Loci protein coding 3 flanking region. Medical search. Frequent questions

They illustrated the activity of the Insv protein in transcriptional regulation of genes and obtained a crystal structure of two Insv BEN domains interacting with their DNA target site. (wikipedia.org)
The loci for these genes are spread throughout the human genome. (wikipedia.org)
Other Htz1-activated genes flank the silent HMR mating-type locus. (sdbonline.org)
It is also possible that this encoded protein functions to regulate fecundity genes so that the OLR1 gene is involved in sheep fecundity [2]. (researchsquare.com)
The region included a high proportion of genes that did not show homology with genes in other bacteria. (microbiologyresearch.org)
Further fine mapping in a large population with over 1,000 F 2 plants narrowed this region to 39.08 Kb harboring two genes, Cla97C01G008760 and Cla97C01G008770 , which encode phytoene synthase ( ClPsy1 ) and GATA zinc finger domain-containing protein, respectively. (researchsquare.com)
In the present study, genes across the 2q24-q33 interval were analyzed to identify an autism susceptibility gene in this region. (neurotransmitter.net)
The first stage involved identifying, in unrelated subjects showing linkage to 2q24-q33, genetic variants in exons and flanking sequence within candidate genes and comparing the frequency of the variants between autistic and unrelated nonautistic subjects. (neurotransmitter.net)
3 Identification of the genes predisposing to cancer could yield targets for treatment or chemoprevention. (bmj.com)
For example, cerebellar granule cells express six subunit genes abundantly (α 1 , α 6 , β 2 , β 3 , γ 2 , and δ), and so they probably have several distinct GABA A receptor subtypes of unknown subunit stoichiometry. (jneurosci.org)
The difference between the batch options of these two tools is that GSR retrieves the entire nucleotide sequence between the coordinates specified in a list, while Batch Download retrieves only the sequences of the features (protein-coding and RNA genes, centromeres, etc.) that are annotated within the specified regions. (candidagenome.org)
In contrast, Hp1 and Dim5 mutants that are impacted in chromatin-associated processes upstream of DNA methylation are severely affected in development and virulence and display transcriptional reprogramming in specific hypervariable genomic regions (so-called adaptive genomic regions) that contain genes associated with host colonization. (biomedcentral.com)
The ~1.5 Mb candidate region was shown to contain five protein-coding genes. (biomedcentral.com)
We also identified several genes that do not appear to be protein coding, and generated 17 kb of novel transcript sequence data from re-sequencing 97 EST clones. (biomedcentral.com)
The candidate interval was shown to exhibit an extraordinary level of alternate splicing - 19 transcripts were identified for the 5 protein coding genes, but it appears that a significant portion (14/19) of these alternate transcripts did not have an open reading frame, hence their functional role is questionable. (biomedcentral.com)
The ms4 locus was fine mapped to a 216 kb region, which contains 23 protein-coding genes including Glyma.02G243200 , an ortholog of Arabidopsis MALE MEIOCYTE DEATH 1 ( MMD1 ), which is a Plant Homeodomain (PHD) protein involved in male fertility. (biomedcentral.com)
Intragenic recombination among ospC genes is known, but the extent to which recombination extended beyond the ospC locus itself is undefined. (cdc.gov)
Over time, OspC genes were transferred between strains through recombinations involving the whole or parts of the gene and one or both flanks. (cdc.gov)
Acquisitions of OspC genes that are novel for the region confer to recipients unique identities to host immune systems and, presumably, selective advantage when immunity to existing types is widespread among hosts. (cdc.gov)
That process identified "61 protein-coding and 33 noncoding loci that map better to this finished chromosome 8 sequence than to GRCh38, including the discovery of novel genes mapping to copy number polymorphic regions," they report. (pacb.com)
Twelve of these new genes were uncovered in that tricky β-defensin locus alone. (pacb.com)
this might involve the replication, propagation or interpretation of early methylation patterns at selected loci (in particular imprinted genes) that are then subsequently able to escape the global genomic demethylation that occurs in later preimplantation development [ 8 ]. (biomedcentral.com)
Later studies confirmed that the RlrA protein acted as a transcription factor recognizing several promoters within the rlrA islet and showed it to be essential for wild-type levels of expression of the pili structural genes and associated sortases [ 6 ]. (biomedcentral.com)
Transposition of this element into coding and regulatory regions of genes is responsible for many heritable diseases. (lookformedical.com)

BEND2 is a protein that in humans is encoded by the BEND2 gene. (wikipedia.org)
The longest and most complete transcript of the gene, variant 1, encodes isoform 1 of the BEND2 protein (NP_699177.2). (wikipedia.org)
Corresponding to the five alternative transcripts of BEND2, the protein encoded by this gene is found in two isoforms (1 and 2) as well as three predicted structures (X1, X2, and X3). (wikipedia.org)
BEN domains are found in a diverse array of proteins and are predicted to be important for chromatin remodeling as well as for the recruitment of chromatin-modifying factors utilized during the process of transcriptional regulation of gene expression. (wikipedia.org)
2013 showed that the Drosophila melanogaster Insensitive (Insv) gene and corresponding protein has no domains of known chemical function yet it contains a single BEN domain. (wikipedia.org)
The biotinylated proteins were affinity-purified for mass spectrometric analysis, and the candidate GRA proteins from BioID data set were identified by gene tagging. (biomedcentral.com)
Using NcGRA17-BirA* fusion protein as bait, we have identified some known GRAs and verified localization of 11 novel GRA proteins by gene endogenous tagging or overexpression in the Nc1 strain. (biomedcentral.com)
This gene encodes OLR1 protein and belongs to the C-type lectin family that functions to absorb and degrade low-density lipoproteins [5], which impacts energy balance, in turn influencing reproductive characteristics [3]. (researchsquare.com)
An SNP within the exon and intron regions of the OLR1 gene is associated with phenotypic traits in cattle, according to Komisarek and Dorynek [6] and Fonseca et al . (researchsquare.com)
The A/C SNP in the 3′-UTR fragment of the OLR1 gene has been linked to lactational traits in Iranian Holstein cattle [15]. (researchsquare.com)
Two loss-of-function mutations in the coding of the filaggrin (filament aggregating protein) gene have been identified in both ichthyosis vulgaris and atopic dermatitis. (medscape.com)
A gene controlling the golden flesh trait in watermelon was firstly discovered and fine-mapped to a 39.08-Kb region on chromosome 1 through a forward genetic strategy, and Cla97C01G008760 (annotated as phytoene synthase protein, ClPsy1 ) was recognized as the most likely candidate gene. (researchsquare.com)
A distinct ZmFCP1-FEA3 ligand-receptor combination, originally identified in maize, prevents WUS gene expression in the region below the OC (also called rib zone, RZ), thus confining WUS expression within the OC of meristems 6 . (nature.com)
Gene/Sequence Resources (GSR) serves as a central point for accessing much of the information available at CGD for a 1) a named DNA sequence, 2) a specified chromosomal region or list of regions, or 3) a raw DNA or protein sequence. (candidagenome.org)
CGD's Gene/Sequence Resources tool and Batch Download tool both allow you to retrieve sequences in batch for a list of regions. (candidagenome.org)
All of the options retrieve the Watson strand (with ascending chromosomal coordinates) of the specified gene or region. (candidagenome.org)
You may also retrieve information about flanking sequences upstream and/or downstream of the entered gene/sequence name. (candidagenome.org)
Phylogenetic analysis showed presence of a homolog protein (MS4_homolog) encoded by the Glyma.14G212300 gene. (biomedcentral.com)
One of the few antigens against which mammals develop protective immunity is the highly polymorphic OspC protein, encoded by the ospC gene on the cp26 plasmid. (cdc.gov)
Besides recombinations with traces limited to the ospC gene itself, there was evidence of lateral gene transfers that involved (i) part of the ospC gene and one of the two flanks or (ii) the entire ospC gene and different lengths of both flanks. (cdc.gov)
Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)
By means of DNA sequencing of a large sample collection of the pathogen from across the United States, we studied the gene for the bacterium's highly diverse OspC protein, protective immunity against which develops in animals. (cdc.gov)
Here, using Next Generation Sequencing we identified a novel gene fusion event between DAXX and the kinesin motor protein, KIFC3, leading to the translation of a chimeric DAXX-KIFC3 fusion protein. (oncotarget.com)
But the chromosome is also home to "one of the most structurally dynamic regions in the human genome-the β-defensin gene cluster located at 8p23.1-as well as a neocentromere located at 8q21.2, which have been largely unresolved for the last 20 years," the scientists write. (pacb.com)
The scientists also tackled that persnickety β-defensin gene cluster, "which we resolved into a single 7.06 Mbp locus-substantially larger than the 4.56 Mbp region in the current human reference genome," they note. (pacb.com)
In the mouse, mutations of the oocyte-specific isoform of the DNA methyltransferase Dnmt1 (Dnmt1o) and of the methyltransferase-like Dnmt3L gene result in specific failures of imprint establishment or maintenance, at multiple loci. (biomedcentral.com)
In the previously-described family with multi-locus imprinting failure, mutation of DNMT1o and of the other known members of this gene family has been excluded. (biomedcentral.com)
the invention also provides non-human animals and cells comprising a transgene encoding an APP comprising the Swedish mutation and further comprising functionally disrupted endogenous APP gene loci, transgenes and targeting constructs used to produce such transgenic cells and animals, transgenes encoding human Swedish mutation APP polypeptide sequences, and methods for using the transgenic animals in pharmaceutical screening and as commercial research animals for modeling neurodegenerative diseases (e.g. (justia.com)
amyloid peptide, a major constituent of the amyloid plaque, can result from mutations in the gene encoding amyloid precursor protein, a protein which when normally processed will not produce the .beta. (justia.com)
The first class of small RNAs identified were the micro RNAs (miRNAs), which are small (~22 nt) non-coding RNAs that regulate gene expression by base pairing to mRNAs where they direct either mRNA cleavage or repress translation [ 8 ]. (biomedcentral.com)
We examined the distribution of the pilus islet, using the presence of the rlrA gene as a marker for the locus, among a collection of invasive isolates recovered in Portugal and analyzed its association with capsular serotypes, clusters defined by the pulsed-field gel electrophoretic profiles (PFGE) and multilocus sequence types. (biomedcentral.com)
Analysis of rlrA negative isolates revealed heterogeneity in the genomic region downstream of the rfl gene, the region where the islet is found in other isolates, compatible with recent loss of the islet in some lineages. (biomedcentral.com)
Flp-mediated recombination, one of a family of site-specific recombination technologies, was used to integrate the DAT1 constructs into a common, transcriptionally-active region of the genome, eliminating several caveats associated with traditional reporter gene methodologies [ 36 ]. (biomedcentral.com)
UMOD risk variants identified in the above-mentioned GWAS are located in the promoter region of the gene, leading to a theory that they altered UMOD expression. (medscape.com)
This disease, previously referred to as MCKD type 1, is due to a mutation in the variable-number tandem repeat region of the MUC1 (Mucin 1) gene. (medscape.com)
The locus at chromosome 1q21 was identified by linkage mapping in 1998, but the gene has only recently been discovered due to difficulty with sequencing this highly repetitive region and was previously missed using next-generation sequencing. (medscape.com)

The locus for BEND2 is on the minus strand of the X chromosome at Xp22.13. (wikipedia.org)
The region between yvsA (293°) and yvqA (289°) of the Bacillus subtilis chromosome has been sequenced within the framework of the B. subtilis 168 international sequencing programme. (microbiologyresearch.org)
BSA-seq and an initial linkage analysis placed the gf locus in a 290-Kb region on watermelon chromosome 1. (researchsquare.com)
The authors recently mapped a susceptibility locus for autism to chromosome region 2q24-q33 (MIM number 606053). (neurotransmitter.net)
This entry option allows you to specify a region by choosing the chromosome number or contig name from the pull-down menu and entering coordinates , if desired. (candidagenome.org)
We previously localized a Quantitative Trait Locus for HPFH in an extensive Asian-Indian kindred to chromosome 6q23. (biomedcentral.com)
Phenotypic analysis of these ' in locus ' mutations based on both expression of Kni protein and adult wing phenotypes, reveals novel unexpected features of L2-CRM function including evidence for a chromosome pairing-dependent process that promotes transcription. (elifesciences.org)
Therefore, microdissected Y-chromosome probes are good for FISH but not suitable for cloning and sequencing of the male-specific or pseudoautosomal regions of the chromosome. (veteriankey.com)

The untranslated regions (UTR) flanking the coding sequence of BEND2 at the 5' and 3' end of the mature mRNA molecule contain sites for RNA-binding proteins, including RBMX, pum2, and EIF4B as well as microRNA binding sites. (wikipedia.org)
The presence of nuclear localization signals within the amino acid sequence or primary structure of the BEND2 protein leads to a prediction of subcellular localization in the nucleus. (wikipedia.org)
Sequence features in the 1 Mb region from map positions 64% to 92% of the genome. (microbiologyresearch.org)
Once you have specified a sequence name or region(s), GSR will present only those options which are available for obtaining information about your entry. (candidagenome.org)
Whenever possible, selecting one of the available options for your entered sequence name or region takes you directly to the results for your entered sequence. (candidagenome.org)
When a list of sequence regions is entered, you will be presented with a link allowing you to download a file containing the sequences. (candidagenome.org)
To do this, type the length of the flanking region you would like to retrieve in the boxes (upstream and/or downstream) below where you entered the sequence name. (candidagenome.org)
In this case, the beta-galactosidase protein coding sequence and a flanked cassette were introduced to replace allele. (bios-mep.info)
The complete chr8 sequence clocks in at 146 Mb and includes more than 3 Mb missing from GRCh38. (pacb.com)
We estimate that the mutation rate of centromeric satellite DNA is accelerated at least 2.2-fold, and this acceleration extends beyond the higher-order α-satellite into the flanking sequence. (pacb.com)
Binding of sequence-specific transcription factors and associated chromatin-modifying enzymes can induce post-translational modification of histone tails and can facilitate nucleosome removal [ 3 - 5 ], which can turn functional sequences such as promoters and enhancers into active, nucleosome-depleted sites [ 2 ]. (biomedcentral.com)
Though the VNTR resides in a region encoding the 3' untranslated region (UTR) and does not alter the protein's amino acid sequence, the prevalent 10-repeat variant has shown both linkage and association to Attention Deficit Hyperactivity Disorder (ADHD). (biomedcentral.com)
Though the VNTR resides in the 3'UTR and therefore does not affect the protein's amino acid sequence, regulatory factors such as mRNA stability and nuclear transport, and protein synthesis are potentially regulated by such variations [ 11 - 14 ]. (biomedcentral.com)
TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. (lookformedical.com)

Lamellar ichthyosis is a rare, autosomal recessive, genetically heterogeneous skin disease caused by mutations involving multiple genetic loci. (medscape.com)
While the precise mechanism underlying activation of the ALT pathway is unclear, mutations in the chromatin remodeling protein ATRX, histone chaperone DAXX, and the histone variant H3.3 correlate with ALT status. (oncotarget.com)
Genetic mutations in ATRX, DAXX, and H3.3 have been detected in ALT positive cancers, however, a subset of ALT samples show loss of ATRX or DAXX protein expression or localization without evidence of genetic alterations suggesting additional uncharacterized defects in ATRX/DAXX/H3.3 function. (oncotarget.com)

To date, most NcGRAs have been discovered individually by bioinformatics searches for proteins exhibiting homology to known Toxoplasma dense granule proteins (TgGRAs). (biomedcentral.com)
The identified ORFs showed homology to proteins involved in the transport of metal ions, two-component signal transducers, ATP-binding-cassette-type transporters and a sigma factor. (microbiologyresearch.org)

The knirps ( kni ) locus encodes transcription factors required for induction of the L2 wing vein in Drosophila . (elifesciences.org)

Interestingly, numerous IS elements (for example, IS1341 , IS809 and IS1136 ) encode TnpB as the only protein (putative transposase), but the supporting evidence for TnpB-mediated transposition is still missing. (biomedcentral.com)
amyloid precursor protein occurs via cleavage by a putative ".alpha. (justia.com)

The BEND2 protein has no known paralogs within the human genome. (wikipedia.org)
Since the announcement of the sequencing of the human genome 20 years ago, human chromosomes have remained unfinished due to large regions of highly identical repeats located within centromeres, segmental duplication, and the acrocentric short arms of chromosomes," the authors note. (pacb.com)
Non-autonomous Helitron2 elements ( CRe - 1 , 2 , 3 ) in the genome of green alga Chlamydomonas reinhardtii are flanked by target site duplications (TSDs) of variable length (approximately 7 to 19 bp). (biomedcentral.com)
The length of the human genome is about 3 billion base pairs. (lookformedical.com)
Common variants in UMOD have also been demonstrated in large genome-wide association studies (GWAS) to confer independent risk for both hypertension and kidney disease illustrating the shared risk for both phenotypes within this locus (see the GWAS in Nephrology team description for more). (medscape.com)

Isolation and sequencing of Glyma.02G243200 from the ms4 mutant line showed a single base insertion in the 3rd exon causing a premature stop codon resulting in truncated protein production. (biomedcentral.com)
The ONX-0914 cell signaling targeting vector contains genomic fragments flanking the cassette which replaces exon 1 and part of exon 2 of when correct homologous recombination occurs in ES cells. (bios-mep.info)
Exon 1o lacks an in-frame initiation codon, so that translation of this mRNA species initiates from a downstream ATG in exon 4, yielding the N-truncated Dnmt1o protein. (biomedcentral.com)

In addition, we sequenced 99 ospC flanking sequences from different lineages and compared the complete cp26 sequences of 11 strains as well as the cp26 bbb02 loci of 56 samples. (cdc.gov)
Bacterial insertion sequences (IS) of IS200 / IS605 and IS607 family often encode a transposase (TnpA) and a protein of unknown function, TnpB. (biomedcentral.com)
These regions are known as CpG islands (CGIs) and consist of short (~ 1000 bp) interspersed CpG-rich and predominantly unmethylated DNA sequences [ 1 ], which are associated with transcriptionally permissive chromatin state [ 2 ]. (biomedcentral.com)
The region of DNA which borders the 3' end of a transcription unit and where a variety of regulatory sequences are located. (lookformedical.com)

A series of four DAT1 constructs, each containing the DAT1 coding region, but varying with respect to the downstream presence or content of the 3'UTR, were engineered and stably transfected into an HEK-293 variant using Flp-In integration, an enzyme-mediated, site-specific recombination technology. (biomedcentral.com)
The present study utilized radioligand binding and immunoblotting techniques to compare in vitro DAT density and ligand affinity across a series of cell lines stably transfected with constructs containing the DAT1 coding region flanked downstream by one of four DAT1 3'UTR variants. (biomedcentral.com)

Centromeres and flanking pericentromeric repeat regions of different chromosomes aggregate and form microscopically visible chromocenters in interphase nuclei [ 26 ]. (biomedcentral.com)

DNA methylation is an important epigenetic control mechanism that in many fungi is restricted to genomic regions containing transposable elements (TEs). (biomedcentral.com)
As these adaptive genomic regions are largely devoid of DNA methylation and of Hp1- and Dim5-associated heterochromatin, the differential transcription is likely caused by pleiotropic effects rather than by differential DNA methylation. (biomedcentral.com)
Dim2 operates in a complex with Heterochromatin Protein-1 (Hp1) that recognizes and directs DNA methylation to genomic regions marked by tri-methylation of histone 3 lysine 9 (H3K9me3) that is deposited by the histone methyltransferase Deficient In Methylation-5 (Dim5) [ 11 , 12 ]. (biomedcentral.com)
The mouse genomic structure comprises an 8.3 kb region, and contains 6 exons, as indicated by numbered blocks. (bios-mep.info)

To modify the PV, the parasite secretes an array of proteins, including dense granule proteins (GRAs). (biomedcentral.com)

In htz1Delta cells, Sir2 and Sir3 spread into flanking euchromatic regions, producing changes in histone H4 acetylation and H3 4-methylation indicative of ectopic heterochromatin formation. (sdbonline.org)
The histone H2A.F/Z (H2AZ) variant is a functionally distinct, highly conserved histone subgroup that likely represents a separate evolutionary lineage of histone H2A proteins. (sdbonline.org)
Eukaryotic DNA associates with histone-protein complexes to form nucleosomes that are the main constituents of chromatin, a highly ordered DNA-structure [ 4 ]. (biomedcentral.com)
ATRX and DAXX facilitate deposition of the histone variant H3.3 within heterochromatic regions suggesting that loss of ATRX, DAXX, and/or H3.3 lead to defects in the stability of telomeric heterochromatin. (oncotarget.com)

The MS4 is a PHD-finger protein which is functionally characterized using Arabidopsis mmd1 mutant. (biomedcentral.com)

The presence of the BEN domains in the BEND2 protein indicates that this protein may be involved in chromatin modification and regulation. (wikipedia.org)
Molecular analysis suggested that Esc2p contributed to silencing in a manner similar to Sir1p and probably helped recruit or stabilize the other Sir proteins, while Htz1p present at HMR assembled a specialized chromatin structure necessary for silencing (Dhillon, 2000). (sdbonline.org)

H2A.Z is preferentially crosslinked in vivo to intergenic DNA at the PH05 and GAL1 loci, and this association changes with transcriptional activation. (sdbonline.org)

4, 5 Four QTLs identified as pulmonary adenoma susceptibility (Pas) loci 1-4 have been mapped, respectively, to mouse chromosomes 6, 17, 19, and 9. (bmj.com)

those containing only the DAT1 coding region or the coding region flanked by a truncated 3' UTR resulted in greater DAT density than either of the naturalistic 9- and 10-repeat variants. (biomedcentral.com)

To verify the biological role of novel identified GRA proteins, we constructed the NcGRA23 and NcGRA11 (a-e) knockout strains using the CRISPR/Cas9 system and analyzed the phenotypes of these mutants. (biomedcentral.com)

This is particularly important at regulatory regions, such as CpG islands (CGIs), which are known to recruit Trithorax (TrxG) and Polycomb group proteins. (biomedcentral.com)

Past studies have mapped four susceptibility loci (Pas1-4) for pulmonary adenoma in which A/J and C57BL/6J (B6) mice have different alleles that affect incidence and multiplicity of tumours. (bmj.com)
Mouse pulmoary adenoma susceptibility loci (Pas) as mapped in crosses of strains A/J and C57BL/6. (bmj.com)

Linkage analysis has identified an ichthyosis vulgaris locus on band 1q22. (medscape.com)

In regions where B. burgdorferi is enzootic, sites as small as a few hectares have between 9 and 15 strains ( 4 - 6 ). (cdc.gov)

A genetic variant in buffalo OLR1 at position 8,232 in the 3′-UTR has been affected by fat content and yield in the Mehsana breed [13]. (researchsquare.com)

In the process called quantitative trait loci (QTL) mapping, attempts are made to find significant correlations between marker alleles and the phenotypic variation, or disease state. (bmj.com)

We have previously shown in humans that an analogous inherited failure to establish imprinting at multiple loci in the female germline underlies a rare phenotype of recurrent hydatidiform mole. (biomedcentral.com)

BEND2 is predicted to be a DNA-binding protein due to the presence of BEN domains at its C-terminus, a hypothesis supported by its localization to the nucleus, the transcription factors found in its promoter region, and the nature of the proteins it interacts with. (wikipedia.org)

Pneumococcal pili have the appearance of flexible rods ranging from 0.3 μm to 3 μm that are formed by a transpeptidase reaction involving sortase-mediated covalent cross-linking of the proteins containing the LPXTG-like motif and several lines of evidence suggest a one-to-one sortase-to-surface-protein correspondence for the proteins encoded by the islet [ 7 ]. (biomedcentral.com)
hence, pneumococcal proteins involved in detection and processing of environmental signals may be targeted to develop new anti-infectives. (frontiersin.org)
A collection of 192 disease-causing pneumococcal isolates was obtained from Kano (n=189) and Abuja (n=3) states, Nigeria, between 1 January 2014 and 31 May 2018. (cdc.gov)

The human dopamine transporter (hDAT), one member of a family of Na + /Cl - dependent transmembrane transport proteins, serves as a critical regulator of dopaminergic neurotransmission throughout much of the brain. (biomedcentral.com)

We present a method enabling simultaneous, ultra-high throughput single-cell barcoding of millions of cells for targeted analysis of proteins and RNAs. (nature.com)

Sequential and mixed infections of reservoirs and tick vectors are common ( 2 , 3 ). (cdc.gov)

In the EV-A71- and mock-infected groups, 210 differentially expressed proteins were found, including 86 upregulated and 124 downregulated proteins, at 24 hpi. (bvsalud.org)
Finally, further in-depth analysis revealed that these differentially expressed proteins contained distinct domains and localized in different subcellular components. (bvsalud.org)

amyloid peptide within the precursor protein. (justia.com)
amyloid precursor protein (.beta.APP), which is expressed in differently spliced forms of 695, 751, and 770 amino acids. (justia.com)
Normal processing of amyloid precursor protein involves proteolytic cleavage at a site between residues Lys.sup.16 and Leu.sup.17 (as numbered for the .nu.AP region where Asp.sup.597 is residue 1 in Kang et al. (justia.com)
This normal pathway cleaves within the region of the precursor protein which corresponds to the .beta. (justia.com)
1992) Science 255:728-730, prepared a series of deletion mutants of amyloid precursor protein and observed a single cleavage site within the .beta. (justia.com)

The mature miRNA is then loaded onto an Argonaute protein (Ago2 in humans) where it then interacts with and regulates the mRNA target. (biomedcentral.com)

The CxxC zinc finger protein 1 (CFP1, also known as CGBP) is a subunit of the TrxG SET1 protein complex, a major catalyst of trimethylation of H3K4 (H3K4me3). (biomedcentral.com)

There are three localizations in PVs within the infected cell where Neospora dense granule proteins (NcGRAs) are exhibited: the vacuolar space, intravacuolar membranous nanotubular network (MNN), and parasitophorous vacuole membrane (PVM). (biomedcentral.com)

To cope with viral infections, vertebrate species have evolved response strategies which can be classified into resistance and tolerance ( 3 ). (frontiersin.org)
The phylogeny and distribution of the TnpB/Fanzor proteins indicate that they may be disseminated among eukaryotic species by viruses. (biomedcentral.com)
The genus is mostly distributed in the Neotropical region and Nearctic region, and partly in the Palaearctic and Afrotripical regions, with more than 190 described species from all over the world (Gielis, 2003). (koreascholar.com)
Among them, approximately 30 species of the genus Hellinsia Tutt have been reported in the Palaeartic region, including 9 species of Japan, 14 of Russia, and 15 of China. (koreascholar.com)

BEND2 is found to interact with the following proteins through experimental yeast two-hybrid screens or pull down assays. (wikipedia.org)

We hypothesize that TnpB/Fanzor proteins may act as methyltransferases. (biomedcentral.com)

Genomatix's MatInspector program predicted 418 transcription factor binding sites within the BEND2 promoter, including for SRY, neurogenin, interferon regulatory factor-3 (IRF-3), Ikaros2, and TCF/LEF-1. (wikipedia.org)

The mechanism by which protein complexes interact to regulate the deposition of post-translational modifications of histones remains poorly understood. (biomedcentral.com)

We demonstrate that this method can be applied to multi-modal protein and RNA analyses. (nature.com)

The receptor of SARS-CoV-2, i.e., angiotensin I converting enzyme 2 (ACE2) is conserved in pangolins ( 18 ) and coronaviruses isolated from pangolins have a receptor binding domain in their spike protein that is uniquely similar to that of SARS-CoV-2 ( 10 , 19 ). (frontiersin.org)

secretase" which cleaves between amino acids 16 and 17 of the protein. (justia.com)

Several proteins have been described in mammals that bind specifically to CGIs. (biomedcentral.com)

Here, removal of intact α 6 protein from cerebellar granule cells allowed perturbations in other subunit levels to be studied. (jneurosci.org)
Because in α 6 −/− neurons the remaining α 1 , β 2/3 , and γ 2 subunits cannot rescue the δ subunit, certain potential subunit combinations may not be found in wild-type cells. (jneurosci.org)

Subsequently, functional enrichment analysis indicated that the up-regulated and down-regulated proteins were individually involved in various biological processes and signaling pathways, including metabolic process, AMPK signaling pathway, Neurotrophin signaling pathway, Viral myocarditis, GABAergic synapse, and so on. (bvsalud.org)

This review emphasizes the potential of analysing chromosomal rearrangements as a means to rapidly define candidate disease loci for further investigation. (neurotransmitter.net)

These data highlight a potentially unrecognized mechanism of DAXX inactivation in ALT positive osteosarcoma and provide rationale for thorough and comprehensive analyses of ATRX/DAXX/H3.3 proteins in ALT positive cancers. (oncotarget.com)
Comparative and phylogenetic analyses show that the higher-order α-satellite structure evolved specifically in the great ape ancestor, and the centromeric region evolved with a layered symmetry," the team writes. (pacb.com)

To ensure the validity and reliability of the proteomics data, 3 randomly selected proteins were verified by Western blot and Immunofluorescence analysis, and the results were consistent with the TMT results. (bvsalud.org)
The frameshift mutation results in the formation of a truncated protein which cannot fold properly, promoting aggregation, and subsequent deposition in tubular cells. (medscape.com)

Filaggrin is an epidermal protein that normally functions as a barrier molecule against environmental allergens, water loss, and infection. (medscape.com)
With minimal instrumentation (four 96-well plates and a multichannel pipette), cell-specific codes are added to each tagged molecule within cells through sequential rounds of classical split-pool synthesis. (nature.com)

The limitations of current methods are particularly evident in the vast noncoding regions of eukaryotic genomes, which, despite important recent progress 3 - 6 , remain poorly annotated and understood. (biorxiv.org)
Here we report two groups of TnpB-like proteins (Fanzor1 and Fanzor2) that are widespread in diverse eukaryotic transposable elements (TEs), and in large double-stranded DNA (dsDNA) viruses infecting eukaryotes. (biomedcentral.com)

Non-LTR retrotransposons need both RT and endonuclease (EN) in their transposition process termed target site-primed reverse transcription (TPRT) [ 12 ]. (biomedcentral.com)

A primary analysis of the 42 ORFs identified in this 43 kb region is presented. (microbiologyresearch.org)

The harmony between Mutation Theory and Mendel model of heredity, the simplicity of the experimental method and the vast accumulation of supporting data, explain the big impact in the biological world [ 3 ]. (intechopen.com)

Isolation of cDNA clone encoding rat senescence marker protein- 30 (SMP30) and its tissue distribution. (microbiologyresearch.org)

The BEND2 protein has 42 known orthologs. (wikipedia.org)

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Information Science5

Named Groups2

Health Care8

Genes24

Gene36

Chromosome8

Sequence14

Mutations3

Homology2

Encodes1

Putative2

Genome5

Exon3

Sequences4

Downstream2

Centromeres1

Genomic4

Array of proteins1

Histone4

Functionally1

Chromatin2

Transcriptional1

QTLs1

Variants1

Phenotypes1

Polycomb1

Susceptibility2

Linkage1

Strains1

Genetic1

Quantitative1

Germline1

Promoter region1

Pneumococcal3

Regulator1

RNAs1

Vectors1

Differentially2

Precursor5

Humans1

Zinc1

Vacuole1

Species4

Yeast1

Methyltransferases1

Regulatory1

Regulate1

Demonstrate1

Receptor1

Amino1

Mammals1

Subunit2

Functional1

Chromosomal1

Analyses2

Results2

Molecule2

Eukaryotic2

Transposition1

Analysis1

Biological1

Marker1

Orthologs1