Lncrna ncrnas rna gene. Medical search. Frequent questions

Non-coding RNAs (ncRNAs), mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), can function as important regulators in gene expression. (biomedcentral.com)
In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
In recent years, noncoding RNAs (ncRNAs), especially microRNAs, long noncoding RNAs and circular RNAs, have been found to be associated with abnormalities of the ASMCs. (ersjournals.com)
MicroRNAs (miRNAs) are the most altered subset of ncRNAs, followed by long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs). (ersjournals.com)
This class of RNA encompasses microRNAs (miRNAs, well-studied post-transcriptional regulators of gene expression), long non-coding RNAs (lncRNAs) and other ncRNAs. (gencat.cat)
The role of non-coding RNAs in determining growth, productivity, and recombinant product quality attributes in Chinese hamster ovary (CHO) cells has received much attention in recent years, exemplified by studies into microRNAs in particular. (lncrnablog.com)
To date, we and others have linked microRNAs and long non-coding RNAs to therapeutic resistance in ALK+ ALCL. (crct-inserm.fr)
Circular RNAs are another class of highly stable lncRNAs that can control gene expression, for example by interacting with microRNAs or proteins. (crct-inserm.fr)
Long ncRNAs (lncRNAs) and microRNAs (miRNAs) are two main groups of ncRNAs that have gained widespread attention recently. (molcells.org)

ncRNAs with more than 200 nucleotides are considered as lncRNAs, which originate from intronic and exonic regions of protein-coding genes in both sense and antisense strands, as well as from the intergenic regions [ 21 ]. (biomedcentral.com)
MiRNAs were identified as single-stranded ncRNAs with a length of approximately 22 nucleotides in 1993 [ 14 ]. (ersjournals.com)
Long non-coding RNAs (lncRNAs) is an important member of non-coding RNAs (ncRNAs) comprising a transcription length of more than 200 nucleotides but not coding proteins [2,3]. (researchsquare.com)
PIWI-interacting RNAs (piRNAs) are a new type of recently discovered small non-coding RNAs with 24-31 nucleotides (nt) in length [7]. (jcimcr.org)
Long noncoding RNAs (LncRNAs) are ncRNAs longer than 200 nucleotides, regulating the transcription and translation of protein-coding genes and they can be found in the peripheral blood, thus holding a promising biomarker potential. (uninsubria.it)
Cancer susceptibility candidate 9 (CASC9) is a conserved lncRNA with 1500 nucleotides (nt) in length. (biomedcentral.com)

The imprinted DLK1-DIO3 locus, containing numerous maternally expressed ncRNAs including the lncRNA maternally expressed gene 3 (MEG3) and a cluster of over 50 miRNAs, has been shown to be a modulator of stemness in embryonic stem cells and in cancer progression, potentially through the tumor suppressor role of MEG3. (nih.gov)
We summarise the pathophysiological regulatory processes of ncRNAs, especially miRNAs, lncRNAs and circRNAs, in hyperplasia, hypertrophy, ECM production and cytokine production in asthmatic ASMCs. (ersjournals.com)
After the validation process, by applying the scoring function, the final protein-miRNA-lncRNA tripartite network was constructed, and significant miRNAs and lncRNAs were identified. (figshare.com)
Long non-coding RNAs (lncRNAs) and miRNAs belong to a class of non-coding RNAs (ncRNAs) that play important roles and functions in the regulation of the expression of genes in main biological processes, such as cell proliferation, apoptosis, and differentiation. (ac.ir)
In this theoretical bioinformatics study, the miRNAs of the target genes (BMP4, NOG, and FGF8) were extracted and examined by MirWalk and TARGETSCAN databases to finally obtain the common miRNAs of these three genes. (ac.ir)

The term epigenetics refers to three levels of gene regulation: (1) DNA methylation, (2) histone modifications, and (3) non-coding RNA (ncRNA) function. (wikipedia.org)
This chromatin structure is mediated by these three levels of gene regulation. (wikipedia.org)
LncRNA and miRNA both participate in the regulation of immune function. (hindawi.com)
The lab investigates mechanisms of RNA mediated epigenetic gene regulation by employing a combination of biochemistry, cell and molecular biological methods, and genome wide approaches. (lncrnablog.com)
The GO and KEGG analyses carried out on the cis target gene of lncRNAs showed that the lncRNAs play an important role in the regulation of flowering spinach. (biomedcentral.com)
This study is the first report on identifying bolting and flowering-related lncRNAs based on transcriptome sequencing in spinach, which provides a useful resource for future functional genomics studies, genes expression researches, evaluating genes regulatory networks and molecular breeding programs in the regulation of the genetic mechanisms related to bolting in spinach. (biomedcentral.com)
RNA-seq performed in humans has determined the molecular regulation mechanisms of fat accumulation between different groups of samples with different genetic backgrounds. (animbiosci.org)
Functional enrichment analysis revealed SNHG4 involvement with regulation of ribosomal RNA synthesis and the RNA processing and surveillance pathway. (xiahepublishing.com)
In particular, there are incremental examples of the participation of the distinct class of long non-coding RNAs (lncRNAs) in AML epigenetic regulation, some of which have translational potential. (frontiersin.org)
The most common PTMs which are well-studied and understood in the context of DNA repair, gene expression, and regulation are acetylation and methylation. (troscriptions.com)
As Hu and team demonstrated (2018), lncRNA can use a host of both cis- and trans-regulation mechanisms to modulate gene expression: LncRNAs can regulate gene expression by acting as assembly points for transcription factors. (enlightenbio.com)
Beyond being the product of gene expression, RNA can also influence the regulation of chromatin. (portlandpress.com)
in some cases, there are clear examples of direct RNA-mediated chromatin regulation mechanisms stemming from these interactions, while others have yet to be determined. (portlandpress.com)
Recent studies have highlighted examples of chromatin regulation via RNA matchmaking, a term we use broadly here to describe intermolecular base-pairing interactions between one RNA molecule and an RNA or DNA match. (portlandpress.com)
Among these candidate genes, CUGBP and Elav-like family member 1 ( CELF1 ) are potential targets of TUG1 in-trans regulation. (biomedcentral.com)
RNA immunoprecipitation was then performed to examine whether TUG1 RNA was bound to PRC2, a TUG1 -involved regulation mechanism reported in previous studies. (biomedcentral.com)
Using TUG1 4C sequencing and bioinformatic analysis, we found CELF1 to be a potential target of TUG1 RNA in in-trans regulation. (biomedcentral.com)
The importance of lncRNA regulation is emphasized by their roles in the etiology human diseases [ 7 - 9 ]. (biomedcentral.com)
lncRNAs have been reported to possess multiple functions including regulation of gene expression, transcriptional activation and silencing of genes and thus play critical roles in a diversity of cellular process [ 14 , 15 ]. (researchsquare.com)
In addition to classical gene regulatory networks noted above, we have recently identified a central role for additional biologic mechanisms, namely gene regulation by chromatin regulators and by noncoding RNAs. (stanford.edu)

Non-coding RNAs (ncRNAs) are ribonucleic acid (RNA) molecules that are not translated into protein products. (nature.com)
Although some key flowering responsive genes have been identified in spinach, non-coding RNA molecules like long non-coding RNAs (lncRNAs) were not investigated yet. (biomedcentral.com)
A growing body of evidence indicates that epigenetic regulators rely, amongst other factors, on their interaction with untranslated RNA molecules for guidance to particular targets on DNA. (frontiersin.org)
Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different classes of molecules with unique lengths, conformations and targets. (frontiersin.org)
One of them is Annotation - a step where you assign function to your RNA molecules. (novogene.com)
The second thing you want to do is Quantification of target RNA molecules - crucial for the differential gene expression analysis, where you aim to determine which genes are upregulated/downregulated across your samples. (novogene.com)
Lastly, one can also perform Target prediction/network study - particularly important when working with non-coding RNA molecules, where you aim to investigate the potential interaction between various RNA molecules, and what are the potential targets of these ncRNAs. (novogene.com)
One of these platforms is the NovaSeq6000 short-read sequencing machine, the most commonly used NGS sequencer which can sequence all types of RNA molecules (up to 500 bp). (novogene.com)
Conclusions Our study successfully discovered many key noncoding RNA molecules related to pathogenesis of asthma and relevant treatment, which may provide novel biomarkers and therapeutic targets for asthmatic diagnose and therapy. (researchsquare.com)

We assembled the sequences from deep RNA sequencing experiments by the Genotype-Tissue Expression (GTEx) project, to create a new catalog of human genes and transcripts, called CHESS. (biomedcentral.com)
These include 224 novel protein-coding genes and 116,156 novel transcripts. (biomedcentral.com)
This gene has 2 transcripts (splice variants). (medchemexpress.cn)
Recent studies have suggested that eukaryotic genomes encode a large number of functional transcripts of non-coding RNAs (ncRNAs), including housekeeping and regulatory RNAs [ 1 - 3 ]. (biomedcentral.com)
2012) that up to 75% of the human genome is transcribed into processed RNA transcripts even though less than 2% of the genome encodes proteins. (enlightenbio.com)
The majority of the human genome has the capacity to be transcribed and the majority of the non-protein-coding transcripts made by RNA Polymerase II are enriched in the nucleus. (portlandpress.com)
The measured intensities were log -normalized and differentially expressed transcripts/genes were filtered for a fold change (FC) ≥ 2 and an FDR ≤ 0.10. (lncrnablog.com)
While opting for long-read sequencing approaches may intuitively seem like a better option since full-length transcripts are obtained (meaning that no short-read assembly is required), and PCR bias and input RNA fragmentation are avoided, it is important to note that there are also some disadvantages that need to be considered before deciding to deploy this method. (novogene.com)
Collectively, this study demonstrated that silence of lncRNA GAS5 protected H9c2 cells against hypoxia-induced injury possibly via sponging miR-142-5p , functionally releasing TP53INP1 mRNA transcripts that are normally targeted by miR-142-5p . (molcells.org)

These results suggest that the noncoding RNA regulatory network may play a potential role in the development of allergic rhinitis (Figure 1 ). (hindawi.com)
This study was performed to explore the gene profile and identify candidate long noncoding RNA (lncRNAs) and mRNAs associated with IMF deposition among Laiwu pigs with different IMF contents. (animbiosci.org)
Long noncoding RNA (lncRNAs) are vital noncoding RNAs (ncRNAs) that regulate fat accumulation, including the processes of proliferation, differentiation, and hypertrophy of adipocytes [ 6 , 7 ]. (animbiosci.org)
This article will discuss the three main epigenetic signatures (DNA methylation, Histone Modification, and noncoding RNA), how they are regulated, and how their disruption cause diseases. (troscriptions.com)
The regulatory role of long noncoding RNA (lncRNA) growth arrest-specific transcript 5 ( GAS5 ) in both cancerous and noncancerous cells have been widely reported. (molcells.org)
Long noncoding RNA NALT1-induced gastric cancer invasion and metastasis via NOTCH signaling pathway. (nih.gov)
Noncoding RNA sequences can regulate gene expression via interactions with epigenetic and other control mechanisms. (stanford.edu)
The function of histone modifying epigenetic regulators and noncoding RNA as central mediators of epithelial stem cell renewal and differentiation represent major emerging areas of study in the lab. (stanford.edu)

LncRNA and miRNA both participate in immune regulatory responses by regulating the differentiation of bone marrow hematopoietic stem cells and activating mononuclear macrophages and DCs [ 13 ]. (hindawi.com)
MiRNA usually binds directly to the 3′-untranslated region (3′-UTR) of target gene mRNA through the RNA-induced silencing complex (RISC) [ 15 , 16 ]. (ersjournals.com)
In this paper, we propose that lncRNA-miRNA interactions, analogous to receptor-ligand interactions, are responsible for cell-type-specific outcomes. (gencat.cat)
Then, protein-microRNA (miRNA) and miRNA-long non-coding RNA (lncRNA) bipartite networks were built and significant ncRNAs were extracted. (figshare.com)
In this study, mRNA, miRNA, and lncRNA gene networks were predicted by web-based programs for three ectodermal pathway markers (BMP4, NOG, FGF8) in the mouse embryonic stem cells. (ac.ir)
Due to the mutual relationships among lncRNA, miRNA, and mRNA, our results provided a novel perspective on lncRNAs for future research and experimental studies on ectodermal differentiation pathways and molecular mechanisms. (ac.ir)
Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue. (ac.ir)
Analyzing the LncRNA, miRNA, and mRNA regulatory network in prostate cancer with bioinformatics software. (ac.ir)

Herein, we used bioinformatic approaches to analyze the transcriptome datasets from two different accessions Viroflay and Kashan at two vegetative and reproductive stages to reveal novel lncRNAs and the construction of the lncRNA-mRNA co-expression network. (biomedcentral.com)
Cieľom predloženého projektu je využitie originálneho prístupu, ktorý umožní skúmať účinky neinvazívneho doručenia exogénnej mediátorovej RNA (mRNA) kódujôcej tieto faktory do CNS na neuronálnu excitabilitu, plasticitu a správanie zvierat. (sav.sk)

Long non-coding RNAs (lncRNAs) are clinically relevant in at least two major ways: as biomarkers for cancer or carcinogenesis and as actual targets for cancer therapy. (enlightenbio.com)
This review summarizes current information regarding the reported roles of lncRNA-encoded micropeptides in cancer, and explores the potential clinical value of these micropeptides in the development of anti-cancer drugs and prognostic tumor biomarkers. (biomedcentral.com)
Consequently, identifying significant ncRNAs and utilizing them as biomarkers could facilitate the early detection of this cross-talk. (figshare.com)
9. Zhang Y, Yu F, Bao S, Sun J. Systematic characterization of circular RNA-associated CeRNA network identified novel circRNA biomarkers in Alzheimer's disease. (ac.ir)

LncRNA NALT1 promotes colorectal cancer progression via targeting PEG10 by sponging microRNA-574-5p. (nih.gov)

During the Human Genome Project, most efforts to estimate and annotate genes focused on protein-coding genes, i.e., regions of the genome that are transcribed into RNA and then translated into proteins. (biomedcentral.com)
Gene Ontology and pathway enrichment analyses and assessment of RNA binding proteins were performed by R software, circlncRNAnet and Encyclopedia of RNA Interactomes (ENCORI). (xiahepublishing.com)
The fate of cells is determined by epigenetics, as it plays a role in allowing the heart cell to turn "on" genes to make proteins important for its job and turn "off" genes important for an immune cell's job. (troscriptions.com)
In other instances, lncRNAs can act as molecular decoys or guides for proteins that bind to DNA or other RNAs. (enlightenbio.com)
PIWI-interacting RNAs (piRNAs) are another subgroup of small non-coding RNAs emerging as key players in different biological activities, including regulating gene and protein expression, epigenetic silencing of transposable elements, and controlling the spermatogenesis by interacting with PIWI proteins. (jcimcr.org)

The Human Genome Project has revealed that protein-coding genes represent less than 2% of the total genome sequence [ 7 ], and the remaining greater portion of human genomes are regarded as "junk DNAs", for they do not encode any protein. (oncotarget.com)
They encode the majority of the human genome and regulate gene expression through a variety of mechanisms. (figshare.com)
Recent discoveries on RNAs reported that non-coding RNAs contain 98% of the human genome, involving different biological pathological activities [4-6]. (jcimcr.org)

In this webinar, Novogene will provide a comprehensive overview of a set of solutions from long non-coding RNA sequencing (lncRNA-seq), small RNA sequencing (sRNA-seq), circular RNA sequencing (circRNA-seq) to whole transcriptome sequencing (WTS) and will discuss their applications in the field of transcriptomics. (novogene.com)
CIRComa : Deciphering the role of circular RNAs in the pathogenesis and therapeutic resistance of anaplastic large cell lymphomas associated with the oncogenic tyrosine kinase ALK. (crct-inserm.fr)

Many ncRNAs have critical roles in tumorigenesis, and some ncRNAs function as competing endogenous RNAs (ceRNAs) to perturb gene expression. (biomedcentral.com)

Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis, and lncRNA taurine-upregulated gene 1 ( TUG1 ) has been proven to be associated with several human cancers. (biomedcentral.com)

RNA modifications have emerged as key gene regulators. (nature.com)
Network analysis pinpointed several well-known flowering-related genes such as ELF , COL1 , FLT , and FPF1 and also some putative TFs like MYB, WRKY, GATA, and MADS-box that are important regulators of flowering in spinach and could be potential targets for lncRNAs. (biomedcentral.com)
Long non-coding RNAs (lncRNAs) are widely recognized as important regulators of gene expression. (mdpi.com)
Among important regulators of these cellular processes are non-coding RNAs (ncRNAs). (nih.gov)
Recently, long noncoding RNAs have been emerged as critical regulators of human disease and prognostic markers in several cancers, including gastric cancer. (oncotarget.com)

Epigenetic therapy is being investigated as a method of correcting the expression levels of misregulated genes in neurodegenerative diseases. (wikipedia.org)
The aim of this mini-review is to discuss emerging epigenetic roles of long non-coding RNAs (lncRNAs) in Acute Myeloid Leukemia (AML). (frontiersin.org)
However, a growing body of evidence suggests that recruitment, stability, and function of epigenetic factors can be mediated by non-protein-coding RNAs. (frontiersin.org)
In this context, we summarize common epigenetic alterations in AML that are relevant for understanding lncRNA potential contribution to the disease. (frontiersin.org)
DNA methylation is one of the key epigenetic modifications that play a role in regulating genes. (troscriptions.com)
On the other hand, environmental factors have been reported to modulate epigenetic modifications and thereby affect gene expression and phenotype [ 11 , 12 ]. (researchsquare.com)
Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)

Studies in recent years have demonstrated that long non-coding RNAs (lncRNAs) have multiple biological functions in cell growth, differentiation and proliferation. (oncotarget.com)
This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)

Bulk RNA-sequencing analysis revealed many more differentially expressed genes (DEGs) in the tongue epithelium than in the mesenchyme in Alk3 cKO versus control. (bvsalud.org)
5%, L). Whole-transcriptome sequencing was performed to explore the differentially expressed (DE) genes between these two groups. (animbiosci.org)

Equally intriguing is the data that indicate lncRNA expression seems to be more cell-type and tissue specific than protein coding genes (Yan et al . (enlightenbio.com)
This may indicate that lncRNA is a later evolutionary arrival than protein-coding genes, and thus may be particularly relevant to the development of higher eukaryotes. (enlightenbio.com)
85% of ALK+ ALCLs are associated with a translocation between the NPM (nucleophosmin) gene and the ALK (Anaplastic Lymphoma Kinase) gene resulting in a constitutively activated, oncogenic fusion protein. (crct-inserm.fr)
A member of the argonaut protein family encoded by the Drosophila piwi gene is involved in DNA methylation, transposon silencing, germline development, and fertility [12-14]. (jcimcr.org)
The results demonstrated that TUG1 RNA was bound to enhancer of zeste protein 2/embryonic ectoderm development (EZH2/EED), which is essential for PRC2. (biomedcentral.com)
Noncoding RNAs (ncRNAs) are a class of RNAs without protein-coding capacity. (molcells.org)

Gene mutations and aberrant signaling pathways play key roles in GBC tumorigenesis. (biomedcentral.com)
In this study, we globally assessed the transcriptomic differences of lncRNAs in gastric cancer using publicly available microarray data from Gene Expression Omnibus (GEO) and identified an oncogenetic lncRNA ZFAS1, which may promote gastric tumorigenesis. (oncotarget.com)

Here the authors identify chromatin-bound RNAs and their binding sites in human embryonic stem cells suggesting that most chromatin-associated RNAs act proximal to their encoding loci and single RNAs are unlikely to alter gene expression. (nature.com)
More interestingly, a large number of noncoding fragments were found in peripheral blood cells of patients with asthma, including natural antisense chains, pseudogenes, and differential expression of ncRNA between genes [ 14 ]. (hindawi.com)
In addition, some scholars found a large number of lncRNA in CD4 + and CD8 + T cells, with phased expression [ 15 , 16 ]. (hindawi.com)
In addition, Th2 cells are important mediators of type I allergy, and it has been reported that ncRNA promotes Th2 cell migration to target organs by regulating chemokine gene expression [ 17 ]. (hindawi.com)
Many software packages that analyze RNA sequencing (RNA-seq) experiments, which measure gene expression, rely on a database of known genes and cannot measure genes or splice variants unless they are included in the database. (biomedcentral.com)
However, the comparative transcriptome analysis of two spinach accessions with different bolting times identified genome-wide gene expression profiling and large-scale discovery of flowering-related genes from vegetative and reproductive leaves [ 13 ]. (biomedcentral.com)
The datasets included transcriptome-wide expression and matched clinical follow-up data to detect and characterize gene fusions in PCa. (biomedcentral.com)
Furthermore, the appropriate analysis and reliable interpretation of the large datasets obtained by GWAS and RNA-seq is critical for gene expression studies. (animbiosci.org)
In this study we analyzed the expression pattern and functional role of ncRNAs from the DLK1-DIO3 locus in epithelial plasticity of the breast. (nih.gov)
In addition, the expression of MEG3 and the maternally expressed ncRNAs was higher in stromal cells compared to epithelial cell types in primary breast tissue. (nih.gov)
We also show that expression of MEG3 is concomitant with the expression of the ncRNAs from the DLK1-DIO3 locus and its expression is therefore likely indicative of activation of all ncRNAs at the locus. (nih.gov)
Gene expression, Kaplan-Meier survival, microRNA and transcription factor target analyses were performed with the University of Alabama Cancer (UALCAN) Database, Kaplan-Meier Plotter, LinkedOmics, WebGestalt and gene set enrichment analysis, respectively. (xiahepublishing.com)
These are responsible for abnormal gene expression, resulting in increased cancer cell proliferation and escape from immune surveillance, which can speed up the process of development into HCC. (xiahepublishing.com)
The Cancer Genome Atlas (TCGA) database has accumulated abundant genomic and gene expression profiles for different diseases in the past decade. (xiahepublishing.com)
However, a definite conclusion on the clinical value of lncRNA SNHG6 expression in human cancers has not been determined. (researchsquare.com)
The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were collected to estimate the prognostic value, and the odds ratios (ORs) with 95% CIs were used to evaluate the relationship between lncRNA SNHG6 expression and clinicopathological features, including tumor invasion depth, lymph node metastasis (LNM), distance metastasis (DM), and TNM stage. (researchsquare.com)
Conclusions High lncRNA SNHG6 expression was correlated with tumor invasion depth, LNM, DM, and advanced TNM stage, suggesting that SNHG6 may serve as a promising prognostic biomarker of human cancers. (researchsquare.com)
Consequently, cancer patients with high lncRNA SNHG6 expression tend to have a poor prognosis. (researchsquare.com)
However, identification of lincRNAs in wheat is still limited comparing with functional gene expression. (biomedcentral.com)
Use of the microarray analysis is often restricted by the known gene sequences arrayed on the chip, whereas RNA sequencing is not dependent on pre-existing databases of expressed genes and, therefore, provides an unbiased and more complete view of gene expression profiles [ 17 ], including lncRNA. (biomedcentral.com)
DNA methylation in the promoter regions acts as a repressor of gene expression. (troscriptions.com)
The histones are subjected to various post-translational modifications (PTMs), which play a vital role in gene expression. (troscriptions.com)
LncRNAs not only appear to be ubiquitous in eukaryotic biology but have the capacity to play many interesting roles in gene expression. (enlightenbio.com)
Non-coding RNA-sequencing (ncRNA-seq) is a powerful technique for studying the regulatory functions of diverse types of ncRNAs in gene expression. (novogene.com)
They then further analyzed the data to identify those lncRNAs whose expression changed the most between growth and stationary phases of culture or between batch and fed-batch culture to identify potential lncRNA targets for further functional studies with regard to their role in controlling growth of CHO cells. (lncrnablog.com)
Deregulated expression of non-coding RNAs (ncRNAs) is known to be an important factor in therapy resistance. (crct-inserm.fr)
To do that, you need to consider your research objectives: for instance, some projects are interested 'only' in comparing transcriptomic profiles across samples in different experimental conditions (e.g Treatment vs. Control), or between different tissue types, to identify tissue-specific gene expression. (novogene.com)
Other research groups might be more interested in analyzing a shift in cellular transcriptomic footprints across time to determine the time-scale gene expression patterns. (novogene.com)
thus, Pnn may affect crucial alternative splicing (AS) decisions and, in turn, impact cell-type specific gene expression. (molvis.org)
Circulating long non-coding RNAs NKILA, NEAT1, MALAT1, and MIAT expression and their association in type 2 diabetes mellitus. (informaticsstudies.org)

The lncRNA TMPO-AS1 promotes cell proliferation, migration, invasion and epithelial-to-mesenchymal transition by regulating the miR-1179/E2F2 axis [ 13 ]. (biomedcentral.com)
LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia. (nih.gov)

We present a schematic that illustrates the role of ncRNAs in pathophysiological changes to ASMCs that may be useful in future research in diagnostic and treatment strategies for patients with asthma. (ersjournals.com)

2017). Since the importance of lncRNA GAS5 in cancer has been well-established, several researchers focused on investigating the role of lncRNA GAS5 in noncancerous cells. (molcells.org)

GBCdb will help to elucidate the potential biological roles of different RNAs and allow for the exploration of RNA interactions in GBC. (biomedcentral.com)
Our findings provide a platform to improve understanding of the detailed multi-omics RNA landscapes of GBC, especially for GBC-associated RNA interactions, which will support future studies on cancer treatment. (biomedcentral.com)
In this review, we summarized the interactions of noncoding RNAs and viruses in the occurrence and development of AR, along with the treatments focusing on the noncoding RNAs in the past five years. (hindawi.com)
This article discusses the relationship between mitochondrial respiration and long noncoding RNAs and further outlines the implications of these interactions in obesity. (informaticsstudies.org)

Herein, to provide better understanding of the molecular events in GBC pathogenesis, we developed GBCdb ( http://tmliang.cn/gbc/ ), a user-friendly interface for the query and browsing of GBC-associated genes and RNA interaction networks using published multi-omics data, which also included experimentally supported data from different molecular levels. (biomedcentral.com)
The interaction networks between ncRNA and virus copromote the occurrence of allergic rhinitis. (hindawi.com)
According to the bioinformatic analysis result of TUG1 4C sequencing data, 83 candidate genes and their interaction regions were identified. (biomedcentral.com)
Furthermore, bioinformatics approaches are employed to provide in silico evidences for the link between long noncoding RNAs and mitochondrial gene interaction in obesity. (informaticsstudies.org)

In several cases, including the MALAT1 gene, lncRNAs appear to play roles in subnuclear architecture to either activate or repress target genes by association with particular domains within the nucleus (Koopp and Mendeell, 2018). (enlightenbio.com)
Vito D, Smales CM. (2018) The Long Non-Coding RNA Transcriptome Landscape in CHO Cells Under Batch and Fed-Batch Conditions . (lncrnablog.com)

Mechanistically, RNA immunoprecipitation and RNA pull-down experiment showed that ZFAS1 could simultaneously interact with EZH2 and LSD1/CoREST to repress underlying targets KLF2 and NKD2 transcription. (oncotarget.com)
RNA immunoprecipitation assay results showed that lncRNA GAS5 worked as a molecular sponge for miR-142-5p . (molcells.org)

Comparing with the progress of long ncRNAs in animals, their study in plants starts relatively late. (biomedcentral.com)

Mechanisms and functions of long non-coding RNAs at multiple regulatory levels. (ac.ir)
Therefore, diverse cellular compartments orchestrated by multiple environment-driving factors make the mechanisms underlying asthma extraordinary complex and unclear, particularly with respect to long noncoding RNAs (lncRNAs). (researchsquare.com)

Methylation of CpG dinucleotides and/or islands within gene promoters is associated with transcriptional repression via interference of transcription factor binding and recruitment of transcriptional repressors with methyl binding domains. (wikipedia.org)
However, none of the prognostic models incorporates parameters reflecting the status of chromosomal rearrangements and transcriptional disorganization in a patient sample, even though gene fusions are known to drive PCa development and progression [ 8 ]. (biomedcentral.com)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (nih.gov)

With the development of high-throughput sequencing, genome-wide association studies (GWAS) and RNA sequencing (RNA-seq) have been extensively used in recent years to identify genomic regions and candidate genes associated with a variety of pork traits [ 3 - 5 ]. (animbiosci.org)
However in recent years with the development of epigenesis, genomic imprinting and the horizontal transferences of the genes, Lamarck's ideas have resurfaced. (intechopen.com)

Researchers at the University of Kent have undertaken the first landscape analysis of the lncRNA transcriptome in CHO using a mouse based microarray that also provided for the surveillance of the coding transcriptome. (lncrnablog.com)
Results In the present study, we performed a systematic transcriptome analysis based on the deep RNA sequencing of ten asthmatic children before and after desensitization treatment. (researchsquare.com)
Purpose: GG-H whole transcriptome array analysis suggested involvement of PININ (PNN) in the alternative splicing of multiple long non-coding RNAs (lncRNAs). (molvis.org)

To relate the occurrence of gene fusions to Gleason Grading Groups and disease prognosis, we performed survival analyses using the Kaplan-Meier estimator, log-rank test, and Cox regression. (biomedcentral.com)
We found evidence that the number of gene fusions was associated with the prognosis of PCa. (biomedcentral.com)

Moreover, subsequent experiments showed that TUG1 RNA could bind to PRC2 in the promotor region of CELF1 and negatively regulate CELF1 expressions in H520 cells. (biomedcentral.com)

the more tightly the DNA is bound by the nucleosome, and the more tightly a string of nucleosomes are compressed among each other, the greater the repressive effect on transcription of genes in the DNA sequences near or wrapped around the histones, and vice versa (i.e. looser DNA binding and relaxed compaction leads to a comparatively derepressed state, resulting in facultative heterochromatin or, even further derepressed, euchromatin). (wikipedia.org)

A cluster of CpG dinucleotides clustered together is called a CpG island, and in mammals, these CpG islands are one of the major classes of gene promoters, onto or around which transcription factors may bind and transcription can begin. (wikipedia.org)
Other lncRNAs are localized in the nucleus, which are involved in crucial molecular processes, including RNA processing, chromatin organization and transcription, and play an important role in genome structure [ 13 , 14 ]. (biomedcentral.com)

Methods: Total RNA was isolated from PNN knockdown human corneal epithelial (HCET) cells or Pnn-deficient mouse corneas, and subjected to real-time-PCR (RT-PCR) assays, and the alternatively spliced lncRNAs were counted. (molvis.org)

Intersection analysis of the target genes of DE lncRNAs and mRNAs revealed seven candidate genes associated with IMF accumulation. (animbiosci.org)

Small ncRNAs are further divided into myriad subclasses, and each subclass has its own biological and medical importance. (biomedcentral.com)
This is one demonstration of a testable form of lncRNA that exists with sufficient stability in a non-invasive biological sample, highlighting the key attributes of stability and ability to be assayed of a viable biomarker. (enlightenbio.com)
This study aimed to explore the biological role of long on-coding RNA (lncRNA) CASC9 and its regulatory mechanism in OC. (biomedcentral.com)

Nevertheless, further studies are needed to fully dissect the molecular pathways influenced by non-coding RNAs at the DLK1-DIO3 locus in breast tissue. (nih.gov)
Silence of lncRNA GAS5 promoted the activation of PI3K/AKT and MEK/ERK signaling pathways in a miR-142-5p -dependent manner. (molcells.org)

Candidates with research interests in chromatin biology, epigenetics, and non-coding RNAs are encouraged to apply. (lncrnablog.com)

Inspiringly, recent studies have demonstrated that long non-coding RNAs (lncRNAs) is a critical factor in the pathogenesis of PC. (oncotarget.com)

Background The long non-coding RNA small nucleolar RNA host gene 16 (lncRNA SNHG6) is dysregulated in various malignant tumor. (researchsquare.com)
LncRNA small nucleolar RNA host gene 16 (SNHG6), also known as U87HG, locates in human chromosome 8q13.1. (researchsquare.com)

Marked upregulation of ncRNAs from the DLK1-DIO3 locus was seen after EMT induction in two cell line models of EMT. (nih.gov)
ENST00000601116.5, a lncRNA in the CEACAM21 locus). (uninsubria.it)

Genome-wide association studies (GWAS) attempt to link genetic variants to nearby genes, relying on standard catalogs of human genes. (biomedcentral.com)
Concretely, genome-wide association studies have detected numerous asthma-associated gene variants, while few of them (less than 10%) can be explained to contribute to the risk of asthma [ 10 ]. (researchsquare.com)

We also discuss the huge potential of the ncRNA regulatory network as the basis for diagnosis and treatment of ASMC dysfunction. (ersjournals.com)

We lose methylation capacity as we age, leading to more genes turned on errantly. (troscriptions.com)

New sequencing technologies have shown that a large number of aberrantly expressed lncRNAs are associated with multiple cancer types and indicated they have emerged as an important class of pervasive genes during the development and progression of cancer. (biomedcentral.com)

They were first discovered in 2001 in Drosophila melanogaster as small RNAs [8]. (jcimcr.org)

The investigation found that there are three subclasses for piRNAs that based on their origin derived from transposons, derived from lncRNAs, and derived from mRNAs, piRNA biogenesis is initiated by Pol II copying RNA from its cluster, and then, with more turnover, the piRNA precursor is transferred to the cytoplasm [18,19]. (jcimcr.org)

This project aims to elucidate their role in ALK+ biology including their impact on lncRNA networks and therapeutic resistance. (crct-inserm.fr)

Germ granules are membraneless organelles that act as organizing centers for small RNA biogenesis during germline development. (nature.com)
In this Journal Club, Edmund Loh explores the pioneering work of Kurt Nordström and colleagues, which uncovers the importance of a small RNA in plasmid replication and elucidates its mechanism of action. (nature.com)
In this regards, they can be separated into small non-coding RNA (small ncRNA) and lncRNA. (biomedcentral.com)
Long non-coding RNA small nucleolar RNA host genes (SNHGs) play a critical role in the occurrence and development of tumors. (xiahepublishing.com)

Anatomy14

Organisms27

Diseases4

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes86

Disciplines and Occupations2

Information Science10

Health Care2

MicroRNAs9

Nucleotides6

MiRNAs5

Regulation20

Molecules9

Transcripts9

Noncoding RNA8

MiRNA8

MRNA2

Biomarkers4

Colorectal cancer1

Proteins5

Human genome3

Circular2

Endogenous1

Roles in tumorigenesis1

Regulators5

Epigenetic7

Differentiation3

Differentially expressed2

Protein6

Tumorigenesis2

Expression30

Cell proliferation2

Role of ncRNAs1

Importance of lncRNA1

Interactions4

Interaction4

20182

Immunoprecipitation2

Long ncRNAs1

Mechanisms2

Transcriptional3

Genomic2

Transcriptome3

Prognosis2

Regulate1

Sequences1

Transcription2

Knockdown1

Target genes1

Biological3

Pathways2

Epigenetics1

Pathogenesis1

Host gene2

Locus2

Genome-wide as2

Regulatory network1

Methylation1

Progression1

20011

MRNAs1

Therapeutic1

Small4