapy. (unboundmedicine.com)
  • Simvastatin, pravastatin, and lovastatin had similar odds of AEs. (unboundmedicine.com)
  • As with atorvastatin, simvastatin, and other statin drugs metabolized via CYP3A4, drinking grapefruit juice during lovastatin therapy may increase the risk of side effects. (wikipedia.org)
  • The ability of lovastatin, mevastatin and simvastatin to inhibit the melanoma cell proliferation was examined using cytotoxicity and apoptosis assays. (biomedcentral.com)
  • Lovastatin, mevastatin and simvastatin inhibited the growth, cell migration and invasion of HT144, M14 and SK-MEL-28 melanoma cells. (biomedcentral.com)
  • HMG-CoA Reductase inhibitors like statins (atorvastatin, lovastatin, simvastatin) acts on the cells which absorbs the lipoproteins by inhibiting the enzyme (HMG CoA reductase) which regulates the cholesterol. (omicsonline.org)
  • The monthly cost of ezetimibe is $78, atorvastatin 20 mg is $108, lovastatin 20 mg is $37-71, and ezetimibe 10 mg/simvastatin 20 mg (Vytorin) is $86. (aafp.org)
  • In the Sprague-Dawley rat, very high, pharmacologically comparable dosages (150-1200 mg/kg/day) of structurally similar HMGRIs (lovastatin, simvastatin, pravastatin and L-647, 318) produced dose-related increases in the incidence and severity of skeletal muscle degeneration. (aspetjournals.org)
  • In one example of such therapy, treatment with Vytorin, which combines ezetimibe (decreases small intestinal absorption of cholesterol) with simvastatin, produced benefit in cardiovascular morbidity and mortality over and above that demonstrated for simvastatin alone. (medscape.com)
  • Concomitant use of indinavir with lovastatin or simvastatin is not recommended by the FDA, and interactions with pravastatin and fluvastatin have not been studied. (medscape.com)
  • Thus, atorvastatin, lovastatin and simvastatin are metabolised by isoform 3. (who.int)
  • Combination therapy also decreased total cholesterol levels 6 to 10 percent more than statins alone, but did not impact HDL or triglyceride levels, whereas atorvastatin alone decreased triglyceride levels. (aafp.org)
  • Men using atorvastatin, pravastatin, or rosuvastatin-but not lovastatin-had a reduction in mortality compared with nonusers, according to the study, which points out that those results were consistent with a recent population-based cohort study using Taiwan National Health Insurance Research Data. (uspharmacist.com)
  • Of the three statins studied, men on atorvastatin also had longer median time to progression on androgen-deprivation therapy compared with those who were not treated with statins. (uspharmacist.com)
  • Lovastatin and other statins have been studied for their chemopreventive and chemotherapeutic effects. (wikipedia.org)
  • However, higher doses of statins may have a role to play in adjuvant therapy by inhibiting growth and invasion of melanoma cells. (biomedcentral.com)
  • Most previous observational studies have been limited by a small number of cases, short follow-up period, unverified self-reports on use and consistency of statins therapy, and no assessment of statins efficacy. (cdc.gov)
  • Reductions in LDL cholesterol levels with combination therapy (32 to 48 percent) were significantly superior to colesevelam or statins alone (7 to 16 percent and 22 to 34 percent, respectively). (aafp.org)
  • Lovastatin belongs to a group of drugs called HMG-CoA reductase inhibitors, also known as statins. (medicineshoppe.com)
  • Two commonly prescribed medications-cholesterol-lowering statins and the diabetes therapy metformin-have shown promise as having anticancer effects, according to a report in Cancer Medicine , but it remained unclear which of the two, often prescribed together, contributes the most and whether they can extended survival in high-risk prostate cancer. (uspharmacist.com)
  • March 12, 2009 - The US Food and Drug Administration (FDA) has approved safety labeling revisions to provide new information regarding the increased risk for cardiovascular events in patients receiving long-term celecoxib therapy, warn of drug interactions between indinavir sulfate and statins, and advise of the need to monitor liver function in certain patients receiving treatment with rifampin as part of a tuberculosis regimen. (medscape.com)
  • Inhibition of HMG-CoA reductase is the basis for an assay in pharmacokinetic studies of the β-hydroxyacid metabolites (active inhibitors) and, following base hydrolysis, active plus latent inhibitors (total inhibitors) in plasma following administration of lovastatin. (nih.gov)
  • In a single dose study in four hypercholesterolemic patients, it was estimated that less than 5% of an oral dose of lovastatin reaches the general circulation as active inhibitors. (nih.gov)
  • Recent clinical evidence indicates a potential for skeletal muscle toxicity after therapy with HMG-CoA reductase inhibitors (HMGRIs) in man. (aspetjournals.org)
  • Evidence shows that antiplatelet agents, antioxidant therapies, amino acid supplementation, angiotensin converting enzyme (ACE) inhibitors, and angiotensin-receptor blockers may be able to prevent or slow the progression of atherosclerosis. (medscape.com)
  • [ 95 ] PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors (eg, alirocumab) dramatically lower LDL-C when added to maximally tolerated statin therapy. (medscape.com)
  • Lovastatin, sold under the brand name Mevacor among others, is a statin medication, to treat high blood cholesterol and reduce the risk of cardiovascular disease. (wikipedia.org)
  • 1 In studies 2 , 3 of the pharmacokinetics of colesevelam, there were no significant effects on absorption of the following concurrently administered drugs: digoxin, warfarin (Coumadin), sustained-release verapamil (Calan), metoprolol (Toprol XL), quinidine, valproic acid (Depakene), and lovastatin (Mevacor). (aafp.org)
  • The primary uses of lovastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease. (wikipedia.org)
  • As a consequence of extensive hepatic extraction of lovastatin, the availability of drug to the general circulation is low and variable. (nih.gov)
  • Evaluation of the potential interaction between the HMGRI, lovastatin and CsA at the level of hepatic microsomal metabolism indicated that CsA did not inhibit the metabolism of lovastatin in isolated microsomes from female rats. (aspetjournals.org)
  • Colesevelam lowers LDL cholesterol levels a small amount (7 to 16 percent) when used alone and provides additional cholesterol lowering when added to statin therapy. (aafp.org)
  • Lovastatin is a prescription medication used to treat high cholesterol levels and to prevent heart disease. (medicineshoppe.com)
  • Homozygous Familial Hypercholesterolemia: Use of lovastatin for this rare genetic disorder (increased cholesterol levels) is not sufficient enough for treatment. (medicineshoppe.com)
  • After oral ingestion, lovastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. (nih.gov)
  • Mevalonate is a required building block for cholesterol biosynthesis and lovastatin interferes with its production by acting as a reversible competitive inhibitor for HMG-CoA, which binds to the HMG-CoA reductase. (wikipedia.org)
  • However, studies in which statin drugs have been given with high-dose niacin therapy suggest that this is not a helpful combination for most people and there are safety concerns. (consumerlab.com)
  • Components of grapefruit juice, the flavonoid naringin, or the furanocoumarin bergamottin inhibit CYP3A4 in vitro, and may account for the in vivo effect of grapefruit juice concentrate decreasing the metabolic clearance of lovastatin, and increasing its plasma concentrations. (wikipedia.org)
  • Grapefruit and grapefruit juice may interact with lovastatin. (medicineshoppe.com)
  • In addition, it was found equivalent to controlled release carbamazepine as first-line therapy for partial-onset seizures, both in efficacy and tolerability. (keywen.com)
  • The mechanism of the LDL-lowering effect of lovastatin may involve both reduction of VLDL-C concentration, and induction of the LDL receptor, leading to reduced production and/or increased catabolism of LDL-C. Apolipoprotein B also falls during treatment with lovastatin. (nih.gov)
  • The updated GTBC recommends a significant paradigm shift in lipid-loweringdrug therapy for atherosclerotic cardiovascular disease (ASCVD) risk reduction, which has led to questions regarding their content and their implementation. (medicalcriteria.com)
  • Shared decision making should be performed between providers and patients when considering the use of statin therapy for ASCVD risk reduction. (medicalcriteria.com)
  • Patients who are discharged on antilipid medications that were begun in the hospital tend to stay on the therapy and to derive significant reduction in the recurrent cardiac event rate. (medscape.com)
  • The concentrations required to inhibit proliferation of melanoma cells (0.8-2.1 μM) have previously been achieved in a phase I clinical trial of lovastatin in patients with solid tumours, (45 mg/kg/day resulted in peak plasma concentrations of approximately 3.9 μM). (biomedcentral.com)
  • and as adjunct therapy for familial adenomatous polyposis . (medscape.com)
  • Breast cancer is the most common malignancy affecting women and there remains a need for effective adjuvant therapies for this disease, for which plant sterols may play a distinctive role. (mdpi.com)
  • Lovastatin, USP is a cholesterol lowering agent isolated from a strain of Aspergillus terreus. (nih.gov)
  • In 1982, some small-scale clinical investigations of lovastatin, a polyketide-derived natural product isolated from Aspergillus terreus, in very high-risk patients were undertaken, in which dramatic reductions in LDL cholesterol were observed, with very few adverse effects. (wikipedia.org)
  • The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) trial to evaluate the efficacy of lovastatin for preventing coronary events, found a significantly decreased incidence of new melanomas in the lovastatin arm compared with the placebo arm. (biomedcentral.com)
  • Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized controlled trials. (keywen.com)
  • Lovastatin has been shown to reduce elevated LDL-C concentrations. (nih.gov)
  • Plasma concentrations of total radioactivity (lovastatin plus 14C-metabolites) peaked at 2 hours and declined rapidly to about 10% of peak by 24 hours postdose. (nih.gov)
  • In animal studies, after oral dosing, lovastatin had high selectivity for the liver, where it achieved substantially higher concentrations than in non-target tissues. (nih.gov)
  • Although the incidence of drug-induced skeletal muscle toxicity is very low (0.1-0.2%) with monotherapy, it may increase following concomitant drug therapy with the immunosuppressant, cyclosporine A (CsA), and possibly with certain other hypolipidemic agents. (aspetjournals.org)
  • Cetuximab, marketed as Erbitux, is one of the key therapies for metastatic colorectal cancer. (sciencedaily.com)
  • Therapeutic intervention occurs at advanced metastatic disease, due to challenges in early-stage diagnosis, with common disease recurrence and therapy resistance despite initial therapy success. (bvsalud.org)
  • Statin therapy was associated with greater odds of AEs compared with placebo but with substantial clinical benefit. (unboundmedicine.com)
  • Compactin and lovastatin, natural products with a powerful inhibitory effect on HMG-CoA reductase, were discovered in the 1970s, and taken into clinical development as potential drugs for lowering LDL cholesterol. (wikipedia.org)
  • The figure summarizes targets for a selection of therapies that are recently licensed or under clinical development for patients with severe treatment resistant asthma. (biomedcentral.com)
  • An earlier study among individuals at high risk for diabetes found significantly higher rates of incident diabetes at 10 years among patients on placebo, metformin , or lifestyle intervention who also initiated statin therapy. (medscape.com)
  • As early and effective antiretroviral therapy has become more widespread, HIV has transitioned from a progressive, fatal disease to a chronic, manageable disease marked by elevated risk of chronic comorbid diseases, including cardiovascular diseases (CVDs). (natap.org)
  • RESEARCH RESULTS ROUNDUP - The psychopharmacologic management of irritability, agitation, aggression, and self-injurious behaviors and drug therapy treatment. (fragilex.org)
  • Therefore, our understanding of CVD pathogenesis, prevention, and treatment in HIV relies on large observational studies, randomized controlled trials of HIV therapies that are underpowered to detect CVD end points, and small interventional studies examining surrogate CVD end points. (natap.org)
  • Monitored by immuno-PET scans, this combination therapy has the potential to personalize treatment for cancer patients and spare them from harmful side effects. (phys.org)
  • Targeting the HER2 protein, which is commonly expressed in ovarian cancer, the therapy (anti-HER2 225Ac-PRIT) is a potential treatment for the otherwise incurable disease. (phys.org)
  • The percentages of new-onset diabetes and cataract are in line with previous studies regarding statin therapy in patients with atherosclerotic cardiovascular disease ," Hong said. (medscape.com)
  • Patients with liver disease should not take lovastatin. (wikipedia.org)
  • Dec. 14, 2021 Patients with colorectal cancer were among the first to receive targeted therapies. (sciencedaily.com)
  • [ 103 ] Before initiating therapy, place patients on a cholesterol-lowering diet for 3-6 months, and continue diet indefinitely. (medscape.com)
  • The significant false-positive rate of metastases on bone scans means that definitive therapy for local disease may have been withheld from patients inappropriately. (phys.org)
  • In elderly patients with suspected prostate cancer, a prostate-specific membrane antigen positron emission tomography (PSMA PET) CT scan can diagnose advanced disease and aid in therapy selection without the need for a biopsy. (phys.org)
  • on it medication, and marketed the same elix category and free over the counter market The identifyle of therapy takes a cinnamon, here is the does parsley lower your blood pressure first trial that is a link between 127% of patients who were taking the drugs, and 60% of patients of hypertension. (kamrytech.com)
  • Health Care Professionals: Health care professionals should discontinue statin therapy in most pregnant patients, or they can consider the ongoing therapeutic needs of the individual patient, particularly those at very high risk for cardiovascular events during pregnancy. (safemedication.com)
  • Azole drugs are considered the first-line therapy in various diseases of aspergillosis. (cdc.gov)
  • The primary target of therapy is LDL cholesterol, unless serum triglycerides are 500 mg/dL in which case triglyceride-lowering therapy should be started immediately because of the high risk of pancreatitis. (who.int)
  • Lovastatin undergoes extensive first-pass extraction in the liver, its primary site of action, with subsequent excretion of drug equivalents in the bile. (nih.gov)
  • Complementary therapies to ease symptoms. (webmd.com)
  • Stroke Supportive Therapy is a comprehensive approach that aims to assist you in recovering lost abilities, managing symptoms, and optimizing your daily life after a stroke. (strokerehabathome.com)
  • Combination therapy in the future may allow for the achievement of greater low-density lipoprotein cholesterol (LDL-C) lowering, with associated cardiovascular benefit. (medscape.com)
  • Our study investigated the role of extracellular methylation in EGFR signaling, and unexpectedly discovered new information about how EGFR renders cancer cells resistant to cetuximab antibody therapy," said Mien Chie Hung, Ph.D., chair of Molecular and Cellular Oncology. (sciencedaily.com)
  • A study at The University of Texas MD Anderson Cancer Center may help explain why the body sometimes becomes resistant to this therapy. (sciencedaily.com)
  • Lipid-lowering statin therapy should be based on the degree of ASCVD risk and the intensity of the statin. (medicalcriteria.com)
  • The same issues are likely to arise with the combination of red yeast rice and high-dose niacin therapy, so this combination should be carefully evaluated. (consumerlab.com)
  • Two recent therapies licensed for use in asthma are omalizumab, a humanized monoclonal antibody that binds circulating IgE antibody, and bronchial thermoplasty, which involves the delivery of radio frequency energy to the airways to reduce airway smooth muscle mass. (biomedcentral.com)
  • Following an oral dose of 14C-labeled lovastatin in man, 10% of the dose was excreted in urine and 83% in feces. (nih.gov)
  • Absorption of lovastatin, estimated relative to an intravenous reference dose, in each of four animal species tested, averaged about 30% of an oral dose. (nih.gov)
  • Read user comments about the side effects, benefits, and effectiveness of niacin-lovastatin oral. (webmd.com)
  • T he authors separately examined the effects of lovastatin on cholesterol level on APP processing beta-amyloid production and senile plaque deposition, in male and female mice. (nih.gov)
  • Owing to its potential to disrupt infant lipid metabolism, lovastatin should not be taken while breastfeeding. (wikipedia.org)
  • In addition, there are new therapies under development for asthma that have good potential to reach the clinic in the next five years. (biomedcentral.com)
  • This can be life-threatening if not recognised and treated in time, so any unexplained muscle pain or weakness whilst on lovastatin should be promptly mentioned to the prescribing doctor. (wikipedia.org)
  • After 3 weeks of therapy, he calls to report generalized muscle aches. (nursewriting.com)