The present invention relates to methods, kits and systems for predicting the benefit from inclusion of taxane in a chemotherapy regimen based on the measurements of gene expression levels in tumor samples of breast cancer patients. (justia.com)
In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
More over, since most tumor specimens Decitabine Antimetabolites inhibitor and tumor derived cell lines utilized in these investigations have now been ovarian SACs, the position of mTOR in CCC remains largely as yet not known. (deubiquitinase.com)
Chromosome6
Hybrid cells are useful in a variety of ways, e.g., (i) to study the control of cell division and gene expression, (ii) to investigate malignant transformations, (iii) to obtain viral replication, (iv) for gene or chromosome mapping and for (v) production of monoclonal antibodies by producing hybridoma (hybrid cells between an immortalised cell and an antibody producing lymphocyte), etc. (wikipedia.org)
If there is a perfect correlation between the presence and absence of a human chromosome and that of a trait in the hybrid clones, the gene governing the trait is taken to be located in the concerned chromosome. (wikipedia.org)
The ITPA gene is located on the short arm of chromosome 20 (20p13). (ectrx.org)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
lt;p>Mutant 84605 which was obtained from wild type Neurospora crassa following X-ray treatment differs from wild type by a single gene located 4.8 units from the centromere of the second chromosome. (caltech.edu)
The GHSR gene (GHSR) is located at chromosome 3q26.31 and consists of two exons and one intron. (xcessbio.com)
In addition, a marker was inserted into the hemolysin gene locus (hlyA) to enable differentiation of the vaccine strain from wild type V. cholerae O1. (rxlist.com)
Prevents1
CVD 103-HgR was constructed from the serogroup O1 classical Inaba strain 569B by deleting the catalytic domain sequence of both copies of the ctxA gene, which prevents the synthesis of active cholera toxin ( CT ). (rxlist.com)
Exons1
9 Sumi and colleagues have previously determined the genomic structure of the ITPA gene, which consists of 8 exons and is about 13 kb long. (ectrx.org)
Substance1
However, this substance was carefully located in the vicinity of the Y143, N155 and Q148 remains, thus confirming the role of these three amino-acids. (deubiquitinase.com)
Cell2
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
Sequence2
Alteration of ITPA gene is one of the phar-macogenetic sequence variants possibly involved in thiopurine metabolism. (ectrx.org)
A gene sequence variant in kidney transplant recipients. (ectrx.org)
Expression1
Methods and materials Reagents/Antibodies Gene expression RAD001 was obtained from Novartis Pharma AG. (deubiquitinase.com)
Cancer1
Finally, City of Hope located in Duarte contributes significantly to the fight against appendix cancer through their four active clinical trials that pursue new avenues of treatment and potentially life-saving interventions. (withpower.com)
Germline mutation of one TP53 allele is found in patients with Li-Fraumeni syndrome who generally inherit a mutated TP53 gene from an affected parent. (medscape.com)
Blocks1
Antimetabolite aminopterin blocks the cellular biosynthesis of purines and pyrimidines from simple sugars and amino acids. (wikipedia.org)
Usually located2
Clinically, cSCC presents as a shallow ulcer with elevated margins, often covered by a plaque and usually located in a sun-exposed area. (medscape.com)
Lipomas These occur most frequently in budgerigars and are usually located on the keel or in the sterno pubic area. (kipdf.com)
Group1
6,7 Inosine triphosphate pyrophosphates (ITPases) represent a ubiquitous group of protective enzymes encoded by the ITPA gene and function to prevent the incorporation of noncanonical (so-called rogue) purine nucleotides into DNA and RNA. (ectrx.org)
Cells1
The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
Area1
Xanthomas These are generally friable, yellow-colored, fatty-appearing masses that may be located anywhere on the body, but are often seen on the distal wing, in the sternopubic area and on the keel (see Chapter 13, Integument). (kipdf.com)
Tumor supp4
1] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene (RB1) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
this finding indicates that ARF is a true tumor suppressor gene. (medscape.com)
Allele loss and loss of expression of fragile histidine triad (FHIT), a putative tumor suppressor gene located in chromosome region 3p14.2, are frequent in several types of cancers. (nih.gov)
The growth of normal and cancerous cells is genetically controlled by the balance or imbalance of oncogene and tumor suppressor gene protein products. (basicmedicalkey.com)
Antineoplastic1
With the exception of rituximab (HR 1.72, 1.10-2.69), there was no increased risk of mechanical ventilation or in-hospital death for the rheumatological, antineoplastic, or antimetabolite therapies examined. (covidreference.com)
Mutations6
Depending upon the precise genetic background of the strain in question, mutations in the pfmdr1 gene can also modulate levels of CQ resistance in parasites, as would be predicted from the study above, [ 56 ] but only if pfcrt is already mutated to a resistant form. (medscape.com)
[ 62 ] A further complication is that mutations in pfcrt alone have also been shown to correlate with changes in the expression levels of at least 45 other genes with a range of functions, relative to wild-type. (medscape.com)
Mutations in the gene that encode this kinase are associated with X-LINKED AGAMMAGLOBULINEMIA. (nih.gov)
BACKGROUND: Fabry disease (FD) is a rare X-linked, lysosomal storage disorder caused by mutations in the alpha-galactosidase gene and characterized by neurological, cutaneous, renal, cardiovascular, cochleo-vestibular and ocular manifestations. (bvsalud.org)
B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. (blogspot.com)
Approximately 20% of ovarian cancers are familial, and although most of these are linked to mutations in either the BRCA1 or BRCA2 gene, several other genes have been implicated. (gvortho.com)
BRAF1
Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. (blogspot.com)
Thymidine1
A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. (lookformedical.com)
Genetic1
Genetic alterations in the p53 gene in the blast crisis of chronic myelogenous leukemia: analysis by polymerase chain reaction based techniques. (sagepub.com)
Commonly2
Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)
5-fluorouracil (5-FU), an antimetabolite in the fluoropyrimidine class, is the third most commonly used chemotherapeutic agent worldwide for the treatment of solid malignancies [1]. (scientificarchives.com)
Patients2
Germline mutation of one TP53 allele is found in patients with Li-Fraumeni syndrome who generally inherit a mutated TP53 gene from an affected parent. (medscape.com)
Depending on where the psoriasis is located on the body, some patients might feel embarrassed about their condition. (contemporaryclinic.com)
Pathway1
Therefore, both INK4A and ARF appear to be tumor suppressor genes, acting through either the Rb protein (INK4A) pathway or the TP53 (ARF) pathway in different tumor subsets. (medscape.com)
Specific4
We investigated 5' CpG island methylation of the FHIT gene in 107 primary non-small cell lung cancer (NSCLC) samples and corresponding nonmalignant lung tissues, 39 primary breast carcinomas, as well as in 49 lung and 22 breast cancer cell lines by a methylation-specific PCR assay. (nih.gov)
Toward monitoring specific DNA lesions in the gene by using pollen systems. (nih.gov)
Specific gene systems expressed in cereal pollen could contribute uniquely to the problem of monitoring our environment for mutagens. (nih.gov)
plate_name plate name A C177536 GDC Property Terminology C181708 Assay Plate Well Identifier The identifier assigned to a single well where a specific sample is located in a plate used in an assay. (nih.gov)
Important1
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
Cell-cycle2
In addition, p19ARF binds to and promotes the degradation of MDM2, the product of the murine double minute 2 gene, and this degradation leads to accumulation of TP53 and to cell cycle arrest. (medscape.com)
The circadian regulation extends beyond clock genes to involve various clock-controlled genes (CCGs) including various cell cycle genes. (biomedcentral.com)
Additional2
[ 36 ] Moreover, even in strains with identical pfcrt and pfmdr1 haplotypes, there is still significant variation in measured levels of CQ resistance, indicating that additional genes can make a contribution to the precise phenotype. (medscape.com)
A data dictionary and additional information is located on the Data Resource Page . (sbir.gov)
Human1
1 NEUPOGEN ® is produced by Escherichia coli (E coli) bacteria into which has been inserted the human granulocyte colony-stimulating factor gene. (nih.gov)
Development4
Therefore, identification of gene markers that can accurately predict the development of adverse drug reactions is useful for selecting effective drugs for therapy. (tokushima-u.ac.jp)
Results: The rs9394992 polymorphism in the SLC29A1 gene and rs3886768 polymorphism in the DCTD gene were associated with the development of rash after Ara-C therapy. (tokushima-u.ac.jp)
Conclusions: Our findings suggest that SNPs in the Ara-C metabolic genes influence the development of adverse reactions to Ara-C, and the results suggest that these genes can be predictive of adverse reactions to Ara-C therapy. (tokushima-u.ac.jp)
This paper considers the development of a mutagen monitor with quantitative endpoints that reflect particular types of lesions at the DNA level, and lesions in particular components of the gene. (nih.gov)
Activity2
Beclin-1 gene overexpression is significantly correlated with disease activity parameters (DAS 28, patient and physician global health assessment). (springeropen.com)
Thirty waxy mutant lines, induced by sodium azide and gamma-rays have been selected and are being characterized for spontaneous and induced reversion frequencies, allelism, karyotype, amylose content, and UDP glucose glucosyltransferase (waxy gene product) activity. (nih.gov)
Study1
Therefore, we conducted an association study between the adverse reactions to cytarabine therapy and single nucleotide polymorphisms (SNPs) in cytarabine metabolic genes. (tokushima-u.ac.jp)
Affect1
In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
Body2
The circadian timing system comprises peripheral oscillators located in most tissues of the body and a central pacemaker located in the suprachiasmatic nucleus (SCN) of the hypothalamus. (biomedcentral.com)
The fimbriated ends of the fallopian tubes are in close apposition to the ovaries and in the peritoneal space, as opposed to the corpus uteri (body of the uterus) that is located under a layer of peritoneum. (gvortho.com)
Include2
J&J/Janssen adenovirus-based vaccine - This vaccine contains an inactivated adenovirus that has been altered to include the gene (DNA) of the spike protein for the original SARS-CoV-2 virus. (chop.edu)
Include any more information that will help us locate the issue and fix it faster for you. (sagepub.com)