• Among these QTLs, 12 were co-localized on chromosome B05 spanning an approximately 0.17 Mb physical interval in comparison with the allotetraploid reference genome of "Tifrunner. (frontiersin.org)
  • Analysis of the co-localized genome region has shown that the putative genes are involved in light and hormones and will facilitate peanut growth habit molecular breeding and study of peanut domestication. (frontiersin.org)
  • The maintenance of a single centromere per chromosome is critical for establishing bipolar microtubule attachments to the mitotic spindle and achieving high-fidelity genome segregation 17 . (nature.com)
  • To advance understanding of its biology and facilitate commercial development, we present a C. zofingiensis chromosome-level nuclear genome, organelle genomes, and transcriptome from diverse growth conditions. (researcher-app.com)
  • The assembly, derived from a combination of short- and long-read sequencing in conjunction with optical mapping, revealed a compact genome of ∼58 Mbp distributed over 19 chromosomes containing 15,274 predicted protein-coding genes. (researcher-app.com)
  • The genome has uniform gene density over chromosomes, low repetitive sequence content (∼6%), and a high fraction of protein-coding sequence (∼39%) with relatively long coding exons and few coding introns. (researcher-app.com)
  • Two genes encoding beta-ketolase ( BKT ), the key enzyme synthesizing astaxanthin, were found in the genome, and both were up-regulated by high light. (researcher-app.com)
  • In this work, a genome-wide identification of the bHLH genes in Chinese white pear was performed, and we characterized the functional roles of these PbrbHLH genes in response to abiotic stresses. (biomedcentral.com)
  • This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. (utsouthwestern.edu)
  • Telomeres are specialized structures at the end of chromosomes essential for maintaining genome stability and cell viability. (biomedcentral.com)
  • We outline various procedures to localize differentially expressed genes on the pig genome and link this with information on published QTL. (biomedcentral.com)
  • Different approaches to localize the differentially expressed (DE) genes to the pig genome showed different levels of success and a clear lack of concordance for some genes between the various approaches. (biomedcentral.com)
  • Using the latest version of the draft sequence, the differentially expressed genes were mapped to the pig genome. (biomedcentral.com)
  • This enabled co-location of DE genes and previously studied QTL regions, but the draft genome sequence is still incomplete and will contain many errors. (biomedcentral.com)
  • A further step to explore links between DE genes and QTL at the pathway level was largely unsuccessful due to the lack of annotation of the pig genome. (biomedcentral.com)
  • The goal is to identify overlap between differentially expressed genes and QTL regions at either the genome or the pathway level. (biomedcentral.com)
  • Differentially expressed genes elsewhere in the genome might share pathways with genes in the QTL region and reflect downstream effects of the QTL. (biomedcentral.com)
  • Panel A shows the two areas of comparing gene expression results with QTL results: 1) co-location at the genome level between differentially expressed genes and QTL, 2) significant overlap at the pathway level between genes in the QTL region and differentially expressed genes elsewhere in the genome. (biomedcentral.com)
  • Notably, the lack of sulfate assimilation genes in the S. fibuligera genome reflects a unique phenotype for Saccharomycopsis clades as natural sulfur auxotrophs. (biomedcentral.com)
  • First, the Human Genome Project laid the foundation for modern genetic studies of disease by determining the basic sequence of the 3 billion building blocks (i.e., base pairs) that make up the human genome and by identifying the approximately 25,000 genes included in this sequence ( http://www.ornl.gov/sci/techresources/Human_Genome/home.shtml ). (nih.gov)
  • FRG is a rare disorder due mainly to mutations in the sodium-glucose cotransporter 2 gene ( SGLT2 ) that are responsible for the majority of cases. (medscape.com)
  • Heterozygosity for mutations suggest a role of nongenetic factors or other genes involved in renal glucose transport. (medscape.com)
  • Mutations in the sodium-glucose cotransporter 2 gene are responsible for the majority of cases. (medscape.com)
  • This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. (novusbio.com)
  • At least 75 mutations in the SALL1 gene have been identified in people with Townes-Brocks syndrome, which is typically characterized by a malformation of the anal opening (imperforate anus), abnormally shaped ears, and hand malformations. (medlineplus.gov)
  • Most SALL1 gene mutations involved in this disorder lead to the production of an abnormally short version of the SALL1 protein that malfunctions within cells. (medlineplus.gov)
  • In humans, mutations affecting the genes of this family are associated with specific diseases. (sdbonline.org)
  • Mutations in the hATRX gene cause severe syndromal mental retardation associated with α-thalassemia. (ox.ac.uk)
  • The unexpected association of a putative transcriptional regulator with highly repetitive DNA provides a potential explanation for the variability in phenotype of patients with identical mutations in the ATRX gene. (ox.ac.uk)
  • We hypothesize that there might be at least three types of autism susceptibility genes/mutations that can be (i) specific to an individual patient or family, (ii) in a genetically isolated sub-population and (iii) a common factor shared amongst different populations. (neurotransmitter.net)
  • The genes/mutations could act alone or interact with other genetic and/or epigenetic or environmental factors, causing autism or related disorders. (neurotransmitter.net)
  • Mutations in this gene are associated with nephronophthisis-like nephropathy-1. (nih.gov)
  • Comparative gene mapping among human, murine, and canine genomes have the potential to rapidly identify mutations that underlie various disease syndromes. (stanford.edu)
  • Finally, it seems appropriate to consider the "sodium channel syndrome" (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment. (bvsalud.org)
  • Most Orp1p, a putative subunit of the fission yeast origin recognition complex (ORC), was found to be associated with chromatin-enriched insoluble components throughout the cell cycle. (elsevierpure.com)
  • We use basic and clinical research to understand the cells, proteins, and genes that lead to successful recovery of function, and also how complications develop that impact quality of life after stroke. (stanford.edu)
  • Proteins/genes with a putative catabolic role and bacterium adaptation mechanisms during OPP degradation were identified via genomic and proteomic analysis. (nature.com)
  • The annotation and classification results showed that a total of 39,584 unigenes had similar hits to the known proteins of four public databases, and 31,501 were classified into 55 Gene Ontology (GO) functional sub-categories. (citrusgenomedb.org)
  • The SALL1 gene is part of a group of related genes that provide instructions for making proteins involved in the formation of tissues and organs before birth. (medlineplus.gov)
  • These proteins are transcription factors, which means they attach (bind) to specific regions of DNA and help control the activity of particular genes. (medlineplus.gov)
  • The SALL1 protein helps turn off (repress) gene activity by interacting with other proteins that alter how tightly regions of DNA are packaged. (medlineplus.gov)
  • This interference prevents the normal proteins from entering the nucleus to regulate gene activity. (medlineplus.gov)
  • The mammalian TRF1 and TRF2 proteins, for example, bind double-stranded telomeres via a Myb-like DNA-binding domain and are involved with telomere length regulation and chromosome end protection. (biomedcentral.com)
  • Telomeres are specialized structures at the end of chromosomes and consist of stretches of repetitive DNA (5'-TTAGGG-3' in vertebrates and trypanosomatids) and associated proteins [ 5 ]. (biomedcentral.com)
  • In contrast, the minichromosome maintenance (Mcm) proteins, SpMcm2p and SpMcm6p, encoded by the nda1 + /cdc19 + and mis5 + genes, respectively, were associated with chromatin DNA only during the G 1 and S phases. (elsevierpure.com)
  • In contrast, the minichromosome maintenance (Mcm) proteins, SpMcm2p and SpMcm6p, encoded by the nda1+/cdc19+ and mis5+ genes, respectively, were associated with chromatin DNA only during the G1 and S phases. (elsevierpure.com)
  • The ank gene product is one of several cell membrane proteins, including ectonucleoside triphosphate pyrophosphohydrolase enzymes and alkaline phosphatase, that regulate extracellular inorganic pyrophosphate levels and thereby regulate mineralization. (biomedcentral.com)
  • Both proteins can localize at the mitochondrion , but the way they control apoptosis still remains unclear. (sdbonline.org)
  • The plastin3 (PLS3) gene, which encodes an actin bundling protein known to inhibit cofilin-mediated depolymerization of actin fiber, has been previously reported to serve an important role in the epithelial-mesenchymal transition (EMT) in cancer. (bvsalud.org)
  • This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. (utsouthwestern.edu)
  • The lilli gene encodes a nuclear protein related to the AF4/FMR2 family. (sdbonline.org)
  • Encodes a putative thioredoxin DCC1 involved in determining shoot regeneration capacity. (utoronto.ca)
  • Map-based cloning revealed that HSA1 encodes a putative OsFLN2. (jipb.net)
  • Plant breeders typically focus on immune receptors or impaired susceptibility genes to develop resistant crops, but these can present challenges in terms of strength, durability or pleotropic effects. (elifesciences.org)
  • DESCRIPTION: (Adapted from investigator's abstract) The long-term goal of this project is to identify tumor susceptibility genes involved in lung cancer development. (cancer.gov)
  • Genomic and cDNA clones complementary to an abundant maternal mRNA were isolated and analyzed with regard to molecular structure, genomic location, transcript expression, and putative gene function. (marquette.edu)
  • Southern blot analysis indicated that this gene shared limited nucleotide similarity with several other Drosophila genomic sequences. (marquette.edu)
  • Moreover, the transcriptome under high light exposure revealed candidate genes that could be involved in critical yet missing steps of astaxanthin biosynthesis, including ABC transporters, cytochrome P450 enzymes, and an acyltransferase. (researcher-app.com)
  • Microarray studies can supplement QTL studies by suggesting potential candidate genes in the QTL regions, which by themselves are too large to provide a limited selection of candidate genes. (biomedcentral.com)
  • As the volume of data from these new technologies increases, the current challenge is to combine existing knowledge gained from linkage studies with new information to propose candidate genes in QTL regions. (biomedcentral.com)
  • Differentially expressed genes in the QTL region are obvious positional candidate genes for the QTL. (biomedcentral.com)
  • The study of genes at the pathway level is also important to identify positional candidate genes in the QTL region that are not represented on the microarray. (biomedcentral.com)
  • METHOD: Mutation screening of positional candidate genes was performed in two stages. (neurotransmitter.net)
  • The first stage involved identifying, in unrelated subjects showing linkage to 2q24-q33, genetic variants in exons and flanking sequence within candidate genes and comparing the frequency of the variants between autistic and unrelated nonautistic subjects. (neurotransmitter.net)
  • The most relevant eleven candidate genes for layer-specific angle modification include those homologous to genes controlling leaf angle in rice and maize or genes associated with cell size/expansion, shape, and cell number. (biomedcentral.com)
  • Considering the predicted functions of candidate genes, their potential undesirable pleiotropic effects should be further investigated across tissues and developmental stages. (biomedcentral.com)
  • In situ hybridization to polytene chromosomes localized this gene within the Minute region M(2)21C1-2, on chromosome 2L. (marquette.edu)
  • The hOAT3 protein was shown to be localized in the basolateral membrane of renal proximal tubules and the hOAT3 gene was determined to be located on the human chromosome 11q12-q13.3 by fluorescent in situ hybridization analysis. (aspetjournals.org)
  • By in situ hybridization expression of the B2t chain was localized to specific epithelial cells in skin, lung, and kidney as opposed to a general epithelial and endothelial cell expression of the laminin B2 chain in the same tissues. (rupress.org)
  • PHENOTYPE: Inactivation of this gene results in molecular abnormalities within the central nervous system, but homozygous mutant mice show no overt phenotype. (utsouthwestern.edu)
  • 2) lilli mutation strongly suppresses the rough eye phenotype of ectopically expressed phyllopod (Tang, 2001), and (3) lilli was identified in a screen for genes that enhance the embryonic lethal phenotype of dpp alleles (Su, 2001). (sdbonline.org)
  • Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. (yeastgenome.org)
  • It is reported to have a phenotype frequency of 1:175,000 and a gene frequency of 1:350,000 5 . (bvsalud.org)
  • In the second part the putative TolC homologue BB0124 of B. burgdorferi, the Lyme borreliosis agent, was studied. (uni-wuerzburg.de)
  • A BLAST search and a conserved domain search showed that BB0142 is a putative TolC homologue in B. burgdorferi. (uni-wuerzburg.de)
  • By coimmunofluorescence, ATRX localizes with a mouse homologue of the Drosophila heterochromatic protein HP1 in vivo , consistent with a previous two-hybrid screen identifying this interaction. (ox.ac.uk)
  • In addition, TSKS, the human homologue of a putative substrate of TSSK 1 and 2, was cloned. (elsevierpure.com)
  • The aim of this study was to identify and compare regions of nucleotide sequence homology between similar genes that are abundantly expressed and maternally transmitted during Drosophila oogenesis. (marquette.edu)
  • Computer analysis of the DNA sequence of the 21C cDNA revealed a 76 percent 3$\sp\prime$ coding sequence similarity with the Drosophila acidic ribosomal protein gene, A1 (Qian et al. (marquette.edu)
  • The search for putative molecular markers among 57,212 unigenes identified 10,276 simple sequence repeats (SSRs) and 64,720 single nucleotide polymorphisms (SNPs). (citrusgenomedb.org)
  • The amino acid sequence contained 21 amino acids of a putative signal peptide and 1,172 residues or alternatively 1,090 residues of a sequence with five distinct domains homologous to domains I-V in laminin chains. (rupress.org)
  • To identify such genes, a Drosophila egg chamber cDNA library was differentially screened such that maternal RNA sequences were readily identified and selected from the recombinant population. (marquette.edu)
  • Also, differentially expressed genes underlying QTL for ACTH response were described. (biomedcentral.com)
  • Panel B illustrates the steps to test for co-location between differentially expressed genes and QTL regions in the pig example. (biomedcentral.com)
  • Panel C illustrates the steps that are required to test for significant enrichment at the pathway level between differentially expressed genes and genes in the QTL region. (biomedcentral.com)
  • In this study, we performed quantitative methylation analyses of six differentially methylated imprinted genes (H19, MEG3, LIT1, NESP55, PEG3 and SNRPN), one hypermethylated pluripotency gene (OCT4) and one hypomethylated tumor suppressor gene (APC) in chorionic villus, fetal and adult cortex, and adult blood samples. (uni-wuerzburg.de)
  • One clone hybridized to the Minute locus 5E, a region containing the gene for acidic ribosomal protein 7/8 (Burns et al. (marquette.edu)
  • The authors recently mapped a susceptibility locus for autism to chromosome region 2q24-q33 (MIM number 606053). (neurotransmitter.net)
  • Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes. (yeastgenome.org)
  • The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. (yeastgenome.org)
  • Both average methylation level and range of methylation variation depended on the gene locus, tissue type and/or developmental stage. (uni-wuerzburg.de)
  • ADC gene expression and enzyme activity increased during embryogenesis, which suggests the involvement of transcriptional regulation in the expression of ADC. (scite.ai)
  • A shortage of functioning SALL1 protein, due to either type of mutation, likely impairs the regulation of genes that direct the development of many different organs and tissues before birth. (medlineplus.gov)
  • DNA methylation is an epigenetic modification that plays an important role in gene regulation. (uni-wuerzburg.de)
  • These results suggest that transcriptional elongation control is especially important for rapidly expressed genes to support digestion and metabolism, many of which have sex-biased function. (sdbonline.org)
  • Transcription analysis of all putative catabolic genes established their role in the metabolism of OPP. (nature.com)
  • Transcription factors (TFs) are protein molecules with special structure and function of regulating gene expression, which plays many crucial roles in plant growth and development [ 1 ]. (biomedcentral.com)
  • These findings suggest a scenario where collisions between DNA replication and transcription are frequent, leading to increased genetic variability, as seen by the increase SNP levels at chromosome subtelomeres and in DGF-1 genes containing putative origins. (biomedcentral.com)
  • Loss of FMR2 gene transcription causes mental retardation. (sdbonline.org)
  • Quantitative reverse transcription polymerase chain reaction and immunoblot analysis revealed that the transcription and translation of PEP-dependent genes were strongly inhibited in fln1 and trxz mutants, indicating that loss of OsFLN1, HSA1/OsFLN2, or OsTRXz function perturbs the stability of the transcriptionally active chromosome complex and PEP activity. (jipb.net)
  • The putative origins identified in T. cruzi show a notable enrichment of GC content, a preferential position at subtelomeric regions, coinciding with genes transcribed towards the telomeres, and a pronounced enrichment within coding DNA sequences, most notably in genes from the Dispersed Gene Family 1 (DGF-1). (biomedcentral.com)
  • GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)
  • The second ben/cat operon was located in a 92-kb scaffold along with (i) an operon ( opp ) comprising genes for the transformation of OPP to BA and 2-hydroxypenta-2,4-dienoate (and genes for its transformation) and (ii) an incomplete biphenyl catabolic operon ( bph ). (nature.com)
  • Furthermore the location of the bb0142 gene within the chromosome is in an operon encoding a multidrug efflux pump. (uni-wuerzburg.de)
  • IglA is a 21 kDa protein encoded by a gene that is part of an iglABCD operon located on the Francisella pathogenicity island (FPI). (biomedcentral.com)
  • Unfortunately, their recessive nature complicates the use of S genes in conventional breeding of autopolyploids and many mutated S genes come with pleiotropic effects. (elifesciences.org)
  • This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. (nih.gov)
  • These studies implicate a potential mechanism suppressing the loss of genetic material after chromosome pulverization, although how distinct patterns of rearrangements arise in cancer and germline disorders remains unclear. (nature.com)
  • The downstream transformation of BA involved a meta -cleavage pathway, although its genetic organization and function was not revealed and the overall network of genes driving the full metabolic pathway of OPP is still not known. (nature.com)
  • With the advent of 'omics technologies such as gene expression microarrays, new ways of studying genetic variation through so called 'endo-phenotypes' are becoming increasingly popular. (biomedcentral.com)
  • Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. (yeastgenome.org)
  • A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. (cancer.gov)
  • Future validation of proposed candidates and exploitation through genetic engineering or gene editing strategies targeted to collar cells will bring researchers closer to the realization of a "smart canopy" sorghum. (biomedcentral.com)
  • AT5G50100 role in shoot regeneration.AT5G50100 is a functional thioredoxin localized in mitochondria. (utoronto.ca)
  • Moreover, the fibrous nature of the tumor has given rise to various other names, such as pleural fibroma, submesothelial fibroma, and localized fibrous tumor. (medscape.com)
  • Synteny analysis uncovered localized but scrambled blocks of genes in putative orthologous relationships with other green algae. (researcher-app.com)
  • The seven chromosome pairs of KJJ81 subgenomes exhibit highly conserved synteny, indicating a very recent hybridization event. (biomedcentral.com)
  • These mutant phenotypes correlate with markedly reduced expression of the early zygotic genes serendipity alpha , fushi tarazu and huckebein , which are essential for cellularization and embryonic patterning (Tang, 2001). (sdbonline.org)
  • The hOAT3 cDNA consisted of 2179 base pairs that encoded a 543-amino-acid residue protein with 12 putative transmembrane domains. (aspetjournals.org)
  • Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. (neurotransmitter.net)
  • if putative loci are localized, to refine the linkage map of the candidate loci. (cancer.gov)
  • Both ADC mRNA and ADC protein localized in dividing cells of embryo meristems and more specifically within the mitotic spindle apparatus and close to the chromosomes, respectively. (scite.ai)
  • Dangshansuli') has already been reported, there is still a lack of clarity regarding the bHLH family genes and their evolutionary history. (biomedcentral.com)
  • Mechanistically, the CIP2A-TOPBP1 complex prematurely associates with DNA lesions within ruptured micronuclei during interphase, which poises pulverized chromosomes for clustering upon mitotic entry. (nature.com)
  • Mitotic clustering facilitates the reassembly of acentric fragments into rearranged chromosomes lacking the extensive DNA copy-number losses that are characteristic of canonical chromothripsis. (nature.com)
  • The malfunctioning protein is thought to interfere with normal copies of the SALL1 protein, which are produced from the other copy of the SALL1 gene that does not have a mutation. (medlineplus.gov)
  • Abnormal development before birth due to unusual gene activity leads to the varied birth defects associated with Townes-Brocks syndrome. (medlineplus.gov)
  • Functional annotation of gene models identified orthologous families for the majority (∼73%) of genes. (researcher-app.com)
  • ATRX is a member of the SNF2 family of helicase/ATPases that is thought to regulate gene expression via an effect on chromatin structure and/or function. (ox.ac.uk)
  • Immunostaining of spread nuclei showed SpMcm6p to be localized at discrete foci on chromatin during the G 1 and S phases. (elsevierpure.com)
  • A chromatin immunoprecipitation assay demonstrated that Orp1p was preferentially localized at the ars2004 and ars3002 origins of the chromosome throughout the cell cycle, while SpMcm6p was associated with these origins only in the G 1 and S phases. (elsevierpure.com)
  • In addition to its association with heterochromatin, at metaphase ATRX clearly binds to the short arms of human acrocentric chromosomes, where the arrays of ribosomal DNA are located. (ox.ac.uk)
  • This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. (utsouthwestern.edu)
  • PA metabolism was analyzed by fitting statistical regression models to the data of free and soluble conjugated PAs, to the enzyme activities of ADC and ornithine decarboxylase (ODC), as well as to the gene expression of ADC. (scite.ai)
  • Both ADC gene expression and ADC enzyme activity were substantially higher than putative ODC gene expression or ODC enzyme activity, respectively. (scite.ai)
  • In the present study, histochemical methods and quantification of the expression levels of the programmed cell death (PCD) and DNA repair processes related genes (MCA, TAT-D, RAD51, KU80, and LIG) were used to investigate the physiological events occurring in the megagametophyte tissue during embryo development. (scite.ai)
  • In this study the expression of an outer membrane component of a putative drug efflux system of B. burgdorferi was shown for the first time. (uni-wuerzburg.de)
  • typically, when DNA is tightly packed, gene expression is lower than when DNA is loosely packed. (medlineplus.gov)
  • Almost half of the genes expressed in adults showed reduced expression, supporting a broad role for the three tested genes in steady-state transcript abundance. (sdbonline.org)
  • Genes showing reduced expression due to these RNAi treatments were short and enriched for genes encoding metabolic or enzymatic functions. (sdbonline.org)
  • Hundreds of genes were observed with sex-biased differential expression following treatment. (sdbonline.org)
  • The general principle of complementing QTL studies with gene expression data is illustrated in Figure 1A . (biomedcentral.com)
  • Expression data are derived from records contained in the Gene Expression Omnibus (GEO) , and are first log2 transformed and normalized. (yeastgenome.org)
  • Human chromosome 21 gene expression atlas in the mouse. (taconic.com)
  • GenePaint.org: an atlas of gene expression patterns in the mouse embryo. (taconic.com)
  • A gene expression map of human chromosome 21 orthologues in the mouse. (taconic.com)
  • Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. (taconic.com)
  • Alternatively spliced transcript variants encoding different isoforms have been noted for this gene, however, expression of some of these isoforms in vivo is not known. (nih.gov)
  • The directed expression of alpha-synuclein , a gene contributing to inherited forms of Parkinson disease (PD), in the dopaminergic neurons (DA) of flies provides a robust model of PD complete with the loss of neurons and accompanying motor defects. (sdbonline.org)
  • The gene codes for a 650 nt transcript which is expressed in greater abundance in ovaries, embryos, and third instar larvae relative to other tissues and developmental stages. (marquette.edu)
  • The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. (novusbio.com)
  • The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. (nih.gov)
  • This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)
  • A total of 39 QTLs for growth habit-related traits was detected on 10 chromosomes explaining 4.55-27.74% of the phenotypic variance, in which 6 QTLs were for lateral branch angle, 8 QTLs were for extent radius, 7 QTLs were for the index of plant type, 11 QTLs were for main stem height, and 7 QTLs were for lateral branch length. (frontiersin.org)
  • it is known to be controlled by a number of genes known as quantitative trait loci (QTLs). (jipb.net)
  • The stochastic inheritance of chromosome fragments by both newly formed daughter cells could in part contribute to the alternating DNA copy-number states that are characteristic of chromothripsis 2 . (nature.com)
  • Based on the phylogenetic analysis and structural characteristics, 197 identified bHLH genes could be well classified into 21 groups. (biomedcentral.com)
  • For the first time, a comprehensive analysis identified the bHLH genes in Chinese white pear and demonstrated that PbrbHLH195 is involved in the production of ROS in response to cold stress, suggesting that members of the PbrbHLH family play an essential role in the stress tolerance of pear. (biomedcentral.com)
  • For a focused analysis on 12 genes, overlapping QTL from the public domain were presented. (biomedcentral.com)
  • Gene reduction analysis revealed that the gene deletion processes are under selective pressure, and many of the inactivations are probably related to the organism's interaction with its host environment. (asm.org)
  • In the present study, genes across the 2q24-q33 interval were analyzed to identify an autism susceptibility gene in this region. (neurotransmitter.net)
  • 5 ] detected significant associations between leaf angle variation and markers in the region but not with Dw3 itself, and thus, authors proposed other genes on the chromosome 7 interval could be controlling the trait as well. (biomedcentral.com)
  • Here we tracked micronucleated chromosomes with live-cell imaging and show that acentric fragments cluster in close spatial proximity throughout mitosis for asymmetric inheritance by a single daughter cell. (nature.com)
  • Here we show that pulverized chromosomes from micronuclei spatially cluster throughout mitosis and identify the CIP2A-TOPBP1 complex as an essential regulator of this process. (nature.com)
  • 6 identified a gene cluster, hbpCAD , encoding the upper metabolic pathway of OPP which involves the transformation of OPP to 2-hydroxypenta-2,4-dienoateand benzoic acid (BA). (nature.com)
  • Native and full length LaTRF and a mutant bearing the putative Myb-like domain expressed in bacteria bound double-stranded telomeric DNA in vitro . (biomedcentral.com)
  • Curated mutant alleles for the specified gene, listed alphabetically. (yeastgenome.org)
  • These complexes, which are abundant at chromosome ends but do not accumulate elsewhere, are present at telomeres throughout the cell cycle and their action is limited to telomeres [ 7 , 8 ]. (biomedcentral.com)
  • High-quality primers of 1174 SSR loci were designed, of which 88.16% were localized to nine chromosomes of sweet orange. (citrusgenomedb.org)
  • Although leaf angle quantitative trait loci (QTL) have been previously reported, only the Dwarf3 ( Dw3 ) auxin transporter gene, colocalizing with a major-effect QTL on chromosome 7, has been validated. (biomedcentral.com)
  • Alternatively, susceptibility ( S ) genes provide recessive resistance that can be both broad-spectrum and durable ( 22 - 24 ). (elifesciences.org)
  • Translocations between MLL (a human trithorax -related gene) and AF4 or AF5q31 are involved in acute lymphoblastic leukemia (Wittwer, 2001, Tang, 2001 and Su, 2001). (sdbonline.org)
  • Variants in blood pressure genes and the risk of Accardi R, Rubino R, Scalise M et col . (2011). (who.int)
  • In contrast, isolates of the antiqua and medievalis biovars are generally limited to localized regions containing long-term plague foci from enzootic rodent hosts in Africa and central Asia. (asm.org)
  • As each chromosome contains a single centromere, it remains unclear how acentric fragments derived from shattered chromosomes are inherited between daughter cells during mitosis 6 . (nature.com)