• Given that some lncRNAs have been reported to have the potential to encode small proteins or micro-peptides, the latest definition of lncRNA is a class of RNA molecules of over 200 nucleotides that have no or limited coding capacity. (wikipedia.org)
  • Long non-coding RNAs include intergenic lincRNAs, intronic ncRNAs, and sense and antisense lncRNAs, each type showing different genomic positions in relation to genes and exons. (wikipedia.org)
  • Quantitatively, lncRNAs demonstrate ~10-fold lower abundance than mRNAs, which is explained by higher cell-to-cell variation of expression levels of lncRNA genes in the individual cells, when compared to protein-coding genes. (wikipedia.org)
  • However an extensive study considering 37 higher plant species and six algae identified ~200,000 non-coding transcripts using an in-silico approach, which also established the associated Green Non-Coding Database (GreeNC), a repository of plant lncRNAs. (wikipedia.org)
  • This generates a vast repertoire of transcripts that includes protein-coding messenger RNAs, long non-coding RNAs (lncRNAs) and repetitive sequences, such as SINEs (short interspersed nuclear elements). (nature.com)
  • The aim of this mini-review is to discuss emerging epigenetic roles of long non-coding RNAs (lncRNAs) in Acute Myeloid Leukemia (AML). (frontiersin.org)
  • In particular, there are incremental examples of the participation of the distinct class of long non-coding RNAs (lncRNAs) in AML epigenetic regulation, some of which have translational potential. (frontiersin.org)
  • This study investigated the role of long non‑coding RNAs (lncRNAs) in glioblastomagenesis progression. (spandidos-publications.com)
  • Additionally, as competitive endogenous RNAs (ceRNAs), lncRNAs and messenger RNAs (mRNAs) can regulate one other by competing for the shared microRNAs (miRNAs/miRs) ( 14 , 15 ). (spandidos-publications.com)
  • The objective of this study is to explore the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles of monocyte-derived dendritic cells (DCs) obtained from peripheral blood mononuclear cells (PBMCs). (frontiersin.org)
  • With the recognition of long non-coding RNAs (lncRNAs), the expression of lncRNAs in serum or tissue samples has been reported as a diagnosis method for some cancers, however, the diagnostic value of lncRNAs for colorectal cancer remains unclear. (jcancer.org)
  • Although some key flowering responsive genes have been identified in spinach, non-coding RNA molecules like long non-coding RNAs (lncRNAs) were not investigated yet. (biomedcentral.com)
  • ncRNAs with more than 200 nucleotides are considered as lncRNAs, which originate from intronic and exonic regions of protein-coding genes in both sense and antisense strands, as well as from the intergenic regions [ 21 ]. (biomedcentral.com)
  • The expression profiles of long noncoding RNAs (lncRNAs) and mRNAs of PEX-treated dendritic cells are unknown. (jcancer.org)
  • For example, exosomes and nanovesicles secreted by living cells serve as intercellular couriers of mRNA, microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and proteins and have thus garnered considerable interest [ 3 ]. (jcancer.org)
  • LAUSANNE, Switzerland I May 20, 2021 I HAYA Therapeutics, SA, a company developing precision medicines that target tissue and cell-specific long non-coding RNAs (lncRNAs), announced the successful closing of its CHF 18 million seed round. (pipelinereview.com)
  • The company's discovery engine focuses on long non-coding RNAs (lncRNAs) within the "dark matter" of the human genome -- key tissue and cell-specific drivers of fibrosis and other disease processes -- to identify novel targets and drug candidates with the potential for greater efficacy and safety than existing treatments. (pipelinereview.com)
  • A large number of experimental studies show that the mutation and regulation of long non-coding RNAs (lncRNAs) are associated with various human diseases. (biomedcentral.com)
  • Long non-coding RNAs (lncRNAs) play an increasingly important role in some fundamental biological processes such as translational regulation, cell cycle regulation, epigenetic regulation, splicing, differentiation, and immune response [ 5 ]. (biomedcentral.com)
  • The genes we found are called long non-coding RNAs, or lncRNAs," said Gay Crooks (photo), M.D., Co-Director of the UCLA Broad Stem Cell Research Center, a member of the UCLA Jonsson Comprehensive Cancer Center, and co-senior author of the Nature Immunology study. (bioquicknews.com)
  • Although all the currently known ASD risk genes code for proteins, long non-coding RNAs (lncRNAs) as essential regulators of gene expression have been implicated in ASD. (figshare.com)
  • Particularly, the knowledge learnt from protein-coding ASD risk genes was transferred to the prediction and prioritization of ASD-associated lncRNAs. (figshare.com)
  • Emerging evidence indicates that Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) play crucial roles in tumor progression, including hepatocellular carcinoma (HCC). (biomedcentral.com)
  • Pseudogene, a subclass of long non-coding RNAs (lncRNAs), are considered as genomic loci that resemble real gene, but lost some functionality because they are lack of protein-coding ability because of disabling mutation, lack of transcription, or their inability to encode RNA [ 3 ]. (biomedcentral.com)
  • A series of studies indicate that lncRNAs serve as competing endogenous RNAs (ceRNA) by sponging miRNAs, and modulate the targets of miRNAs [ 15 , 16 ]. (biomedcentral.com)
  • Long noncoding RNAs (lncRNAs) have been identified as important regulators of gene expression in plants. (mdpi.com)
  • One of the novel approaches is based on long non-coding RNAs (lncRNAs). (iyte.edu.tr)
  • At a conference of the National Congress of the Spanish Diabetes Society, researchers revealed new studies regarding the potential role of long non-coding RNAs (lncRNAs) in the development of type 1 diabetes, as well as the risk of cardiovascular problems in individuals with the disease. (diabetesresearchconnection.org)
  • Long non-coding RNAs (lncRNAs) have shown promise as biomarkers in other cancer types and in some cases functionally contribute to tumor development and progression. (biomedcentral.com)
  • Long non-coding RNAs (lncRNAs) have moved into the focus of cancer research as good candidates for tumor biomarkers and as regulators of various neoplastic cell properties. (biomedcentral.com)
  • In general, lncRNAs are defined as being longer than 200 nucleotides and lacking a functional open reading frame. (biomedcentral.com)
  • Some lncRNAs (referred to as long intergenic non-coding RNAs, lincRNAs) are transcribed from separate loci, whereas others are transcribed divergently from promoters of protein-coding genes or in antisense direction to these. (biomedcentral.com)
  • One such class are the non-coding RNAs known collectively as long non-coding RNAs (lncRNAs). (lncrnablog.com)
  • This extracellular vesicles play a major role in cell-to-cell communication and contain materials, such as proteins, mRNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). (upm.edu.my)
  • Long non-coding RNAs (lncRNAs) are non-protein-coding RNAs consisting of more than 200 nucleotides in length. (upm.edu.my)
  • It has been shown that lncRNAs play an important role in various cellular processes including angiogenesis by interacting with RNA, DNA or proteins through diverse mechanisms to regulate gene expression. (upm.edu.my)
  • Early reports indicate that long non-coding RNAs (lncRNAs) are novel regulators of biological responses. (bath.ac.uk)
  • We identify 76 enhancer RNAs (eRNAs), 40 canonical lncRNAs, 65 antisense lncRNAs and 35 regions of bidirectional transcription (RBT) that are differentially expressed in response to bacterial lipopolysaccharide (LPS). (bath.ac.uk)
  • The Green Non-Coding Database (GreeNC) is one of the reference databases for the study of plant long non-coding RNAs (lncRNAs). (sequentiabiotech.com)
  • Using nascent RNA expression profiles, we identify a total of 1768 lncRNAs, of which 718 (~41%) are novels in P. falciparum. (bvsalud.org)
  • The subcellular localization and stage-specific expression of several putative lncRNAs are validated using RNA -FISH. (bvsalud.org)
  • While long non-coding RNAs (lncRNAs) are found abnormally expressed in cancer, how dysregulated lncRNAs contribute to carcinogenesis remains largely unknown. (cdc.gov)
  • Aims/hypothesis: The aim of this study was to identify differentially expressed long non-coding RNAs (lncRNAs) and mRNAs in whole blood of people with type 2 diabetes across five different clusters: severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), mild diabetes (MD) and mild diabetes with high HDL-cholesterol (MDH). (lu.se)
  • Whole blood RNA-seq was used to identify differentially expressed lncRNAs. (lu.se)
  • Whole blood RNA-seq was used to identify differentially expressed lncRNAs and mRNAs in a cluster compared with all others. (lu.se)
  • Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. (wikipedia.org)
  • Long intervening/intergenic noncoding RNAs (lincRNAs) are sequences of lncRNA which do not overlap protein-coding genes. (wikipedia.org)
  • long non-coding RNA ANRIL (lncRNA ANRIL) has been demonstrated to play a crucial role in cancer progression. (nih.gov)
  • Small interfering RNA (siRNA) was used to silence lncRNA ANRIL and to explore the effects of reduced lncRNA ANRIL expression on cell growth and metastasis. (nih.gov)
  • Long non-coding RNA (lncRNA) is a type of RNA that contains over 200 nucleotides and that does not encode protein ( 5 , 6 ). (spandidos-publications.com)
  • The expression of HOX transcript antisense RNA lncRNA is increased in GBM and is significantly associated with high grade brain tumors ( 13 ). (spandidos-publications.com)
  • LncHERG is an lncRNA that acts as a competing RNA of miR-940. (spandidos-publications.com)
  • This study aims to explore the role of serum long non-coding RNA (lncRNA) colon cancer-associated transcript 2 (CCAT2) as a diagnostic marker for gastric cancer (GC). (techscience.com)
  • In this regards, they can be separated into small non-coding RNA (small ncRNA) and lncRNA. (biomedcentral.com)
  • Luciferase reporter assay and RNA pull-down assay were carried out to detect the interaction between miR-383 and LncRNA PTTG3P. (biomedcentral.com)
  • In this study, target lncRNA was determined based on RNA-Seq data. (iyte.edu.tr)
  • Then apoptosis was induced in HeLa cells with cisplatin and qRT-PCR was performed with isolated RNAs from the cells to validate the data with regard to upregulation of GTF2A-1 anti-sense lncRNA in apoptosis. (iyte.edu.tr)
  • RNA sequencing (RNA-seq) transcriptomic analysis of L. salivarius strain UCC118 identified the presence of a novel unusually abundant long non-coding RNA (lncRNA) encoded by the megaplasmid, and which represented more than 75 % of the total RNA-seq reads after depletion of rRNA species. (ucc.ie)
  • Researchers at the University of Kent have undertaken the first landscape analysis of the lncRNA transcriptome in CHO using a mouse based microarray that also provided for the surveillance of the coding transcriptome. (lncrnablog.com)
  • Many intergenic long noncoding RNA (lncRNA) loci regulate the expression of adjacent protein coding genes. (ox.ac.uk)
  • Here, we report both genomically local and distal RNA-dependent roles of Dali, a conserved central nervous system expressed intergenic lncRNA. (ox.ac.uk)
  • The goal of this study is to investigate the mechanism of Cr(VI)-induced lung carcinogenesis focusing on the role of the lncRNA ABHD11 antisense RNA 1 (tail to tail) (ABHD11-AS1). (cdc.gov)
  • Together, these findings indicate that lncRNA ABHD11-AS1 interacts with SART3 and regulates CD44 RNA alternative splicing to promote cell malignant transformation and lung carcinogenesis. (cdc.gov)
  • This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs, such as microRNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and other short RNAs. (wikipedia.org)
  • The role of non-coding RNAs in determining growth, productivity, and recombinant product quality attributes in Chinese hamster ovary (CHO) cells has received much attention in recent years, exemplified by studies into microRNAs in particular. (lncrnablog.com)
  • Sofia Elmroth and her research team primarily study microRNAs, which are molecules that influence protein levels in the cells of the body indirectly by binding to messenger RNA. (lu.se)
  • There are many different types of microRNAs involved in the regulation of different proteins and of other RNA molecules. (lu.se)
  • In 2007 a study found only one-fifth of transcription across the human genome is associated with protein-coding genes, indicating at least four times more long non-coding than coding RNA sequences. (wikipedia.org)
  • While some long ncRNAs are located within the intergenic stretches, the majority are overlapping sense and antisense transcripts that often include protein-coding genes, giving rise to a complex hierarchy of overlapping isoforms. (wikipedia.org)
  • Using the GSE2223 and GSE59612 datasets, and RNA sequencing data of GBM from The Cancer Genome Atlas, differentially expressed (DE) genes including DE messenger RNAs (DEmRNAs) and DElncRNAs between GBM and normal controls were identified. (spandidos-publications.com)
  • Cumulative evidence shows that only ∼ 2 percent of protein-coding genes are in the human genome and the remaining ∼ 98 percent of the human genome are classified as non-coding RNAs (ncRNAs) [ 1 ]. (biomedcentral.com)
  • They make up much of what we used to think of as the 'dark matter' of our genome because, unlike the better-known messenger RNA genes, they do not produce [code for the production of] proteins. (bioquicknews.com)
  • In the present study, we identified differentially expressed genes, long non-coding RNAs and RNA binding proteins for each BC subtype from a public dataset applying bioinformatics algorithms. (iusspavia.it)
  • Together, our results show that individuals in the MOD cluster show aberrant RNA expression of genes that have a suggested causal role on multiple diabetes-relevant traits. (lu.se)
  • These elements appear to influence the expression of both protein-coding genes and non-coding transcripts in the human brain through various mechanisms," says Raquel Garza. (lu.se)
  • Non-coding RNA may also recruit proteins to modify histones to turn genes "on" or "off. (cdc.gov)
  • Research has long focused on transcription from our genes that uses RNA messengers to code for the formation of proteins, the building blocks of the body. (lu.se)
  • We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)
  • We also synthesize a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes which, upon activation, confer resistance to a BRAF inhibitor. (cdc.gov)
  • A growing body of evidence indicates that epigenetic regulators rely, amongst other factors, on their interaction with untranslated RNA molecules for guidance to particular targets on DNA. (frontiersin.org)
  • Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different classes of molecules with unique lengths, conformations and targets. (frontiersin.org)
  • Many recent functional studies have demonstrated clear visible phenotypes for long non-coding RNAs, quieting some skeptics trying to wrap their heads around these enigmatic molecules. (epigenie.com)
  • These RNA molecules are transcribed from the genome but do not encode proteins, and they have diverse roles in plant growth, development, stress responses, and other biological processes. (mdpi.com)
  • What we used to call 'junk DNA' has proved to be made up of areas that produce small molecules known as non-coding RNAs. (lu.se)
  • Around ten years ago, it was discovered that these areas code for a number of small RNA molecules that are now called non-coding RNAs because they don't code for proteins. (lu.se)
  • Thousands of long non-coding RNAs have been discovered in recent years, leading some to claim there may be as many functional RNAs as proteins. (epigenie.com)
  • Coding RNA is used to make proteins. (cdc.gov)
  • Non-coding RNA helps control gene expression by attaching to coding RNA, along with certain proteins, to break down the coding RNA so that it cannot be used to make proteins. (cdc.gov)
  • PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element. (nature.com)
  • Genomic sequences within these transcriptional foci are often shared within a number of coding and non-coding transcripts in the sense and antisense directions For example, 3012 out of 8961 cDNAs previously annotated as truncated coding sequences within FANTOM2 were later designated as genuine ncRNA variants of protein-coding cDNAs. (wikipedia.org)
  • Identifying ncRNAs within these cDNA libraries is challenging since it can be difficult to distinguish protein-coding transcripts from non-coding transcripts. (wikipedia.org)
  • Antisense Uchl1 function is under the control of stress signalling pathways, as mTORC1 inhibition by rapamycin causes an increase in UCHL1 protein that is associated to the shuttling of antisense Uchl1 RNA from the nucleus to the cytoplasm. (nature.com)
  • Antisense Uchl1 RNA is then required for the association of the overlapping sense protein-coding mRNA to active polysomes for translation. (nature.com)
  • However, a growing body of evidence suggests that recruitment, stability, and function of epigenetic factors can be mediated by non-protein-coding RNAs. (frontiersin.org)
  • After induction of apoptosis, total RNA and protein were isolated from the cells. (iyte.edu.tr)
  • Apoptozun tetiklenmesinden sonra, hücrelerden total RNA ve protein izole edilmiştir. (iyte.edu.tr)
  • IGF2 , or insulin-like growth factor 2, is a paternally expressed protein-coding gene. (medscape.com)
  • KCNQ1OT1 , or potassium voltage-gated channel subfamily Q member 1 opposite transcript 1 is the antisense transcript of the protein-coding gene KCNQ1 . (medscape.com)
  • After 4 weeks of conversion, we performed global analyses of RNA and protein levels by RNA-sequencing and mass spectrometry. (lu.se)
  • Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)
  • The 9th Annual Oxford RNAi Conference, RNAi2014, will discuss short and long non-coding RNAs, their roles in gene regulation, functional studies, RNA biomarkers and their therapeutic applications. (lncrnablog.com)
  • What Is the Promise of Long Non-Coding RNA Biomarkers? (genengnews.com)
  • In 2005 the landscape of the mammalian genome was described as numerous 'foci' of transcription that are separated by long stretches of intergenic space. (wikipedia.org)
  • Given our fund's focus on mechanisms of aging and age-related diseases we already had non-coding RNA aka 'The Dark Matter of the Genome' on our radar. (pipelinereview.com)
  • Strand-specific, massively parallel cDNA sequencing (RNA-seq) is a powerful tool for transcript discovery, genome annotation and expression profiling. (nature.com)
  • To estimate the causal effects of RNAs on traits, a two-sample Mendelian randomisation analysis was performed using public genome-wide association study (GWAS) data. (lu.se)
  • The genome of NV-B is 18,252 nt in length, 6 nt longer than NV-Malaysia (NV-M), the prototype strain of NV (SPB199901924). (cdc.gov)
  • Genome sequence lacks part of non-coding region. (cdc.gov)
  • To date, various genome-scale loss-of-function screening methods have been developed, including approaches employing RNA interference 1 , 2 and the RNA-guided endonuclease Cas9 from the microbial CRISPR (clustered regularly interspaced short palindromic repeat) adaptive immune system 3 , 4 . (cdc.gov)
  • Chen J, Wang S, Jia S, Ding G, Jiang G, Cao L. Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profile in Pancreatic Cancer Derived Exosomes Treated Dendritic Cells by Microarray Analysis. (jcancer.org)
  • Association between genetic polymorphisms in long non-coding RNAs and pancreatic cancer risk. (cdc.gov)
  • Are Long Intergenic Non-ccoding RNAs Central Regulators of Inflammation and the Innate Immune Response? (bath.ac.uk)
  • The long non-coding RNA Dali is an epigenetic regulator of neural differentiation. (ox.ac.uk)
  • Negative-sense genomic RNA is shown in 3´ to 5´ orientation. (cdc.gov)
  • RNA maps reveal new RNA classes and a possible function for pervasive transcription. (nature.com)
  • Crucially, we demonstrate that knockdown of nuclear-localized, NF-κB-regulated, eRNAs (IL1β-eRNA) and RBT (IL1β-RBT46) surrounding the IL1β locus, attenuates LPS-induced messenger RNA transcription and release of the proinflammatory mediators, IL1β and CXCL8. (bath.ac.uk)
  • We found that the regulation of TE transcription during brain development is essential for the establishment of long-term transcriptional repression carried to adulthood (Paper I and IV). (lu.se)
  • Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)
  • Based on the competing endogenous RNA hypothesis, DElncRNA‑micro RNA (miRNA)‑DEmRNA interactions were obtained by target gene prediction. (spandidos-publications.com)
  • It may act as a competing endogenous RNA and influence tumorigenesis of GBM. (spandidos-publications.com)
  • Mechanistically, PTTG3P upregulated the expression of miR-383 targets Cyclin D1 (CCND1) and poly ADP-ribose polymerase 2 (PARP2) by sponging miR-383, acting as a competing endogenous RNA (ceRNA). (biomedcentral.com)
  • Long non-coding RNA H19 regulates FOXM1 expression by competitively binding endogenous miR-342-3p in gallbladder cancer. (biomedcentral.com)
  • Long noncoding RNA NEAT1 (nuclear-enriched abundant transcript 1) inhibited hepatocyte proliferation in fulminant hepatic failure via strengthened recruitment of EZH2 to the LATS2 (large tumor-suppressor kinase 2) promoter region [ 18 ]. (biomedcentral.com)
  • The plan is to use GATK Mutect2 ( ​ https://gatk.broadinstitute.org/hc/en-us/articles/13832710384155-Mutect2 ) for variant calling on tumor/normal pairs. (lu.se)
  • The FANTOM3 project identified ~35,000 non-coding transcripts that bear many signatures of messenger RNAs, including 5' capping, splicing, and poly-adenylation, but have little or no open reading frame (ORF). (wikipedia.org)
  • Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. (nature.com)
  • The samples were analysed on a mouse array containing all the coding and non-coding transcripts stored in the main public databases. (lncrnablog.com)
  • According to its size, regulatory ncRNAs can be further classified as small ncRNA ( ∼ 18-31nt, such as miRNA, siRNA, and piRNA), medium ncRNA ( ∼ 31-200nt) and long ncRNA (from 200nt up to several hundred kb, such as lincRNA and microRNA) [ 4 ]. (biomedcentral.com)
  • Hypermethylation-mediated downregulation of long non-coding RNA MEG3 inhibits osteogenic differentiation of bone marrow mesenchymal stem cells and promotes pediatric aplastic anemia. (stembook.org)
  • Expression quantitative trait loci (eQTLs) for differentially expressed RNAs were obtained from a publicly available dataset. (lu.se)
  • Previous studies have indicated that the colorectal cancer patients in the early stage would gain longer survival time with standard treatment [ 3 - 5 ]. (jcancer.org)
  • It has been suggested through multiple studies that testis, and neural tissues express the greatest amount of long non-coding RNAs of any tissue type. (wikipedia.org)
  • Neuroscience focusing on human development and disease has long been hampered due to ethical rea¬sons, low tissue availability, and low translatability from animal models. (lu.se)
  • Long noncoding RNA ABHD11-AS1 interacts with SART3 and regulates CD44 RNA alternative splicing to promote lung carcinogenesis. (cdc.gov)
  • Nuclear localized USP15 interacts with pre-mRNA processing factor 19 (PRPF19) to increase CD44 RNA alternative splicing activating β-catenin and enhancing cancer stemness. (cdc.gov)
  • The article is titled "Long Non-Coding RNA Profiling of Human Lymphoid Progenitor Cells Reveals Transcriptional Divergence of B Cell and T Cell Lineages. (bioquicknews.com)
  • Both DNA and RNA play a role in determining cells' function and purpose. (diabetesresearchconnection.org)
  • Sequencing of DNA gives a direct picture of our genetic make-up, while sequencing of the RNA that is naturally present in cells gives a picture of which parts of our non-coding DNA are used and in what way. (lu.se)
  • N6-methyl-adenosine modification in messenger and long non-coding RNA. (uchicago.edu)
  • [ 12 ] In his review of liver tumors and tumorlike liver lesions, Edmondson included a report of a 14-year-old girl with an unusually long survival following hepatic resection for liver cancer. (medscape.com)
  • RNA immunoprecipitation assay and chromatin immunoprecipitation assays were performed to uncover the interaction between SNHG1 and EZH2. (biomedcentral.com)
  • MELOE-1 and MELOE-2, two highly specific melanoma antigens involved in T cell immunosurveillance are produced by IRES-dependent translation of the long « non coding » and polycistronic RNA, meloe . (oncotarget.com)
  • Further investigation is required to validate the functions and associations of these RNAs. (jcancer.org)
  • Small interfering RNA demonstrated that silencing DLEU1 downregulated TRAF4. (spandidos-publications.com)
  • Considerable attention will be given to chemical design and in vitro and in vivo delivery strategies for small RNAs. (lncrnablog.com)
  • Hastings, M. L., Ingle, H. A., Lazar, M. A. & Munroe, S. H. Post-transcriptional regulation of thyroid hormone receptor expression by cis-acting sequences and a naturally occurring antisense RNA. (nature.com)
  • Evolutionarily conserved untranslated regions facilitate the cloning of complete coding sequences of chondriogenes encoding NADH dehydrogenase subunits. (techscience.com)
  • AY988601) as NV-Bangladesh (NV-B). The sequences of the open reading frame (ORF) coding for nucleoprotein (N) were obtained for the other 3 isolates. (cdc.gov)