Long chain fatty acid transport proteins. Medical search. Frequent questions

Polyphenols and phenolic acids from strawberry and apple may decrease glucose uptake by blocking transport through human intestinal cells, according to a new study. (nutraingredients.com)
"There is recent evidence that some bioactive compounds, in particular polyphenols, phenolic acids and tannins (PPTs), can affect the shape of the blood glucose curve … Some studies have shown that these compounds may result in an altered pattern of intestinal glucose uptake, possibly due to interactions between compounds and sugar transporters," said the authors. (nutraingredients.com)
"The results obtained demonstrate that polyphenols, phenolic acids and tannin-rich extracts from strawberry and apple were able to influence glucose uptake into the cells and transport … by inhibiting activities of the glucose transporters," said the authors. (nutraingredients.com)
Increased OLR1 expression, resulting either from TZD treatment or adenoviral gene delivery, significantly augments adipocyte cholesterol content and enhances fatty acid uptake. (jci.org)
It binds long-chain fatty acids and participates in the uptake, transport, and metabolism. (chiropracticscientist.com)
Uptake and degradation is facilitated if the protein is structurally modified. (eclinpath.com)
1993), as well uptake and translocation of long-chain fatty acids as NMR solution structures (Hodsdon et al. (lu.se)

Overexpression of SREBP1 (sterol regulatory element binding protein 1) promotes de novo fatty acid synthesis and triacylglycerol accumulation in goat mammary epithelial cells. (oregonstate.edu)

Because the treatment affects fatty acid metabolism, which can be elevated in other types of cancers, the researchers say their type of additive Platin-L therapy may also be applicable to additional aggressive and chemotherapy-resistant cancers. (acs.org)
Alteration in fatty acid metabolism is usually a hallmark of cancer and several lines of evidence showed that limiting fatty acid availability controls malignancy cell proliferation 22 23 As fatty acids are required for the formation of membrane components energy sources and the production of cellular signaling molecules during cancer cell proliferation FABPs might play an important role PIK-293 in cellular proliferation. (mdm2-inhibitors.com)
This receptor protein helps with expenditure regulation through stimulating thermogenesis and lipid metabolism in adipose tissue. (chiropracticscientist.com)
We investigated androgen receptor inhibition on fat metabolism and long-chain fatty acid (LCFA) transport proteins in skeletal muscle during exercise. (biomedcentral.com)
After the metabolism measurement, the expression levels of LCFA transport proteins (FAT/CD36, CPTI) were analyzed in skeletal muscle. (biomedcentral.com)
This study observed metabolism during acute exercise but did not examine the effect of AR inhibition on a long-term exercise training program that would more accurately reflect a general health regimen. (biomedcentral.com)
Carnitine is an important small water-soluble molecule that binds to long-chain fatty acids and facilitates their transport across the inner mitochondrial membrane and into the mitochondrial matrix to undergo fatty acid oxidation (metabolism). (medscape.com)

This gene provides instructions for making a protein called carnitine-acylcarnitine translocase (CACT). (medlineplus.gov)
A group of fats called long-chain fatty acids must be attached to a substance known as carnitine to enter mitochondria. (medlineplus.gov)
Once these fatty acids are joined with carnitine, the CACT protein transports them into mitochondria. (medlineplus.gov)
Fatty acids and long-chain acylcarnitines (fatty acids still attached to carnitine) may also build up in cells and damage the liver, heart, and muscles. (medlineplus.gov)
Carnitine-acylcarnitine translocase (CACT) deficiency is a life-threatening, inherited disorder of fatty acid oxidation which usually presents in the neonatal period with severe hypoketotic hypoglycemia, hyperammonemia, cardiomyopathy and/or arrhythmia, hepatic dysfunction, skeletal muscle weakness, and encephalopathy. (orpha.net)
It is an essential component of the carnitine cycle that regulates the transport of long chain fatty acids into the mitochondria where fatty acid oxidation takes place. (orpha.net)
and propionyl-L-carnitine, combined with acetyl-L-carnitine and alpha lipoic acid, each in a higher dose. (tahomaclinicblog.com)
L-carnitine is an amino acid from which certain proteins are made. (healthysunshine.mobi)
The body requires l-carnitine for the transport of long-chain fatty acids into the cells. (healthysunshine.mobi)
The diagram (top left corner) shows long chain fatty acids going through the plasma membrane converted to acyl CoA within the mitochondrion (between the mitochondrial double membranes) where it combines with carnitine (catalyzed by CPT I) to produce acylcarnitine, which can cross the inner mitochondrial membrane (IMM). (mcatquestionoftheday.com)
Thus the figure suggests carnitine attaches to a fatty acid thus the fatty acid is a part of the acylcarnitine molecule. (mcatquestionoftheday.com)
Note that, according to the diagram, carnitine and acylcarnitine are not membrane transporters but rather they are transported through membrane transporters (i.e. (mcatquestionoftheday.com)
Acylcarnitine's "job" seems over as it is converted back to carnitine and acyl CoA which, as fatty acids are known to do, undergoes beta-oxidation. (mcatquestionoftheday.com)
L-carnitine is an amino acid (a building block for proteins) that is naturally produced in the body. (walmark.eu)
Analysis of urine organic acids, serum amino acids, and acylcarnitine panels can be used to distinguish this condition from other causes of carnitine deficiency. (medscape.com)
Carnitine-acylcarnitine translocase deficiency (CACT) typically presents in an autosomal-recessive fashion with seizures, apnea, and an irregular heart beat in the neonatal period (although presentation can occur as late as age 15 months) and results from mutations in the CACT protein ( SLC25A20 gene), a carnitine-acylcarnitine exchanger on the inner mitochondrial membrane. (medscape.com)

They said that PPTs have the potential to "readily affect glucose absorption in the small intestine," noting that many polyphenols, phenolic acids and tannins can interact with certain sugar transporters - for example, inhibition of sodium-dependent glucose transporter 1 (SGLT1 - an active transport mechanism in which glucose is co-transported with sodium ion) or by inhibition of GLUT2. (nutraingredients.com)
Fatty acid transporter proteins (FATPs) are a family (SLC27) of six transporters (FATP1-6). (guidetopharmacology.org)
Before entering lipid synthesis pathways, different kinds of acyl-CoA transporters which acts as the major carrier of acyl-CoAs, such as fatty acid binding protein (FABP), sterol carrier protein 2 (SCP2) and acyl-CoA-binding protein (ACBP), would activate and convert fatty acids to fatty acyl-CoA esters via a reaction catalyzed by fatty acyl-CoA synthetase and transported to various metabolic locations [ 11 ]. (biomedcentral.com)

As a matter of fact, if I went into describing the uses of every amino acid separately I'd already have a nice novella. (bodybuilding.com)
It is a precursor to the non-essential amino acid histamine, which is released by the immune system as a response to allergic reactions. (bodybuilding.com)
Different types and quality of protein can affect amino acid bioavailability following protein supplementation. (biomedcentral.com)
Bound to cysteine in place of sulfur and called the "21st amino acid," selenocysteine is the active site in some 35 proteins. (tahomaclinicblog.com)
We have identified a cytosolic acyl-CoA binding protein, with highly conserved amino acid residues and a typical acyl-CoA binding domain in N. caninum . (biomedcentral.com)

Next to the 8 essential amino acids, there are around 14 non-essential amino acids and a whole host of other metabolites classed as amino acids which are derived from the 8 essential ones. (bodybuilding.com)
Acute protein doses should strive to contain 700-3000 mg of leucine and/or a higher relative leucine content, in addition to a balanced array of the essential amino acids (EAAs). (biomedcentral.com)
Rapidly digested proteins that contain high proportions of essential amino acids (EAAs) and adequate leucine, are most effective in stimulating MPS. (biomedcentral.com)

These are glycerolipids lipids containing a common glycerol backbone to which at least one fatty acyl group is esterified. (hmdb.ca)
If the capacity of the adipocyte to store lipids is exceeded, it can no longer regulate the release of FFAs into the circulation, which ultimately leads to the abnormal accumulation of lipid in nonadipose depots. (jci.org)
Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)

2. Matsufuji T, Ikeda M, Naito A, Hirouchi M, Kanda S, Izumi M, Harada J, Shinozuka T. (2013) Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. (guidetopharmacology.org)
Data indicate that the polyphenols, phenolic acids and tannins from strawberry and apple are potent inhibitors of GLUT2 and SGLT1 at concentrations predicted after dietary ingestion. (nutraingredients.com)

Long-chain fatty acid transport protein 4 is a protein that in humans is encoded by the SLC27A4 gene. (wikipedia.org)
Although mutations in the SLC25A20 gene change the structure of the CACT protein in different ways, they all lead to a shortage (deficiency) of the transporter. (medlineplus.gov)
This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. (nih.gov)
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. (origene.com)
At sufficient levels of incorporation, EPA and DHA influence the physical nature of cell membranes and membrane protein-mediated responses, eicosanoid generation, cell signaling and gene expression in many different cell types. (soton.ac.uk)
Vitamins D and K2 work together in this regard because vitamin D expresses the gene that makes matrix Gla protein. (tahomaclinicblog.com)
It might be interesting to assess if the regulatory systems root the upregulation of gene appearance and the features of FABP5 proteins in tumor cells are mediated with a common signaling pathway. (mdm2-inhibitors.com)
Our in silico results showed a significant specificity of the union of the protein products of the FABP6 gene as well as the known action of Abemaciclib as an inhibitor of the CDK4/6 protein and therefore, of the cell cycle. (biomedcentral.com)
Next, the MD analysis showed that the drug Abemaciclib characteristic affinity for the different protein structures of the FABP6 gene. (biomedcentral.com)

Pancreatic enzymes (lipase and colipase) split long-chain triglycerides into fatty acids and monoglycerides, which combine with bile acids and phospholipids to form micelles that pass through jejunal enterocytes. (msdmanuals.com)

An acute exercise stimulus, particularly resistance exercise, and protein ingestion both stimulate muscle protein synthesis (MPS) and are synergistic when protein consumption occurs before or after resistance exercise. (biomedcentral.com)
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. (joplink.net)
To explore the regulatory function of SREBP1 on de novo fatty acids and triacylglycerol synthesis in GMEC, we overexpressed the mature form of SREBP1 (active NH2-terminal fragment) in GMEC using a recombinant adenovirus vector (Ad-nSREBP1), with Ad-GFP (recombinant adenovirus of green fluorescent protein) as control, and infected the GMEC for 48 h. (oregonstate.edu)
In infected cells, we assessed the expression of 20 genes related to milk fat synthesis using real time-quantitative PCR, the protein abundance of SREBP1 and FASN by Western blot, the production of triacylglycerol, and the fatty acid profile. (oregonstate.edu)
Lipid synthesis requires bulk carbon skeleton acyl-CoAs, the transport of which depends on the acyl-CoA binding protein (ACBP). (biomedcentral.com)
Fatty acids provide the acyl skeleton for lipid synthesis. (biomedcentral.com)

Without enough functional CACT protein, long-chain fatty acids cannot be transported into mitochondria. (medlineplus.gov)
It transports long-chain fatty acids into the mitochondria so they can be oxidized ('burned') to produce energy. (walmark.eu)

The research, published in Molecular Nutrition & Food Research , suggests that some polyphenols, phenolic acids and tannins extracted from apples and strawberries may block the transport of glucose across intestinal tissues, potentially blunting post-meal glucose spikes. (nutraingredients.com)
They added that their study is the first to show an inhibition of glucose transport across intestinal tissue by phenolic fruit extracts, and further characterize the contribution of individual phenolic components for their role in the inhibition of glucose transport. (nutraingredients.com)

It is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages. (hmdb.ca)
Glycerol-3-phosphate is first acylated with acyl-coenzyme A (acyl-CoA) to form lysophosphatidic acid, which is then acylated with another molecule of acyl-CoA to yield phosphatidic acid. (hmdb.ca)
Then they screened several cisplatin-containing prodrug compounds, which release the platinum-based molecule when they're broken down, to see if they could inhibit fatty acid oxidation. (acs.org)
The cisplatin prodrug Platin-L, which has a cisplatin molecule bound to a 12-carbon fatty acid on one side and succinate on the other side, had the greatest effect by binding to a key protein required for long chain fatty acid transport, a primary step in this metabolic process. (acs.org)
Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. (origene.com)
a single fatty acid molecule with high af®nity in Cistola et al. (lu.se)

In a healthy person, excess fat is stored as triglycerides in the adipose tissue, and fatty acids are released into the bloodstream only in response to an increased energy requirement, for example, during fasting. (jci.org)

Long chain free fatty acids enter the metabolizing cells (i.e. most living cells in the body except red blood cells and neurons in the central nervous system) through specific transport proteins, such as the SLC27 family fatty acid transport protein. (searchandrestore.com)

In summary, acylcarnitine transported long-chain fatty acids across the IMM. (mcatquestionoftheday.com)
Prior studies have indicated a role for acylcarnitine testing in the diagnosis of some peroxisomal diseases through the detection of long chain dicarboxylic acylcarnitine abnormalities (C16-DC and C18-DC). (bvsalud.org)

Adrenoleukodystrophy protein (ALDP) is responsible for the transport of very-long-chain fatty acids (VLCFAs) and corresponding CoA-esters across the peroxisomal membrane. (elifesciences.org)
The adrenoleukodystrophy protein (ALDP) or ABCD1 is an ABC transporter that participates in the transport of free very long-chain fatty acids and their CoA esters across the peroxisomal membrane. (elifesciences.org)
Fatty acid-binding proteins are low molecular weight (100-130 aa) chaperones for long chain fatty acids, fatty acyl CoA esters, eicosanoids, retinols, retinoic acids and related metabolites and are usually regarded as being responsible for allowing the otherwise hydrophobic ligands to be mobile in aqueous media. (guidetoimmunopharmacology.org)
The NcACBP recombinant protein was able to specifically bind acyl-CoA esters in vitro . (biomedcentral.com)

It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. (origene.com)

Since diacylglycerols are synthesized via phosphatidic acid, they will usually contain a saturated fatty acid at the C-1 position on the glycerol moiety and an unsaturated fatty acid at the C-2 position. (hmdb.ca)
When we eat fats, they are metabolized into short, medium and long-chain fatty acids and glycerol. (searchandrestore.com)
They are composed of glycerol and fatty acids which can be broken down in a process known as lipogenesis. (searchandrestore.com)
When cells need energy, a hormone-sensitive lipase enzyme in the adipose cells breaks apart the triglycerides to release the glycerol and fatty acids into the blood, where they are available for other energy-hungry cells. (searchandrestore.com)

It also serves as a carrier protein for many insoluble organic substances (e.g., unconjugated bilirubin, long chain fatty acids) and drugs. (eclinpath.com)

Additionally, folic acid increases jejunal glycolytic enzymes and is involved in the desaturation and hydroxylation of long-chain fatty acids in the brain. (nih.gov)

Medium-chain triglycerides are absorbed directly. (msdmanuals.com)

1994) Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. (guidetopharmacology.org)
The adipocyte is the major site of fatty acid storage in the body and plays a critical role in maintaining normal glucose and lipid homeostasis. (jci.org)
Obesity can be viewed as a state of long-term lipid disequilibrium that is marked by massive adipocyte hypertrophy and is a major risk factor for developing insulin resistance and type 2 diabetes. (jci.org)

By determining the cryo EM structure of human ABCD1 the study represents a valuable insight into its transport mechanism and the mechanistic basis for mutations causing the severe neurodegenerative disorder, X-linked adrenoleukodystrophy. (elifesciences.org)
The mechanism in unclear and could be due to pH changes altering binding of the bromcresol green dye to the protein. (eclinpath.com)
However, little is known about the fatty acid transport mechanism in N. caninum . (biomedcentral.com)
It serves as a mechanism for transport of long-chain fatty acids from the cytoplasm across the inner mitochondrial membrane and into the mitochondrial matrix, the site of b-oxidation of fatty acids for energy generation. (medscape.com)

Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. (origene.com)
WT or mutant GST-actin blend proteins was incubated at 30C for 30 minutes with or without recombinant PHD3 proteins supplemented with 50 millimeter Tris/HCl (pH 8.0), 100 millimeter NaCl, 100 M DTT, 100 M FeSO4, 5 millimeter ascorbate, and 1 millimeter -ketoglutarate. (forgetmenotinitiative.org)
The recombinant NcACBP protein was expressed to verify the binding activities of NcACBP in vitro , and the heterologous expression of NcACBP in Δacbp yeast in vivo . (biomedcentral.com)

The purified protein shows enzyme activity (EC 6.2.1.3), esterifying long and very long chain fatty acids with Coenzyme A. It is debated whether it is also a fatty acid transporter at the plasma membrane. (wikipedia.org)
There is growing evidence that nutritional supplements-vitamins, minerals, amino acids, fatty acid nutrients, herbal and botanical products, and various other natural compounds like coenzyme Q10 and alpha lipoic acid-have specific health benefits, in addition to those provided by the right diet, daily exercise, reducing stress, and getting a good night's sleep. (tahomaclinicblog.com)
These are acyl CoAs where the group acylated to the coenzyme A moiety is a long aliphatic chain of 13 to 21 carbon atoms. (ymdb.ca)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Based on the structure, we performed integrative analysis of the cellular trafficking, protein thermostability, ATP hydrolysis, and the transport activity of representative mutations. (elifesciences.org)

Functional and structural characterization of human adrenoleukodystrophy protein (ALDP). (elifesciences.org)

Exercise training increases the expression of LCFA transport proteins (FAT/CD36, CPTI). (biomedcentral.com)

Gastric pepsin initiates digestion of proteins in the stomach (and also stimulates release of cholecystokinin that is critical to the secretion of pancreatic enzymes). (msdmanuals.com)
Active pancreatic enzymes hydrolyze proteins into oligopeptides, which are absorbed directly or hydrolyzed into amino acids. (msdmanuals.com)
[ 12 ] The activity of key mitochondrial enzymes of the tricarboxylic acid cycle, β-oxidation, and the electron transport system, conversely, were unchanged, [ 12 ] leaving many unanswered questions regarding the effects of CR on muscle-specific mitochondrial function in humans. (medscape.com)

Fatty acid‐binding proteins (FABPs) are in charge of binding and storing AGAP1 hydrophobic ligands such as for example long‐chain essential fatty acids as well as for transporting these ligands to the correct compartments inside the cell. (mdm2-inhibitors.com)
Fatty acidity‐binding protein (FABPs) PIK-293 are members of the intracellular lipid‐binding proteins that bind intracellular hydrophobic ligands such as long‐chain fatty acids. (mdm2-inhibitors.com)

Multiple dicarboxylic acylcarnitines were significantly elevated in PBD patients including medium to long chain (C8-DC to C18-DC) species as well as previously undescribed elevations of malonylcarnitine (C3-DC) and very long chain dicarboxylic acylcarnitines (C20-DC and C22-DC). (bvsalud.org)

We studied drug repurposing following a molecular docking (MD) analysis, where the different protein data bank (PDB) structures of the genes of the meta-signature (in total 155) were confronted with 81 anti-cancer drugs approved by the FDA. (biomedcentral.com)

This new approach has been shown to preserve mobility and enzymatic activity of transmembrane proteins in the resulting nSLB. (lu.se)

Folic Acid: Folic Acid is one of the important hematopoetic agents necessary for proper regeneration of the blood-forming elements and their function. (nih.gov)
Folic acid is a precursor of a large family of compounds which serve as coenzymes in carbon transfer reactions. (nih.gov)
A deficiency in folic acid results in megaloblastic anemia. (nih.gov)

Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)

Detection of mitochondrial function includes measures of fatty acid oxidation and oxidative phosphorylation. (biomedcentral.com)

Palmityl-CoA, also known as palmitoyl CoA or CoA, palmitoyl, belongs to the class of organic compounds known as long-chain fatty acyl coas. (ymdb.ca)

This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)

Previously, researchers have shown in mouse models that as the disease advances, tumor cells shift from glycolysis toward fatty acid oxidation to support their growth and division. (acs.org)

However, the MCT formula should be as low as possible in C10 and C12 fatty acids as high dietary intake of these can lead to decompensation. (orpha.net)
On the basis of the recognized health improvements brought about by long chain -3 fatty acids, recommendations have been made to increase their intake. (soton.ac.uk)
A complete spectrum of amino acids and optimum health can only be brought forth by gearing your protein intake to these 8 aminos. (bodybuilding.com)
The International Society of Sports Nutrition (ISSN) provides an objective and critical review related to the intake of protein for healthy, exercising individuals. (biomedcentral.com)
For building muscle mass and for maintaining muscle mass through a positive muscle protein balance, an overall daily protein intake in the range of 1.4-2.0 g protein/kg body weight/day (g/kg/d) is sufficient for most exercising individuals, a value that falls in line within the Acceptable Macronutrient Distribution Range published by the Institute of Medicine for protein. (biomedcentral.com)
Recommendations regarding the optimal protein intake per serving for athletes to maximize MPS are mixed and are dependent upon age and recent resistance exercise stimuli. (biomedcentral.com)
While it is possible for physically active individuals to obtain their daily protein requirements through the consumption of whole foods, supplementation is a practical way of ensuring intake of adequate protein quality and quantity, while minimizing caloric intake, particularly for athletes who typically complete high volumes of training. (biomedcentral.com)
Pre-sleep casein protein intake (30-40 g) provides increases in overnight MPS and metabolic rate without influencing lipolysis. (biomedcentral.com)
In the past ten years, there have been continued efforts to advance the science and application of dietary protein intake for the benefit of athletes and fitness-minded individuals. (biomedcentral.com)
Most of the scientific research investigating the effects of protein intake on exercise performance has focused on supplemental protein intake. (biomedcentral.com)
The SNPs influence fat intake by causing treating the binding of the fatty acids. (chiropracticscientist.com)
It is best to take a high-quality omega-3 fatty acid to provide the body with the healthy fat it needs to properly function while avoiding high carbohydrate intake. (chiropracticscientist.com)

We have the ability to genetically test individuals to see what diet is best for them based on their genetic predisposition and ultimately reduce their risk of inflammation , joint pain , and long-term chronic illness. (chiropracticscientist.com)
Now a large and ever increasing number of genetic subtypes has been described, and major advances in molecular and cellular biology have clarified the understanding of the role of different proteins in the physiology of peripheral nerve conduction in health and in disease. (medscape.com)

Specifically although FABP5 may be the most upregulated proteins in the FABP family members comprising ten isoforms 18 the molecular features of FABP5 in CRC cells stay badly characterized. (mdm2-inhibitors.com)

Absorbed fatty acids are resynthesized and combined with protein, cholesterol, and phospholipid to form chylomicrons, which are transported by the lymphatic system. (msdmanuals.com)

EMD, E. Merck, Darmstadt) and substrates of endogenous transport systems of liver cells were studied in isolated rat hepatocytes. (nih.gov)
Several substrates of other endogenous transport systems (e.g. bilirubin, cyclopeptides, monovalent cations, dipeptides, amino acids, fatty acids, hexoses) did not interfere with the transport of EMD 56133. (nih.gov)

Our studies showed that ACBD5 deficiency leads to accumulation of very long-chain fatty acids (VLCFAs) due to impaired peroxisomal β-oxidation. (bmj.com)

So, Shanta Dhar and colleagues from Sylvester Comprehensive Cancer Center at the University of Miami wanted to develop a therapy that would inhibit fatty acid oxidation in cancer cells by targeting a mitochondrial protein that is vital to the metabolic process, making the cells susceptible to cisplatin. (acs.org)
This is a lipid sensing factor that is known to help with energy, metabolic, lipid storage, lipid transport, and inflammation. (chiropracticscientist.com)

Background Acyl-CoA binding domain containing protein 5 (ACBD5) is a peroxisomal membrane protein with a cytosolic acyl-CoA binding domain. (bmj.com)

To date, there have been no randomized controlled trials that have examined the effects of long-term CR on muscle mitochondrial function in humans. (medscape.com)

Activated protein C resistance and low molecular weight lipoprotein (a): dual pathogens for atherothrombosis? (mcmaster.ca)
Albumin is a globular protein with a molecular weight of 66-69,000 daltons (66-69 kDa). (eclinpath.com)

Serum very long-chain fatty acids were significantly elevated. (bvsalud.org)

PHD2 is certainly the major prolyl hydroxylase that adjusts HIF-1 proteins balance in nonhypoxic cells, whereas knockdown of PHD1 or PHD3 will not really affect HIF-1 proteins amounts in many tumor cell lines (Berra range 350C1700 at a quality of 30,000. (forgetmenotinitiative.org)

The lipidomic analysis showed that disruption of NcACBP caused no obvious changes in the overall abundance and turnover of fatty acids while knockout resulted in the accumulation of triacylglycerol. (biomedcentral.com)

Anatomy7

Diseases4

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes7

Information Science3

Uptake7

Sterol regulat1

Metabolism7

Carnitine16

Transporters3

Amino acid5

Essential Amino3

Lipids4

Inhibitors2

Gene12

Bile acids1

Synthesis6

Mitochondria2

Intestinal2

Molecule6

Adipose tissue1

SLC271

Acylcarnitine2

Esters4

Binds1

Glycerol4

Unconjugated bilirubin1

Desaturation1

Triglycerides1

Adipocyte3

Mechanism4

Recombinant3

Coenzyme3

Mutations2

Characterization1

CD361

Enzymes3

Ligands2

Acylcarnitines1

Genes1

Transmembrane1

Folic acid3

Expression1

Oxidative1

CoAs1

Subunit1

Tumor cells1

Intake12

Genetic2

FABP51

Phospholipid1

Endogenous2

Deficiency1

Metabolic2

Peroxisomal membrane1

Mitochondrial function1

Molecular2

Serum1

Cell1

Triacylglycerol1