• Clinical tumor volume (CTV) included tumor, anal canal and inguinal, peri-rectal, and internal/external iliac nodes (plus pre-sacral nodes for T4/N2-3 tumors). (springer.com)
  • Bcl-2 and particularly the combination of p53 and Bcl-2 expression may prove to be useful predictors of tumor response to RT or radiochemotherapy in anal carcinomas. (aacrjournals.org)
  • Early pancreatic cancer does not tend to result in any symptom, but when a tumor is advanced, a patient may experience severe pain in the upper abdomen, possibly radiating to the back. (wikipedia.org)
  • A review of the 1973-2000 SEER database has shown that the incidence of anal carcinoma has been increasing over the last 30 years in the general population, especially among all men [ 2 ]. (oncotarget.com)
  • To compare the dosimetric advantage of three different intensity-modulated radiation therapy (IMRT) plans to a three dimensional (3D) conventional radiation treatment for anal cancer with regards to organs-at-risk (OAR) avoidance, including iliac bone marrow. (springer.com)
  • IMRT is superior to 3D conformal radiation treatment for anal carcinoma with respect to OAR sparing, including bone marrow sparing. (springer.com)
  • IMRT is well suited for anal cancer because of the many critical structures adjacent to the target volume, which receive significant doses with conventional (AP-PA) field arrangements or 3D conformal treatment. (springer.com)
  • RTOG 0529: a phase II evaluation of dose-painted IMRT in combination with 5-fluorouracil and mitomycin-C for reduction of acute morbidity in carcinoma of the anal canal. (springer.com)
  • A second study found that, for patients with locally advanced anal cancer, the use of intensity modulated radiation therapy (IMRT) instead of conventional radiation treatment improved tolerance of radiation treatments and reduced the need for ostomy (surgery to re-route how waste exits the body). (biospace.com)
  • She has experience with advanced radiation therapy techniques such as intensity modulated radiation therapy (IMRT), three dimensional conformal radiation therapy (3D-CRT), stereotactic body radiation therapy (SBRT), radioembolization, and image guided radiation therapy (IGRT) using endoscopically implanted fiducial markers. (moffitt.org)
  • According to the Surveillance Epidemiology and End Results (SEER) database, 50% of patients with anal cancer have disease localized to the anus, 29% have regional lymph node involvement or direct spread beyond the primary, and 12% have metastatic disease, while 9% have an unknown stage. (cancernetwork.com)
  • Part 1 of this review will provide an overview of anal cancer epidemiology, risk factors, screening, prevention, and diagnosis. (cancernetwork.com)
  • Anal Carcinoma: impact of TN category of disease on survival, disease relapse, and colostomy failure in US Gastrointestinal Intergroup RTOG 98-11 Phase 3 Trial. (springer.com)
  • 10-years: 2008 PMID 18472363 -- "Evaluation of planned treatment breaks during radiation therapy for anal cancer: update of RTOG 92-08. (wikibooks.org)
  • Pre and post menopausal women undergoing definitive (not palliative) treatments for a pelvic malignancy, including rectal, endometrial, cervical, or anal canal carcinoma. (knowcancer.com)
  • Primary prevention of anal cancer may be the avenue with the widest potential for disease burden reduction, 24-26 though screening remains controversial 27 . (cancernetwork.com)
  • 33,40-44 Additionally, increased secondary prevention in the form of evaluation of screening programs for individuals at increased risk of AIN and anal cancer is warranted. (cancernetwork.com)
  • Efforts are in progress to define the efficacy of secondary prevention programs for prevention of anal cancer. (springer.com)
  • In 2015, there are expected to be about 7270 new cases of anal carcinoma with 1010 deaths from the disease in the United States [ 1 ]. (oncotarget.com)
  • Anal cancer affected an estimated 5,290 patients (2,100 men and 3,190 women), and led to approximately 710 deaths in 2009. (cancernetwork.com)