• Since population genetics and species-specific molecular tools remain unknown for all members of the Curimatidae family, this study developed a set of microsatellite loci and studied the population genetics of C. mivartii in the lower section of the Colombian Magdalena-Cauca basin. (peerj.com)
  • 13,790 primer pairs to amplify unique microsatellite loci in S. haematobium , (available at http://www.cebio.org/projetos/schistosoma-haematobium-genome ). (biomedcentral.com)
  • The genetic structure was accessed by analyzing six microsatellite loci in 74 individuals of A. aestiva , including samples from the two subspecies ( A. a. aestiva and A. a. xanthopteryx ), from five populations: four in Brazil and one in Argentina. (geneticsmr.com)
  • Analyses of high-resolution SNP markers (including candidate loci under selection) illustrated patterns of spatial structure and genetic connectivity not reflected by telemetry data alone. (frontiersin.org)
  • To this aim, we estimated and assessed genetic diversity levels and genetic structure of Egyptian Vulture populations across much of the species' range using both neutral and non-neutral candidate loci involved in migration. (uni-halle.de)
  • Genotype data showed that fshr represents a previously unknown sex-determining locus, though the incomplete association pattern between fshr genotype and sex-phenotype, the variability of such pattern across different populations, and the presence of other candidate loci, reveal that a greater complexity underlies sex determination in the flathead grey mullet. (unica.it)
  • Better (cheaper, quicker, more accurate) ways to validate functionality of candidate loci? (who.int)
  • 0.1), but new risk loci were not found. (ucl.ac.uk)
  • In the past, genome-wide association studies (GWAS) have identified an important number of risk loci associated with AD pathology 3 , but a causal relationship remains difficult to establish. (nature.com)
  • Methods We performed a large-scale exome-wide study in 5004 SLE cases and 8179 healthy controls in a Han Chinese population using a custom exome array, and then genotyped 32 variants with suggestive evidence in an independent cohort of 13 246 samples. (bmj.com)
  • To identify new risk variants and to confirm reported associations, we conducted a genome-wide association study in 1,701 CRC cases and 14,082 cancer-free controls from the Finnish population. (ucl.ac.uk)
  • Mapping and analysis of Pool-Seq data against the draft genome(s) revealed >30 loci potentially associated with sex, the most promising locus of which, encoding the follicle stimulating hormone receptor (fshr) and harbouring two missense variants, was genotyped on 245 fish from four Mediterranean populations. (unica.it)
  • 30 loci potentially associated with sex, the most promising locus of which, encoding the follicle stimulating hormone receptor (fshr) and harbouring two missense variants, was genotyped on 245 fish from four Mediterranean populations. (unica.it)
  • Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project. (bvsalud.org)
  • and several missense variants at the α- globin gene locus were associated with lower hemoglobin . (bvsalud.org)
  • By identifying low-frequency missense variants associated with blood cell traits not previously reported by genome-wide association studies , we establish that exome sequencing followed by imputation is a powerful approach to dissecting complex, genetically heterogeneous traits in large population -based studies. (bvsalud.org)
  • Immunoglobulin ( IG ) loci harbor inter-individual allelic variants in many different germline IG variable, diversity and joining genes of the IG heavy ( IGH ), kappa ( IGK ) and lambda ( IGL ) loci, which together form the genetic basis of the highly diverse antigen-specific B-cell receptors. (molepi.nl)
  • These allelic variants can be shared between or be specific to human populations. (molepi.nl)
  • We could relate the genetic variants to population-specific immune responses, e.g. (molepi.nl)
  • We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. (ox.ac.uk)
  • At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. (ox.ac.uk)
  • and a locus encompassing several genes near NCAN, with variants strongly associated with both triglycerides and LDL cholesterol). (ox.ac.uk)
  • All 10 variants were tested in the Swedish MrOS Cohort (n = 3014), providing evidence for two novel BMD loci (SRR and MSH3). (nih.gov)
  • Methods used in the study are limited by uncertainties in translating genetic loci to causal variants, which restricts the biological interpretation of the shared genetic variants. (medscape.com)
  • The associations between the variants and HNC were evaluated by adjusting for population structure, imputation batch and gender. (who.int)
  • A quantitative trait locus (QTL) is a region of DNA which is associated with a particular phenotypic trait, which varies in degree and which can be attributed to polygenic effects, i.e., the product of two or more genes, and their environment. (wikipedia.org)
  • NEW YORK (GenomeWeb) - The severity of malaria infections caused by Plasmodium falciparum in African children appears to be partly influenced by a locus falling near genes coding for glycophorin proteins involved in red blood cell invasion. (genomeweb.com)
  • This new resistance locus is particularly interesting because it lies so close to genes that are gatekeepers for the malaria parasite's invasion machinery," co-corresponding author Dominic Kwiatkowski, with the Wellcome Trust Sanger Institute and the Wellcome Trust Centre for Human Genetics, said in a statement. (genomeweb.com)
  • After accounting for known malaria risky loci and other potential confounders such as parasite diversity, they narrowed in on a suspicious new chromosome 4 site falling between the FREM3 gene and the GYPE, GYPB, and GYPA genes, which code for glycophorin proteins expressed in the red blood cell membrane. (genomeweb.com)
  • OBJECTIVES: To identify and strengthen additional loci associated with AD and confirm these in an independent sample and to examine the contribution of recently identified genes to AD risk prediction in a 3-stage analysis of new and previously published GWAS on more than 35,000 persons (8371 AD cases). (ox.ac.uk)
  • To explore the genetic predisposition to health-related traits of the Turkish population, we analyzed 34 genes associated with different health-related traits (for example, lipid metabolism, cardio-vascular diseases, hormone metabolism, cellular detoxification, aging and energy metabolism). (maastrichtuniversity.nl)
  • We observed relevant differences between the Turkish population and populations with non-European ancestries (that is, Africa and East Asia) in some of the investigated genes (that is, AGT, APOE, CYP1B1, GNB3, IL10, IL6, LIPC and PON1). (maastrichtuniversity.nl)
  • Genetic studies have repeatedly implicated the DYX2 locus, specifically the genes DCDC2 and KIAA0319 , in RD, with recent studies suggesting they also influence LI, verbal language, and cognition. (springer.com)
  • The INK4/ARF locus encodes three tumor suppressor genes (p15 Ink4b , Arf and p16 Ink4a ) and is frequently inactivated in a large number of human cancers. (plos.org)
  • There is an extensive genetic overlap between schizophrenia and smoking, but there are also schizophrenia genes that may protect against obesity , illustrating the bidirectional effects of shared loci across cardiovascular disease (CVD) risk factors, results of new research suggest. (medscape.com)
  • A genome-wide study in a northern European population replicated the association of SLE with susceptibility genes related to B-cell receptor pathway signaling, as well as confirmed the association of SLE with genes at the interferon regulatory factor 5 (IRF5)-TNPO3 locus. (medscape.com)
  • Variation at 4 polymorphic loci, including the diagnostic creatine kinase (CK-A2*) locus, indicated that 19 populations were of southern origin, 5 of northern origin, and 32 of mixed genetic origin. (intechopen.com)
  • These results replicate the effects of multiple loci on the risk of CRC and identify shared risk alleles between the Finnish population isolate and outbred populations. (ucl.ac.uk)
  • Nevertheless, our results demonstrate that to prevent further population contraction and loss of adaptive alleles, releasing individuals of different origin would also be appropriate. (uni-halle.de)
  • New River drainage populations exhibited the southern allele at high frequency, suggesting their historic native character as southern, with presence of northern alleles due to stocking or stream capture events. (intechopen.com)
  • Genetic variability was higher among mainland P. gunnii than in Tasmanian populations (higher APDs, number of alleles, and heterozygosity at one locus), despite the known decline and subdivision of the Hamilton population. (edu.au)
  • AH alleles at both loci were unique to either Hamilton or Tasmanian P. gunnii. (edu.au)
  • Frequencies of alleles at these loci and their associations were analyzed after two, four and ten years of resowing. (unboundmedicine.com)
  • The ratio of alleles at the studied loci was changed as reproduction occurred. (unboundmedicine.com)
  • Combination of alleles at two, three, and five loci was not accidental. (unboundmedicine.com)
  • The current immunogenetics resources gather the germline alleles, however, lack the population specificity of the alleles which poses limitations for disease-association studies related to immune responses in different human populations. (molepi.nl)
  • Therefore, we systematically identified germline alleles from 26 different human populations around the world, profiled by "1000 Genomes" data. (molepi.nl)
  • The lack of diverse ethnic representation in these data has created a gap in knowledge about the alleles present in non-White populations and their relative frequencies. (cdc.gov)
  • To obtain a more complete picture of the PGx alleles present in a diverse US population, approximately 5,000 DNA samples from the population-based NHANES will be tested to determine the PGx allele frequencies of 970 unique haplotypes in 150 pharmacogenes. (cdc.gov)
  • The PGx alleles will be correlated with sample ethnicity to determine the allele frequency of each pharmacogene in the various population groups. (cdc.gov)
  • This will facilitate development and validation of PGx tests capable of detecting important PGx alleles in African American, Asian, Hispanic, and White populations. (cdc.gov)
  • Nonetheless, carriage of specific alleles of HLA imparts about a 2-fold risk of SLE above that of the general population. (medscape.com)
  • This information provides a baseline for designing conservation and management programs for C.mivartii and constitutes the first study of population genetics in Curimatidae. (peerj.com)
  • Wright and others formalized population genetics theory that had been worked out over the preceding 30 years explaining how such traits can be inherited and create stably breeding populations with unique characteristics. (wikipedia.org)
  • Quantitative trait genetics today leverages Wright's observations about the statistical relationship between genotype and phenotype in families and populations to understand how certain genetic features can affect variation in natural and derived populations. (wikipedia.org)
  • 9 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA. (nih.gov)
  • The methods treated cover a large number of topics from traditional population genetics to large-scale genomics with high-throughput sequencing data. (routledge.com)
  • The search led to a haplotype falling in a chromosome 4 locus that's undergone balancing selection early in the human lineage. (genomeweb.com)
  • Chromosome 4q locus associated with insulin resistance in Pima Indians. (ox.ac.uk)
  • The higher risk of SLE in women and men with Klinefelter syndrome may be associated with enhanced expression of toll-like receptor 7 (TLR7), a key pathogenic factor in SLE that is encoded on an X chromosome locus. (medscape.com)
  • Here, we introduce a simple, robust, and generalizable platform for quantitative and massively parallel single cell sequencing of target genetic loci in microbes using ultrahigh-throughput droplet microfluidics (Droplet Targeted Amplicon Sequencing or DoTA-seq). (biorxiv.org)
  • The novel intergenic variant rs10750836 exhibited an expression quantitative trait locus effect on the TPCN2 gene in immune cells. (bmj.com)
  • A quantitative trait locus (QTL) is a locus (section of DNA) that correlates with variation of a quantitative trait in the phenotype of a population of organisms. (wikipedia.org)
  • Castle's was perhaps the first attempt made in the scientific literature to direct evolution by artificial selection of a trait with continuous underlying variation, however the practice had previously been widely employed in the development of agriculture to obtain livestock or plants with favorable features from populations that show quantitative variation in traits like body size or grain yield. (wikipedia.org)
  • We find that PM20D1 is a methylation and expression quantitative trait locus coupled to an AD-risk associated haplotype, which displays enhancer-like characteristics and contacts the PM20D1 promoter via a haplotype-dependent, CCCTC-binding-factor-mediated chromatin loop. (nature.com)
  • Twenty‐seven quantitative trait loci ( QTL ) were detected for manually collected traits associated with biomass production. (osti.gov)
  • We carried out an expression quantitative trait loci (eQTL) study of primary human osteoblasts (HOb) derived from 95 unrelated donors of Swedish origin, each represented by two independently derived primary lines to provide biological replication. (nih.gov)
  • ConjFDR identified 79 unique loci associated with depression and coronary artery disease or cardiovascular risk factors. (plos.org)
  • We then evaluated the effects of the currently proposed population management scheme and candidate source populations on retaining allelic diversity. (uni-halle.de)
  • Landscape genetic analyses showed a pattern of IBD for all loci and the panel of NTL, but genetic differentiation estimated at TL was only explained by IBR models considering high resistance for natural vegetation and low resistance for agricultural lands. (datadryad.org)
  • Evidence of population sub-structuring across The Bahamas was demonstrated and supported by discriminate analysis of principal components (DAPCs) along with analyses of molecular variance (AMOVAs). (frontiersin.org)
  • Functional analyses of the shared loci implicated metabolism of alpha-linolenic acid pathway for type 2 diabetes. (plos.org)
  • Interethnic analyses of blood pressure loci in populations of East Asian and European descent. (ox.ac.uk)
  • Six loci were polymorphic using the 0.05 criterion of polymorphism. (udg.edu)
  • These WBC subtype-related loci demonstrated a variety of patterns of pleiotropic associations within the WBC subtypes, or with total WBC count, platelet count, or red blood cell-related traits (n = 30,454), which suggests unique and common functional roles of these loci in the processes of hematopoiesis. (figshare.com)
  • As most complex traits are highly polygenic, we developed polygenic scores associated with different health-related traits to explore the genetic diversity of the Turkish population with respect to other human groups. (maastrichtuniversity.nl)
  • Plant area index ( PAI ) estimated from below‐canopy hemispherical images, as well as a suite of thirteen traits assessed by manual destructive harvests, were measured in a Setaria recombinant inbred line mapping population segregating for aboveground productivity and architecture. (osti.gov)
  • Single cell genetic heterogeneity is ubiquitous in microbial populations and an important aspect of microbial biology. (biorxiv.org)
  • Hybrid population with heterogeneity for five gliadin-coding loci was created by crossing of five winter common wheat cultivars (Belozerskaya 47, Ilyichevka, Kyyanka, Mironovskaya 808, Polesskaya 70) by the complete scheme. (unboundmedicine.com)
  • AU - Koliuchiĭ,V T, AU - Sozinov,A A, PY - 2000/6/17/pubmed PY - 2000/8/19/medline PY - 2000/6/17/entrez SP - 32 EP - 8 JF - TSitologiia i genetika JO - Tsitol Genet VL - 34 IS - 2 N2 - Hybrid population with heterogeneity for five gliadin-coding loci was created by crossing of five winter common wheat cultivars (Belozerskaya 47, Ilyichevka, Kyyanka, Mironovskaya 808, Polesskaya 70) by the complete scheme. (unboundmedicine.com)
  • Together, our linkage data from the informative family 1270 and the association data in the population-based early-onset AD patient-control sample strongly support the identification of a novel AD locus at 7q36 and re-emphasize the genetic heterogeneity of AD. (ox.ac.uk)
  • The study of the factors structuring genetic variation can help to infer the neutral and adaptive processes shaping the demographic and evolutionary trajectories of natural populations. (datadryad.org)
  • Overall, our study shows that markers located in different genomic regions can yield contrasting inferences on landscape-level patterns of realised gene flow in natural populations. (datadryad.org)
  • 10(-3)) in a sample of 3006 AD cases and 14,642 controls by combining new data from the population-based Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (1367 AD cases [973 incident]) with previously reported results from the Translational Genomics Research Institute and the Mayo AD GWAS. (ox.ac.uk)
  • Genomic DN A variability was compared within and between surviving populations of P. gunnii using variable number of tandem repeat (VNTR) markers in one of two ways. (edu.au)
  • Graduate students and post-doctorate researchers will find resources to analyze their population genetic and genomic data as well as help them design new studies. (routledge.com)
  • The first four chapters review the basics of population genomics, data acquisition, and the use of R to store and manipulate genomic data. (routledge.com)
  • The other five chapters cover linkage disequilibrium, population genomic structure, geographical structure, past demographic events, and natural selection. (routledge.com)
  • The analysis of natural selection, a traditional issue in evolutionary biology, has known a revival with modern population genomic data. (routledge.com)
  • CONCLUSIONS: Two genetic loci for AD were found for the first time to reach genome-wide statistical significance. (ox.ac.uk)
  • ABSTRACT A cross-sectional multistage stratified cluster survey of 1798 Kuwaiti male adults investigated the relationship between health locus of control (HLC) beliefs, health beliefs about smoking and smoking status. (who.int)
  • Secondly, because one of these combinations revealed two multiallelic VNTR loci, genotypes were assigned and analysed for homogeneity of allele frequencies among subpopulations, for deviation of heterozygosity from Hardy‐Weinberg equilibrium within populations and for genetic structuring among individuals from different subpopulations. (edu.au)
  • A significant correlation was observed between PAI and biomass production across the population at maturity ( r 2 = .60), as well as for select diverse genotypes sampled repeatedly over the growing season ( r 2 = .79). (osti.gov)
  • The top 10 BMD loci with SNPs showing strong cis-effects on gene expression in HObs (P = 6 x 10(-10) - 7 x 10(-16)) were selected for further validation using a staged design in two cohorts of Caucasian male subjects. (nih.gov)
  • It is concluded that VNTR markers can be of benefit for use in studies of population differentiation and for conservation management. (edu.au)
  • Microsatellite DNA loci are genetic markers in wide use by Schistosoma researchers, but there are few primers available for S. haematobium . (biomedcentral.com)
  • About half of the primers in the database of Schistosoma haematobium microsatellite DNA loci should yield amplifiable and easily scored polymorphic markers, thus providing thousands of potential markers. (biomedcentral.com)
  • These markers will assist in the management of isolated populations and the evaluation of wildlife corridors. (researchgate.net)
  • Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). (ox.ac.uk)
  • In order to determine this differentiation, established allozyme markers were used to classify 56 southwest Virginia populations as southern, northern, or introgressed. (intechopen.com)
  • We examined the genetic population structure of the european hake (Merluccius merluccius) using electrophoretically detectable population markers in 35 protein loci. (udg.edu)
  • Despite these significant findings, it is important to note that imputed data for the HLA locus may pose challenges due to high level of linkage disequilibrium and polymorphism. (who.int)
  • Our results show low differentiation values among populations and absence of genetic structure which point to past high gene flow. (uni-halle.de)
  • We now need to drill down at this locus to characterize these complex patterns of genetic variation more precisely and to understand the molecular mechanisms by which they act," Kwiatkowski added. (genomeweb.com)
  • For the current study, the team set out to expand on those findings, first assessing genetic patterns in 5,633 children with severe malaria from The Gambia, Kenya, and Malawi and more than 5,900 unaffected children from the same populations. (genomeweb.com)
  • Population genetic differentiation was mostly detected using the panel of NTL. (datadryad.org)
  • Population genetic evidence suggests differentiation among evolutionarily significant units of southern and northern Appalachian brook trout, with the zone of contact in southwestern Virginia. (intechopen.com)
  • Eleven per cent of the variability detected in Hamilton was attributed to genetic differentiation between east and west subdivisions of the population. (edu.au)
  • A significant genetic differentiation (θ = 0.007, p = 0.005) could be detected only between the most distant populations, Tocantins and Argentina, localized at the northeast and southwest limits of the sample sites, respectively. (geneticsmr.com)
  • Genome-wide association studies (GWAS) have detected several loci associated with CVD risk factors, including body mass index (BMI), waist-to-hip ratio, type 2 diabetes , lipids , and blood pressure, with increasing evidence suggesting genetic overlap between such risk factors and schizophrenia. (medscape.com)
  • In 2014, Genome-Wide Association Study (GWAS) was performed with 2,398 individuals with laryngeal squamous cell carcinoma cases and 2,804 cancer-free controls from Chinese populations, and identified a novel susceptibility loci in complex human leukocyte antigen (HLA), which plays crucial role in immune response. (who.int)
  • More GWAS (new populations, larger numbers)? (who.int)
  • There was a pattern of mixed effect directions among loci jointly associated with schizophrenia and lipids, blood pressure, type 2 diabetes, waist-to-hip ratio, and coronary artery disease , which may reflect variation in genetic susceptibility to CVD across subgroups of schizophrenia. (medscape.com)
  • In conclusion, the present study suggests that management of southern Appalachian brook trout should include: (1) genetically cognizant planning of stocking events, (2) management of populations on a stream-by-stream basis, (3) prioritized conservation of pure southern brook trout populations, and (4) use of southern Appalachian hatchery stocks in restoration efforts. (intechopen.com)
  • Loci associated with increased risk for depression were also associated with increased risk of coronary artery disease and higher total cholesterol, low-density lipoprotein and c-reactive protein levels, while there was a mixed pattern of effect direction for the other risk factors. (plos.org)
  • Upon senescence, Jmjd3 is overexpressed and the MLL1 protein is recruited to the locus provoking the dissociation of Polycomb from the INK4/ARF locus, its transcriptional activation and its replication during early S-phase. (plos.org)
  • Description of protein loci and genetic divergence between Atlantic and Mediterranean populations = Anàlisi de la variabilitat genètica en el lluç europeu, Merluccius merluccius. (udg.edu)
  • Since the present-day Omani population is the result of an admixture of Caucasian, African and Asian ancestries, we compared the pharmacogenetic profile of these three loci in this population. (elsevierpure.com)
  • However, limitations and usefulness of such comparisons warrant caution, as the data from pharmacogenetic literature do not always represent bona fide population categories. (elsevierpure.com)
  • Furthermore, definition of study population based on microgeographical scale would be more appropriate in pharmacogenetic research rather than the flawed racial, ethnic, or social categorizations since pharmacogenetic variation is clinal, and genetic influences will be further altered by lifestyle and environmental factors. (elsevierpure.com)
  • Most population-based genetic studies, including those examining pharmacogenetic loci, have been conducted primarily on individuals of European ancestry . (cdc.gov)
  • Here, we analyse the role of isolation-by distance (IBD), isolation-by-resistance (IBR, defined by landscape composition), and isolation by environment (IBE, estimated as habitat and elevation dissimilarity) in structuring genetic variation of 25 blue tit (Cyanistes caeruleus) populations. (datadryad.org)
  • A review of morphological variation together with the genetic data presented here suggest that the populations of hake from these areas are subdivided into two different stocks: the North-Atlantic stock and the Mediterranean stock. (udg.edu)
  • Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. (ox.ac.uk)
  • Genetic loci were functionally annotated using FUnctional Mapping and Annotation (FUMA). (plos.org)
  • It remains to be determined whether PAXIP1 has a functional role in the expression of AD in family 1270 or whether another mutation at this locus explains the observed linkage and sharing. (ox.ac.uk)
  • We used the bivariate causal mixture model (MiXeR) to quantify genome-wide polygenic overlap and the conditional/conjunctional false discovery rate (pleioFDR) method to identify shared loci, based on genome-wide association study summary statistics on depression (n = 450,619), coronary artery disease (n = 502,713) and nine cardiovascular risk factors (n = 204,402-776,078). (plos.org)
  • We further evaluated associations in the identified loci using 15,600 subjects from Caucasian populations. (figshare.com)
  • Here, we characterize the relationship of the DYX2 locus with RD, LI, and IQ. (springer.com)
  • Fine characterisation of a recombination hotspot at the DPY19L2 locus and resolution of the paradoxical excess of duplications over deletions in the general population. (medlineplus.gov)
  • The results were further evaluated by simulation to assess the probability of obtaining significant evidence in favor of linkage by chance as well as to take into account the possible influence of the BRCA2 locus, located at a recombination fraction of 0.25 from the new locus. (lu.se)
  • Curimata mivartii , a member of this family, is considered a short-distance migratory species (≤100 km), categorized by the International Union for Conservation of Nature as a near threatened species, based on its declining population densities and habitat disturbance and fragmentation. (peerj.com)
  • Genome sequences and population genetic parameters can give insight into the potential for population- or species-level drug resistance. (biomedcentral.com)
  • We assembled and aligned the S. haematobium sequences to the genomes of S. mansoni and S. japonicum , identifying microsatellite DNA loci across all three species and designing primers to amplify the loci in S. haematobium . (biomedcentral.com)
  • Thus, for the management and conservation of the species, the populations from Argentina and Tocantins should be considered as different management units, and the other populations from the center of the geographical distribution as another management unit. (geneticsmr.com)
  • There is substantial overlap between our iron loci and loci affecting erythrocyte and lipid phenotypes. (ox.ac.uk)
  • Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (ox.ac.uk)
  • To accomplish this, we developed a marker panel densely covering the 1.4 Mb DYX2 locus and assessed association with reading, language, and IQ measures in subjects from the Avon Longitudinal Study of Parents and Children. (springer.com)
  • This study evaluates the Leadership and Organizational Change for Implementation (LOCI) strategy and its effect on implementation leadership, transformational leadership, and implementation climate. (biomedcentral.com)
  • The objectives of the present study were to analyze the genetic structure of A. aestiva to identify management units and support conservation planning and to verified if A. aestiva populations have undergone a recent bottleneck due to habitat loss and capture for the pet trade. (geneticsmr.com)
  • In this study, we are presenting an analysis of GlobalFiler STR loci on 209 unrelated individuals from Serbia. (edu.au)
  • This is the first study to evaluate the spectrum and prevalence of dose-predictive genetic polymorphisms of the CYP2C9, CYP4F2 and VKORC1 loci together, in a geographically defined, ethnically admixed healthy adult Omani population sharing common lifestyle/environmental factors. (elsevierpure.com)
  • We obtained conclusive linkage of Alzheimer disease (AD) with a candidate region of 19.7 cM at 7q36 in an extended multiplex family, family 1270, ascertained in a population-based study of early-onset AD in the northern Netherlands. (ox.ac.uk)
  • Our study highlights how including proportionally more participants from underrepresented populations improves genetic prediction of PSA levels, with potential to personalize prostate cancer screening. (lu.se)
  • Allele frequencies will also be correlated with prescription drug use among the different ethnic groups to study whether drugs prescribed for each are appropriate given the PGx allele frequency determined for the population and how the drugs prescribed could be modified if more comprehensive PGx testing were available. (cdc.gov)
  • The results of this study could be used to promote the uptake of clinical PGx testing to enhance precision medicine, especially in underrepresented populations. (cdc.gov)
  • Therefore, in this study, we are investigating the relationship between HNC and HLA loci using an advanced fine-mapping approach and a significantly larger dataset. (who.int)
  • Novel HLA loci associated with HNC are expected to be discovered in this study. (who.int)
  • This theoretical study discusses the case of mental health care from the perspective of social determinants of health considering the concrete territories of rural populations. (bvsalud.org)
  • We here investigated overlap at the genome-wide level and in individual loci between depression, coronary artery disease and cardiovascular risk factors. (plos.org)
  • Changing this trajectory will require coordinated research and management approaches to develop a more robust understanding of population demographics and ecology at both small and large spatial scales. (frontiersin.org)
  • The results of both the APD and defined locus approaches showed consistent trends within and between populations. (edu.au)
  • One of the primary goals of conservation translocation programs should be the maintenance of both population demographic stability and genetic diversity. (uni-halle.de)
  • Furthermore, there was no predicted significant impact of different source populations on the genetic diversity of the recipient Balkan population. (uni-halle.de)
  • We also found that the declining Egyptian Vulture population in the Balkans still retains high levels of genetic diversity and therefore genetic diversity restoration is not currently needed. (uni-halle.de)
  • However, without any management, diversity is likely to decrease fast because of increased genetic drift as the population size continues to decline. (uni-halle.de)
  • On average over loci, 96.92 % of the total gene diversity was contained within samples, 0.23 % expressed differences among locations within areas, and 2.64 % differences between regions. (udg.edu)
  • Most of the human SNP diversity at a given locus may be described as a set of "canonical" haplotypes, representing common haplotypes in a population. (bmj.com)
  • Previous studies have people who score external on locus of con- found an association and an influence of trol are more likely to attribute life's suc- cultural origin over generalized locus of cesses and failures to factors such as fate, control. (who.int)
  • mentioned "an internal locus of indeed, an association between internality control may facilitate selection into higher and the likelihood of making healthy choic- status groups and occupations by fostering es [ 3,4 ]. (who.int)
  • Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample. (ox.ac.uk)
  • Genome-wide association studies have identified more than 100 genetic loci for SLE susceptibility across populations, with most of the genetic risk shared across borders and ethnicities. (medscape.com)
  • Subsequently, two separate GWASs has been conducted and consistently identified locus in HLA region in association with HNC. (who.int)
  • Data collection for an additional 200 workers is planned to further evaluate the relationships among respiratory outcomes and exposures in this population. (cdc.gov)
  • Creation of the comprehensive PGx data set proposed in this project will, for the first time, help to establish the allele frequencies in 150 pharmacogenes across ethnicities in the US population. (cdc.gov)
  • These loci did not improve AD risk prediction. (ox.ac.uk)
  • The allele frequency was 3.5% in the normal Tunisian population. (who.int)
  • Molecular tools, in particular, will allow researchers to determine whether changes in gene frequencies provide insight into the effectiveness of treatment, understand the impacts of treatment on the gene pool and population structure of Schistosoma parasites, and establish whether movement of humans from refugia or non-treated areas introduces new parasites into local populations [ 4 ]. (biomedcentral.com)
  • We applied a strategy to identify predisposition loci for breast cancer by using mathematical models to identify early somatic genetic deletions in tumor tissues followed by targeted linkage analysis. (lu.se)
  • These unusual haplotypes could represent hemizygous loci resulting from intragenic deletions. (bmj.com)
  • This approach showed significant differences between the Turkish population and populations with non-European ancestries, as well as between Turkish and Northern European individuals. (maastrichtuniversity.nl)
  • In addition, databases that aggregate allele frequencies, such as gnomAD are also biased toward European populations and contain very little information from individuals of African or other ancestries. (cdc.gov)
  • One goal of the SCORE program is to understand and document whether changes in drug tolerance arise during different drug administration programs, and specific genetic assays are needed to better monitor population structure and potential changes in Schistosoma populations under praziquantel treatment. (biomedcentral.com)
  • At least two P. falciparum proteins bind host blood cells via interactions with the glycophorin proteins Glycophorin A and Glycophorin B, the team noted, consistent with a potential role for the glycophorin locus in helping to dodge severe malaria infection. (genomeweb.com)
  • Our results suggest that in young cells Polycomb proteins are recruited to the INK4/ARF locus through CDC6 and the resulting silent locus is replicated during late S-phase. (plos.org)
  • Together, these results provide a unified model that integrates replication, transcription and epigenetics at the INK4/ARF locus. (plos.org)
  • The results warrant studies of this putative breast cancer predisposition locus in other populations. (lu.se)
  • Instead Darwin used the emergence of such features in breeding populations as evidence that mutation can occur at random within breeding populations, which is a central premise of his model of selection in nature. (wikipedia.org)
  • This last finding is in agreement with the genetic structure of European and Middle East populations, and may also agree with epidemiological evidences about the health disparities of Turkish communities in Northern European countries. (maastrichtuniversity.nl)
  • However, the LD structure of the locus suggests that associations within TDP2 , ACOT13 , and C6orf62 are capturing a previously reported risk variant in KIAA0319 . (springer.com)