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  • hairpin
  • A sharp bend in the loop-loop helix, documented by gel electrophoresis, narrows the major groove and allows bridging of the phosphodiester backbones across the major groove in order to close the hairpin loops at their 5'-ends. (sciencemag.org)
  • Furthermore, free energy parameters are revised to account for recent experimental results for terminal mismatches and hairpin, bulge, internal, and multibranch loops. (pnas.org)
  • 8 ). Hairpin loop parameters (Tables 1 and 2 ) are revised on the basis of recent experimental results ( 47 , 48 ) and the previous database of RNA hairpin stabilities ( 49 - 55 ). (pnas.org)
  • A hairpin loop protruding from RidL inserts into a conserved pocket on VPS29 that is also used by cellular ligands, such as Tre-2/Bub2/Cdc16 domain family member 5 (TBC1D5) and VPS9-ankyrin repeat protein for VPS29 binding. (sebbm.es)
  • demonstrate
  • Our results demonstrate activation of autophagy shortly after axotomy with autophagosome formation, upregulation of the autophagy regulator Atg5 and apoptotic death of 50% of the retinal ganglion cells (RGCs) after 5 days. (sebbm.es)
  • proteins
  • Sequence alignment of 52 papillomavirus L1 proteins from different host species demonstrates that there is considerable homology with the exception of 5 hypervariable regions, each ranging from 10 to 30 amino acids in length and located within a surface-exposed loop. (biomedcentral.com)
  • nuclear
  • We show, in live cells, that Ddx19 transiently relocalizes from the nucleopore to the nucleus upon DNA damage, in an ATR /Chk1‐dependent manner, and that Ddx19 nuclear relocalization is required to clear R‐loops. (embopress.org)
  • peptide
  • Recent discoveries have shown that RNA plays a larger role in biology than previously realized, e.g., in posttranscriptional regulation ( 1 ), development ( 2 , 3 ), immunity ( 4 , 5 ), and peptide bond formation ( 6 , 7 ). (pnas.org)
  • cognitive
  • Researchers at UC Davis have identified a new feature of the genetic mutation responsible for the progressive neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome (FXTAS) - the formation of "R-loops," which they believe may be associated with the disorder's neurological symptoms, such as tremors, lack of balance, features of Parkinsonism, and cognitive decline. (redorbit.com)
  • The formation of neurites is an important process affecting the cognitive abilities of an organism. (sebbm.es)
  • reactions
  • D) Two-dimensional gel electrophoresis of D-loop reactions extended by Pol δ in the presence or absence of RFC, PCNA after 30 min extension time. (nih.gov)
  • regions
  • These results suggest that non-contiguous loop regions of L1 display critical components of a type-specific, conformational epitope. (biomedcentral.com)
  • Given that the crystallography model predicts the hypervariable regions to be displayed as surface-exposed loops [ 25 ]and that the loops are highly immunogenic, it is quite likely that the loop epitopes are the determinants of type-specificity. (biomedcentral.com)
  • These R-loops are visualized by electron microscopy and reveal intron regions of DNA by creating unbound loops at these regions. (wikipedia.org)
  • Actively transcribed regions of DNA often form R-loops that are vulnerable to DNA damage . (wikipedia.org)
  • active
  • Calcium is required for efficient filament formation by hRAD51, and chelation is necessary to allow ATP hydrolysis, necessary for maximum D-loop formation, and to allow for DNA polymerases to be active. (nih.gov)
  • The analysis provides a seamless continuum for the catalytic cycle, incorporating large motions by four loops that surround the active site. (sebbm.es)
  • cause
  • A. Formation of loops in the colon can cause patient discomfort, difficulty in advancing the scope, and may increase the risk of perforation. (sages.org)
  • When unscheduled R-loops form, they can cause damage by a number of different mechanisms. (wikipedia.org)
  • highly
  • Not only do the papillomavirus loop sequences display potentially virus-neutralizing B cell epitopes, but the manner in which they are presented to the host immune system makes them highly immunogenic. (biomedcentral.com)
  • length
  • In FXTAS, the number of excessive CGG repeats and the length of the R-loops are correlated, Hagerman said. (redorbit.com)
  • step
  • The formation of TPMG is an important step in formalizing the leadership of the health system's medical group practices and in refining the role of its group practice in achieving the health system's research, teaching, patient care and community engagement goals. (ucdavis.edu)