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  • lncRNAs
  • Quantitatively, lncRNAs demonstrate ~10-fold lower abundance than mRNAs in a population of cells, which is explained by higher cell-to-cell variation of expression levels of lncRNA genes in the individual cells, when compared to protein-coding genes. (wikipedia.org)
  • There have been several attempts to delineate the different categories of selection signatures seen amongst lncRNAs including: lncRNAs with strong sequence conservation across the entire length of the gene, lncRNAs in which only a portion of the transcript (e.g. 5' end, splice sites) is conserved, and lncRNAs that are transcribed from syntenic regions of the genome but have no recognizable sequence similarity. (wikipedia.org)
  • Indeed, the finding that only 14% of the well-defined mouse long intergenic ncRNAs (lncRNAs) identified in the FANTOM projects [ 6 , 7 ] have a transcribed ortholog in human (based on analyses of known EST and cDNA data sets) [ 2 ] argues against their functionality. (biomedcentral.com)
  • Despite increasing evidence to indicate that long non-coding RNAs (lncRNAs) are novel regulators of immunity, there has been no systematic attempt to identify and characterize the lncRNAs whose expression is changed following the induction of the innate immune response. (frontiersin.org)
  • We show differential expression of 204 human and 210 mouse lncRNAs, with positional analysis demonstrating correlation with immune-related genes. (frontiersin.org)
  • Presently, lncRNAs are classified by their relative position to protein-coding mRNAs and include the long intergenic ncRNAs (lincRNAs), antisense (AS), and pseudogenes ( 8 ). (frontiersin.org)
  • ncRNA
  • This dearth of information is partially attributable to a lack of established non-protein-coding RNA (ncRNA) orthologs among birds and mammals within sequence and expression databases. (biomedcentral.com)
  • functional
  • Long considered to be the building block of life, it is now apparent that protein is only one of many functional products generated by the eukaryotic genome. (biomedcentral.com)
  • Instead, their preservation across diverse amniotes, their apparent conservation in exon structure, and similarities in their pattern of brain expression during embryonic and early postnatal stages together indicate that these are functional RNA molecules, of which some have roles in vertebrate brain development. (biomedcentral.com)
  • human genome
  • High-throughput sequencing indicates that much of the human genome is transcribed into non-coding RNAs (ncRNAs) with estimates of the proportion varying from ~62% predicted by the ENCODE project ( 1 ) to ~10% based on evolutionary conservation ( 2 ). (frontiersin.org)