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  • Candida
  • They show that in the pathogenic yeast Candida albicans , loss of heterozygosity (LOH) is also induced by stress. (pubmedcentralcanada.ca)
  • To facilitate analysis of copy number variations, single nucleotide polymorphisms and loss of heterozygosity events in these pathogens, we developed a pipeline for analyzing diverse genome-scale datasets from microarray, deep sequencing, and restriction site associated DNA sequence experiments for clinical and laboratory strains of Candida albicans , the most prevalent human fungal pathogen. (beds.ac.uk)
  • genes
  • A significant yet limited set of metabolic genes that explained the partial divergence of ccRCC metabolism correlated with loss of von Hippel-Lindau tumor suppressor ( VHL ) and a potential activation of signal transducer and activator of transcription 1. (pnas.org)
  • Notably, this behavior is recapitulated by recurrent loss of heterozygosity in multiple metabolic genes adjacent to VHL . (pnas.org)
  • Adelaide Research & Scholarship: Localisation of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. (edu.au)
  • CRCs with chromosomal instability frequently demonstrate loss of heterozygosity (LOH) involving numerous genes, but particularly the APC (Adenomatous Polyposis Coli) and DCC (Deleted in Colorectal Cancer) genes, as well as point mutations in the KRAS (Ki-ras2 Kirsten rat sarcoma) gene. (biomedcentral.com)
  • single nucleotide p
  • The mechanisms by which hyperactive alleles become homozygous was addressed by comparative genome hybridization and single nucleotide polymorphism arrays and indicated that loss of TAC1 heterozygosity can occur by recombination between portions of chromosome 5 or by chromosome 5 duplication. (genetics.org)
  • Genome-wide detection of chromosomal changes was performed using the Affymetrix GeneChip 10 K single nucleotide polymorphism (SNP) array, including loss of heterozygosity (LOH) and copy number alterations (CNA), for 26 pairs of matched germ-line and micro-dissected tumor DNA samples. (springer.com)
  • Insights into molecular karyotyping using comparative genomic hybridization (CGH) and single nucleotide polymorphism (SNP) arrays enable the identification of copy number variations (CNVs) at a higher resolution and facilitate the detection of copy neutral loss of heterozygosity (CN-LOH) otherwise undetectable by conventional cytogenetics. (upm.edu.my)
  • markers
  • Proliferative-Enriched for neural stem cell markers, PTEN loss, EGFR amplified or normal, Akt (protein kinase B) cell signaling pathway activation, shorter survival than proneural subgroup. (mdpi.com)
  • deletion
  • Loss of heterozygosity is the observation that malignant tissues present in an individual bearing a tumor supressor gene mutation or deletion tend to have a mutated or deleted allelomorph at the locus of the tumor suppresor gene in question in the transformed tissue. (bio.net)
  • This study therefore shows how loss of heterozygosity, hallmarked by VHL deletion in ccRCC, may uniquely shape tumor metabolism. (pnas.org)
  • mechanism
  • While, in general, etiology of relapses after haploidentical transplantation may overlap with other types of allogeneic transplants, a unique relapse mechanism with loss of heterozygosity is only observed after haplo-identical transplantation. (omixon.com)
  • amplification
  • Regions frequently targeted by CNA, as determined by array CGH, such as amplification of 5p and 20q, and loss of 8p were confirmed by fluorescent in situ hybridization FISH. (duhnnae.com)
  • regions
  • Fifteen CNA-loss regions (200 kb to 4.3 Mb) and 36 CNA-gain regions (200 kb to 9.3 Mb) were also identified. (springer.com)
  • specific
  • B) Schematic representation of low-resolution HLA typing by forward PCR sequence-specific oligonucleotide probing (SSOP) of DNA from a donor and a haploidentical patient's leukemia at diagnosis or at HLA loss relapse after transplantation. (omixon.com)