• Indanomycin is biosynthesized by a hybrid nonribosomal peptide synthase/polyketide synthase (NRPS/PKS) followed by a number of `tailoring' steps to form the two ring systems that are present in the mature product. (iucr.org)
  • Dihydromonacolin L acid is synthesized while bound to an acyl-carrier protein domain of the lovastatin nonaketide synthase (EC 2.3.1.161 ). (genome.jp)
  • Since that enzyme lacks a thioesterase domain, release of the dihydromonacolin L acid moiety from the polyketide synthase requires this dedicated enzyme. (genome.jp)
  • LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. (genome.jp)
  • The gedCΔ mutant was created by inserting the antibiotic marker hygromycin B (hyg) within the gedC gene that encodes emodin anthrone polyketide synthase (PKS), a primary gene responsible for initiating (+)-geodin biosynthesis. (upm.edu.my)
  • Finally, combined quantum mechanical/molecular mechanical (QM/MM) modelling of the IdmH reaction shows that the active site of the enzyme provides an appropriate environment to promote indane-ring formation, supporting the assignment of IdmH as the key Diels-Alderase catalysing the final step in the biosynthesis of indanomycin through a similar mechanism to other recently characterized Diels-Alderases involved in polyketide-tailoring reactions. (iucr.org)
  • The effects of emodin anthrone PKS gene disruption on (+)-geodin and lovastatin biosynthesis and the production of the precursors acetyl-CoA and malonyl-CoA were investigated with cultures based on glycerol alone and in combination with lactose. (upm.edu.my)
  • The gedCΔ strain showed improved lovastatin production, particularly when cultivated on the glycerol-lactose mixture, increasing lovastatin production by 80% (113 mg/L) while simultaneously inhibiting (+)-geodin biosynthesis compared to the wild-type strain. (upm.edu.my)
  • Cultivation of Aspergillus terreus (ATCC 20542) with carbohydrates or low-value feedstocks such as glycerol produces lovastatin as a secondary metabolite and (+)-geodin as a by-product. (upm.edu.my)
  • This study thus shows that suppression of the (+)-geodin pathway increases lovastatin yield and demonstrates a practical approach of manipulating carbon flux by modulating enzyme activity. (upm.edu.my)
  • Polyketides are a group of secondary metabolites, exhibiting diversity in terms of their structure and function. (springeropen.com)
  • Polyketides are produced by bacteria and, due to their diverse chemical structures, have equally diverse biological activities. (nd.edu)
  • Many filamentous fungi produce polyketide-derived pigments, which have been studied for their biological activity and taxonomic value. (springeropen.com)
  • Lovastatin is widely prescribed to reduce elevated levels of cholesterol and prevent heart-related diseases. (upm.edu.my)
  • Mevacor ( medical name Lovastatin ) is a medicine that helps patients to lower cholesterol in their body and they need to keep a suitable diet along with it. (tabletsmanual.com)
  • Natural products classed as polyketides, nonribosomal peptides and hybrids of both are often biosynthesized by giant, complex enzymes known as polyketide synthases (PKS) and nonribosomal peptide synthetases (NRPS). (iucr.org)
  • Taylor's own expertise focuses on exploring the potential of polyketide natural products as chemotherapeutic agents particularly directed at cancer and certain rare genetic disorders. (nd.edu)
  • SMs are biosynthesized from primary metabolites in specialized pathways (i.e. polyketides or mevalonate pathways derived from Acetyl Coenzyme A, or amino acids) and some genes are clustered together. (123dok.org)
  • Lovastatin belongs to the medicine-group named HMG CoA reductase inhibitors. (tabletsmanual.com)
  • Prominent examples for fungal natural products on the market or serving as lead structures are the antibiotic penicillin, the immunosuppressant cyclosporine, the HMG-CoA reductase inhibitor lovastatin (cholesterol-lowering drug) as well as the fungizide strobilurin (lead structure for agricultural fungicide). (ibwf.de)
  • Functional similarity with commercial drug lovastatin sans the side effects has catapulted its popularity in other parts of the world as well. (nih.gov)
  • However, these results were still slightly lower than lovastatin titres obtained in the shake flasks. (edu.pl)