Spontaneous locomotor activityMiceStimulationMDMAActivityExcess locomotorAmphetaminesPsychomotor stimulantRatsAmphetamineEffectsCaffeineSensitizationHyperactivityHallucinogensMethamphetamineMethylphenidatePharmacokineticsDrugsADHDSyntheticBehavioralDosesPreferenceIncreaseHumansResponseSymptomsDrugCentralEffectGeneralActsPlace
Spontaneous locomotor activity3
- Moreover, the effect of (-)-linalool on spontaneous locomotor activity (25, 50, 75 and 100 mg/kg) was evaluated. (researchgate.net)
- The aim of this study was to establish the highest no-effect dose (HNED) of cocaine on the spontaneous locomotor activity (SLA) of horses in a behavior chamber, and thereby to determine the maximal acceptable threshold of the urinary drug concentration in horses. (unesp.br)
- Furthermore, ampakines do not stimulate spontaneous locomotor activity in either mice or rats, unlike the stimulants presently used for the treatment of ADHD, nor do they increase the stimulation produced by amphetamine or cocaine. (respirerx.com)
Mice6
- These results explore the toxicology of stimulant vapor inhalation in mice using an e-cigarette device. (rti.org)
- Vallöf D, Vestlund J, Engel JA , Jerlhag E. The Anorexigenic Peptide Neuromedin U (NMU) Attenuates Amphetamine-Induced Locomotor Stimulation, Accumbal Dopamine Release and Expression of Conditioned Place Preference in Mice. (neurotree.org)
- Suchankova P, Engel JA , Jerlhag E. Sub-chronic Ghrelin Receptor Blockade Attenuates Alcohol- and Amphetamine-Induced Locomotor Stimulation in Mice. (neurotree.org)
- Acute sensitivity of FAST and SLOW mice to the effects of abused drugs on locomotor activity. (rutgers.edu)
- Additionally, 5-IT gave mice stimulant and locomotor effects comparable to those of 3,4-methylenedioxymethamphetamine (MDMA). (mephedrone.com)
- tBu-d-Gly5]NPS activity was evaluated in vitro in the calcium mobilization assay at the rat NPSR and in vivo in the locomotor activity and righting reflex tests in mice and in the elevated plus maze and defensive burying assays in rats. (unife.it)
Stimulation7
- Tolerance to caffeine-induced stimulation of locomotor activity has been shown in animals. (medscape.com)
- They also exhibited comparable sensitivity to cocaine-induced locomotor stimulation. (elsevierpure.com)
- Hence, SSR504734 not only confers resistance to NMDAR blockade, but also enhances the locomotor response to dopaminergic stimulation. (tau.ac.il)
- Nevertheless, validation studies on the feeding and activity cages, applying 0.5-mgkg Norgestimate custom synthesis 9-THC-containing formulations, resulted inside the expected stimulation of feeding behaviours but did not increase locomotor activity (unpublished observations). (icbinhibitor.com)
- Offered these data, and video observations showing that the majority of animals' activities within the cages had been exploratory rather than food in search of, it is actually apparent that the activity data do certainly represent generalised locomotor stimulation. (icbinhibitor.com)
- For this locomotor stimulation to become the main driver of improved food intake, by means of a general arousal mechanism, patterns of activity and meals intake would have to closely mirror 1 an additional, each in terms of temporal profile and dose response. (icbinhibitor.com)
- While beyond the scope from the present study, this apparent stimulant effect of greater CBG doses warrants further investigation in models which can assess locomotor activation over extended time periods, with out any confounding effects of feeding stimulation. (icbinhibitor.com)
MDMA3
- The Behavioral Pattern Monitor, which quantifies locomotor and investigatory responses of rats, was used to characterize the effects of AET in a paradigm that distinguishes between the effects of traditional hallucinogens, amphetamine-like stimulants, and MDMA-like drugs. (erowid.org)
- Locomotor hyperactivity is produced by MDMA or amphetamine-like stimulants, but not by classical hallucinogens, such as LSD or mescaline. (erowid.org)
- Second, as with MDMA, the locomotor hyperactivity induced by AET was attenuated by pretreatment (10 mg/kg) with the serotonin reuptake inhibitor fluoxetine. (erowid.org)
Activity18
- Effects of hallucinogens on locomotor and investigatory activity and p. (erowid.org)
- First, a dose-response study revealed that all doses of AET tested (5, 10, 20 mg/kg) significantly increased locomotor activity. (erowid.org)
- All compounds were tested in a locomotor activity paradigm to rule out non-specific stimulant effects. (nih.gov)
- Dose-effect curves were determined for locomotor activity and a functional observational battery (FOB). (rti.org)
- Females showed greater METH-induced locomotor activity, and greater incidence of a few somatic signs in the FOB than males. (rti.org)
- All drugs increased locomotor activity, with different compounds showing different potencies and time courses in locomotor activity. (safetylit.org)
- Outbred, male Sprague-Dawley rats can be classified as either low or high cocaine responders (LCRs or HCRs, respectively) based on cocaine-induced locomotor activity in an open-field arena. (illinois.edu)
- The CNS depressant drugs such as barbiturates & alcohol reduce the motor activity while the stimulants such as caffeine & amphetamines increase the activity. (pharmawiki.in)
- In other words, the locomotor activity can be an index of wakefulness (alertness) of mental activity. (pharmawiki.in)
- The locomotor activity (horizontal activity) can be easily measured using an actophotometer which operates on photoelectric cells which are connected in circuit with a counter. (pharmawiki.in)
- Increase in the motor activity indicates CNS stimulant property of the drug. (pharmawiki.in)
- Modafinil is less likely to produce side effects such as jitteriness, anxiety, or excess locomotor activity or to lead to a hypersomnolent rebound effect. (medscape.com)
- In rodents, it mimics the action of cocaine by stimulating locomotor activity. (zanettisview.com)
- Acute nicotine and phencyclidine increase locomotor activity of the guinea pig with attenuated potencies relative to their effects on rat or mouse. (omeka.net)
- Locomotor activity was measured on days 1, 5 and 13 immediately after injection. (sciencedaily.com)
- In mouse locomotor activity experiments, supraspinal injection of [tBu-d-Gly5]NPS (1-10 nmol) dose dependently counteracted NPS (0.1 nmol) stimulant effects. (unife.it)
- For the initial interpretation to become valid, anycompound which increases food intake by a equivalent magnitude within this technique would have to also improve locomotor activity levels. (icbinhibitor.com)
- These data thus argue against the interpretation that the hyperphagic activity of CBG is driven by generalised arousal, but rather that this compound directly stimulates motivation to feed, with coincident feedingindependent locomotor activation apparent at the highest dose. (icbinhibitor.com)
Excess locomotor1
- Such as excess locomotor activities or jitteriness. (worldnewsspot.com)
Amphetamines1
- Amphetamines are a group of central nervous system stimulants that include amphetamine, dextroamphetamine and methamphetamine. (motorextremeblog.es)
Psychomotor stimulant2
- Repeated intermittent administration of psychomotor stimulant drugs al. (erowid.org)
- Lack of significant cross-sensitization between bromocriptine and either cocaine or heroin and lack of permanence of the cross-sensitization between bromocriptine and quinpirole raise questions as to the biological basis of psychomotor stimulant sensitization. (eurekamag.com)
Rats6
- To investigate the relationship between initial cocaine locomotor responsiveness and cocaine reward, here we first classified rats as either LCRs or HCRs in a conditioned place preference (CPP) apparatus. (illinois.edu)
- Our findings show that the initial locomotor response to cocaine can predict CPP in male Sprague-Dawley rats under conditions when place conditioning develops, and that LCRs may be more prone to develop conditioning in the context of cocaine reward. (illinois.edu)
- SEQ CHAPTER \h \r 1Rats that were isolated during all three developmental periods, showed a higher locomotor response to cocaine than control rats. (sciencedaily.com)
- The study indicates that the developmental period most susceptible to isolation stress, particularly in males, is the neonatal period, since males isolated as neonates show an increase in the locomotor, and sensitized response to cocaine, compared to male control and to female rats. (sciencedaily.com)
- We examined acute and sensitized locomotor effects of methylphenidate in adolescent and early adult male Sprague Dawley (SD), spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats using a drug regimen that differentiates clearly between initial and enduring differences in drug responsiveness. (biomedcentral.com)
- Here we examined strain and age differences in the acute and cross-sensitizing behavioral effects of methylphenidate by pretreating rats with the drug in an environment other than home, as administering the drug to rats in the environment in which they live is known to attenuate the locomotor activating effects of stimulant drugs [ 13 ]. (biomedcentral.com)
Amphetamine3
- Amphetamine derivatives induce locomotor hyperactivity by acting as in. (erowid.org)
- SSR504734 attenuated phencyclidine-induced (5 mg/kg, i.p.) hyperlocomotion, but potentiated the motor stimulant and motor depressant effects of amphetamine (2.5 mg/kg, i.p.) and apomorphine (0.75 mg/kg, s.c.), respectively. (tau.ac.il)
- Currently available treatments for ADHD include amphetamine-type stimulants and non-stimulant agents targeting monoaminergic neurotransmitter systems in the brain. (respirerx.com)
Effects14
- In the FOB, both routes of administration produced typical stimulant effects, and injection also increased some bizarre behaviors (e.g. licking, teeth chattering, darting). (rti.org)
- The two routes of administration had comparable efficacy in locomotor activation, with vapor producing longer lasting effects than injection. (rti.org)
- The FOB showed that in addition to typical stimulant induced effects, some synthetic cathinones produced ataxia, convulsions, and increased exploration. (safetylit.org)
- These results suggest that individual synthetic cathinones differ in their profile of effects, and differ from known stimulants of abuse. (safetylit.org)
- Finally, recent studies have begun to highlight potential damaging effects of stimulant exposure in healthy juveniles. (frontiersin.org)
- Repeated bromocriptine in the test box but not in the home cage caused progressive increases in sensitivity to the locomotor-stimulating effects of bromocriptine and increases in the subsequent sensitivity to quinpirole but caused only trivial signs of cross-sensitization to cocaine or heroin. (eurekamag.com)
- These areas are normally involved in mediating pleasure, and also regulate the psycho-stimulant effects of drugs such as cocaine. (sciencedaily.com)
- This makes it an excellent choice for people who want to be more productive without the negative side effects of stimulants. (worldnewsspot.com)
- Behavioral effects of stimulant drugs are influenced by non-pharmacological factors, including genetic variability and age. (biomedcentral.com)
- Acute and chronic locomotor and neurochemical effects of stimulant drugs are determined not only by the pharmacological properties of the drug itself, but also by a multitude of non-pharmacological factors, such as genetic variability and age [ 1 - 8 ]. (biomedcentral.com)
- 1,4-DMAA is a chemical with stimulant effects. (motorextremeblog.es)
- Approved non-stimulant treatments, such as atomoxetine (Strattera and its generic equivalents), can take four to eight weeks to become effective and undesirable side effects also have been observed. (respirerx.com)
- Wellbeing Effects Methylphenidate is a stimulant of the central tactile framework (CNS). (mexicoonlinepharmacy.org)
- The misused for its stimulant effects: covetousness covering and rest, extended thought/obsession and bliss. (mexicoonlinepharmacy.org)
Caffeine5
- Caffeine is a bitter white crystalline xanthine alkaloid that acts as a psychoactive stimulant drug and a mild diuretic (speeds up urine production) [1] in humans and other animals. (wikidoc.org)
- In humans, caffeine is a central nervous system (CNS) stimulant , having the effect of temporarily warding off drowsiness and restoring alertness. (wikidoc.org)
- Many natural sources of caffeine also contain widely varying mixtures of other xanthine alkaloids , including the cardiac stimulants theophylline and theobromine and other substances such as polyphenols which can form insoluble complexes with caffeine. (wikidoc.org)
- Caffeine is the most common stimulant used in pre-workouts and fat burners - but that doesn't stop companies from trying out new things to make their products stand out. (motorextremeblog.es)
- DMAA is a neurological stimulant that causes a quick burst of energy similar to caffeine and other classic stimulants, but through different mechanisms in the brain. (motorextremeblog.es)
Sensitization1
- Subsequently, we conducted cocaine conditioning trials, twice-daily over 4 days with vehicle and cocaine (10 mg/kg, i.p. or 1 mg/kg, i.v.). When cocaine was administered by the i.p. route, similar to previous findings in the open-field, LCRs and HCRs were readily classified and locomotor sensitization developed in LCRs, but not HCRs. (illinois.edu)
Hyperactivity1
- APTENSIO XR is a central nervous system (CNS) stimulant indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years and older. (nih.gov)
Hallucinogens1
- Humans have sought substances to improve our cognitive function for centuries, from ancient civilizations using hallucinogens in an attempt to raise their consciousness to commune with their gods, to the rise of coffee, to the more recent development of drugs such as stimulants and glutamate activators. (frontiersin.org)
Methamphetamine1
- People who use methamphetamine can face risks, including stimulant overdose or overamping. (motorextremeblog.es)
Methylphenidate2
- 5.6) The studies have moreover found that appeared differently in relation to those ADHD untreated, those with ADHD respected with stimulants, for instance, methylphenidate are less disposed to mistreat prescriptions and alcohol when they are more prepared. (mexicoonlinepharmacy.org)
- 7) However, as an aftereffect of its stimulant properties, starting late there have been reports Abuse of methylphenidate by persons not requiring this solution. (mexicoonlinepharmacy.org)
Pharmacokinetics1
- Its main application in scientific research has been in studies investigating the influence of pharmacokinetics on the abuse potential of stimulant drugs, with its rapid entry into the brain thought to be a key factor in producing its high propensity for development of dependence in animals. (wikipedia.org)
Drugs3
- Vaporizing drugs in e-cigarettes is becoming a common method of administration for synthetic cathinones and classical stimulants. (rti.org)
- however, literature on the safety of consuming these drugs in youth is starkly lacking despite the significant increase in teen misuse and abuse of stimulants reported in a recent national study ( Goldberg, 2013 ). (frontiersin.org)
- Most of the CNS acting drugs influence the locomotor activities in man & animals. (pharmawiki.in)
ADHD4
- Stimulants used to treat ADHD are associated with peripheral vasculopathy, including Raynaud's phenomenon. (nih.gov)
- Careful observation for digital changes is necessary during treatment with ADHD stimulants. (nih.gov)
- Based on these clinical results, ampakines such as CX717 and CX1739 might represent a breakthrough opportunity to develop a non- stimulating therapeutic for ADHD with the rapidity of onset normally seen with stimulants. (respirerx.com)
- 2,3,4) .The treatment of ADHD with stimulants, for instance, Ritalin and psychotherapy improve the unpredictable practices of ADHD, and what's more self-respect , acumen, and social and family work patient.2 Research shows that people with ADHD don't get the opportunity to be subject to stimulant pharmaceuticals when taken in the estimation and path suggested by the pro. (mexicoonlinepharmacy.org)
Synthetic3
- Synthetic stimulants commonly sold as "bath salts" are an emerging abuse problem in the U.S. Users have shown paranoia, delusions, and self-injury. (safetylit.org)
- Mephedrone is a synthetic stimulant that was first detected in Germany in 2007. (zanettisview.com)
- MDPV is a synthetic stimulant related to cathinone. (zanettisview.com)
Behavioral1
- Behavioral assays of the responses to psychomotor stimulants can be used to model certain aspects of CNS pathologies such as psychosis and addiction. (omeka.net)
Doses1
- Sudden death has been reported in association with CNS stimulant treatment at recommended doses in pediatric patients with structural cardiac abnormalities or other serious heart problems. (nih.gov)
Preference1
- Here he made use of models of addiction such as locomotor sensitisation, conditioned place preference and drug self-administration. (uclan.ac.uk)
Increase2
- Phenylpiracetam is typically prescribed as a general stimulant or to increase tolerance to extreme temperatures and stress. (qualitypowders.com)
- Unsafe Spikes in Blood Pressure: Studies show that as a central nervous system stimulant, DMAA can quickly increase your heart rate and blood. (motorextremeblog.es)
Humans1
- It has been used in humans as a CNS stimulant, a locomotor stimulant, a sports performance enhancer, and a nootropic (in which case, it can be up to 30-60 times more potent than piracetam). (qualitypowders.com)
Response1
- The animals were then tested in the photocell boxes for their locomotor response to cocaine (10.0 mg/kg IP), heroin (0.5 mg/kg IP), or quinpirole (0.1 mg/kg IP). (eurekamag.com)
Symptoms1
- Use of stimulants may cause psychotic or manic symptoms in patients with no prior history, or exacerbation of symptoms in patients with pre-existing psychiatric illness. (nih.gov)
Drug5
- RTI-126 (RTI-4229-126 or (-)-2β-(1,2,4-oxadiazol-5-methyl)-3β-phenyltropane) is a phenyltropane derivative which acts as a potent monoamine reuptake inhibitor and stimulant drug, and has been sold as a designer drug. (wikipedia.org)
- It was developed as a pharmaceutical stimulant in the 1960s and re-emerged as a recreational drug within the last decade. (zanettisview.com)
- It has a role as a neurotoxin, a psychotropic drug, a central nervous system stimulant, a xenobiotic and an environmental contaminant. (motorextremeblog.es)
- In addition, approved stimulant treatments are DEA (US Drug Enforcement Agency) classified as controlled substances and present logistical issues for distribution and protection from diversion. (respirerx.com)
- Honestly, it has been represented that stimulant treatment in children is associated with a diminishment in peril joined with drug and alcohol use issue. (mexicoonlinepharmacy.org)
Central1
- Addictiveness of central stimulants. (rutgers.edu)
Effect1
- Both are powerful stimulants and DMAA may even have a greater effect on the mind than Ephedrine does. (motorextremeblog.es)
General1
- In classic American country medicine Prickly Ash was also used by Country Doctors as a general health stimulant. (doctorschar.com)
Acts1
- Acts as a digestive aid and appetite stimulant. (infinityhealth4u.com.my)
Place1
- The case of behavior conventionally develops some place around 3 and 5 years old and is broke down in grade school in view of over the top locomotor development, carelessness and rash behavior. (mexicoonlinepharmacy.org)