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  • protein
  • a) Protein domain structure of BRCA1 showing the location of nuclear localization signals (NLSs), nuclear export signals (NESs), and binding sites for BARD1 and gamma-tubulin. (hindawi.com)
  • However, no significant association of Bad translocation with phosphatidylinositol 3-kinase/Akt and protein kinase A signaling pathways was noted when treated cells were examined in relation to phosphorylation status of Bad by Western blot and localization of Bad to mitochondria by confocal analysis. (aacrjournals.org)
  • Owing to its promising intrinsic binding capability of drug molecules, HSA offers favorable characteristics and can be directly used as its monomeric formula or can be fabricated into protein based nanoparticle platforms to realize the effective delivery of therapeutic molecules into targeted diseases areas. (jove.com)
  • Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo. (menchange.site)
  • tumours
  • According to the invention, drug uptake in tumours will be markedly increased at the same time as the interaction of the drug with healthy organs and tissues can be minimized. (google.com)
  • New ultra-small hybrid nanoparticles, developed by Jiangfang Zhang and a team based at the University of California, have proven highly effective at delivering anti-cancer drugs in mice - the nanoparticles, which are under 25nm in size, could penetrate deep into the tumours of the mice to release the drug where it would be most effective. (rsc.org)
  • Cancer drug carriers work best at sizes below 50nm, where they can more easily infiltrate tumours, but preventing such small particles from aggregating once synthesised can be a challenge. (rsc.org)
  • lipid
  • and (b) a drug enclosed in said lipid carrier and provided with a DNA targeting agent to target the drug to the nuclei of specific target cells. (google.com)
  • Zhang's team used both lipids and polymers to make their nanoparticles highly stable, even in physiological conditions - the polymer cores took up the hydrophobic drug, while the lipid coating provided stability and protection from the aqueous environment of the body. (rsc.org)
  • delivery
  • Type 1: Th e microcapsules are subcutaneously injected in the area surrounding the tumor, followed by delivery of radiations. (omicsonline.org)
  • 8 . A method as in claim 7 , wherein the inhibitor comprises a coating that encapsulates the drug, and wherein treating the patient so that the inhibitor is overcome comprises applying a magnetic field such that the delivery packages generate heat, motion, or a combination thereof sufficient to disrupt the inhibitory function of the coating. (google.de)
  • 2. A drug delivery system according to claim 1 , wherein the cell targeting agent is selected from the group consisting of ligands, antibodies and antibody fragments. (google.com)
  • 3. A drug delivery system according to claim 1 , wherein the DNA targeting agent is a DNA intercalator or an agent that interacts electrostatically or reacts chemically with DNA. (google.com)
  • inhibitor
  • b4) treating the patient such that the inhibitor is overcome and drug acts on the cells characteristic of the disease. (google.de)
  • compound
  • b) as the DNA targeted drug, the compound 1,8-diamino-4-N-3-(12-(N-9-acridinyl-3-aminopropyl)-p-carborane-1-yl) propyl-4-azooctane hydrogen chloride (WSA1). (google.com)
  • time
  • Most of the present day diseases are life style diseases However there is again a revival of drugs being obtained from vegetable sources than at any time in history. (science20.com)
  • mice
  • What's more, the anti-cancer drug docetaxel could be loaded into the nanoparticles and used to treat the mice, with highly promising results. (rsc.org)
  • studies
  • Recently, several studies have been conducted on Ayurvedic crude drugs for cure of digestive diseases, leprosy and skin diseases, malaria and paralysis, herbal cosmetics. (science20.com)
  • mostly
  • The plants used in ayurvedic drugs were mostly collected from the field conditions and this has resulted in considerable loss of biodiversity and endangering several plant species. (science20.com)
  • response
  • In this study, we proposed a multi-scale mathematical model to simulate the dynamic changes of tumour microvasculature and microenvironment in response to anti-angiogenic drug endostatin (ES). (cancerindex.org)