Named after its discoverer, the German anatomist Friedrich Gustav Jakob Henle, the loop of Henle's main function is to create a concentration gradient in the medulla of the kidney. (wikipedia.org)
By means of a countercurrent multiplier system, which uses electrolyte pumps, the loop of Henle creates an area of high urea concentration deep in the medulla, near the papillary duct in the collecting duct system. (wikipedia.org)
The loop has a sharp bend in the renal medulla going from descending to ascending thin limb. (wikipedia.org)
The interstitium of the kidney increases in osmolarity outside as the loop of Henle descends from 600 mOsm/L in the outer medulla of the kidney to 1200 mOsm/L in the inner medulla. (wikipedia.org)
Located at corticomedullary junction and their loops extend deep into the medulla to the tip of the papilla. (rahulgladwin.com)
Their loops extend into the peripheral medulla. (rahulgladwin.com)
The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE. (harvard.edu)
Glomerulus1
Students can also color the image to identify the major structures of the nephron: glomerulus, bowman's capsule, proximal and distal tubules, loop of Henle, collecting duct and capillaries. (biologycorner.com)
Kidney2
In the kidney, the loop of Henle (English: /ˈhɛnli/) (or Henle's loop, Henle loop, nephron loop or its Latin counterpart ansa nephroni) is the portion of a nephron that leads from the proximal convoluted tubule to the distal convoluted tubule. (wikipedia.org)
ROMK is an apical K(+) channel expressed in the thick ascending limb of Henle (TALH) and throughout the distal nephron of the kidney. (nih.gov)
Diuretics3
The functional relevance of NKCC2 in human is illustrated by the many abnormalities that result from the inactivation of this transport system through the use of loop diuretics or in the setting of inherited disorders. (nih.gov)
Ethacrynic acid acts on the ascending limb of the loop of Henle and on the proximal and distal tubules. (nih.gov)
occurs in the loop of henle, 2 tubules running in the opposite direction to one another - one thin descending, one thick ascending. (brainscape.com)
Renal tubules consist of four main segments with different anatomies and functions: proximal convoluted tubule (PCT), thick ascending limb of Henle's loop (TAL), distal convoluted tubule (DCT), and collecting duct (CD). (chikd.org)
TALH2
Completely dysfunctional mutations in the receptors and ion channels in the thick ascending limb of the loop of Henle (TALH) are probably not compatible with life. (medscape.com)
SLC12A1) is an integral membrane protein that comes as three splice variants and mediates the cotranslocation of Na + , K + , and Cl - ions through the apical membrane of the thick ascending loop of Henle (TALH). (nih.gov)
Henle's2
Bartter syndrome is a group of rare renal tubular disease characterized by impaired salt reabsorption in the thick ascending limb of Henle's loop and clinically by the association of hypokalemic alkalosis, hypercalciuria/nephrocalcinosis, increased levels of plasma renin and aldosterone, low blood pressure and vascular resistance to angiotensin II. (orpha.net)
Bartter syndrome results from a defect in sodium, potassium and chloride reabsorption at the level of Henle's loop. (orpha.net)
Nephron1
The loop is also sometimes called the nephron loop. (wikipedia.org)
Descending limb2
The loop of Henle can be divided into four parts: Thin descending limb of loop of Henle The thin descending limb has low permeability to ions and urea while being highly permeable to water. (wikipedia.org)
The ascending limb of the loop of Henle receives an even lower volume of fluid and has different characteristics compared to the descending limb. (wikipedia.org)
Urine2
Ascending limb of loop of HenleSodium (Na+), potassium (K+) and chloride (Cl−) ions are reabsorbed from the urine by secondary active transport by a Na-K-Cl cotransporter (NKCC2). (wikipedia.org)
citation needed] The loop of Henle is supplied by blood in a series of straight capillaries descending from the cortical efferent arterioles. (wikipedia.org)
These capillaries have a hairpin configuration similar to that of the loops of Henle. (medscape.com)
Oxygen1
20. Anandamide inhibits transport-related oxygen consumption in the loop of Henle by activating CB1 receptors. (nih.gov)
Inhibits1
Bumetanide inhibits sodium reabsorption in the ascending limb of the loop of Henle, as shown by marked reduction of free-water clearance (CH 2 O) during hydration and tubular free-water reabsorption (T C H 2 O) during hydropenia. (nih.gov)
Fluid4
citation needed] The descending loop of Henle receives isotonic (300 mOsm/L) fluid from the proximal convoluted tubule (PCT). (wikipedia.org)
Since water is also reabsorbed the volume of fluid in the loop of Henle is less than the PCT, approximately one-third of the original volume. (wikipedia.org)
The 300 mOsm/L fluid from the loop loses water to the higher concentration outside the loop and increases in tonicity until it reaches its maximum at the bottom of the loop. (wikipedia.org)
It must also usually be given with a diuretic, frequently one acting in the ascending limb of the loop of Henle, to prevent serious fluid accumulation. (nih.gov)
Diuretic1
Bumetanide is a loop diuretic with a rapid onset and short duration of action. (nih.gov)
Ions2
Thin ascending limb of loop of Henle The thin ascending limb is impermeable to water, but it is permeable to ions. (wikipedia.org)
The descending portion of the loop of Henle is extremely permeable to water and is less permeable to ions, therefore water is easily reabsorbed here and solutes are not readily reabsorbed. (wikipedia.org)
Increases1
As flow increases, the ability of the loop to maintain its osmolar gradient is reduced. (wikipedia.org)
Tissue1
The tissue type of the loop is simple squamous epithelium. (wikipedia.org)
Thin1
Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. (uchicago.edu)
MeSH1
Loop of Henle" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)