• Extra copies of the gene increase longevity in creatures as diverse as yeast, roundworms and fruit flies, and we are working to determine whether it does the same for larger animals, such as mice. (scientificamerican.com)
  • Researchers have found that levels of a regulatory protein called ATF4, and the corresponding levels of the molecules whose expression it controls, are elevated in the livers of mice exposed to multiple interventions known increase longevity. (eurekalert.org)
  • So, if it's really so easy to increase longevity, why aren't more people following in the footsteps of the Japanese? (infobarrel.com)
  • Although over 200 gene variants have been associated with longevity according to a US-Belgian-UK research database of human genetic variants, these explain only a small fraction of the heritability. (wikipedia.org)
  • This implies that both genetic makeup and hormonal profile played an important role in ensuring longevity. (medicalnewstoday.com)
  • An international group of scientists studied the effects of 17 different lifespan-extending interventions on gene activity in mice and discovered genetic biomarkers of longevity. (eurekalert.org)
  • If the mutated gene is producing longer-living worms, then it's the first time genetic researchers have been able to identify a single gene responsible for longevity in an organism, according to geneticists interviewed by The Times. (latimes.com)
  • The nematode, Johnson said, is perfect for longevity research because of its simple genetic makeup, its low cost to obtain and the fact that its life span is usually less than a month. (latimes.com)
  • These generations were watched, day by day, and when they died their life spans were recorded on genetic "maps," not unlike a family tree, which helped the researchers to trace the longevity effect back to a single gene. (latimes.com)
  • Although genes responsible for longevity have existed in theory, genetic makeup has been identified as the culprit in more than one exotic disease that shortens life. (latimes.com)
  • Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. (nature.com)
  • Hence, centenarian genomes may harbor genetic variants associated with health and longevity 10 . (nature.com)
  • This study hints at the existence of underlying genetic linkages between personality, metabolism, and longevity""meaning that selection for personality traits also invokes unintentional results on energetic and life history traits. (redorbit.com)
  • Of course, longevity is a genetic, hereditary phenomenon. (baltictimes.com)
  • In July last year I wrote about some fairly glaring flaws in a paper published in Science on the genetics of extreme longevity. (wired.com)
  • P rotestant Christians differ from each other in their opinions on nearly everything, including science and technology, and so we should expect that Protestant responses to the prospect of extreme longevity will range from condemnation to enthusiastic endorsement. (springer.com)
  • Cole-Turner R. (2009) Extreme Longevity Research: A Progressive Protestant Perspective. (springer.com)
  • What we're doing now is identifying longevity genes," Dr. Barzilai said, adding that having parents who lived to 100 also seemed to predict protection against age-related cognitive impairment. (nytimes.com)
  • Centenarians are the fastest growing age demographic in the world, and now Danish researchers are attempting to uncover the secrets behind their longevity. (redorbit.com)
  • The research is reported online April 3, 2006 in PLoS Biology by Dr Gil Atzmon and colleagues: the same group published work in the Journal of the American Medical Association three years ago detailing the first gene found in centenarians associated with longevity. (medscape.com)
  • Association of FOX03A variation with human longevity confirmed in German centenarians," Proceedings of the National Academy of Sciences of the United States of America , vol. 106, no. 8, pp. 2700-2705, 2009. (hindawi.com)
  • Han Chinese centenarians may be more likely to have longevity-associated and/or disease-preventive genes than their centenarian counterparts in the West since they survived the brutal mortality regimes of the past when famine, wars, and starvation operated on birth cohorts of many millions. (nature.com)
  • Also, future studies could identify additional longevity genes by recruiting more centenarians for analysis. (thirdage.com)
  • Evidence-based studies indicate that longevity is based on two major factors, genetics and lifestyle choices. (wikipedia.org)
  • Each book contains articles from scientists working on the diverse aspects of the study of longevity: biology and genetics, medicine and psychology, social sciences and demography. (springer.com)
  • Is longevity determined by genetics? (medlineplus.gov)
  • The duration of human life (longevity) is influenced by genetics, the environment, and lifestyle. (medlineplus.gov)
  • Longer life spans tend to run in families, which suggests that shared genetics, lifestyle, or both play an important role in determining longevity. (medlineplus.gov)
  • It is estimated that about 25 percent of the variation in human life span is determined by genetics, but which genes, and how they contribute to longevity, are not well understood. (medlineplus.gov)
  • It is unclear how having low levels of growth hormone are protective, but prior studies of longevity in both yeast and mice have pointed to growth hormone as an important factor. (reuters.com)
  • In our lab, we subjected mice of different sexes and ages to 8 longevity interventions and analyzed gene expression changes induced by these treatments. (eurekalert.org)
  • The inheritance of longevity in animal populations such as fruit flies and mice is determined by comparing the life tables of numerous inbred populations and some of their hybrids. (britannica.com)
  • The longevity of sample populations has been measured for more than 40 inbred strains of mice. (britannica.com)
  • Two experiments concur in finding that about 30 percent of longevity variation in female mice is genetically determined, whereas the heritability in male mice is about 20 percent. (britannica.com)
  • Scientists at the Salk Institute have found a specific gene in worms (there's a very similar one in people) that is directly involved in the longevity effect . (slashdot.org)
  • A group of scientists from Skoltech, Moscow State University and Harvard University decided to fill this gap and identify crucial molecular processes associated with longevity. (eurekalert.org)
  • The scientists identified a group of genes, whose activity was associated with longevity in response to various interventions, serving as biomarkers of lifespan extension. (eurekalert.org)
  • In addition to their scientific research, the scientists developed GENtervention, an application that offers fast and user-friendly tools for investigating the associations between the activity of individual genes and longevity. (eurekalert.org)
  • Thanks to modern scientific technology, researchers have already discovered genes related to Alzheimer's, heart disease, and diabetes, and now drug companies have begun attempting to create products based on that information while scientists have been attempting to find ways to copy "longevity genes. (redorbit.com)
  • Earlier, Dutch scientists reported that they have managed to find a part of the DNA, which "provides" longevity, even if a person leads an unhealthy lifestyle. (baltictimes.com)
  • An immediate consequence from this observation is that there is no fixed upper limit to human longevity - there is no special fixed number, which separates possible and impossible values of lifespan. (wikipedia.org)
  • Many people tend to see "longevity" and "lifespan" as being the same thing, when in actual fact it isn't. (infobarrel.com)
  • The link between leaving the house and longevity, however, remained after the researchers accounted for medical or mobility issues such as chronic pain, vision or hearing impairment, diabetes, hypertension, heart disease and kidney disease. (yahoo.com)
  • However, it came as a surprise to the researchers that the drug seemed to have no effect on longevity. (newscientist.com)
  • Squirming in petri dishes, swimming in solutions, moving under the constant scrutiny of the microscope, thousands of tiny roundworms are providing researchers with clues that longevity may be controlled by a single gene. (latimes.com)
  • But researchers at Albert Einstein College of Medicine and Ferkauf Graduate School of Psychology of Yeshiva University have found that personality traits like being outgoing, optimistic, easygoing, and enjoying laughter as well as staying engaged in activities may also be part of the longevity genes mix. (eurekalert.org)
  • Research out of the University of Texas Medical Branch at Galveston suggests the herbal tea may boost longevity. (newsmax.com)
  • The effect on longevity, however, is much the same for those two scenarios. (psychcentral.com)
  • We think there may be quite a number of genes that may contribute to longevity. (latimes.com)
  • The sexual differences in longevity and athletic performances are attributed to the tradeoff between viability (survival) and competitive ability that belongs to the physical makeup of an individual, but not related to the tradeoff between survival and reproduction. (nature.com)
  • It is difficult to assess how these symptoms might affect longevity since we don't have a current cause or treatment plan associated with them. (thebody.com)
  • Biodemographic studies are important for understanding the driving forces of the current longevity revolution (dramatic increase in human life expectancy), forecasting the future of human longevity, and identification of new strategies for further increase in healthy and productive life span. (wikipedia.org)
  • Michael Guo, another investigator, said, "We found that intermittent fasting caused a slight increase to SIRT3, a well-known gene that promotes longevity and is involved in protective cell responses. (huffingtonpost.com)
  • These findings indicate that policies and programs to promote resilience would have long-term and positive effects on the well-being and longevity for senior citizens and their families. (hindawi.com)
  • A study of the regions of the world known as blue zones, where people commonly live active lives past 100 years of age, speculated that longevity is related to a healthy social and family life, not smoking, eating a plant-based diet, frequent consumption of legumes and nuts, and engaging in regular physical activity. (wikipedia.org)
  • A New Study on Adopted Kids Takes on the Tiny Question of Nature Versus Nurture Which matters more when it comes to longevity? (nymag.com)
  • This project was designed to study the longevity of thinning by looking at the temporal impacts on biomass equations. (fed.us)
  • The study of longevity genes is a developing science. (medlineplus.gov)
  • And he and study co-authors Lou M. Kunkel, Ph.D. and Annibale A. Puca, M.D., believe they now can proceed to locate the precise genes responsible for such longevity -- that is, for the delay or deflection of age-related diseases. (cnn.com)
  • This study suggests protective mechanisms including immunity and nutrient metabolism and their interactions with environmental stress play key roles in human longevity. (nature.com)
  • A team led by Vincent Careau, a PhD student at University of Sherbrooke, gathered data on many aspects of dog biology published in disparate fields of study such as psychology, longevity, and veterinary research. (redorbit.com)
  • According to Dr. Kripke's study, sleeping more than seven hours and less than five and a half hours has been found to decrease longevity. (psychologytoday.com)
  • The study is an example of using Big Data to glean information about an extremely complicated trait such as longevity. (thirdage.com)
  • Y. Zeng and D. Gu, "Reliability of age reporting among the Chinese oldest-old in the CLHLS datasets," in Healthy Longevity in China: Demographic, Socioeconomic, and Psychological Dimension , Y. Zeng, D. L. Poston Jr., D. A. Vlosky et al. (hindawi.com)
  • Other genes that are associated with blood fat (lipid) levels, inflammation, and the cardiovascular and immune systems contribute significantly to longevity because they reduce the risk of heart disease (the main cause of death in older people), stroke, and insulin resistance. (medlineplus.gov)
  • FEATUREThe Longevity Dividend Redrawn from Koloman Moser's Frommes KalendarIllustrations by Joelle Boltan intervention, such as a pill, that could significantly reduce your risk of cancer. (the-scientist.com)
  • Biodemographic studies found that even genetically identical laboratory animals kept in constant environment have very different lengths of life, suggesting a crucial role of chance and early-life developmental noise in longevity determination. (wikipedia.org)
  • The word "longevity" is sometimes used as a synonym for "life expectancy" in demography - however, the term "longevity" is sometimes meant to refer only to especially long-lived members of a population, whereas "life expectancy" is always defined statistically as the average number of years remaining at a given age. (wikipedia.org)
  • Longevity is best thought of as a term for general audiences meaning 'typical length of life' and specific statistical definitions should be clarified when necessary. (wikipedia.org)
  • Reflections on longevity have usually gone beyond acknowledging the brevity of human life and have included thinking about methods to extend life. (wikipedia.org)
  • Fiction, legend, and folklore have proposed or claimed life spans in the past or future vastly longer than those verified by modern standards, and longevity narratives and unverified longevity claims frequently speak of their existence in the present. (wikipedia.org)
  • As the primary financial objective in retirement is to maintain a suitable standard of living for the reminder of one's life, one basic approach could be to treat longevity as the fundamental risk facing retirees. (forbes.com)
  • Altogether, Ames calls these nutrients "longevity vitamins" due to the role he believes they play in promoting a long and healthy life. (healthline.com)
  • The word " longevity " is sometimes used as a synonym for " life expectancy " in demography . (rug.nl)
  • However, the term longevity is sometimes meant to refer only to especially long-lived members of a population, whereas life expectancy is always defined statistically as the average number of years remaining at a given age. (rug.nl)
  • Over the past century human life expectancy has risen substantially around the world, and longevity in the modern world is largely determined by the age at which adults die. (repec.org)
  • These connections between behavior, metabolism, and longevity represent greatly what is predicted by the "pace-of-life" syndrome hypothesis. (redorbit.com)
  • The most well-known biological sex difference is sex-specific survivorship and longevity (life span or life expectancy at birth), where females live longer than males on average 2 , 3 , 4 . (nature.com)
  • Longevity has more to do with the quality of one's life. (infobarrel.com)
  • To find out if the Okinawa way of life can really improve longevity, one can simply board a flight to Okinawa and witness it firsthand. (infobarrel.com)
  • Our novel finding on the association of starch, sucrose and xenobiotic metabolism pathway with longevity is consistent with the previous results from Drosophilia. (nature.com)
  • The idea of triage theory is simple: that if your body is limited in any specific nutrients, vitamins and minerals, and about 80 percent of us in the U.S. are low in something, be it magnesium, calcium, vitamin C, you can go on and on -- then in fact your body triages that and uses it for short term survival and procreation at the expense of longevity. (kqed.org)
  • The sex-specific differences in survival and longevity and athletic performance can be explained by the difference in a tradeoff between viability and competitive ability. (nature.com)
  • Eight independent SNPs overlapped across Han Chinese, European and U.S. populations, and APOE and 5q33.3 were replicated as longevity loci. (nature.com)
  • Our work also represents the first GWAS of longevity in Asian populations and in developing countries more generally. (nature.com)
  • Harvard Professor of Public Policy Lisa Berkman cites social isolation as a significant factor in longevity. (mercola.com)
  • We will identify molecular biological predictors of disease and longevity and develop an epigenetic clock that predicts biological age in dogs. (washington.edu)
  • Epigenetic mechanisms, including histone post-translational modifications, control longevity in diverse organisms. (nih.gov)