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  • progression
  • In clinical medicine, autoantibodies have been used to establish diagnosis, estimate prognosis, follow the progression of a specific autoimmune disease, and, finally, increase our knowledge of the pathophysiology of autoimmunity. (rupress.org)
  • Nucleoside modifications are interesting due to their already known roles in translation fidelity, enzyme recognition, disease progression, and RNA stability. (mdpi.com)
  • mutations
  • Telomerase deficiency because of mutations in human telomerase RNA (hTR) has also been linked to several inherited human diseases, such as dyskeratosis congenita, aplastic anemia, myelodysplasia, and idiopathic pulmonary fibrosis ( 13 - 26 ). (pnas.org)
  • receptors
  • Ligand-gated chloride channels are important insecticide targets and here we highlight copy number and functional divergence in insect lineages, raising the potential that order-specific receptors could be isolated within an effective class of insecticide targets. (g3journal.org)
  • accumulation
  • Unlike other reverse transcriptases, telomerase is unique in that it is a ribonucleoprotein complex, where the RNA component [telomerase RNA (TR)] not only provides the template for the synthesis of telomere DNA repeats but also plays essential roles in catalysis, accumulation, TR 3′-end processing, localization, and holoenzyme assembly. (pnas.org)
  • embryo
  • According to this view, inappropriate UPR activation can cause specific patterning defects during embryo development. (biologists.org)
  • nanos RNA is localized to the posterior pole during oogenesis and the posteriorly synthesized Nanos protein is sequestered into the germ cells as they form in the embryo. (biologists.org)
  • found
  • Post-transcriptional RNA modifications have been found to be present in a wide variety of organisms and in different types of RNA. (mdpi.com)
  • analysis
  • Our analysis points to usage of alternative 3'UTR isoforms as a novel mechanism to provide for differential localization of functionally diverse alternative protein isoforms. (mdc-berlin.de)
  • Marker-assisted analysis of six BMP signaling components ( dpp, gbb, scw, tkv, sax, sog ) by RNA interference revealed that both serosa and amnion specification of M. abdita are dependent on BMP activity. (biologists.org)
  • interact
  • These high-resolution structures have significantly advanced our understanding of how TERT catalyzes the reverse transcription of telomere DNA and how TERT could potentially interact with the ss telomere DNA and the template RNA/DNA hybrids. (pnas.org)
  • cells
  • This response to replication stress was cell-type specific, with neuroblast stem cells of the larval brain having the largest increase in Dup protein. (biologists.org)
  • role
  • Immunofluorescence with monoclonal and polyclonal antibodies against multiple epitopes of vertebrate titin further supports its localization to condensed mitotic human chromosomes, suggesting a role for titin not only in myofibrillar assembly and muscle elasticity, but potentially in the architecture of mitotic chromosomes. (rupress.org)
  • Overexpression of CG11340 increased sensitivity to dietary copper, and RNAi and ends-out knockout of CG11340 resulted in copper tolerance, providing evidence for a specific nonneuronal role for this subunit in D. melanogaster . (g3journal.org)
  • activation
  • The heterotrimeric G protein, defined by its alpha-subunit Concertina, contributes to the localization and activation of RhoGEF2 ( 37 ). (asm.org)
  • Transfer
  • We apply our internal standards and quantify the modification content of transfer RNA (tRNA) from bacteria and various eukaryotes. (mdpi.com)
  • addition
  • The 3′ ends of telomeres are replicated by telomerase, a unique reverse transcriptase discovered almost three decades ago ( 7 ), which catalyzes the addition of telomere DNA repeats onto the ends of linear chromosomes using an embedded RNA as the template ( 8 , 9 ). (pnas.org)
  • The TEN domain interacts with the ss telomere DNA repeats, the TRBD domain binds multiple sites of TR, and the RT and C-terminal extension domains bind the RNA/DNA hybrid and catalyze the addition of DNA repeats onto the 3′ end ( 27 , 31 - 34 ). (pnas.org)
  • sets
  • Description: RNA profiling data sets generated by the Mouse ENCODE project. (nih.gov)
  • human
  • We review this progress to determine the overall architecture of human telomerase RNA. (pnas.org)
  • common
  • The metazoan LGIC lineages expanded from clades present in the last common bilaterian ancestor, and extant metazoa now exhibit lineage-specific clades ( Dent 2006 ). (g3journal.org)