Genus specific (C. trachomatis, C. pneumoniae & C. psittaci). (idhinhibitor.com)
C. trachomatis and C. pneumoniae, have an immense impact on public health in the US and globally. (ku.edu)
Intracellular5
Chlamydia trachomatis are obligate intracellular bacterial pathogens that cause ocular and genital infections, which are a significant public health concern worldwide. (europa.eu)
The obligate intracellular bacteria Chlamydia replicate within an intracellular vacuole, termed an inclusion. (pasteur.fr)
Diagrammatic representation of the specificity of the antigen - antibody reaction that enables detection and localization of a single target in a milieu of thousands of intracellular molecules. (technologynetworks.com)
Liang P, Rosas-Lemus M, Patel D, Fang X, Tuz K, Juárez O (2017) Dynamic Energy Dependency of Chlamydia trachomatis on Host Cell Metabolism during Different Stages of Intracellular Growth: Possible role of Sodium -based energetics in Chlamydial ATP generation. (iit.edu)
Chlamydia (klah-MID-e-a) are obligate intracellular bacteria that are propagated and maintained through a phylum defining bi-phasic developmental cycle. (ku.edu)
Proteins12
Then, we selected 48 genes that may encode uncharacterised effectors (e. g. no detectable amino acid identity to other proteins or with a particular putative biochemical activity) from the genome of C. trachomatis strain L2/434/Bu. (europa.eu)
we tested if these 22 C. trachomatis proteins with an N-terminal T3S signal were also secreted as full-length proteins after PyopE-dependent expression in Y. enterocolitica. (europa.eu)
Thirteen proteins showed a statistically significant higher level of secretion than full-length C. trachomatis RplJ. (europa.eu)
In summary, we have identified 22 novel putative C. trachomatis T3S effectors, seven of which were also secreted as full-length proteins by Y. enterocolitica in different experimental conditions. (europa.eu)
Therefore, these 7 proteins are very likely novel effectors of C. trachomatis. (europa.eu)
We have raised rabbit polyclonal antibodies against 5 of these proteins and we are currently analysing their subcellular localisation in C. trachomatis infected cells. (europa.eu)
To study the function of known effectors, we focused on the C. trachomatis Inc proteins, an important group of potential chlamydial virulence factors. (europa.eu)
The DUF582 proteins of Chlamydia trachomatis bind to components of the ESCRT machinery, which is dispensable for bacterial growth in vitro. (pasteur.fr)
Legionella pneumophila and Chlamydia trachomatis are the two pathogens that, once inside the host cell, reside inside a compartment that is continuously modified by the action of effector proteins to escape killing and allow the creation of a replicative niche for the bacteria. (unl.pt)
Currently, ongoing projects include the elucidation of the functions of L. pneumophila effector proteins that are involved in actin dynamics or are targeted to the nucleus, as well as a C. trachomatis Golgi associated protein. (unl.pt)
cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins. (gzsys.org.cn)
Localization of organelle proteins by isotope tagging (LOPIT). (joplink.net)
Bacterial5
Worldwide, C. trachomatis is the leading preventable cause of blindness and bacterial sexually transmitted infections (STIs). (cdc.gov)
To screen for novel T3S effectors of C. trachomatis, we used Yersinia enterocolitica as a genetically tractable surrogate bacterial species assembling a T3S apparatus, which has been shown to recognise heterologous T3S substrates. (europa.eu)
NLRX1 also plays a role in host immunity during bacterial infections, such as Chlamydia trachomatis and Helicobacter pylori, by regulating bacterial burden and inflammation in mononuclear phagocytes. (wikipedia.org)
Our lab conducts biomedical research directed to establish the metabolic strategies and host- pathogen relationship in bacterial pathogenic species, such as Chlamydia trachomatis , the most prevalent sexually transmitted disease in the world, and Vibrio cholerae , which produces severe gastrointestinal disease to millions of people in developing countries. (iit.edu)
Dr. Maurelli has over 30 years of research experience in the field of molecular genetics of bacterial pathogenesis, specifically in the study of Shigella and Chlamydia. (ufl.edu)
Infections7
Chlamydia trachomatis is a global cause of blinding trachoma and sexually transmitted infections (STIs). (cdc.gov)
A better understanding of C. trachomatis basic biology is important to eventually develop new ways to combat infections caused by these bacteria. (europa.eu)
Chlamydia infections disproportionately affect men who have sex with men. (chlamydiaexplained.com)
Chlamydia infections disproportionately affect non-Hispanic Black populations. (chlamydiaexplained.com)
Development of a vaccine has been hindered by the lack of vertebrate animal models that more closely mimics human immune responses as well as characterization of the correlates for immunity to human Chlamydia infections. (ku.edu)
Antibiotic resistance is a major public health threat and while two major classes of antibiotics (e.g., macrolides and tetracyclines) are effective at clearing Chlamydia infections, resistance to one of these has already been observed in pigs strains (yes…there is pig Chlamydia ! (ku.edu)
Chlamydia is a major cause of sexually transmitted infections worldwide. (ufl.edu)
Vacuole1
They share a unique hydrophobic motif thought to target them to the membrane of the large vacuole where Chlamydia resides intracellularly. (europa.eu)
Antibody1
Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer. (gzsys.org.cn)
Isolates1
We used comparative genomics of the family Chlamydiaceae to select conserved housekeeping genes for C. trachomatis multilocus sequencing, characterizing 19 reference and 68 clinical isolates from 6 continental/subcontinental regions. (cdc.gov)
Trachoma4
Multilocus and SNP typing can now be used to detect diverse and emerging C. trachomatis strains for epidemiologic and evolutionary studies of trachoma and STI populations worldwide. (cdc.gov)
Trachoma is initiated during childhood following repeated conjunctival infection with Chlamydia trachomatis, which causes a chronic inflammatory response in some individuals that leads to scarring and in-turning of the eyelids in later life. (bvsalud.org)
Every 3 months for 4 years, children were examined for clinical signs of trachoma, and conjunctival swabs were collected for C. trachomatis detection and to analyze the expression of 46 immunofibrogenic genes. (bvsalud.org)
C. trachomatis also is the leading cause of preventable blindness (trachoma) worldwide. (ku.edu)
Ribosomal1
As negative control, we used a fusion between the first 20 amino acids of a C. trachomatis ribosomal protein and TEM-1 (RplJ20-TEM-1). (europa.eu)
Species1
Here we identify SNARE-like motifs in the inclusion protein IncA, which are conserved among most Chlamydia species. (pasteur.fr)
Ectopic1
Yes, treatment is necessary for chlamydia, particularly in women of childbearing age, because it reduces the risk of chlamydia-associated ectopic pregnancy, fertility problems, and the transmission of chlamydia to neonates during birth. (chlamydiaexplained.com)
Genital1
Chlamydia trachomatis causes both genital tract and ocular diseases. (ku.edu)
Eukaryotic1
After directing entry into a eukaryotic cell, the EBs quickly modifies the early endosome into a Chlamydia specific vessicle termed an inclusion. (ku.edu)
Asymptomatic1
When compared to previous years, 2019 infection rates increased among people of all genders, all races and ethnicities, and in every region of the U.S. Most cases of chlamydia are asymptomatic, which means there are no signs or symptoms of an infection. (chlamydiaexplained.com)
Immunity1
He has served as Secretary-Treasurer of the Chlamydia Basic Research Society and Mini-reviews Editor for Infection and Immunity. (ufl.edu)
Azithromycin2
Phagocytes deliver azithromycin to places of localization of an infection where it is released in the course of phagocytosis. (rxeli.com)
IHC employs a combination of histology, anatomy, immunology and biochemistry to detect the amount, distribution and localization of a specific target within a tissue. (technologynetworks.com)
IncA1
We first confirmed that known T3S substrates (IncA and IncC effectors) of C. trachomatis possess a T3S signal within their first 20 amino acids, which is recognised by the Y. enterocolitica T3SS as efficiently as a Yersinia endogenous T3S substrate. (europa.eu)
Chlamydia trachomatis Infection Is Related to Premature Ejaculation in Chronic Prostatitis Patients: Results from a Cross-Sectional Study. (medscape.com)
Protein1
2013) The Joubert Syndrome Associated Missense Mutation (V443D) in the Abelson-helper Integration Site 1 (AHI1) Protein Alters Its Localization and Protein-Protein Interactions. (iit.edu)
Infection among2
Young women in this age group are targeted for chlamydia screenings, and the rate of infection among those who are tested is high. (chlamydiaexplained.com)
According to the CDC, C. trachomatis has the highest incidence of infection among ALL reportable infectious diseases in the US! (ku.edu)
Fundamental2
The overall scientific objective of this project was to increase our fundamental understanding of mechanisms underlying C. trachomatis virulence. (europa.eu)
The Chlamydia developmental cycle is fascinating and there are many fundamental aspects that are still poorly understood. (ku.edu)
Clinical1
For localization of UTI, the four-glass test is still considered the diagnostic standard, but it is cumbersome and has little use in the clinical setting. (medscape.com)
There are many priorities and challenges associated with Chlamydia research. (ku.edu)
Type1
For this, specifically we aimed to (i) identify novel C. trachomatis type III secretion (T3S) effectors and (ii) further understand the secretion and function of known effectors. (europa.eu)
Despite excellent educational and awareness programs, conditional prevention strategies are insufficiently addressing the public health challenge associated with Chlamydia infection rates. (ku.edu)
Close1
Chlamydia trachomatis is spread by close social contact or sexual activity. (cdc.gov)
Studies1
Studies in infectious disease models have provided a wealth of information regarding memory CD8 T cell generation and localization. (frontiersin.org)
Test1
If you're under 25 years of age, you should be offered a repeat test for chlamydia 3 to 6 months after finishing your treatment because you're at a higher risk of catching it again. (chlamydiaexplained.com)