Local anesthetic with bupivacaine. Medical search. Frequent questions

Lidocaine has been used successfully in bupivacaine-induced dysrhythmias, but its additive CNS toxicity is still a major concern. (rwmansiononpeachtree.com)
Local anesthetics, such as lidocaine and bupivacaine, function by blocking ion channels thereby preventing impulse conduction of pain. (vin.com)
Amide local anesthetics available for dental usage include lidocaine, mepivacaine, articaine, prilocaine and bupivacaine. (dentalcare.com)
The duration of pulpal anesthesia for bupivacaine (240 minutes) is greater than lidocaine (85 minutes) and articaine (90 minutes) and is also greater for soft tissue (340 minutes) compared to lidocaine and articaine (around 180 minutes). (dentalcare.com)
Analysis of the fluid from the bag revealed the presence of bupivacaine, epinephrine and lidocaine. (dallasnews.com)
The common suffix for local anesthetics is -caine, like procaine , tetracaine , lidocaine , Michael Caine - no wait, that's the actor. (osmosis.org)
In late March, California's Board of Pharmacy barred the distribution of medications - including lidocaine and other local anesthetics - from a Texas factory belonging to the company PharMEDium. (latimes.com)
Doctors, determined to spare their patients pain, consequently have turned to second-choice pain drugs and increased their use of local anesthetics such as lidocaine. (latimes.com)
But now, even those local anesthetics - lidocaine, ropivacaine and bupivacaine - are in short supply due to manufacturing problems and back orders, according to doctors and federal regulators. (latimes.com)
Administration of narcotics through an epidural catheter usually involves a combination of narcotic (Fentanyl, Morphine, or Dilaudid) mixed with low doses of a local anesthetic (Lidocaine, Bupivacaine, or Ropivacaine) without epinephrine. (medleague.com)
Bupivacaine 0.5%, lidocaine 2%, mepivacaine 20 mg/ml or procaine 4% were injected intratesticularly with an additional subcutaneous depot. (uni-muenchen.de)
Lidocaine, bupivacaine, pramoxine and W 6211 also caused a lower degree of attenuation of the response to substance P than the responses to acetylcholine, histamine and barium chloride. (aspetjournals.org)
Lidocaine belongs to a group of drugs called local anesthetics. (rxwiki.com)
Injectable lidocaine is used as an anesthetic during surgical procedures. (rxwiki.com)
Topical 1% lidocaine (Xylocaine) is a commonly used anesthetic. (medscape.com)
Although most respondents reported being likely to choose local anesthetics at less toxic concentrations (including 2% mepivacaine or lidocaine), they were also likely to have similar vasoconstrictor solutions (epinephrine) as the second choice. (bvsalud.org)
articaine showed a greater anesthetic effect in vestibular mucosa (88.9%) and tip of tongue (55.6%), compared with lidocaine. (bvsalud.org)
The rates of anesthetic success in the lidocaine and articaine groups were 5.6% and 22.2% respectively, but this difference was not statistically significant ( p = 0.633). (bvsalud.org)
dental differences were found in the anesthetic efficacy of 2% lidocaine and 4% articaine in lower molars with pulp, pulpitis, vital pulp. (bvsalud.org)
No statistically significant differences local anesthesia, were found when comparing the anesthetic efficacy in molars with normal pulp and molars with inflamed lidocaine, articaine pulp--although the percentage of success in normal pulp was greater than in teeth with irreversible pulpitis. (bvsalud.org)

Local anesthetics produce anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. (medscape.com)
It is the most commonly used local anesthetic in epidural anesthesia during labor, as well as in postoperative pain management. (wikipedia.org)
There have been reports of cardiac arrest with difficult resuscitation or death during use of bupivacaine hydrochloride for epidural anesthesia in obstetrical patients. (nih.gov)
The 0.75% (7.5 mg/mL) concentration of bupivacaine hydrochloride is not recommended for obstetrical anesthesia and should be reserved for surgical procedures where a high degree of muscle relaxation and prolonged effect are necessary ( 5.1 ). (nih.gov)
Bupivacaine hydrochloride injection contains bupivacaine hydrochloride, an amide local anesthetic indicated in adults for the production of local or regional anesthesia or analgesia for surgery, oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. (nih.gov)
For each type of block indicated to produce local or regional anesthesia or analgesia, specific concentrations and presentations are recommended. (nih.gov)
There have been reports of cardiac arrest and death during the use of bupivacaine for intravenous regional anesthesia (Bier Block). (nih.gov)
Oraqix is an amide local anesthetic indicated for adults who require localized anesthesia in periodontal pockets during scaling and/or root planing. (drugs.com)
Zorcaine ® is a combination of articaine HCl, an amide local anesthetic, and epinephrine, a vasoconstrictor, is indicated for local, infiltrative, or conductive anesthesia in both simple and complex dental procedures. (nih.gov)
Zorcaine ® is indicated for local, infiltrative, or conductive anesthesia in both simple and complex dental procedures in adults and pediatric patients 4 years of age or older. (nih.gov)
In this prospective, randomized, double- blind study, we investigated the postoperative analgesic efficacy of intrathecal midazolam 2.5mg as an adjunct to bupivacaine for spinal anesthesia in 80 patients undergoing lower limb orthopedic surgery. (ispub.com)
Spinal anesthesia with bupivacaine is administered routinely for lower limb surgery 1 and provides effective analgesia in the early postoperative period. (ispub.com)
The investigation of whether local anesthesia provides sufficient analgesia for this procedure and fulfills the requirements of the Animal Welfare Act is the aim of a comprehensive overall study consisting of several sections. (uni-muenchen.de)
An amide-type local anesthetic used for local or regional anesthesia during surgery and for short-term management of acute pain. (drugbank.com)
A local anesthetic used for local or regional analgesia or anesthesia. (drugbank.com)
A local anesthetic used for inducing local, infiltrative, or conductive anesthesia in both simple and complex dental procedures. (drugbank.com)
An anesthetic used for local or regional anesthesia. (drugbank.com)
Local wound infiltration (infiltration anesthesia) is commonly done and often considered procedurally simpler than nerve blockade (regional anesthesia). (msdmanuals.com)
Local anesthesia for laceration treatment Lacerations are tears in soft body tissue. (msdmanuals.com)
Full wound evaluation may require probing or manipulation, and thus local anesthesia, but sensory examination should precede administration of a local anesthetic. (merckmanuals.com)
Zynrelef is contraindicated for use in patients undergoing obstetrical paracervical block anesthesia or coronary artery bypass graft (CABG) surgery, as well as among patients with a history of asthma, urticaria, other allergic-type reactions after taking aspirin or other NSAIDs or in those with hypersensitivity to any local anesthetic agent of the amide-type. (empr.com)
Bupivacaine Hydrochloride Injection/Bupivacaine Hydrochloride and Epinephrine Injection is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and. (pfizermedicalinformation.com)
A safe and effective local anesthesia, which is one of the most frequent and important approaches for controlling the pain in Dentistry, is essential towards achieving the patient care. (bvsalud.org)
Hence, among other factors, it is important for local anesthetics to show rapid onset of action, provide adequate duration of anesthesia, and be composed by substances (i.e. local anesthetics, vasoconstrictors) with minimal or no systemic toxicity 1-2 . (bvsalud.org)
the inferior alveolar dental nerve block is the method most commonly used by endodontists to achieve local anesthesia during treatments. (bvsalud.org)
The researchers conducted a randomized clinical trial protocol to assess autonomic function at motor recovery in patients receiving spinal anesthesia with isobaric bupivacaine alone or clonidine-associated isobaric bupivacaine. (bvsalud.org)

Local anesthetic systemic toxicity (LAST) is a rare but serious critical event. (medscape.com)
In patients with severe cardiac toxicity, prolonged resuscitation or full cardiopulmonary support on extracorporeal membrane oxygenation (ECMO) or cardiopulmonary bypass (CPB) may be necessary, particularly in cases of bupivacaine toxicity. (medscape.com)
Other complications of local anesthetic use include neural toxicity, allergic reactions, and metabolic abnormalities, including methemoglobinemia (beyond the scope of this article). (medscape.com)
Our goal was to evaluate the potential local and systemic toxicity of EXPAREL after a bolus injection into the brachial plexus (i.e., a large, complex bundle of nerves in the shoulder). (hindawi.com)
What is bupivacaine toxicity? (rwmansiononpeachtree.com)
The toxicity of bupivacaine is more apparent in tissues with high aerobic demand and low tolerance for hypoxia. (rwmansiononpeachtree.com)
What is local anesthetic systemic toxicity? (rwmansiononpeachtree.com)
Local anesthetic systemic toxicity (LAST) is a life-threatening adverse event that may occur after the administration of local anesthetic drugs through a variety of routes. (rwmansiononpeachtree.com)
What are the symptoms of local anaesthetic toxicity? (rwmansiononpeachtree.com)
Why does local anaesthetic toxicity occur? (rwmansiononpeachtree.com)
Local anaesthetic toxicity generally occurs as a result of therapeutic error. (rwmansiononpeachtree.com)
Situations leading to toxicity include inadvertent venous or arterial injection as well as too high a dose of ingested or topically administered local anaesthetic-containing preparations. (rwmansiononpeachtree.com)
How is bupivacaine toxicity treated? (rwmansiononpeachtree.com)
Use of 20% intravenous lipid emulsion can be efficacious in the resuscitation of life-threatening local anesthetic toxicity , especially from bupivacaine, Lavonas indicated. (medscape.com)
To evaluate the knowledge of dentists about signs and symptoms that may be indicative of systemic toxicity associated with the use of local anesthetic solutions. (bvsalud.org)
The group of dentists involved in this study showed limited knowledge about the toxicity of local anesthetics, as well as some inconsistent background over the choice of vasoconstrictors. (bvsalud.org)

In 2011, the US Food and Drug administration (FDA) approved liposomal bupivacaine (Exparel), a longer-acting form of bupivacaine in which the anesthetic is delivered via a multivesicular liposomal system. (medscape.com)
Slow release of bupivacaine from its liposomal vehicle results in decreased opioid requirements postoperatively for up to 24 hours. (medscape.com)
Liposomal formulations of bupivacaine (brand name EXPAREL) have not shown clinical benefit compared to plain bupivacaine when used in traditional perineural injections, although some industry-funded studies have suggested benefits when used in local infiltration. (wikipedia.org)
Patients are interested in receiving the long-acting local anesthetic liposomal bupivacaine to help manage third-molar surgery pain. (drbicuspid.com)
Researchers hope to learn whether giving the longer-acting local anesthetic liposomal bupivacaine prior to closing the sternum is more effective in managing pain following sternotomy, than in patients who received standard bupivacaine before sternal closure. (centerwatch.com)
Liposomal bupivacaine is approved for use in interscalene blocks with the potential to provide longer pain control. (umn.edu)
However, the impact of liposomal bupivacaine on the phrenic nerve has not been evaluated. (umn.edu)
It was hypothesized that patients who received an interscalene block with both bupivacaine and liposomal bupivacaine would have a decreased diaphragmatic excursion when compared to bupivacaine alone at 24 h. (umn.edu)
METHODS: This was a double-blinded study of adult patients who were randomized to receive an interscalene block with either 20 ml 0.5% bupivacaine (bupivacaine group) or 10 ml 0.5% bupivacaine plus 10 ml liposomal bupivacaine (liposomal bupivacaine group). (umn.edu)
Five patients in the liposomal bupivacaine group had a greater than 25% reduction in diaphragmatic excursion at 24 h versus zero in the bupivacaine group. (umn.edu)
CONCLUSIONS: The addition of liposomal bupivacaine to bupivacaine in an interscalene block results in statistically significant reductions in diaphragm excursion and pulmonary function testing 24 h after block placement when compared to bupivacaine alone. (umn.edu)

The fixed-dose combination of bupivacaine with Type I collagen (brand name Xaracoll) is indicated for acute postsurgical analgesia (pain relief) for up to 24 hours in adults following open inguinal hernia repair. (wikipedia.org)
Bupivacaine (Posimir) is indicated in adults for administration into the subacromial space under direct arthroscopic visualization to produce post-surgical analgesia for up to 72 hours following arthroscopic subacromial decompression. (wikipedia.org)
We conclude that intrathecal midazolam 2.5mg provided moderate prolongation of postoperative analgesia when used as an adjunct to bupivacaine. (ispub.com)
Various adjuvants have been added to spinal local anesthetic to prolong postoperative analgesia. (ispub.com)
A sustained-release DepoFoam injection formulation of bupivacaine (EXPAREL, 15 mg/mL) is currently being investigated for postsurgical analgesia via peripheral nerve block (PNB). (hindawi.com)
14 In domestic chickens, bupivacaine has produced effective analgesia in two pain models. (vin.com)
The Food and Drug Administration (FDA) has approved Zynrelef™ (bupivacaine and meloxicam) extended-release solution for use in adults for soft tissue or periarticular instillation to produce postsurgical analgesia for up to 72 hours in adults after bunionectomy, open inguinal herniorrhaphy and total knee arthroplasty. (empr.com)
Additionally, a significant proportion of patients in the Zynrelef arm did not receive opioid analgesia (29% vs 11% for bupivacaine HCl and 2% for saline placebo). (empr.com)
The new product is designed to extend the duration of analgesia provided by bupivacaine. (medscape.com)

Bupivacaine is contraindicated in patients with known hypersensitivity reactions to bupivacaine or amino-amide anesthetics. (wikipedia.org)

Single-dose toxicology studies of EXPAREL (9, 18, and 30 mg/kg), bupivacaine solution (Bsol, 9 mg/kg), and saline injected around the brachial plexus nerve bundle were performed in rabbits and dogs. (hindawi.com)
EXPAREL (bupivacaine liposome injectable suspension) is a sterile suspension of multivesicular liposomes using proprietary DepoFoam formulation technology to release bupivacaine over several days. (hindawi.com)
Specifically, the study was designed to assess whether EXPAREL did not produce nerve damage in the setting of peripheral nerve block by comparison with unencapsulated bupivacaine or saline control. (hindawi.com)
The ASCRS/SAGES guidelines state that local anesthetics, such as EXPAREL ® (bupivacaine liposome injectable suspension), that are administered via wound infiltration or transverse abdominis plane (TAP) block may effectively manage pain associated with both open and laparoscopic colorectal surgery. (hcplive.com)
bupivacaine extended-release liposome injection ( Exparel , Pacira Pharmaceuticals). (medscape.com)

Epinephrine causes vasoconstriction, which enhances hemostasis and prolongs the anesthetic effect. (msdmanuals.com)
Use of topical anesthetics containing epinephrine may also help reduce bleeding. (merckmanuals.com)
Bupivacaine 0.25% with or without epinephrine may be used. (medscape.com)
Bupivacaine Hydrochloride Injection/Bupivacaine Hydrochloride and Epinephrine. (pfizermedicalinformation.com)

An implantable formulation of bupivacaine (Xaracoll) was approved for medical use in the United States in August 2020. (wikipedia.org)
A formulation of bupivacaine that provides prolonged release of the active ingredient after a single administration would simplify pain management in the postoperative period and eliminate the undesired peak plasma concentrations as a result of excessively high concentrations and reduce the risk of local and systemic reactions [ 7 ]. (hindawi.com)

Known hypersensitivity to bupivacaine or to any local anesthetic agent of the amide-type or to other components of bupivacaine hydrochloride injection. (nih.gov)

10 In this prospective, randomized, double-blind study, we evaluated the analgesic efficacy of a combination of intrathecal midazolam and bupivacaine and compared it with bupivacaine alone in patients undergoing lower limb orthopedic surgery. (ispub.com)
Bupivacaine is a local anesthetic/analgesic widely used in the perioperative and postsurgical settings. (hindawi.com)
In Cohort 2 (n=15), the patients who were administered SABER-Bupivacaine showed better pain relief, lower pain intensity and reduced supplemental analgesic usage compared with the patients using commercial bupivacaine as measured during the first 4 days after treatment. (durect.com)
In Cohort 3 (n=60), no significant difference was observed in pain relief, pain intensity and supplemental analgesic usage between the patients who were administered SABER-Bupivacaine compared with the patients using commercial bupivacaine as measured during the first 4 days after treatment. (durect.com)
An extended-release local anesthetic will simplify and improve pain control for many procedures, improve side effects, and reduce some of the burdens and complexities of pump-driven technologies, failures of technology, and resulting analgesic gaps," he explained. (medscape.com)

These highlights do not include all the information needed to use BUPIVACAINE HYDROCHLORIDE INJECTION safely and effectively. (nih.gov)
Recommended concentrations and dosages of bupivacaine hydrochloride injection according to type of block. (nih.gov)
Bupivacaine hydrochloride injection is available in multiple concentrations. (nih.gov)
Monitor cardiovascular and respiratory vital signs and patient's state of consciousness after injection of bupivacaine hydrochloride. (nih.gov)
A single injection of local anesthetic around the brachial plexus nerve bundle results in block of arm tissue innervated by several peripheral nerves. (hindawi.com)
Most emergencies are not due to reactions to the local anesthetic itself, but to the anxiety associated with the injection. (rwmansiononpeachtree.com)
The purpose of this investigation was to determine the fate of bupivacaine following a single subcutaneous injection. (vin.com)
Plasma concentration of bupivacaine (µg/ml) following subcutaneous injection of 2 mg/kg of a 0.5% solution in female mallard ducks. (vin.com)
An injection of local anesthetic (numbing medication) will be administered in the area where you are experiencing pain. (ucihealth.org)

However, articaine showed a better anesthetic success rate. (bvsalud.org)

Oraqix is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type or to any other component of the product. (drugs.com)

Physicochemical characteristics, such as lipophilicity and molecular weight, are different between ropivacaine and bupivacaine and are caused by the replacement of the butyl- by a propyl-group. (rwmansiononpeachtree.com)

Birds may be more sensitive to the toxic effects of local anesthetics compared to mammals, but the pharmacokinetics of bupivacaine are unknown in birds. (vin.com)

The recommended dosages of ZORCAINE in healthy adults serve only as a guide to the amount of anesthetic required for most routine dental procedures. (nih.gov)
Clinicians can reduce the amount of anesthetic gas, including nitrous oxide, used during procedures without negatively affecting patient care and help fight global warming, according to research presented at the American Society of Anesthesiologists (ASA) Advance 2023 event. (drbicuspid.com)

Based on the well known efficacy of immediate release bupivacaine, the clinical experience generated from local infusions of bupivacaine via catheter around surgical sites, and the good safety and pharmacokinetics data from this trial, we feel confident that the remainder of our Phase II program will define the optimum dosing of SABER-Bupivacaine for local post-surgical pain management. (durect.com)

The appearance of subsequent high levels of plasma bupivacaine is unique to this study and may also contribute to the apparent avian sensitivity to toxic effects of local anesthetics. (vin.com)
Six and 12 hour samples represent high levels in plasma bupivacaine concentration. (vin.com)

Animal evidence indicates intralipid, a commonly available intravenous lipid emulsion, can be effective in treating severe cardiotoxicity secondary to local anaesthetic overdose, and human case reports of successful use in this way. (wikipedia.org)
Can you overdose on bupivacaine? (rwmansiononpeachtree.com)
If bupivacaine is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. (rwmansiononpeachtree.com)
Some excellent science has shown that giving IV lipid emulsion can save the life of someone with an accidental overdose of local anesthetic medications, particularly bupivacaine ," he added. (medscape.com)
however, they showed a lack of knowledge regarding signs and symptoms related to an overdose of local anesthetics. (bvsalud.org)

Bupivacaine is indicated for local infiltration, peripheral nerve block, sympathetic nerve block, and epidural and caudal blocks. (wikipedia.org)
Table 1 summarizes the recommended dosages of ZORCAINE administered by intraoral submucosal infiltration or nerve block for various types of anesthetic dental procedures in healthy adults and pediatric patients. (nih.gov)
There is variation in duration between anesthetics, pulp and soft tissue, and maxillary infiltration and mandibular blocks. (dentalcare.com)
In addition, surgical wound instillation or infiltration with local anaesthetics prior to wound closure is recommended. (springer.com)

Blood samples of 1.0 ml were drawn from the jugular vein prior to bupivacaine administration (0 hour) and at 0.25, 0.5, 1, 2, 3, 4, 6, and 12 hours after administration. (vin.com)

From a systemic standpoint, high doses of bupivacaine may be associated with a wide range of systemic complications, such as central nervous and cardiovascular effects [ 6 ]. (hindawi.com)
9,11 Birds may be more sensitive to the toxic effects of local anesthetics compared to mammals, as higher doses (3.5-4.5 mg/kg) 15 produce toxic effects in dogs compared with birds (2.7-3.3 mg/kg) 11 . (vin.com)
Another difference among injectable anesthetic agents is the maximum recommended doses. (dentalcare.com)
Refer to Table 1 that summarizes the maximum recommended doses of local anesthetic agents as per the American Academy of Pediatric Dentistry (AAPD) Guidelines. (dentalcare.com)

Concentrations of bupivacaine in plasma were determined by high-performance liquid chromatography. (vin.com)

Intra-articular infusions of local anesthetics including bupivacaine hydrochloride following arthroscopic and other surgical procedures is an unapproved use, and there have been post-marketing reports of chondrolysis in patients receiving such infusions. (nih.gov)
Local anesthetics are medications used to reversibly block pain sensation in a specific part of the body in order to perform small surgical procedures. (osmosis.org)
Ultimately, they would like to measure carbon footprints from anesthetic agent waste for each surgical case. (drbicuspid.com)

Local anesthetic solutions like ZORCAINE that contain a vasoconstrictor should be used cautiously, especially in patients with impaired cardiovascular function or vascular disease. (nih.gov)
This is extremely relevant in pediatric dentistry where there is a wide variation in weight between patients and thus not all patients should receive equal amounts of local anesthetic for the same procedure. (dentalcare.com)
Using the maximum recommended dosages (Table 2), one can calculate the maximum recommended dosage and amount of local anesthetic agent for patients of specific weight and type of anesthetic. (dentalcare.com)
Cohorts 2 and 3 included control groups of 5 and 15 patients, respectively, who received commercial bupivacaine as a comparator. (durect.com)
Study Results The results to date from the study are as follows: All primary end-points of the study were achieved: -- Safety -- Good safety was observed across all Cohorts, with no clinically significant drug related adverse events observed with 61 patients exposed to SABER-Bupivacaine. (durect.com)
SABER-Bupivacaine injections also appeared to be well tolerated by patients. (durect.com)
Among patients undergoing unilateral simple bunionectomy (N=412), treatment with Zynrelef was associated with a significant reduction in pain intensity compared with either bupivacaine HCl or saline placebo for up to 72 hours. (empr.com)
This study also included a group of patients treated with Zynrelef plus ropivacaine, as well as those who received bupivacaine only. (empr.com)
The main selection criteria of anesthetic solutions reported were the duration of procedures and patients' individual characteristics. (bvsalud.org)
Patients were divided into two groups: one group received Bupivacaine with clonidine, and the other group received only bupivacaine at a dose of 15 mg. (bvsalud.org)

Comment: Local anesthetics may increase the risk of developing methemoglobinemia when concurrently exposed to drugs that also cause methemoglobinemia. (medscape.com)
All drugs and techniques that induce the anesthetic state act in some way in the Autonomic Nervous System (ANS). (bvsalud.org)
Current local anesthetics, Dr. Viscusi explained, have a duration of action less than the pain duration of most procedures, leading to pain later or to the need for cumbersome indwelling catheter and pump delivery systems for these drugs. (medscape.com)

Clinically significant adverse events result from systemic absorption of bupivacaine and primarily involve the central nervous and cardiovascular systems. (wikipedia.org)

Table 1 demonstrates the variation in duration of action of injectable local anesthetics in minutes. (dentalcare.com)
Duration of Injectable Local Anesthetics (in minutes). (dentalcare.com)
It is an injectable local anesthetic during surgery, labor, and delivery. (drugbank.com)

Later additions to clinically available local anesthetics, namely ropivacaine and levobupivacaine, represent exploitation of the S enantiomer of these chemicals to create anesthetics that are less toxic, more potent, and longer acting. (medscape.com)
The absorption time (T ½abs =13.9 min) appeared to be shorter than the elimination time (T ½elim =28.1 min) which may, in part, explain why birds are susceptible to toxic effects of local anesthetics. (vin.com)
however, the Dallas County medical examiner's office later determined her cause of death was the toxic effects of bupivacaine, a local anesthetic. (dallasnews.com)

Be familiar with commonly used local anesthetics and their characteristics. (saem.org)

Cohort 3), of SABER-Bupivacaine was evaluated following repair of inguinal hernia. (durect.com)

Zynrelef is a dual-acting local anesthetic that delivers a fixed-dose combination of bupivacaine, an amide local anesthetic, and meloxicam, a nonsteroidal anti-inflammatory drug (NSAID). (empr.com)

Chemical structure of the 2 classes of local anesthetics, amino esters and amino amides. (medscape.com)
Two basic classes of local anesthetics exist, the amino amides and the amino esters. (medscape.com)
Anyway, so there are two classes of local anesthetics - called esters and amides. (osmosis.org)

Compared to other local anaesthetics, bupivacaine is markedly cardiotoxic. (wikipedia.org)
Why is bupivacaine more cardiotoxic than ropivacaine? (rwmansiononpeachtree.com)
Which of the following is the most cardiotoxic local anesthetics drug? (rwmansiononpeachtree.com)
Bupivacaine is the most cardiotoxic of the LAs (Table 3.10), the cardiotoxic effects being enhanced by hypoxia, hypercapnia, acidosis and hyperkalaemia. (rwmansiononpeachtree.com)

Regional anesthetic techniques provide an excellent means for managing postoperative pain following orthopedic procedures. (ispub.com)
Bupivacaine solutions have been used for many years by multiple routes for the relief of postoperative pain [ 1 ]. (hindawi.com)

Bupivacaine crosses the placenta and is a pregnancy category C drug. (wikipedia.org)

Additionally, bupivacaine can cause chondrolysis after continuous infusion into a joint space. (wikipedia.org)
The court found as a matter of law that the information allegedly possessed by defendant was insufficient to trigger AstraZeneca's duty to warn of the risk of cartilage damage from continuous infusion of bupivacaine into a patient's joint. (masstortdefense.com)
Several practice changes were implemented between 2011 and 2017, namely a more uniform epidural loading dose of local anesthetic that includes fentanyl, an increase in both the hourly baseline offer and maximum allowed hourly amount of bupivacaine, and the change from a continuous epidural infusion to a programmed intermittent epidural bolus (PIEB) regimen. (iasp-pain.org)

6 In avian species, local anesthetics are used for operative and/or post-operative pain relief. (vin.com)
AstraZeneca did not in any way promote the use of bupivacaine with pain pumps, and that use was not mentioned in the instructions and warnings provided with the drug - an off-label use. (masstortdefense.com)
An MRI allegedly revealed that plaintiff had developed chondrolysis in her shoulder, which she alleged was caused by the post-surgery administration of the bupivacaine with the pain pump. (masstortdefense.com)
1, 8, 9] The infectious process begins in the lateral perionychium and is characterized by the development of erythema, intense inflammation, swelling, pain, and local tenderness. (medscape.com)
An otherwise healthy 29-year-old man arrives by private car with severe ankle pain after being thrown from a mechanical bull at a local bar. (saem.org)
Nasdaq: DRRX), an emerging specialty pharmaceuticals company, provided an update on its post-operative pain relief depot, SABER(TM)-Bupivacaine program. (durect.com)
This pain relief is often the result of the local anesthetic and will usually only last a few hours. (ucihealth.org)
Both Zynrelef treatment groups demonstrated a reduction in pain intensity compared with the bupivacaine arm. (empr.com)
Local anesthetics are used for local pain relief. (medscape.com)

Dilaudid, Morphine, or Fentanyl is used along with a local anesthetic such as bupivacaine or ropivacaine. (medleague.com)

What is the most common adverse reaction to local anesthetic? (rwmansiononpeachtree.com)

Administration of local anesthetics into the intrathecal space blocks sensory, motor and sympathetic nerve conduction. (bvsalud.org)

Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to decrease feeling in a specific area. (wikipedia.org)
Ducks were given bupivacaine (2 mg/kg, 0.4 ml/kg of a 0.5% solution, Marcaine, Sanofi Winthrop, Chatham, Ontario, Canada) subcutaneously in the ventral abdomen, between 0900 and 1100 hours. (vin.com)

Minimizing the risk of LAST, recognizing it early, and initiating prompt treatment are imperative for the safe use of perioperative local anesthetics. (medscape.com)

There have been reports of cardiac arrest with difficult resuscitation or death during use of Bupivacaine Hydrochloride. (pfizermedicalinformation.com)

The administration of local anesthetics in the subarachnoid space produces motor, sensitive and sympathetic block, with latencies and variable and independent block levels. (bvsalud.org)

This is achieved by anesthetics reversibly binding to and inactivating sodium channels. (medscape.com)
The order of affinity of local anesthetics for different sodium channel states is open is better than inactivated, which is better than resting. (medscape.com)
Thus, the open state of the sodium channel is the primary target of local anesthetic molecules. (medscape.com)
The main mechanism of action proposed for local anesthetics (LAs) is related to the binding of these substances to sodium channels receptors (Na+), leading to the reduction or elimination of the permeability of these ions and interruption of the nervous conduction 3-4 . (bvsalud.org)

Anatomy11

Organisms4

Diseases8

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Psychiatry and Psychology3

Phenomena and Processes17

Disciplines and Occupations2

Health Care5

Lidocaine20

Anesthesia26

Toxicity16

Liposomal11

Analgesia9

Contraindicated in patients with1

Exparel5

Epinephrine4

Formulation of bupivacaine2

Hypersensitivity to bupiv1

Analgesic5

Injection9

Articaine1

Amide-type1

Ropivacaine and bupivacaine1

Pharmacokinetics of bupivacaine1

Amount of anesthetic2

Release bupivacaine1

Plasma bupivacaine2

Overdose5

Infiltration4

0.251

Doses4

Concentrations1

Surgical3

Patients10

Drugs3

Central nervous and cardiovascular systems1

Injectable local3

Toxic3

Commonly1

Inguinal hernia1

Fixed-dose combin1

Amides3

Cardiotoxic4

Postoperative2

Placenta1

Infusion3

Pain9

Fentanyl1

Adverse1

Intrathecal1

Marcaine2

Perioperative1

Resuscitation1

Sympathetic block1

Sodium4