Localization chromosomal proteins non histone. Medical search. Frequent questions

Lamin B2 promotes the malignant phenotype of non-small cell lung cancer cells by upregulating dimethylation of histone 3 lysine 9. (nih.gov)
The E3 ubiquitination step determines the overall specificity for ubiquitination of the target protein, and the activated ubiquitin is usually transferred to a lysine residue in the substrate. (bmbreports.org)
This role involves its DNA-binding domain, which is composed of a tandem array of zinc fingers, and PRDM9-dependent trimethylation of histone H3 at lysine 4. (springer.com)
Wu and Lichten 1994 ), where the level of trimethylation of histone H3 at lysine 4 (H3K4me3) is constitutively high (Borde et al. (springer.com)
2010 ). PRDM9 includes several functional domains, such as a DNA-binding zinc finger array, a histone lysine methyltransferase PR/SET (PRDI-BF1 and RIZ1 homology) domain, and a Krüppel-associated box (KRAB)-related domain. (springer.com)
Histone 3 Lysine 27 triple methylated and it is associated with genes. (usadellab.org)
Histone lysine methylation is part of the histone code that regulated chromatin function and epigenetic control of gene function. (embl-heidelberg.de)
Histone lysine methyltransferases (HMTase) differ both in their substrate specificity for the various acceptor lysines as well as in their product specificity for the number of methyl groups (one, two, or three) they transfer. (embl-heidelberg.de)
Whilst MLL1/2 also have inherent histone lysine N-methyltransferase activity, CFP1 does not, instead forming complexes with SET1A and SET1B methyltransferases, TrxG subunits of the SET1 family [ 11 ]. (biomedcentral.com)

Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. (rupress.org)
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors. (lookformedical.com)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
Phosphorylation from the histone variant H2AX from the phosphoinositide-3-kinase-related proteins kinase ATM/ATR constitutes among the preliminary signals upon harm detection and is necessary for the next build up of DNA harm detectors and mediators near DNA lesions (17). (healthweeks.com)
Modifications include methylation, acetylation and phosphorylation, preferentially in the N-terminal regions of histones H3 and H4, but also in histone H2A and H2B. (biomedcentral.com)

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. (thermofisher.com)
Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. (lookformedical.com)
An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. (lookformedical.com)
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. (lookformedical.com)
The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. (lookformedical.com)
In this study, we show that a reduction in the levels of the JIL-1 histone H3S10 kinase results in the spreading of the major heterochromatin markers dimethyl H3K9 and HP1 to ectopic locations on the chromosome arms, with the most pronounced increase on the X chromosomes. (silverchair.com)
They bind to structural components (emerin, nesprin), chromatin components (histone), signal transduction molecules (protein kinase C), and several gene regulatory molecules. (medscape.com)

10-13 ⇓ ⇓ ⇓ MeCP2 has been shown to promote the association of histone deacetylases and transcriptional repressors with methylated DNA. (neurology.org)
Histone deacetylases (HDAC) reverse the acetylation of histone and nonhistone proteins and thereby modulate chromatin structure and function of nonhistone proteins. (aacrjournals.org)
2023. The P. falciparum alternative histones Pf H2A.Z and Pf H2B.Z are dynamically acetylated and antagonized by PfSir2 histone deacetylases at heterochromatin boundaries . (hmc.edu)

8 The MeCP2 protein, initially characterized by its ability to bind single methylated CG nucleotides, 9 plays a significant role in the transcriptional silencing of genes. (neurology.org)
Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
Complex patterns of posttranslational modifications of chromatin including acetylation of histones establish combinatorial signals that are apparently interpreted by chromatin-binding proteins and the gene expression machinery to control transcriptional activity of individual genes. (aacrjournals.org)
Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different classes of molecules with unique lengths, conformations and targets. (frontiersin.org)
Due to the role of oncogenic transcriptional activators NFĸB and STAT3 in survivin protein expression, and APE1/Ref-1 redox activity regulating their transcriptional activity, we assessed selective inhibition of APE1/Ref-1's redox function as a novel method to halt prostate cancer cell growth and survival. (oncotarget.com)
Inhibition of APE1/Ref-1 redox function significantly reduced NFĸB transcriptional activity, survivin mRNA and survivin protein levels. (oncotarget.com)
These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
the ortholog of BAP1, can be a Polycomb group (PcG) proteins that interacts with the transcriptional regulator ASX and assembles the Polycomb-repressive DUB complicated that deubiquitinates histone L2A Lys-118 (L2A Lys-119 in vertebrates, hereafter L2Aub) and encourages PcG focus on gene dominance (32). (researchensemble.com)
ASX proteins can be an atypical PcG element, because it can be included in both transcriptional silencing and service (34, 35). (researchensemble.com)

Non-histone chromosomal protein HMG-17 is a protein that in humans is encoded by the HMGN2 gene. (wikipedia.org)
Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked methyl CpG binding protein 2 ( MeCP2 ) gene. (neurology.org)
7 The Rett gene was recently identified as the methyl CpG binding protein 2 ( MeCP2 ) gene. (neurology.org)
Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. (wikigenes.org)
Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. (nih.gov)
In this report, we describe a testis zinc finger protein (Tzfp) that binds to the upstream flanking sequence of the Aie1 gene. (lookformedical.com)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
Chromatin immunoprecipitation assay was performed to evaluate the histone modification of gene loci that are regulated by lunasin and cytokine. (weeksmd.com)
Here, using Next Generation Sequencing we identified a novel gene fusion event between DAXX and the kinesin motor protein, KIFC3, leading to the translation of a chimeric DAXX-KIFC3 fusion protein. (oncotarget.com)
The chromo and SET domains are conserved sequence motifs present in chromosomal proteins that function in epigenetic control of gene expression, presumably by modulating higher order chromatin. (embl-heidelberg.de)
The protein is associated with microtubules , and Chatterjee and colleagues silenced the gene via short interfering RNA (siRNA) a molecular biological mechanism to study genes, targeting the CKAP5 encapsulated in lipid nanoparticles for in vivo delivery. (medicalxpress.com)
In 5 of 6 gene mutations that have been shown to cause EDMD, the affected protein is present in the LINC (linker of nucleoskeleton and cytoskeleton) complex. (medscape.com)
EDMD1 is caused by mutations in the EMD gene on the X chromosome that codes for the nuclear envelope protein emerin. (medscape.com)
Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)
New mutations have been found in the synaptic nuclear envelope protein 1 ( SYNE1 ) gene and in the synaptic nuclear envelope protein 2 ( SYNE2 ) gene in a few families, also termed Nesprin-1 and Nesprin-2, respectively. (medscape.com)

SMC3 with retained acetylation is loaded onto chromatin, and chromatin immunoprecipitation sequencing analysis demonstrates decreased occupancy of cohesin localization sites that results in a consistent pattern of altered transcription seen in CdLS cell lines with either NIPBL or HDAC8 mutations. (nih.gov)
Reversible acetylation of histone proteins is considered to affect local structure of chromatin. (aacrjournals.org)

In this model, large portions of genomic DNA operate as 'sinks', which are filled by 'sources', such as available histone variants, covalent modifications to histones, the readers of these modifications and non-coding RNAs. (biologists.com)

The covalent attachment of ubiquitin to a target protein is catalyzed by the sequential action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin ligase (E3). (bmbreports.org)
Protein including ubiquitin-binding domain names (UBDs) are accountable for the particular and non-covalent reputation of free of charge ubiquitin and of mono- or polyubiquitinated substrates. (researchensemble.com)

The centromere is epigenetically established across cell generations by CENP-A, a histone H3 variant. (berkeley.edu)
2003). Until recently, our knowledge of ARP6 function lagged behind that of the other nuclear ARPs and was limited to a few qualitative observations in yeast and SWR1 chromatin remodeling complex that functions to replace histone H2A with the variant H2A.Z at specific chromosomal locations (Krogan et al. (irpa2006europe.com)
2004). This conserved histone variant acts partly to antagonize the spread of silent heterochromatin into euchromatic regions (Meneghini et al. (irpa2006europe.com)
A large proportion of the cell cycle-regulated histone H3.1 is replaced by H3.3, a histone variant encoded outside the histone repeat cluster and not subject to cell cycle controlled expression. (biomedcentral.com)
Certain histone modifications correspond to either the cell cycle-regulated histone H3.1 or to the testis-specific variant H3.3. (biomedcentral.com)
In spermatogonia we found H3K9 methylation in cytoplasmic histones, most likely corresponding to the H3.3 histone variant. (biomedcentral.com)
The cell cycle-regulated histone variant H3.1 and H3.3, expressed throughout the cell cycle, also vary in their modification patterns. (biomedcentral.com)
While the precise mechanism underlying activation of the ALT pathway is unclear, mutations in the chromatin remodeling protein ATRX, histone chaperone DAXX, and the histone variant H3.3 correlate with ALT status. (oncotarget.com)
ATRX and DAXX facilitate deposition of the histone variant H3.3 within heterochromatic regions suggesting that loss of ATRX, DAXX, and/or H3.3 lead to defects in the stability of telomeric heterochromatin. (oncotarget.com)

Genetic interaction assays demonstrated that JIL-1 functions in vivo in a pathway that includes Su(var)3-9 , which is a major catalyst for dimethylation of the histone H3K9 residue, HP1 recruitment, and the formation of silenced heterochromatin. (silverchair.com)
Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. (embl-heidelberg.de)

In this issue of Genome Biology, Fortin and Hansen report how they have used such a principle to predict chromosomal compartments from epigenetic domains as defined by DNA methylation data [ 9 ]. (biomedcentral.com)
Epigenetic regulation refers to the multiple chemical modifications of DNA or DNA-associated proteins that alter chromatin structure and DNA accessibility in a heritable manner, without changing DNA sequence. (frontiersin.org)
To date, most of our understanding of epigenetic regulation and its participation in leukemogenesis is based on the enzymatic activities and protein-protein interactions of histone and DNA modifiers. (frontiersin.org)
However, a growing body of evidence suggests that recruitment, stability, and function of epigenetic factors can be mediated by non-protein-coding RNAs. (frontiersin.org)

Subcellular localization critically influences protein function, and cells control protein localization to regulate biological processes. (elifesciences.org)
Protein function is critically determined by subcellular localization, as organelles offer different chemical environments and interaction partners. (elifesciences.org)
In order to regulate protein activity, many biological processes involve changes in protein subcellular localization. (elifesciences.org)
Based on their subcellular localization, the ARPs can be broadly categorized as either cytoplasmic or nuclear. (irpa2006europe.com)

All of the nuclear ARPs that have been studied in detail are constituents of either ATP-dependent nucleosome remodeling complexes or histone acetyltransferase complexes, both of which are involved in the modification of chromatin structure and, thus, the regulation of transcription and other DNA transactions (Olave et al. (irpa2006europe.com)
These can change the localization of the nucloesomes with respect to the DNA Give ONE example of nucleosome remodelling complexes. (usadellab.org)
In the nucleus it behaves as a DNA chaperone, sustains nucleosome dynamics and chromosomal stability, and contributes to telomere maintenance [ 10 ]. (hindawi.com)

Histone methyltransferase What is H3K27me3 short for and with what is this histone modification associated? (usadellab.org)

Integration of the massive amounts of epigenomic data, including DNA methylation and histone modifications, thus represents a major hurdle for understanding how chromatin organization governs cell identity epigenetically. (biomedcentral.com)
Condensation and decondensation of chromatin is to a large extent controlled or accompanied by both postranslational modifications of nucleosomal histones and sometimes by DNA methylation. (biomedcentral.com)

Post-translational modifications change function of most proteins. (bmbreports.org)
The three-dimensional organization of chromosomes into TADs corresponds with epigenetically defined domains that are marked by specific histone modifications [ 2 ]. (biomedcentral.com)
The machine learning technique known as 'random forests' applied to genomic data profiling histone modifications by means of chromatin immunoprecipitation and sequencing (ChIP-Seq) has recently allowed the prediction of Hi-C matrices and TAD borders [ 7 ]. (biomedcentral.com)
No there are tails extending from the core, these are often the target of chemical histone modifications Where does H1 come into play? (usadellab.org)
What histone modifications do you know? (usadellab.org)
Most histone modifications persist throughout the meiotic divisions. (biomedcentral.com)
Postmeiotically, we observed a highly complex pattern of the histone modifications until late spermatid nuclear elongation stages. (biomedcentral.com)
This observation, the special characteristics of the first meiotic prophase in Drosophila and the availability of antibodies specific for particular histone modifications [ 15 ] led us to study the patterns of histone modifications in the male germ line. (biomedcentral.com)
Our observations reveal that the male germ line of Drosophila shows a characteristic pattern of histone modifications. (biomedcentral.com)
We also observe that certain histone modifications are specific of spermatid nuclei. (biomedcentral.com)
The mechanism by which protein complexes interact to regulate the deposition of post-translational modifications of histones remains poorly understood. (biomedcentral.com)

Genetic mutations in ATRX, DAXX, and H3.3 have been detected in ALT positive cancers, however, a subset of ALT samples show loss of ATRX or DAXX protein expression or localization without evidence of genetic alterations suggesting additional uncharacterized defects in ATRX/DAXX/H3.3 function. (oncotarget.com)
Lastly, mutations in the transmembrane protein 43 (TMEM43), also termed LUMA, which binds to emerin and SUN2, has also been reported to cause an EDMD phenotype in a few families. (medscape.com)
Whatever the true mechanism, the discovery of mutations in several different nuclear membrane proteins that cause similar diseases will likely eventually lead to a better understanding of nuclear membrane physiology and the pathophysiology of diseases caused by mutations in these proteins. (medscape.com)

All living organisms package their DNA with chromatin proteins. (biologists.com)

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. (embl-heidelberg.de)

SMC3 is acetylated during S-phase to establish cohesiveness of chromatin-loaded cohesin, and in yeast, the class I histone deacetylase Hos1 deacetylates SMC3 during anaphase. (nih.gov)
Histone deacetylase. (usadellab.org)

The 32-aa MYND domain (for myeloid, Nervy, and Deaf-1) contains non-DNA-binding zinc fingers that are thought to mediate protein-protein interactions (Gross, 1996). (sdbonline.org)
The structured post-SET region brings in the C-terminal residues that participate in S-adenosylmethine-binding and histone tail interactions. (embl-heidelberg.de)

Several proteins have been described in mammals that bind specifically to CGIs. (biomedcentral.com)
We found that the FERM domain in the tail region, which is known to bind to lipids as well as other proteins, is essential for both nuclear and chloroplast positioning, whereas the proximal MyTH4 domain plays a supporting role in chloroplast transport. (go.jp)

Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells. (wikigenes.org)
The deubiquitinase (DUB) and tumor suppressor BAP1 catalyzes ubiquitin removal from histone L2A Lys-119 and coordinates cell expansion, but how BAP1 companions modulate its function continues to be understood poorly. (researchensemble.com)

These data highlight a potentially unrecognized mechanism of DAXX inactivation in ALT positive osteosarcoma and provide rationale for thorough and comprehensive analyses of ATRX/DAXX/H3.3 proteins in ALT positive cancers. (oncotarget.com)

This review focuses on an up-to-date understanding of the functions of E3 ligases in cancers and debates the perspectives of cancer cells that rely on inhibition or activation of ubiquitylation of target proteins. (bmbreports.org)
consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)

The centromere, a unique chromosomal domain required for kinetochore formation and faithful chromosome segregation, is a plausible source of CIN as its misregulation has been implicated to cause neo-centromere formation, dicentric behavior, and chromosome bridges, resulting in aneuploidy, genome rearrangements, and micronuclei. (berkeley.edu)

With my project, I plan to investigate how the overexpression of CENP-A affects the centromeric identity and to localization of key kinetochore proteins in human cells by elucidating its effects on the CCAN and KMN. (berkeley.edu)

MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)

2012 ), generalizing the observation that hotspot localization is determined by the DNA-binding specificity of the zinc finger array (Grey et al. (springer.com)
We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)

In S. cerevisiae , this interaction is at least in part provided by Spp1 that directly interacts with both methylated H3K4 near DSB sites and the axis-localized protein Mer2 (Acquaviva et al. (springer.com)

2003). The functions of the nuclear ARPs are less clearly defined, but like the cytoplasmic ARPs, most are known to be stable components of large protein complexes that often contain more than one ARP and sometimes monomeric actin. (irpa2006europe.com)

The capability to temporally and spatially control these parts can be endowed by an evergrowing set of posttranslational adjustments which when covalently mounted on their substrates govern procedures including protein-protein relationships proteins localization and actions and proteins degradation (10). (healthweeks.com)

ALT is a recombination-based mechanism where one telomere uses other chromosomal, or extrachromosomal, telomeric DNA sequences as a template for telomere elongation. (oncotarget.com)

Immunodetection of endogenous Suv39h1/SUV39H1 proteins in a variety of mammalian cell lines reveals enriched distribution at heterochromatic foci during interphase and centromere-specific localization during metaphase. (embl-heidelberg.de)

Residues 28 - 44 and 180 - 185 contain a nuclear localization signal (NLS). (thermofisher.cn)

1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
One such protein is the cytoskeleton-associated protein 5 (CKAP5), widely expressed in a variety of cells to regulate the dynamics of microtubules in human cells. (medicalxpress.com)

The CxxC zinc finger protein 1 (CFP1, also known as CGBP) is a subunit of the TrxG SET1 protein complex, a major catalyst of trimethylation of H3K4 (H3K4me3). (biomedcentral.com)

Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. (thermofisher.com)

We investigated histone modification patterns in testes of D. melanogaster and D. hydei . (biomedcentral.com)
Histone modification patterns in the male germ line differ from expected patterns. (biomedcentral.com)

2023. Synthesis and characterization of I-BET151 derivatives for use in identifying protein targets in the African trypanosome . (hmc.edu)

The lamin family of proteins make up the matrix and are highly conserved in evolution. (nih.gov)
During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. (nih.gov)
Lamin B2 contributes to the proliferation of bladder cancer cells via activating the expression of cell division cycle‑associated protein 3. (nih.gov)
Chromosomal aneuploidies induced upon Lamin B2 depletion are mislocalized in the interphase nucleus. (nih.gov)
This complex includes nuclear membrane integral and associated proteins including emerin, lamin A/C, SUN1, SUN2, nesprin-1, and nesprin-2 that are proposed to form a mechanical link between the nucleoskeleton and cytoskeleton. (medscape.com)

Cell mitosis is an attractive target to effectively treat a variety of cancer forms, where microtubule-associated proteins (MAPs) assist cells to maintain the stability of cell dynamics. (medicalxpress.com)

Using affinity chromatography coupled to multidimensional protein identification technology (MudPIT), DEAF-1 was identified as a candidate regulator. (sdbonline.org)
PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. (springer.com)
The PI3K/Akt/mTOR signaling pathway is a key regulator of diverse physiological functions such as proliferation, global protein, and lipid synthesis as well as many metabolic pathways interacting to increase secretory capabilities. (go.jp)

This is particularly important at regulatory regions, such as CpG islands (CGIs), which are known to recruit Trithorax (TrxG) and Polycomb group proteins. (biomedcentral.com)

A recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human HMGB1. (thermofisher.cn)
The premature transition from vegetative to reproductive development in mutants results at least in part from a reduction in the expression of the floral repressor genes ((ARP6 Is usually a Member of the Conserved Eukaryotic ARP6 Class Based on overall amino acid sequence similarity, the protein that we have named ARP6 is usually most closely related to members of the ARP6 class. (irpa2006europe.com)
One pathway, which has been extensively studied in yeast, is mainly guided by chromatin structure and the other, analyzed in detail in mice, is driven by the sequence-specific DNA-binding PR domain-containing protein 9 (PRDM9). (springer.com)
Potential C. elegans orthologs for II of the 12 protein-coding genes predicted in the B. malayi sequence were identified. (biomedcentral.com)

A major transcript of 14982 bp produces a 3969 amino acids protein from 36 of the 37 exons. (atlasgeneticsoncology.org)

once we know what compartment a protein is in, it is easier to narrow down what it might be doing. (elifesciences.org)

HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). (thermofisher.cn)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)

DEAF-1 is maternally expressed, and the encoded protein is broadly distributed throughout the early embryo. (sdbonline.org)
UBD-containing protein are broadly included in the appropriate and well-timed initiation therefore, distribution, or end of contract of ubiquitin-mediated signaling occasions (3, 9). (researchensemble.com)

The 10nm fiber is further packaged into a 30nm fiber requiring the linker histone H1 Sometimes "packed" chromosomal DNA needs to be accessed, how is this problem solved? (usadellab.org)

This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. (thermofisher.com)
Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional protein that is essential in activating oncogenic transcription factors. (oncotarget.com)

This facilitates TrkAIII tk-mediated binding of gamma-tubulin, which is regulated by endogenous protein tyrosine phosphatases and geldanamycin-sensitive interaction with Hsp90, paving the way for TrkAIII recruitment to the centrosome. (cnr.it)

1991). "Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. (wikipedia.org)
The resulting technique maps the location of most of the proteins in a human cancer cell line and, in addition, determines how many copies of each protein there are. (elifesciences.org)
This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)

Moreover, since changing the location of a protein can change its activity, it is also important to be able to detect changes in the location of proteins under different circumstances, such as before and after drug treatment. (elifesciences.org)
We further provide evidence that JIL-1 activity and localization are not affected by the absence of Su(var)3-9 activity,suggesting that JIL-1 is upstream of Su(var)3-9 in the pathway. (silverchair.com)
Earlier research indicated that BAP1 growth suppressor function needs DUB activity and nuclear localization (21). (researchensemble.com)

In humans, the multisubunit complex cohesin is made up of SMC1, SMC3, RAD21 and a STAG protein. (nih.gov)
In humans and mice, hotspots are specified by PRDM9, a meiosis-specific PRDM family protein (Baudat et al. (springer.com)

Anatomy36

Organisms15

Chemicals and Drugs102

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology1

Phenomena and Processes80

Disciplines and Occupations3

Information Science3

Lysine9

Phosphorylation6

Kinase7

Deacetylases3

Transcriptional11

Gene15

Acetylation2

Variants1

Covalent2

Variant9

Heterochromatin2

Epigenetic4

Subcellular localization4

Nucleosome3

Methyltransferase1

Methylation2

Modifications11

Mutations3

Chromatin proteins1

Genomic1

Deacetylase2

Interactions2

Bind2

Tumor2

H3.31

Inhibition2

Chromosome segregation1

Kinetochore1

Lipids2

Specificity2

Interacts1

Cytoplasmic1

Degradation1

Telomere1

Heterochromatic1

Residues1

Regulate2

Zinc finger1

Ubiquitination1

Modification2

Characterization1

Lamin5

Stability1

Regulator3

Polycomb1

Sequence4

Exons1

Compartment1

Receptor3

Broadly2

Linker1

Transcription factors2

Endogenous1

Human3

Activity3

Humans2