Local_anesthetic. Medical search. Frequent questions

The toxicity of local and infiltration anesthetics can be local or systemic. (medscape.com)
Manifestations of local anesthetic toxicity typically appear 1 to 5 minutes after the injection, but onset may range from 30 seconds to as long as 60 minutes. (medscape.com)
The evaluation of patients with possible toxicity from a local anesthetic should be guided by the clinical presentation. (medscape.com)
Blood levels of the anesthetic may be measured, although blood levels may not correlate with toxicity or may not be obtained at a clinically useful time. (medscape.com)
See also Local Anesthetic Systemic Toxicity (LAST) Under Anesthesia . (medscape.com)
Local anesthetic systemic toxicity (LAST) is a rare but serious critical event. (medscape.com)
Other complications of local anesthetic use include neural toxicity, allergic reactions, and metabolic abnormalities, including methemoglobinemia (beyond the scope of this article). (medscape.com)
However, pediatric patients have a higher risk of experiencing toxicity and serious adverse events with local anesthetics due to their decreased body weight and also to the frequent use of sedation. (rdhmag.com)
Many times, the cause of toxicity in children from local anesthetics is overdose. (rdhmag.com)
American Society of Regional Anesthesia and Pain Medicine checklist for managing local anesthetic systemic toxicity: 2012 version. (medscape.com)
Guidelines for the Management of Severe Local Anaesthetic Toxicity. (medscape.com)
Lipid resuscitation for local anesthetic toxicity: is it really lifesaving? (medscape.com)
Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection. (medscape.com)
Local anesthetic toxicity, seizures and allergic reactions will be discussed. (vivalearning.com)
As well, how to recognize and manage local anesthetic toxicity and local anesthetic related allergic reactions will be discussed. (vivalearning.com)
[5] There is no difference between the infraclavicular block and all other upper extremity blocks in the observed risk of pneumothorax, vascular puncture, Horner's syndrome, transient neurological deficit, or systemic local anesthetic toxicity. (asra.com)
Doses of ≤50 mg bupivacaine equivalents (20 ml 0.25% bupivacaine on each side, for example) are recommended on each side to balance analgesia efficacy with risk of local anesthetic systemic toxicity (LAST). (asra.com)
CAUTION: All topical anesthetic preparations are absorbed from mucosal surfaces and toxicity may result when dose limits are exceeded. (msdmanuals.com)

Dextran (low-molecular-weight) when added to local anesthetic solutions result in increased peripheral nerve block anesthesia duration, probably due to a reduction in local anesthetic systemic absorption. (pharmacology2000.com)
One patient had an equivocal local skin reaction with subcutaneous challenge without systemic effects. (elsevierpure.com)

Local anesthetic + epinephrine: increased cardiac irritability which may cause an increased risk of cardiac arrhythmias. (pharmacology2000.com)
3,4] Chondrolysis is listed among the possible adverse incidents in the device labelling of pain pumps.1,2 The device labelling states that the continuous intra-articular infusion of anesthetics, particularly when epinephrine is also used, is not recommended. (pharmacologycorner.com)
Health care professionals are encouraged to follow the instructions for use and refrain from using postoperative pain pumps for continuous intra-articular infusion of local anesthetics, particularly with epinephrine, after shoulder surgery. (pharmacologycorner.com)
For information on calculating appropriate amounts of local anesthetic/epinephrine, please refer to the Calculating Concentrations and Dilutions section below. (medscape.com)

Short Duration of Action and Low Potency Benzocaine Procaine Chloroprocaine Medium Duration of Action and Medium Potency Lidocaine Prilocaine High Duration and High Potency Tetracaine Bupivacaine Cinchocaine Ropivacaine Local anesthetics may be used to prevent and/or treat acute pain, to treat chronic pain, and as a supplement to general anesthesia. (wikipedia.org)
Amide local anesthetics available for dental usage include lidocaine, mepivacaine, articaine, prilocaine and bupivacaine. (dentalcare.com)
Bupivacaine is an anesthetic commonly used with postoperative pain pumps. (pharmacologycorner.com)
Lidocaine (1% or 2%) and bupivacaine (0.25%) are the 2 most commonly used local anesthetics. (medscape.com)

Long acting local anesthetic abdominal nerve blocks during laparoscopic ventral hernia repair were associated with decreased post anesthesia care unit time and length of stay. (sages.org)

Large doses of lidocaine (up to 55 mg/kg, versus the conventional maximum of 4.5 mg/kg) are used for tumescent anesthesia, in which a dilute local anesthetic solution is injected into subcutaneous tissue until it becomes firm and tense. (medscape.com)
Another difference among injectable anesthetic agents is the maximum recommended doses. (dentalcare.com)
Refer to Table 1 that summarizes the maximum recommended doses of local anesthetic agents as per the American Academy of Pediatric Dentistry (AAPD) Guidelines. (dentalcare.com)
maximum recommended doses of local anesthetics should be calculated by body weight and strictly adhered to, whenever possible. (rdhmag.com)
No previous studies have looked at the dose-response relationship curve (DRC) between local anesthetic volume in a supraclavicular block and the degree of HDP, but studies investigating dosing in ultrasound-guided supraclavicular blocks have found HDP at various doses. (newswise.com)
The study used an up-down methodology which would help prevent patients from receiving unnecessary subtherapeutic anesthetic doses. (newswise.com)

An amide-type local anesthetic used for local or regional anesthesia during surgery and for short-term management of acute pain. (drugbank.com)
An anesthetic used for local or regional anesthesia. (drugbank.com)

Benzocaine hydrochloride is a local anesthetic in the form of hydrochloride salt benzocaine, pharmacological effects with benzocaine, procaine than anesthetic effect is weak. (rawsgearpharma.com)
Benzocaine hydrochloride is the hydrochloride form of local anesthesia benzocaine, and benzocaine has the same pharmacological effect and weaker anesthesia compared to procaine. (rawsgearpharma.com)
Benzocaine HCL is the main local anesthesia of gums, teeth and pain that relieves sore throat. (rawsgearpharma.com)

Lidocaine Hydrochloride Topical Solution USP 4% contains a local anesthetic agent and is administered topically. (drugs.com)
The anesthetic can be applied topically for the skin or mucous membranes, or perhaps inhaled via a nasal spray for some kinds of procedures. (jamiecooperimages.com)
The anesthetic can even be applied topically to the skin or mucous membranes, or perhaps inhaled via a nasal spray for some kinds of procedures. (9appsdownloadi.com)
Local anesthetic can be administered topically in the form of a gel or injected directly into the treatment area. (smilliedental.com)
Lidocaine Ointment USP, 5% contains a local anesthetic agent and is administered topically. (nih.gov)

A topical anesthetic can first be placed on your gums or inner cheek to numb you from feeling the injection. (asmilebydesign.com)
Local necrosis has been associated with the use of subcutaneous or intradermal use of intravenous diphenhydramine hydrochloride injection. (nih.gov)
Recently, a computer-controlled local anesthetic delivery system (CCLAD) has been developed to reduce pain related to the local anesthetic injection. (dentaleducationhub.co.nz)

They are used in various techniques of local anesthesia such as: Topical anesthesia (surface anesthesia) Topical administration of cream, gel, ointment, liquid, or spray of anesthetic dissolved in DMSO or other solvents/carriers for deeper absorption Infiltration Brachial plexus block Epidural block (extradural) Spinal anesthesia (subarachnoid block) Iontophoresis Diagnostic purposes (e.g. dibucaine) Anti-arrhythmic agents (e.g. lidocaine). (wikipedia.org)
In general, the rate of absorption of local anesthetic agents following topical application occurs most rapidly after intratracheal administration. (drugs.com)
Lidocaine Hydrochloride Topical Solution USP is contraindicated in patients with a known hypersensitivity either to local anesthetics of the amide type or to the components of the topical solution. (drugs.com)
If you have a toothache, you might consider an at-home topical anesthetic to ease your pain until you can get in to see your Dansville dentist. (asmilebydesign.com)
Lidocaine Ointment 5% effects local, topical anesthesia. (nih.gov)
Topical anesthetics are used to reduce the pain caused by needle insertion. (medscape.com)

Thus the difference is due to varying concentration of the local anesthetic in the cartridge (1.8cc). (dentalcare.com)
Several different things are continuously monitored while you're under - pulse oximetry (oxygen level in the blood), heart rate, blood pressure, respiratory rate, carbon dioxide exhalation levels, temperature, the concentration of the anesthetic and brain activity. (howstuffworks.com)

The study concluded that 0.5% ropivacaine alone does not affect the cardiovascular system and ropivacaine can be useful for oral and maxillofacial surgeons who are looking for a local anaesthetic with minimal cardiovascular risk and without a vasoconstrictor to provide regional anaesthesia for long procedures. (medscape.com)

The majority (98%) of players would repeat the procedure if they had their injury again, although 32% felt that there were side effects associated with the procedure (including 22% who thought that the recovery of the primary injury was delayed and 6% who thought that the injury was worsened by playing with local anesthetic). (nih.gov)
The goal of pharmacotherapy is to provide local anesthesia, both superficial and deep, before and throughout the procedure. (medscape.com)
Local anesthetic agents are used to increase patient comfort during the procedure. (medscape.com)
This is extremely relevant in pediatric dentistry where there is a wide variation in weight between patients and thus not all patients should receive equal amounts of local anesthetic for the same procedure. (dentalcare.com)
As with any dental procedure, we will ask you many questions about your current health and any previous medical conditions or issues before offering local anaesthetic. (smile2o.com)
President Biden, in fact, had a local anesthetic administered prior to the procedure. (npr.org)
You will find different techniques used in administering local anesthetics, based on the kind of procedure as well as the area being treated. (jamiecooperimages.com)
You will find different techniques employed in administering local anesthetics, based on the sort of procedure and the area receiving treatment. (9appsdownloadi.com)
After a procedure needing local anesthesia, it's recommended to take a rest and not do any strenuous activities. (smilliedental.com)
The vast majority of the side effects are minor and harmless, but it helps to get some rest after any procedure involving local anesthesia. (smilliedental.com)
Your health care provider applies numbing medicine (local anesthetic) to the area before the procedure. (medlineplus.gov)

In all my years of practice and the thousands of people I treated, I never had a genuine case of allergic reaction to any local anesthetic . (mynewsmile.com)
In this two-part column, we will explore the pharmacokinetic and pharmacodynamic challenges we face in treating children, with specific emphasis placed on the most frequently used medications in our practice: local anesthetics, analgesics, and antibacterial agents. (rdhmag.com)
If you've been in practice for any period of time as a dental hygienist, you know that it's common to use local anesthetics at your office. (rdhmag.com)
3 The ease with which a pediatric patient may be overdosed with local anesthetics is compounded by the practice of multiple quadrant dentistry and the concomitant use of sedative drugs. (rdhmag.com)
However, in routine clinical practice, local anesthesia is produced by several compounds whose mechanism of action is similar, although they have different durations of action, and from which recovery is normally spontaneous, predictable, and complete. (aneskey.com)
Provision of Day-Case Local Anesthetic Thoracoscopy: A Multicenter Review of Practice. (ox.ac.uk)

2,4 It is strongly recommended to include a vasoconstrictor in the local anesthetic solutions used in children, especially when multiple quadrants are anesthetized in smaller pediatric patients, unless there is a compelling reason to exclude it. (rdhmag.com)

Local anesthetics are most commonly used to eliminate pain during or after surgery. (wikipedia.org)
Local anesthesia is commonly used safely and effectively with little to no side effects. (asmilebydesign.com)
Time and length of procedures, positioning of the patient in the dental chair, most commonly prescribed local anesthetics and vasoconstrictors recommended for elderly patients and their maximum recommended dose. (bvsalud.org)
Local anesthetics are commonly used medications and can result in adverse reactions. (elsevierpure.com)
Commonly used for minor procedures, this involves smaller amounts of general anesthetics to keep patients awake yet relaxed and unaware. (howstuffworks.com)

A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, as opposed to a general anesthetic, which eliminates all sensation in the entire body and causes unconsciousness. (wikipedia.org)
The suffix "-caine" at the ends of these medication names is derived from the word "cocaine", because cocaine was formerly used as a local anesthetic. (wikipedia.org)
Local anaesthetic is a medication used to numb a specific area of the body, such as the mouth, to reduce pain during dental procedures. (smile2o.com)
The effectiveness of local anesthetics is determined by several factors, for example the type and level of anesthetic used, the process of administration, as well as the individual's reaction to the medication. (jamiecooperimages.com)
The effectiveness of local anesthetics is determined by several factors, like the type and quantity of anesthetic used, the technique of administration, and the individual's response to the medication. (9appsdownloadi.com)
Medication used as a local anesthetic numbs the nerves in the area that will be subjected to treatment. (smilliedental.com)

Table 1 demonstrates the variation in duration of action of injectable local anesthetics in minutes. (dentalcare.com)
Other agents which may be added to local anesthetics that affect duration of action. (pharmacology2000.com)

As such, a pediatric patient in need of extensive dental work should have a treatment plan that includes multiple appointments and single quadrant dentistry, whenever possible, to avoid exceeding the recommended maximum dose of local anesthetic. (rdhmag.com)
A precise dose of local anaesthetic delivered by an expert can make any dental visit less painful, more relaxing, and more comfortable. (smile2o.com)
At the end of the CE webinar, participants will be able to understand how to calculate the maximum dose of local anesthetic allowable for specific individuals, especially children. (vivalearning.com)

This study was designed to determine the effectiveness of skin testing for local anesthetic allergy evaluation. (elsevierpure.com)
McClimon, B , Rank, M & Li, J 2011, ' The predictive value of skin testing in the diagnosis of local anesthetic allergy ', Allergy and Asthma Proceedings , vol. 32, no. 2, pp. 95-98. (elsevierpure.com)

Our computer-controlled anaesthetic system delivers an exact dosage to the local area to help to reduce the risk of complications and adverse reactions. (smile2o.com)
They take several drugs, which, in many cases, might lead to undesirable interactions or complications, especially those involving local anesthetics. (bvsalud.org)
However, when used properly, local anesthetics offers effective pain alleviation with minimal probability of complications. (jamiecooperimages.com)
However, when used properly, local anesthetics can offer effective pain relief with minimal likelihood of complications. (9appsdownloadi.com)

It is provided by means of local infiltration of 1% lidocaine buffered with sodium bicarbonate. (medscape.com)
There is variation in duration between anesthetics, pulp and soft tissue, and maxillary infiltration and mandibular blocks. (dentalcare.com)
A nerve block is used instead of local anesthetic infiltration when accurate approximation of wound edges is important (eg, skin repair), because a nerve block does not distort the tissue as does local infiltration. (msdmanuals.com)

Local anesthetic blocks your nerves in a small, specific part of your body. (asmilebydesign.com)
The mechanism of action of local anesthetics necessitates the disruption in the electrical signals carried by nerves. (jamiecooperimages.com)

The effects of local anesthesia in dentistry usually fade away after a few hours. (smilliedental.com)

Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block. (medscape.com)
These changes may be attributable to a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system. (drugs.com)
Avoid using local anesthetics in at-risk patients (eg, those with cardiovascular disease). (medscape.com)

However, many anesthetists, surgeons, patients and nurses believe that it is safer to perform major surgeries under local anesthesia than general anesthesia. (wikipedia.org)
One significant advantage is the fact that local anesthesia minimizes the health risks linked to general anesthesia. (jamiecooperimages.com)
For nearly 200 years, scientists weren't entirely clear on how general anesthesia worked, but a 2019 study found that these anesthetic drugs tap into a part of the brain that regulates several bodily functions, including sleep. (howstuffworks.com)

Duration of Injectable Local Anesthetics (in minutes). (dentalcare.com)
2 All injectable local anesthetics have vasodilating properties. (rdhmag.com)

One hundred seventy-eight patients underwent 227 local anesthetic skin tests. (elsevierpure.com)

Long acting local anesthetic abdominal nerve blocks were used as part of a CQI program to improve outcomes. (sages.org)
SOAP guidelines also recommend consideration of local anesthetic (LA) techniques, including regional nerve blocks, in situations when long acting neuraxial morphine is not used. (asra.com)

Typical operations performed under conduction anesthesia include: Diagnostic tests such as bone marrow aspiration, lumbar puncture (spinal tap) and aspiration of cysts or other structures are made to be less painful upon administration of local anesthetic before insertion of larger needles. (wikipedia.org)
Local anesthetics block conduction in the following order: small myelinated axons (e.g. those carrying nociceptive impulses), non-myelinated axons, then large myelinated axons. (wikidoc.org)
Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. (drugs.com)

Local absorption is slow, sustained effect. (rawsgearpharma.com)

Nurse preparing a syringe for local anesthesia. (howstuffworks.com)

While generally safe, local anesthetic agents can be toxic if administered inappropriately, and in some cases may cause unintended reactions even when properly administered. (medscape.com)
For more information, see Local Anesthetic Agents, Infiltrative Administration . (medscape.com)

If you receive a local anesthetic at the dentist, the numbing effects may stick around for a few hours after your appointment. (asmilebydesign.com)

Whenever a local anesthetic is administered, it inhibits the flow of sodium ions across nerve cell membranes, which are needed for the production and transmission of electrical signals. (jamiecooperimages.com)
Whenever a local anesthetic is administered, it inhibits the flow of sodium ions across nerve cell membranes, that happen to be essential for the production and transmission of electrical signals. (9appsdownloadi.com)

Newswise - Will reducing the volume of local anesthetic prevent the incidence of hemidiaphragmatic paresis (HDP) in patients receiving an ultrasound-guided supraclavicular block? (newswise.com)
evaluated anesthetic dose levels ranging from 5 cc to 35 cc in 21 patients undergoing a supraclavicular block as the primary anesthetic for right upper-extremity surgery. (newswise.com)

Using the maximum recommended dosages (Table 2), one can calculate the maximum recommended dosage and amount of local anesthetic agent for patients of specific weight and type of anesthetic. (dentalcare.com)
The long acting local anesthetic block group comprised of 65 patients: 54% were female, mean age was 58, mean BMI was 35, and 51% had a recurrent hernia. (sages.org)
Younger patients do not need large volumes of a local anesthetic agent for pain control. (rdhmag.com)
4 Because of differences in anatomy, smaller volumes of local anesthetics provide the depth and duration of pain control usually necessary to successfully complete the planned dental treatment in younger patients. (rdhmag.com)
As a specialist in providing local anaesthetic, Dr Wayne Williams uses his expertise to reduce patient discomfort and make patients feel more at ease during procedures. (smile2o.com)
The use of local anaesthesia allows patients to undergo dental procedures with minimal discomfort and pain, which can help reduce anxiety and improve the overall experience for the patient. (smile2o.com)
Local anaesthetics are a safe and proven way to increase the comfort of dental patients during procedures. (smile2o.com)
Therefore, this literature review is aimed at dental surgeons' attitude toward use of local anesthetics in elderly patients undergoing oral implant rehabilitation. (bvsalud.org)
A retrospective chart review was performed on patients undergoing local anesthetic skin testing. (elsevierpure.com)
Three patients with six negative skin tests had a local reaction during the open subcutaneous challenge. (elsevierpure.com)
Seven skin tests on five patients met the criteria for a positive skin test with local anesthetics. (elsevierpure.com)
Ninety-eight percent of patients receiving local anesthetics in the clinical setting after open subcutaneous challenge tolerated the medications. (elsevierpure.com)

The latter helps a patient "go under," while local anaesthetic only numbs a specific area of the mouth or body. (smile2o.com)

Charts were further systematically reviewed to evaluate response to local anesthetics in the clinical setting after open subcutaneous challenge. (elsevierpure.com)

Local adverse effects include neurovascular manifestations such as prolonged anesthesia and paresthesias, which may become irreversible. (medscape.com)

Clinical use of local anesthetics began with cocaine in the 1880s. (aneskey.com)

The amount of anesthetic solution absorbed by the mesh was estimated using weight-based calculations. (sages.org)
The volume of anesthetic taken up by the mesh averaged 0.034 cc/cm2 mesh. (sages.org)
Introduction of mesh soaked in local anesthetic did not significantly reduce the immediate post-operative narcotic requirement after LVHR. (sages.org)

Three wide cotton pledgets soaked in local anesthetic solution are applied along the 3 walls of the cavity. (medscape.com)
The most common technique involves injecting the anesthetic solution straight into the tissue or nerve bundle surrounding the region of pain. (jamiecooperimages.com)
The device consists of a reservoir containing the local anesthetic solution, which is delivered by gravity or by electric pump through a catheter implanted directly into the surgical wound. (pharmacologycorner.com)

And whether you work in a state that allows dental hygienists to administer anesthesia, you know that local anesthetics are generally considered safe when properly administered. (rdhmag.com)
A local anesthetic used in dental procedures. (drugbank.com)
A local anesthetic used for inducing local, infiltrative, or conductive anesthesia in both simple and complex dental procedures. (drugbank.com)
Local anaesthetics for dental procedures are both proven and safe. (smile2o.com)
This CE webinar will focus on emergencies in the dental office that are related to the administration of local anesthetics. (vivalearning.com)
Most often, dental work only requires a local anesthetic. (asmilebydesign.com)
Local anesthetics are widely used to numb a specific portion of the body, providing effective pain alleviation for medical and dental procedures. (jamiecooperimages.com)
But, the reality is that many dental procedures require the use of a local anesthetic to block pain when the doctor performs the treatment. (smilliedental.com)

Clinical local anesthetics belong to one of two classes: aminoamide and aminoester local anesthetics. (wikidoc.org)
Local anesthetics occupy a prime position in clinical medicine as they temporarily relieve the pain by blocking voltage-gated sodium channels. (ox.ac.uk)

Levamisole hydrochloride (99% levamisole hcl, cas 16595-80-5) is another type of local anesthetic which is used to get rid of worms from the gastrointestinal system. (jamiecooperimages.com)

Anatomy16

Organisms7

Diseases13

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment70

Psychiatry and Psychology6

Phenomena and Processes24

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science2

Named Groups1

Health Care20

Toxicity18

Systemic2

Epinephrine4

Bupivacaine4

Laparoscopic ventral hernia repair1

Doses6

Regional Anesthesia2

Benzocaine3

Topically5

Injection3

Topical6

Concentration2

Ropivacaine1

Procedure11

Practice6

Vasoconstrictor1

Commonly5

Medication6

Duration of Action2

Dose of local3

Allergy2

Complications4

Infiltration3

Nerves2

Dentistry1

Cardiovascular3

General anesthesia3

Injectable Local Anesthetics2

Underwent1

Nerve blocks2

Conduction3

Absorption1

Syringe1

Agents2

Dentist1

Inhibits2

Supraclavicular2

Patients12

Numbs1

Subcutaneous1

Adverse effects1

Cocaine1

MeSH3

Solution3

Dental8

Clinical2

Hydrochloride1