AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceHealth CareGeographicals
ChemoradiotherapyCombined Modality TherapyRadiotherapyRadiotherapy DosageRadiotherapy, AdjuvantCisplatinChemoradiotherapy, AdjuvantCarcinoma, Squamous CellRadiotherapy, ConformalAntineoplastic Combined Chemotherapy ProtocolsFluorouracilNasopharyngeal NeoplasmsHead and Neck NeoplasmsDose FractionationNeoplasm StagingTreatment OutcomeEsophageal NeoplasmsChemotherapy, AdjuvantRadiotherapy, Intensity-ModulatedNeoadjuvant TherapyDisease-Free SurvivalSurvival RateInduction ChemotherapyMucositisRadiation InjuriesLung NeoplasmsSurvival AnalysisEsophagitisHypopharyngeal NeoplasmsLaryngeal NeoplasmsRetrospective StudiesTaxoidsCarcinoma, Non-Small-Cell LungNeoplasm Recurrence, LocalKaplan-Meier EstimateRectal NeoplasmsCarboplatinDrug Administration ScheduleAntineoplastic AgentsBrachytherapyOropharyngeal NeoplasmsRadiation-Sensitizing AgentsRadiotherapy, High-EnergyPrognosisDeoxycytidineDeglutition DisordersPaclitaxelRadiotherapy Planning, Computer-AssistedPharyngectomyOxonic AcidUterine Cervical NeoplasmsFollow-Up StudiesAdenocarcinomaTegafurAntimetabolites, AntineoplasticNeoplasms, Squamous CellFeasibility StudiesEsophagectomyEtoposideRemission InductionPositron-Emission TomographyCarcinoma, Small CellTime FactorsRadiotherapy, Computer-AssistedRadiotherapy, Image-GuidedOrgan Sparing TreatmentsLymphatic MetastasisTreatment FailureRadiation OncologyDose-Response Relationship, RadiationRandomized Controlled Trials as TopicRadiation PneumonitisPreoperative CarePelvic NeoplasmsBrain NeoplasmsRadiation DosageRadiation ToleranceTomography, X-Ray ComputedAnus NeoplasmsRadiosurgeryLaryngectomyFluorodeoxyglucose F18Lymphatic IrradiationDigestive System Surgical ProceduresCranial IrradiationCarcinomaVincristinePancreatic NeoplasmsOrganoplatinum CompoundsLeucovorinHydroxyureaDacarbazineRadiopharmaceuticalsSalvage TherapyStomatitisOtorhinolaryngologic NeoplasmsProspective StudiesEsophagogastric JunctionPostoperative CareLymph Node Excision
Cervical cancerChemo-radiotherapyCisplatinConventionally fractionated radiotherapySurvivalCCRTNSCLCResistance to radiotherapyOutcomesMetastaticIntensity Modulated RadiotherapyExternal beam radiothPaclitaxelCombination with radiotherapyRadiation therapyRectal cancerEsophagealSquamous cell carcinoma trClinicalHigh risk of recurrenceReceive radiotherapyPrecision radiotherapyPreoperative chemoradiotherapyChemotherapy followedRetrospective StudyPelvicAdjuvantInductionTotal mesorectBrachytherapyMethodsAdenocarcinomaDoseHead and neckOncologyCancerTherapyLymph node metastasisRadiochemotherapyTumorUnderwentSurgery
Cervical cancer19
  • The standard treatment approach for locally advanced cervical cancer (LACC) is concurrent chemoradiotherapy (CCRT). (researchsquare.com)
  • One report from a developing country has shown that over 80% of new cervical cancer cases are found at advanced stages [5]. (researchsquare.com)
  • In spite of the improvement in survival of cervical cancer after concurrent chemoradiotherapy, the outcomes of patients with LACC have been unsatisfactory. (researchsquare.com)
  • Aim: The main objective of this study was evaluation of bone marrow sparing IMRT versus standard IMRT as a planning limitation in cervical cancer therapy receiving concurrent chemo radiotherapy for evaluation of the response of treatment,toxicity profile and quality of life of both radiotherapy treatment modalities. (oncologyradiotherapy.com)
  • Concurrent chemo-radiotherapy is the usual treatment for locally advanced cervical cancer. (oncologyradiotherapy.com)
  • Evaluation of bone marrow sparing IMRT versus standard IMRT as a planning limitation in cervical cancer therapy cases receiving concurrent chemo radiotherapy. (oncologyradiotherapy.com)
  • 1. Kokka F, Bryant A, Brockbank E, Powell M, Oram D. Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer. (koreamed.org)
  • 5. Platt SL, Patel A, Humphrey PJ, Al-Booz H, Bailey J. Completion surgery after chemoradiotherapy for cervical cancer - is there a role? (koreamed.org)
  • UK Cancer Centre experience of hysterectomy post chemo-radiotherapy treatment for cervical cancer. (koreamed.org)
  • Prognostic factors and morbidities after completion surgery in patients undergoing initial chemoradiation therapy for locally advanced cervical cancer. (koreamed.org)
  • Results of surgery after concurrent chemoradiotherapy in advanced cervical cancer: comparison of extended hysterectomy and extrafascial hysterectomy. (koreamed.org)
  • Merck Inc., known as MSD outside of the United States and Canada, announced the FDA has accepted for priority review a new supplemental Biologics License Application (sBLA) seeking approval for Keytruda, Merck's anti-PD-1 therapy, in combination with external beam radiotherapy (EBRT) plus concurrent chemotherapy, followed by brachytherapy (also known as concurrent chemoradiotherapy) as treatment with definitive intent for newly diagnosed patients with high-risk locally advanced cervical cancer. (medthority.com)
  • Herein, we examine treatment patterns and survival of cervical cancer patients treated in Tikur Anbessa Hospital Radiotherapy Center (TAHRC), the only hospital with radiotherapy facility in the country. (biomedcentral.com)
  • The survival of cervical cancer patients remains low in Ethiopia because of late presentation and delay in receipt of radiotherapy, leading to stage migration in substantial proportion of the cases. (biomedcentral.com)
  • Concerted and coordinated multisectoral efforts are needed to promote early presentation of cervical cancer and to shorten the unacceptable, long waiting time for radiotherapy. (biomedcentral.com)
  • One of the major challenge of cervical cancer care is Ethiopia is delay in diagnosis, since most of the patients seek medical care at advanced stage of the disease [ 7 , 9 ]. (biomedcentral.com)
  • Patients with cervical cancer were referred from all over Ethiopia to Tikur Anbessa Hospital Radiotherapy center for radiotherapy. (biomedcentral.com)
  • The purpose of this study is to evaluate the efficacy and safety of pembrolizumab plus concurrent chemoradiotherapy compared to placebo plus concurrent chemoradiotherapy in participants with locally advanced cervical cancer. (msdoncologyclinicaltrials.com)
  • Multimodal treatment including hysterectomy improves survival in patients with locally advanced cervical cancer: A population-based, propensity score-matched analysis. (nih.gov)
Chemo-radiotherapy4
  • We investigated the outcome and the prognostic factors of patients with locally advanced esophageal cancer who were treated with concurrent chemo-radiotherapy. (e-roj.org)
  • This study has shown that results of concurrent chemo-radiotherapy in patients with locally advanced esophageal cancer is comparable to those of other studies. (e-roj.org)
  • Introduction: Neoadjuvant chemo-radiotherapy (nCRT) before surgery was a standard treatment strategy for locally advanced rectal cancer (LARC). (bvsalud.org)
  • Concurrent Chemo-Radiotherapy (cCRT) is standard treatment in "fit patients" (pts) affected with locally advanced (LA) NSCLC, with surgery limited to few selected cases. (esmo.org)
Cisplatin15
  • Concurrent chemoradiotherapy with 3x-weekly cisplatin is recommended if patient refuses surgery. (medscape.com)
  • If cisplatin cannot be administered, then cetuximab concurrent to radiotherapy. (medscape.com)
  • radiotherapy (based on initial stage) ± cisplatin/cetuximab (based on induction chemotherapy [ICT] toxicity). (medscape.com)
  • If the main objective is organ preservation, consider concomitant radiotherapy (RT) (with cisplatin or cetuximab). (medscape.com)
  • concomitant RT (with cisplatin or cetuximab) or consider surgery followed by radiotherapy. (medscape.com)
  • For concomitant chemoradiotherapy with 3x-weekly cisplatin, several studies have demonstrated benefit in locoregional control and overall survival over radiotherapy alone with a significant increase in acute and chronic toxicity. (medscape.com)
  • On the other hand, superselective cisplatin infusion with concomitant radiotherapy has emerged as a promising chemotherapeutic method ( 11 - 14 ). (brieflands.com)
  • She noted the study's premise starts with the recognition that for locally advanced nasopharyngeal cancer, gemcitabine/cisplatin induction chemotherapy is now accepted as a standard of care. (ascopost.com)
  • However, in the sintilimab arm, fewer patients completed concurrent chemortherapy, and the cumulative cisplatin dose was slightly lower. (ascopost.com)
  • For the induction treatment of locally advanced inoperable SCCHN, the recommended dose of TAXOTERE is 75 mg/m 2 as a 1-hour intravenous infusion followed by cisplatin 75 mg/m 2 intravenously over 1 hour, on day one, followed by fluorouracil as a continuous intravenous infusion at 750 mg/m 2 per day for five days. (drugs.com)
  • For the induction treatment of patients with locally advanced (unresectable, low surgical cure, or organ preservation) SCCHN, the recommended dose of TAXOTERE is 75 mg/m 2 as a 1-hour intravenous infusion on day 1, followed by cisplatin 100 mg/m 2 administered as a 30-minute to 3 hour infusion, followed by fluorouracil 1000 mg/m 2 /day as a continuous infusion from day 1 to day 4. (drugs.com)
  • The GT-201 study enrolled 223 patients with locally advanced head and neck cancer and had been given at least 7 weeks of standard-of-care radiotherapy plus cisplatin. (targetedonc.com)
  • Phase IIb, randomized, double-blind trial of GC4419 versus placebo to reduce severe oral mucositis due to concurrent radiotherapy and cisplatin for head and neck cancer. (targetedonc.com)
  • Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. (helsedirektoratet.no)
  • Received weekly cisplatin 40 mg m2 for 5 to 6 cycles as concurrent chemotherapy with radiation therapy. (who.int)
Conventionally fractionated radiotherapy4
  • Patients received conventionally fractionated radiotherapy of 5×2 Gy per week (on 5 consecutive days). (iiarjournals.org)
  • All patients were treated with conventionally fractionated radiotherapy combined with induction (platinum- and 5-fluorouracil-based) or concurrent platinum chemotherapy. (ox.ac.uk)
  • Biospies on the day after the delivery of 20 Gy of conventionally fractionated radiotherapy showed residual cancer cell nests, frequently of high vascularization and of intense nuclear TP reactivity. (ox.ac.uk)
  • A detrimental effect of RP on overall survival was observed in only few previous studies.s18-20sMaterials/MethodssPatient characteristicssAll consecutive patients with locally advanced NSCLC who underwent conventionally fractionated radiotherapy and concomitant chemotherapy (no immunotherapy) at our institution between 2009 and beginning of 2018 were included in this analysis. (sagepub.com)
Survival13
  • After 2 years, researchers found no significant differences in overall and disease-free survival between patients on active surveillance and those who received surgery either immediately following neoadjuvant chemoradiotherapy or who switched from active surveillance to surgery. (medscape.com)
  • Concomitant radiotherapy and cetuximab have shown a benefit in locoregional control and overall survival compared to radiotherapy alone with a better toxicity profile compared to chemotherapy. (medscape.com)
  • Randomized trials have compared definitive chemoradiotherapy with surgery with or without chemoradiotherapy and reported comparable survival [ 4 - 6 ]. (oncotarget.com)
  • To compare patient survival outcomes between completion hysterectomy and conventional surveillance in locally advanced adenocarcinoma of the cervix after concurrent chemoradiotherapy (CCRT). (koreamed.org)
  • Although advances in chemotherapy and the development of specific antibody therapies, surgery as well as radiation therapy have been made, long-term outcome and disease-free survival rates still have not improved. (jcancer.org)
  • The intra-arterial CRT (60 Gy) without surgery yielded improved survival outcomes in patients with advanced MSSCC as compared to the neoadjuvant intra-arterial CRT (40 Gy) followed by surgery. (brieflands.com)
  • According to several studies, use of concurrent chemoradiotherapy can improve the locoregional control and overall survival (OS) of patients with locally advanced head and neck carcinomas, compared to radiotherapy alone ( 3 - 5 ). (brieflands.com)
  • As expected, survival was lower in patients with advanced stage at initiation of radiotherapy and in those treated as palliative care. (biomedcentral.com)
  • The long-term survival rate of lung cancer patients receiving radiotherapy was not low, but the cumulative incidence of CPI gradually increased to 6.8% at 7 years after radiotherapy. (e-crt.org)
  • Overall lung cancer survival rates have improved over the past few decades with the advances made in diagnostic and therapeutic modalities [ 1 ]. (e-crt.org)
  • It is concluded that thymidine phosphorylase is associated with angiogenesis, with resistance to radiotherapy and cytotoxic therapy, and with poorer survival in squamous cell head and neck cancer. (ox.ac.uk)
  • has transformed the management of locally advanced forms (T3 T4 and/or N +) of middle and low rectal cancer, with a significant gain on local recurrence and an improvement in overall survival [3]. (waocp.com)
  • Palliative Radiotherapy for Non-metastatic Non-small-cell Lung Cancer: Impact of Blood Test Results on Survival. (cdc.gov)
CCRT2
  • Although concurrent chemoradiotherapy (CCRT) coupled with image-guided radiotherapy (IGRT) is associated with a theoretical benefit in non-operated localized esophageal squamous cell carcinoma (NOL-ESCC) patients, there is currently no clinical evidence to support this. (oncotarget.com)
  • Definitive concurrent chemoradiotherapy (CCRT) is one of the standards of care for localized esophageal SqCC cases beyond the early stage [ 3 ]. (oncotarget.com)
NSCLC12
  • Also, many patients with locally advanced non-small-cell lung cancer (NSCLC) receive radiotherapy, if they are not candidates for surgery. (iiarjournals.org)
  • Radiotherapy combined with targeted therapy has considerably furthered the study of non-small-cell lung carcinoma (NSCLC) under the joint efforts of the two disciplines, yielding both exciting results and worrisome reports. (dovepress.com)
  • 1 Early clinical studies of the EGFR monoclonal antibody in combination with radiotherapy primarily included head and neck squamous cell carcinoma, and the study of its combination with radiation therapy for NSCLC was performed relatively late. (dovepress.com)
  • In case of progression under initial treatment, repeat biopsy is a new option procedure in advanced non-small cell lung cancer (NSCLC). (iaslc.org)
  • The aim of this pragmatic prospective multicenter study was to assess feasibility and clinical utility of re-biopsy in real world setting in advanced NSCLC. (iaslc.org)
  • Patient's main inclusion criteria was advanced NSCLC with an indication of repeat biopsy by the referent clinician. (iaslc.org)
  • The current standard of care for locally advanced non-small cell lung cancer (NSCLC) includes radiation, chemotherapy, and surgery in certain individualized cases. (frontiersin.org)
  • More recently, phase I/II studies using SBRT for dose escalation after conventional chemoradiation in locally advanced NSCLC have been promising with good apparent safety. (frontiersin.org)
  • By building on the proven concept of conventional chemoradiation for patients with locally advanced NSCLC with a subsequent radiation dose intensification to residual disease with SBRT concurrent with immunotherapy, we hope address the issues of metastatic and local failures. (frontiersin.org)
  • However, for patients with more locally advanced NSCLC, 5-year OS after treatment with definitive radiation therapy and concurrent chemotherapy remains modest, at approximately 15-20% ( 4 ). (frontiersin.org)
  • Multiple studies have examined the issue of the optimal dose of radiotherapy in NSCLC but are complicated by the heterogeneity of the disease itself in terms of size and location of the primary tumor, number and size of involved lymph nodes, and the patient's comorbidities, all of which limit the treatment tolerability and risks. (frontiersin.org)
  • Adjuvant durvalumab after concurrent chemoradiotherapy for patients with unresectable stage III NSCLC harbouring uncommon genomic alterations. (cdc.gov)
Resistance to radiotherapy1
Outcomes9
Metastatic5
  • Stage III lung cancer, though heterogeneous in its classification, includes non-metastatic but locally advanced disease with involvement of N1-N3 nodal stations and/or T3 and T4 primaries. (frontiersin.org)
  • In this study, participants with multiple types of advanced (unresectable and/or metastatic) solid tumors who have progressed on standard of care therapy will be treated with pembrolizumab (MK-3475). (msdoncologyclinicaltrials.com)
  • RT, one of the main treatment options, has played a key role in all stages of therapy, including as a curative modality for medically inoperable early-stage lung cancer and as a palliative tool for advanced and metastatic stages. (e-crt.org)
  • For locally advanced or metastatic breast cancer after failure of prior chemotherapy, the recommended dose of TAXOTERE is 60 mg/m 2 to 100 mg/m 2 administered intravenously over 1 hour every 3 weeks. (drugs.com)
  • Koukourakis GV, Zacharias G, Tsalafoutas J, Theodoridis D, Kouloulias V. Capecitabine for locally advanced and metastatic colorectal cancer: A review. (wjgnet.com)
Intensity Modulated Radiotherapy2
  • For example, when comparing proton therapy to the most advanced types of photon therapy-intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT)-proton therapy can give similar or higher radiation doses to the tumor with a 50%-60% lower total body radiation dose. (wikipedia.org)
  • Intensity Modulated Radiotherapy (IMRT)for Whole Pelvic Radiation Therapy (WPRT) is considered superior to 3D conformal radiotherapy in dose distribution to targets and to spare normal tissue as (BM) supported by many dosimetric studies [ 7 ]. (oncologyradiotherapy.com)
External beam radioth1
Paclitaxel3
  • Patients received neoadjuvant chemoradiotherapy with carboplatin and paclitaxel for 5 weeks. (medscape.com)
  • 1 - 3 In patients with node-negative small tumors, chemotherapy burden can be de-escalated by administering weekly paclitaxel for 3 months and concurrent trastuzumab for 1 year. (jnccn.org)
  • The purpose of this study is to assess the safety and efficacy of treatment with pembrolizumab (MK-3475) compared to a combination of carboplatin and paclitaxel in women with mismatch repair deficient (dMMR) advanced or recurrent endometrial carcinoma who have not previously been treated with prior systemic chemotherapy. (msdoncologyclinicaltrials.com)
Combination with radiotherapy1
Radiation therapy2
  • The administration of stereotactic body radiation therapy (SBRT) through the use of CyberKnife therapy appears to be a safe and effective salvage treatment for women with previously irradiated, locally recurrent gynecologic cancers, according to study results presented at the 2018 Society of Gynecologic Oncology (SGO) Annual Winter Meeting. (cyberknifemiami.com)
  • Finally, neoadjuvant therapy consisting of Capecitabine plus radiation therapy, for locally advanced rectal cancer was analysed. (wjgnet.com)
Rectal cancer2
  • This study was designed to explore whether an intensified chemoradiotherapy (CRT) led to a better clinical outcome in locally advanced rectal cancer. (biomedcentral.com)
  • Therefore, in some views, tumor downstaging, especially pCR, was regarded as a goal in neoadjuvant treatment of locally advanced rectal cancer, which motivated the combination of systemic chemotherapy and advanced RT technique in this approaches. (biomedcentral.com)
Esophageal5
  • Two hundred forty six patients with esophageal cancer that were treated by radiotherapy between January 1994 and July 2007. (e-roj.org)
  • MADRID - More than one third of patients with locally advanced esophageal cancer who have a complete clinical response to neoadjuvant chemoradiotherapy may be able to safely avoid major surgery, findings from the Dutch SANO-trial suggest. (medscape.com)
  • To compare active surveillance with standard surgery, the team conducted a phase 3 noninferiority stepped-wedge cluster randomized trial involving patients with locally advanced esophageal cancer. (medscape.com)
  • Comparative effectiveness of image-guided radiotherapy for non-operated localized esophageal squamous cell carcinoma patients receiving concurrent. (oncotarget.com)
  • This first edition book on 'Esophageal Cancer' which contains a diverse range of articles taken from AME journals and include authors with expertise in molecular biology, diagnosis and treatment, therapeutic endoscopy, surgery, radiotherapy and medical treatment, and prognosis. (amegroups.com)
Squamous cell carcinoma tr1
Clinical8
  • In these patients developing pneumonitis following radiotherapy, clinical and treatment characteristics were analyzed to detect potential risk factors for this treatment-related complication. (iiarjournals.org)
  • The combination of radiotherapy and targeted therapy is an important approach in the application of targeted therapy in clinical practice, and represents an important opportunity for the development of radiotherapy itself. (dovepress.com)
  • More than 300 patients who achieved a complete clinical response 12 weeks after completing chemoradiotherapy were randomly assigned to undergo standard surgery or active surveillance. (medscape.com)
  • Partly because of these advances in technology, and partly because of the continually increasing amount of proton clinical data, the number of hospitals offering proton therapy continues to grow. (wikipedia.org)
  • Therefore, we designed this randomized trial to explore whether a combined regimen of oxaliplatin-added chemoradiotherapy and a concomitant boost to the primary tumor would further lead to a better clinical outcome. (biomedcentral.com)
  • Background: This phase 2 prospective randomized double-arm study carried out at Clinical Oncology Department Tanta University, Radiotherapy Department, NCI, Cairo University and Gharbia cancer society through the period from May 2018 to December 2019 and enrolled 60 patients with cervical carcinoma. (oncologyradiotherapy.com)
  • Clinical use of a combination of radiotherapy and chemotherapy continues to increase, while the development of immunotherapy, such as checkpoint inhibitors, offers hope in improving treatment outcome. (hkmj.org)
  • A strong rationale is provided for subsequent clinical trials of concurrent radiotherapy and chemotherapy with antiangiogenic agents or with specific TP inhibitors. (ox.ac.uk)
High risk of recurrence1
Receive radiotherapy1
Precision radiotherapy2
  • Thus, more studies are required to properly identify the rate of symptomatic pneumonitis, particularly studies using modern precision radiotherapy techniques. (iiarjournals.org)
  • Predicting tumour radiosensitivity to deliver precision radiotherapy. (cdc.gov)
Preoperative chemoradiotherapy2
  • A concomitant boost to oxalipatin-combined preoperative chemoradiotherapy demonstrated a slightly higher pCR rate but delayed incision healing after surgery. (biomedcentral.com)
  • All other patients received a preoperative chemoradiotherapy (CRT) with 50.4 Gy and concomitant 5-fluorouracil (5-FU) or 5-FU+oxaliplatin followed by postoperative chemotherapy with 5-FU or 5-FU+oxaliplatin. (jcancer.org)
Chemotherapy followed2
  • Therefore, chemotherapy followed by surgical resection, with or without radiotherapy, is the treatment of choice for patients with locally advanced maxillary sinus squamous cell carcinoma (MSSCC) ( 7 - 10 ). (brieflands.com)
  • The CONTINUUM trial sought to answer that question by assessing 425 patients with advanced-stage disease who were randomly assigned between induction chemotherapy followed by chemoradiation or the same plus the incorporation of the PD-1 inhibitor sintilimab, with sintilimab continued for a total of 12 cycles. (ascopost.com)
Retrospective Study1
  • In this retrospective study, which was approved by the ethics committee of the University of Lübeck, 278 patients irradiated for locally advanced lung cancer between 2016 and 2019 were evaluated with respect to the development of symptomatic (grade ≥2) pneumonitis. (iiarjournals.org)
Pelvic2
  • In pelvic malignancy treated with CHTRT, bone marrow sparing radiotherapy is an option to minimize toxicity [ 6 ]. (oncologyradiotherapy.com)
  • They identified 29 patients who had undergone prior RT and had been diagnosed with radiologically confirmed, locally recurrent gynecologic cancer in the central pelvis, pelvic side wall, or para-aortic lymph nodes. (cyberknifemiami.com)
Adjuvant3
Induction1
Total mesorect1
  • The advent of neoadjuvant radiotherapy in association with TME (Total Mesorectal Excision) surgery described by RJ Heald in 1982 [2]. (waocp.com)
Brachytherapy1
Methods1
  • Patients and Methods: This study included 278 patients irradiated for locally advanced lung cancer between 2016 and 2019. (iiarjournals.org)
Adenocarcinoma2
Dose3
  • FLASH radiotherapy is a technique under development for photon and proton treatments, using very high dose rates (necessitating large beam currents). (wikipedia.org)
  • Ninety-five percent patients completed a full-dose chemoradiotherapy as planning. (biomedcentral.com)
  • Although intra-arterial chemoradiotherapy (CRT) followed by surgery has been the standard of care for patients with advanced maxillary sinus squamous cell carcinoma (MSSCC), concurrent intra-arterial chemotherapy and high-dose radiotherapy without surgery has emerged as a promising alternative. (brieflands.com)
Head and neck7
  • This study sought to investigate the efficacy and safety of a three-drug combination antiemetic regimen of olanzapine combined with aprepitant and palonosetron for the prevention of chemoradiotherapy-induced nausea and vomiting in locally advanced head and neck squamous cell carcinoma. (centerwatch.com)
  • Unlike other head and neck malignancies, maxillary sinus carcinomas are often diagnosed in locally advanced stages ( 2 ), owing to their localization and lack of symptoms in early stages. (brieflands.com)
  • The advanced-stage head and neck cancer (HNC) patients respond poorly to platinum-based treatments. (researchgate.net)
  • The FDA has approved avasopasem for patients with head and neck cancer to treat their radiotherapy-induced severe oral mucositis. (targetedonc.com)
  • The FDA has issued a complete response letter regarding the new drug application (NDA) for avasopasem manganese (GC4419) for the treatment of radiotherapy-induced severe oral mucositis (SOM) in patients with head and neck cancer who are receiving standard-of-care treatment. (targetedonc.com)
  • In the phase 2 study, the results confirmed that this method protected patients from radiotherapy-induced SOM without negating treatment benefits for patients with head and neck cancer. (targetedonc.com)
  • The microvessel score and TP expression were examined immunohistochemically on paraffin-embedded bioptical material from 94 locally advanced squamous cell head and neck carcinomas. (ox.ac.uk)
Oncology3
  • The American Society for Radiation Oncology Model Policy for Proton Beam therapy says proton therapy is considered reasonable if sparing the surrounding normal tissue "cannot be adequately achieved with photon-based radiotherapy" and can benefit the patient. (wikipedia.org)
  • Nine patients who were treated with intravenous chemoradiotherapy or radiotherapy alone were excluded from the study due to impaired renal function or poor performance, according to the definition by the Eastern Cooperative Oncology Group (ECOG) ( 15 ). (brieflands.com)
  • The study was carried out in adult oncology department of Tikur Anbesa Specialized Hospital (TASH) radiotherapy center, under the Addis Ababa University. (biomedcentral.com)
Cancer9
  • Background/Aim: Radiotherapy of locally advanced lung cancer often requires high doses potentially leading to pneumonitis. (iiarjournals.org)
  • Therefore, this study was performed aiming to identify the prevalence of pneumonitis and potential risk factors for this complication in patients with locally advanced lung cancer irradiated with volume-modulated arc therapy (VMAT). (iiarjournals.org)
  • In medicine, proton therapy, or proton radiotherapy, is a type of particle therapy that uses a beam of protons to irradiate diseased tissue, most often to treat cancer. (wikipedia.org)
  • Aim: Pancreatic cancer is a highly lethal malignancy and in locally advanced disease, chemotherapy (CT) or chemoradiotherapy (CRT) are implemented. (yyu.edu.tr)
  • Despite modern advances in technology, significant challenges still plague the development of new cancer drugs and cancer care. (researchgate.net)
  • This study aimed to investigate cumulative incidence and risk factors associated with chronic pulmonary infection (CPI) development after radiotherapy for lung cancer. (e-crt.org)
  • We retrospectively analyzed 1,872 patients with lung cancer who received radiotherapy for lung cancer from 2010-2014, had a follow-up period of ≥ 3 months after radiotherapy, and did not have CPI at the time of radiotherapy. (e-crt.org)
  • Expression of ERCC1 and TUBB3 in locally advanced cervical squamous cell cancer and its correlation with different therapeutic regimens. (nih.gov)
  • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. (helsedirektoratet.no)
Therapy3
  • A number of studies of radiotherapy combined with targeted therapy in non-small-cell lung carcinoma have been completed or are ongoing. (dovepress.com)
  • Differences in the experimental results prompted this summary for a more comprehensive and rational understanding of radiotherapy combined with targeted therapy. (dovepress.com)
  • This retrospective review of the literature indicates that numerous drugs have been used for targeted therapy and that the studies of radiotherapy combined with targeted therapy are diverse and complicated by their variable quality. (dovepress.com)
Lymph node metastasis2
  • Maxillary sinus tumors often advance locally without lymph node metastasis due to limited lymphatic drainage ( 6 ). (brieflands.com)
  • Neoadjuvant chemotherapy does not improve the prognosis and lymph node metastasis rate of locally advanced cervical squamous cell carcinoma: A retrospective cohort study in China. (nih.gov)
Radiochemotherapy1
Tumor3
  • Up on first oncologist consultation and/or radiotherapy planning, tumor stage were classified according to the International Federation of Gynecology and Obstetrics (FIGO) staging system [ 11 ]. (biomedcentral.com)
  • The association of chemotherapy with radiotherapy has further improved the carcinological and functional prognosis of this disease, favoring tumor regression (downstaging) or even tumor sterilization in some cases (4). (waocp.com)
  • This combination of chemotherapy and radiotherapy has a special role in tumor down staging and in sphincter preservation for lower rectal tumors. (wjgnet.com)
Underwent2
  • Patient underwent bilateral ante grade stenting and completed concurrent chemoradiotherapy. (jpalliativecare.com)
  • Between January 2009 and December 2014, 90 patients underwent preoperative RCT at the radiotherapy department at University Hospital Mohamed VI, Oujda, Morocco. (waocp.com)
Surgery1