Loci achaete scute complex genome region. Medical search. Frequent questions

Folate plays an important role in the modulation of one-carbon metabolism and DNA methylation through a complex biosynthesis pathway. (bvsalud.org)
Genome-wide placental DNA methylation patterns were relatively stable and not significantly affected by levels of one-carbon metabolites. (bvsalud.org)
MTHFR genotype was associated with DNA methylation of several loci, including a locus in the MTHFR region. (bvsalud.org)
RBC folate and particularly the SAM:SAH ratio did affect overall CpG DNA methylation in some CpG regions when the loci were split according to their CpG island relation. (bvsalud.org)
The study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis, methylation quantitative trait loci, colocalization, and promoter-anchored chromatin interaction. (inra.fr)

Genetic Loci" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)

During embryogenesis Drosophila constructs a complex pattern of larval muscles beneath the newly forming epidermis. (biologists.com)
The Enhancer of split complex (E[spl]-C) includes eight genes spread over 50 kilo bases on the Drosophila third chromosome. (sdbonline.org)
Other examples of Drosophila gene complexes include the Antennapedia complex (ANTP-C), the bithorax complex (BX-C) and the achaete-scute complex (AS-C). The hallmark of all these gene complexes, including the E(spl)-C is that within any complex the genes are evolutionarily related and jointly regulated. (sdbonline.org)
In Drosophila, the majority of Notch target genes known so far is located in the Enhancer of split complex , encoding small basic helix-loop-helix (bHLH) proteins that presumably act as transcriptional repressors. (sdbonline.org)

TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme that performs the transcription of genetic information from DNA to RNA) to specific genes. (wikipedia.org)
Therefore, approximately 10% of genes in the genome code for transcription factors, which makes this family the single largest family of human proteins. (wikipedia.org)
Transcription factors bind to either enhancer or promoter regions of DNA adjacent to the genes that they regulate. (wikipedia.org)
Other transcription factors differentially regulate the expression of various genes by binding to enhancer regions of DNA adjacent to regulated genes. (wikipedia.org)
The phenomenon of a group of genes with the same function and location on the chromosome signifies a so-called gene complex. (sdbonline.org)
Each gene in any given cluster or complex of genes will have a similar function and structure to the others in its group. (sdbonline.org)
We also observed hypermethylation at the promotor regions of autophagy genes (LC3B, ATG-5, and ATG-7). (bvsalud.org)

The number of transcription factors found within an organism increases with genome size, and larger genomes tend to have more transcription factors per gene. (wikipedia.org)
There are approximately 2800 proteins in the human genome that contain DNA-binding domains, and 1600 of these are presumed to function as transcription factors, though other studies indicate it to be a smaller number. (wikipedia.org)
Hence, the combinatorial use of a subset of the approximately 2000 human transcription factors easily accounts for the unique regulation of each gene in the human genome during development. (wikipedia.org)

Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. (childrensmercy.org)
For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. (childrensmercy.org)

Initially documented by Papez (1937) and elaborated by MacLean (1949) , social cognition occurs through a complex neural network of interconnected structures, which includes areas in the ventromedial aspect of the temporal and frontal lobes, and their connections with the hypothalamus and brainstem. (frontiersin.org)

The preinitiation complex binds to promoter regions of DNA upstream to the gene that they regulate. (wikipedia.org)
The region is believed to regulate GENETIC TRANSCRIPTION by opening and remodeling CHROMATIN structure. (bvsalud.org)

There are 1500-1600 TFs in the human genome. (wikipedia.org)
A regulatory region first identified in the human beta-globin locus but subsequently found in other loci. (bvsalud.org)

This graph shows the total number of publications written about "Genetic Loci" by people in this website by year, and whether "Genetic Loci" was a major or minor topic of these publications. (childrensmercy.org)

Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma. (childrensmercy.org)

Fundamental differences exist between proteins when comparing one complex to another. (sdbonline.org)

Other transcription factors differentially regulate the expression of various genes by binding to enhancer regions of DNA adjacent to regulated genes. (wikipedia.org)
Here, we found that methylation of the Ascl2 promoter (bp -1670 ∼ -1139) was significantly increased compared to the other regions of the Ascl2 locus in CRC cells and was associated with elevated Ascl2 mRNA expression. (nih.gov)

The number of transcription factors found within an organism increases with genome size, and larger genomes tend to have more transcription factors per gene. (wikipedia.org)
Hence, the combinatorial use of a subset of the approximately 2000 human transcription factors easily accounts for the unique regulation of each gene in the human genome during development. (wikipedia.org)
The preinitiation complex binds to promoter regions of DNA upstream to the gene that they regulate. (wikipedia.org)
Promoters are considered distinct if they originate from different gene loci or different species. (expasy.org)

The region contains genes encoding BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS that play a critical role in the regulation of pattern formation during EMBRYONIC DEVELOPMENT. (nih.gov)

A 20 cM region of mouse chromosome 17 that is represented by a least two HAPLOTYPES . (nih.gov)
The chromosome region which is active in nucleolus formation and which functions in the synthesis of ribosomal RNA . (nih.gov)
Homologous chromosomal regions at either end of the X CHROMOSOME or Y CHROMOSOME. (bvsalud.org)

Multiple isolates of viruses or transposable elements are considered distinct if at least one promoter region fails to fulfill the above similarity criterion. (expasy.org)

These two regions pair regularly at male MEIOSIS and undergo RECOMBINATION. (bvsalud.org)