Lncrna gene ncrnas rna gene. Medical search. Frequent questions

In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
This generates a vast repertoire of transcripts that includes protein-coding messenger RNAs, long non-coding RNAs (lncRNAs) and repetitive sequences, such as SINEs (short interspersed nuclear elements). (nature.com)
Although some key flowering responsive genes have been identified in spinach, non-coding RNA molecules like long non-coding RNAs (lncRNAs) were not investigated yet. (biomedcentral.com)
Herein, we used bioinformatic approaches to analyze the transcriptome datasets from two different accessions Viroflay and Kashan at two vegetative and reproductive stages to reveal novel lncRNAs and the construction of the lncRNA-mRNA co-expression network. (biomedcentral.com)
The GO and KEGG analyses carried out on the cis target gene of lncRNAs showed that the lncRNAs play an important role in the regulation of flowering spinach. (biomedcentral.com)
Network analysis pinpointed several well-known flowering-related genes such as ELF , COL1 , FLT , and FPF1 and also some putative TFs like MYB, WRKY, GATA, and MADS-box that are important regulators of flowering in spinach and could be potential targets for lncRNAs. (biomedcentral.com)
This study is the first report on identifying bolting and flowering-related lncRNAs based on transcriptome sequencing in spinach, which provides a useful resource for future functional genomics studies, genes expression researches, evaluating genes regulatory networks and molecular breeding programs in the regulation of the genetic mechanisms related to bolting in spinach. (biomedcentral.com)
ncRNAs with more than 200 nucleotides are considered as lncRNAs, which originate from intronic and exonic regions of protein-coding genes in both sense and antisense strands, as well as from the intergenic regions [ 21 ]. (biomedcentral.com)
Recent studies have discovered that long noncoding RNAs (lncRNAs) are novel regulatory molecules that play important roles in various biological processes. (biomedcentral.com)
We categorized the testis-specific lncRNAs and found that a large portion corresponded to long intergenic ncRNAs (lincRNAs). (biomedcentral.com)
LncRNAs are arbitrarily defined as noncoding RNAs longer than 200 nucleotides. (biomedcentral.com)
However, although numerous studies have investigated the protein-coding genes that show tissue-specific expression and play important roles during spermatogenesis, no previous study has comprehensively identified and characterized the mouse testis-specific lncRNAs. (biomedcentral.com)
By comparing the lncRNA and mRNA expression profiles among the tissues, we identified lncRNAs and mRNAs that showed differential expression in each tissue. (biomedcentral.com)
After the validation process, by applying the scoring function, the final protein-miRNA-lncRNA tripartite network was constructed, and significant miRNAs and lncRNAs were identified. (figshare.com)
Studies in recent years have demonstrated that long non-coding RNAs (lncRNAs) have multiple biological functions in cell growth, differentiation and proliferation. (oncotarget.com)
Inspiringly, recent studies have demonstrated that long non-coding RNAs (lncRNAs) is a critical factor in the pathogenesis of PC. (oncotarget.com)
Although there is little knowledge about lncRNAs at present, their potential implications in gene transcriptomics have aroused great interest and attention in the most recent years [ 12 ]. (oncotarget.com)
MicroRNAs (miRNAs) are the most altered subset of ncRNAs, followed by long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs). (ersjournals.com)
We summarise the pathophysiological regulatory processes of ncRNAs, especially miRNAs, lncRNAs and circRNAs, in hyperplasia, hypertrophy, ECM production and cytokine production in asthmatic ASMCs. (ersjournals.com)
Circular RNAs are another class of highly stable lncRNAs that can control gene expression, for example by interacting with microRNAs or proteins. (crct-inserm.fr)
This study was performed to explore the gene profile and identify candidate long noncoding RNA (lncRNAs) and mRNAs associated with IMF deposition among Laiwu pigs with different IMF contents. (animbiosci.org)
Intersection analysis of the target genes of DE lncRNAs and mRNAs revealed seven candidate genes associated with IMF accumulation. (animbiosci.org)
Long noncoding RNA (lncRNAs) are vital noncoding RNAs (ncRNAs) that regulate fat accumulation, including the processes of proliferation, differentiation, and hypertrophy of adipocytes [ 6 , 7 ]. (animbiosci.org)
Increasing evidence has indicated that long noncoding RNAs (lncRNAs) play various important roles in the development of cancers. (biomedcentral.com)
Next, the target miRNAs of hub genes were predicted, and then the lncRNAs regulating miRNAs was discovered, thus forming the lncRNA-miRNA-mRNA interaction chain. (aging-us.com)
The aim of this mini-review is to discuss emerging epigenetic roles of long non-coding RNAs (lncRNAs) in Acute Myeloid Leukemia (AML). (frontiersin.org)
In particular, there are incremental examples of the participation of the distinct class of long non-coding RNAs (lncRNAs) in AML epigenetic regulation, some of which have translational potential. (frontiersin.org)
Long non-coding RNAs (lncRNAs) is an important member of non-coding RNAs (ncRNAs) comprising a transcription length of more than 200 nucleotides but not coding proteins [2,3]. (researchsquare.com)
Purpose: GG-H whole transcriptome array analysis suggested involvement of PININ (PNN) in the alternative splicing of multiple long non-coding RNAs (lncRNAs). (molvis.org)
Methods: Total RNA was isolated from PNN knockdown human corneal epithelial (HCET) cells or Pnn-deficient mouse corneas, and subjected to real-time-PCR (RT-PCR) assays, and the alternatively spliced lncRNAs were counted. (molvis.org)
Alternatively spliced lncRNAs were detected with in situ hybridization with variant-specific RNA probes on human cornea sections. (molvis.org)
These regions are usually transcribed into long non-coding RNAs (lncRNAs). (biomedcentral.com)
New sequencing technologies have shown that a large number of aberrantly expressed lncRNAs are associated with multiple cancer types and indicated they have emerged as an important class of pervasive genes during the development and progression of cancer. (biomedcentral.com)
We highlight the role of SE-driven genes, enhancer RNAs (eRNAs), lncRNAs, and miRNAs in the digestive system tumor growth and progression. (ijbs.com)
Previously, non-coding RNAs (ncRNAs), including micro-RNAs (miRNAs) and other long non-coding RNAs (lncRNAs), have been generally considered unable to encode proteins both in plants and animals [1-9]. (fortunepublish.com)
Other lncRNAs are localized in the nucleus, which are involved in crucial molecular processes, including RNA processing, chromatin organization and transcription, and play an important role in genome structure [ 13 , 14 ]. (biomedcentral.com)
Our preliminary experiment screened several lncRNAs from OS tissues and paired adjacent tissues by performing qRT-PCR, and identified lncRNA CASC9 was highly expressed in GC tissues. (biomedcentral.com)
This class of RNA encompasses microRNAs (miRNAs, well-studied post-transcriptional regulators of gene expression), long non-coding RNAs (lncRNAs) and other ncRNAs. (gencat.cat)
Long non-coding RNAs (lncRNAs) and miRNAs belong to a class of non-coding RNAs (ncRNAs) that play important roles and functions in the regulation of the expression of genes in main biological processes, such as cell proliferation, apoptosis, and differentiation. (ac.ir)
Due to the mutual relationships among lncRNA, miRNA, and mRNA, our results provided a novel perspective on lncRNAs for future research and experimental studies on ectodermal differentiation pathways and molecular mechanisms. (ac.ir)
One such class are the non-coding RNAs known collectively as long non-coding RNAs (lncRNAs). (lncrnablog.com)
They then further analyzed the data to identify those lncRNAs whose expression changed the most between growth and stationary phases of culture or between batch and fed-batch culture to identify potential lncRNA targets for further functional studies with regard to their role in controlling growth of CHO cells. (lncrnablog.com)
In this study, we globally assessed the transcriptomic differences of lncRNAs in gastric cancer using publicly available microarray data from Gene Expression Omnibus (GEO) and identified an oncogenetic lncRNA ZFAS1, which may promote gastric tumorigenesis. (oncotarget.com)
The investigation found that there are three subclasses for piRNAs that based on their origin derived from transposons, derived from lncRNAs, and derived from mRNAs, piRNA biogenesis is initiated by Pol II copying RNA from its cluster, and then, with more turnover, the piRNA precursor is transferred to the cytoplasm [18,19]. (jcimcr.org)
Long noncoding RNAs (LncRNAs) are ncRNAs longer than 200 nucleotides, regulating the transcription and translation of protein-coding genes and they can be found in the peripheral blood, thus holding a promising biomarker potential. (uninsubria.it)
Methods: We profiled by RNA-Sequencing a panel of 2906 lncRNAs to investigate their modulation in PBMCs of a pilot group of COVID-19 patients, followed by qPCR validation in 111 hospitalized COVID-19 patients. (uninsubria.it)

MIR22HG ncRNA is greater than 200 nucleotides in length and therefore informally classified as a long non-coding RNA, i.e. lncRNA. (wikipedia.org)
MiRNAs were identified as single-stranded ncRNAs with a length of approximately 22 nucleotides in 1993 [ 14 ]. (ersjournals.com)
Cancer susceptibility candidate 9 (CASC9) is a conserved lncRNA with 1500 nucleotides (nt) in length. (biomedcentral.com)
PIWI-interacting RNAs (piRNAs) are a new type of recently discovered small non-coding RNAs with 24-31 nucleotides (nt) in length [7]. (jcimcr.org)

PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element. (nature.com)

The imprinted DLK1-DIO3 locus, containing numerous maternally expressed ncRNAs including the lncRNA maternally expressed gene 3 (MEG3) and a cluster of over 50 miRNAs, has been shown to be a modulator of stemness in embryonic stem cells and in cancer progression, potentially through the tumor suppressor role of MEG3. (nih.gov)
Despite the well-known fact that primiRNAs are acting as non-protein-coding RNAs, the published data suggest that, in the plant genomes, some pri-miRNAs can also be found in polysomes, and the expression of these miRNA precursors may results in formation of micropeptides which may be involved in regulation of gene expression. (fortunepublish.com)
In this theoretical bioinformatics study, the miRNAs of the target genes (BMP4, NOG, and FGF8) were extracted and examined by MirWalk and TARGETSCAN databases to finally obtain the common miRNAs of these three genes. (ac.ir)

In recent years, noncoding RNAs (ncRNAs), especially microRNAs, long noncoding RNAs and circular RNAs, have been found to be associated with abnormalities of the ASMCs. (ersjournals.com)
To date, we and others have linked microRNAs and long non-coding RNAs to therapeutic resistance in ALK+ ALCL. (crct-inserm.fr)
The role of non-coding RNAs in determining growth, productivity, and recombinant product quality attributes in Chinese hamster ovary (CHO) cells has received much attention in recent years, exemplified by studies into microRNAs in particular. (lncrnablog.com)

In this review, we summarized the interactions of noncoding RNAs and viruses in the occurrence and development of AR, along with the treatments focusing on the noncoding RNAs in the past five years. (hindawi.com)
This review highlights findings concerning noncoding RNAs (ncRNAs) in asthmatic ASMCs so far and proposes a schematic diagram that helps us to better understand how ncRNAs are involved in pathophysiological behavioural changes in asthmatic ASMCs. (ersjournals.com)
Many noncoding RNAs (ncRNAs) have been identified in asthmatic ASMCs in recent years [ 5 ]. (ersjournals.com)
The core transcription regulatory loop of the digestive system tumors is complex and a high density of transcription regulatory complexes in the SEs and the crosstalk between SEs and the noncoding RNAs. (ijbs.com)
Aberrant changes in epigenetic mechanisms regulating DNA methylation, histone methylation and acetylation, expression of noncoding RNAs, and mRNA methylation are associated with the initiation, growth, and progression of digestive system tumors [ 2 , 4 ]. (ijbs.com)
Recently, long noncoding RNAs have been emerged as critical regulators of human disease and prognostic markers in several cancers, including gastric cancer. (oncotarget.com)

NcRNAs are a class of RNA molecules that do not encode proteins, and they play an important role in regulating cellular transcription and post-transcriptional processes [ 7 ]. (ijbs.com)
Han Y , He X , Lee S , Mao Y , Liu X , Sun H , Jin M , Kwon T , . Network analysis for the identification of hub genes and related molecules as potential biomarkers associated with the differentiation of bone marrow-derived stem cells into hepatocytes. (aging-us.com)
A growing body of evidence indicates that epigenetic regulators rely, amongst other factors, on their interaction with untranslated RNA molecules for guidance to particular targets on DNA. (frontiersin.org)
Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different classes of molecules with unique lengths, conformations and targets. (frontiersin.org)
One of them is Annotation - a step where you assign function to your RNA molecules. (novogene.com)
The second thing you want to do is Quantification of target RNA molecules - crucial for the differential gene expression analysis, where you aim to determine which genes are upregulated/downregulated across your samples. (novogene.com)
Lastly, one can also perform Target prediction/network study - particularly important when working with non-coding RNA molecules, where you aim to investigate the potential interaction between various RNA molecules, and what are the potential targets of these ncRNAs. (novogene.com)
One of these platforms is the NovaSeq6000 short-read sequencing machine, the most commonly used NGS sequencer which can sequence all types of RNA molecules (up to 500 bp). (novogene.com)

Antisense Uchl1 RNA is then required for the association of the overlapping sense protein-coding mRNA to active polysomes for translation. (nature.com)
We also profiled lncRNA and mRNA expression in three mouse male germ cell-related cell lines (F9, GC-1 and GC-2). (biomedcentral.com)
MiRNA usually binds directly to the 3′-untranslated region (3′-UTR) of target gene mRNA through the RNA-induced silencing complex (RISC) [ 15 , 16 ]. (ersjournals.com)
The results indicate that the lncRNA-miRNA-mRNA interaction chain may play an important role in the differentiation of BMSCs into hepatocytes, which provides a new therapeutic target for liver disease treatment. (aging-us.com)
In this study, mRNA, miRNA, and lncRNA gene networks were predicted by web-based programs for three ectodermal pathway markers (BMP4, NOG, FGF8) in the mouse embryonic stem cells. (ac.ir)
Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue. (ac.ir)
Analyzing the LncRNA, miRNA, and mRNA regulatory network in prostate cancer with bioinformatics software. (ac.ir)

Background The long non-coding RNA small nucleolar RNA host gene 16 (lncRNA SNHG6) is dysregulated in various malignant tumor. (researchsquare.com)
LncRNA small nucleolar RNA host gene 16 (SNHG6), also known as U87HG, locates in human chromosome 8q13.1. (researchsquare.com)

LncRNA and miRNA both participate in the regulation of immune function. (hindawi.com)
LncRNA and miRNA both participate in immune regulatory responses by regulating the differentiation of bone marrow hematopoietic stem cells and activating mononuclear macrophages and DCs [ 13 ]. (hindawi.com)
Then, protein-microRNA (miRNA) and miRNA-long non-coding RNA (lncRNA) bipartite networks were built and significant ncRNAs were extracted. (figshare.com)
In this paper, we propose that lncRNA-miRNA interactions, analogous to receptor-ligand interactions, are responsible for cell-type-specific outcomes. (gencat.cat)

During the Human Genome Project, most efforts to estimate and annotate genes focused on protein-coding genes, i.e., regions of the genome that are transcribed into RNA and then translated into proteins. (biomedcentral.com)
Gene Ontology and pathway enrichment analyses and assessment of RNA binding proteins were performed by R software, circlncRNAnet and Encyclopedia of RNA Interactomes (ENCORI). (xiahepublishing.com)
The fate of cells is determined by epigenetics, as it plays a role in allowing the heart cell to turn "on" genes to make proteins important for its job and turn "off" genes important for an immune cell's job. (troscriptions.com)
What about all that non-coding RNA (ncRNA) stuff being transcribed from DNA in the genome which does not go on to produce proteins, is it meaningless and nonfunctional? (phoenixrising.me)
There is a family of proteins called argonaute ( for reasons that would take us way off-topic ) which can use short RNA sequences to identify the location on which to operate on longer strands. (phoenixrising.me)
Because MMP-13 and its regulatory networks are suitable targets for the development of effective early treatment strategies for OA, we discuss the specific targets of MMP-13, including upstream regulatory proteins, DNA methylation, non-coding RNAs, and autophagy-related proteins of MMP-13, and their therapeutic potential to inhibit the development of OA. (biomedcentral.com)
Finally, we discuss clinical significance of the CRISPR-Cas9 gene editing system and inhibitors of SE-related proteins such as BET and CDK7 as potential cancer therapeutics. (ijbs.com)
PIWI-interacting RNAs (piRNAs) are another subgroup of small non-coding RNAs emerging as key players in different biological activities, including regulating gene and protein expression, epigenetic silencing of transposable elements, and controlling the spermatogenesis by interacting with PIWI proteins. (jcimcr.org)

Kong M, Yu X, Guo W, Guo R. The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors. (ijbs.com)
The aberrant expression of methylation and ncRNAs, two crucial regulators of epigenetic modifications, has been widely demonstrated in cancer. (ijbs.com)
Therefore, we summarize the interrelation process between ncRNAs and methylation modifications in GI tumors, including the detailed mechanism of methylation enzyme regulation of ncRNAs, the molecular mechanism of ncRNAs regulation of methylation modifications, and the correlation between the interactions between ncRNAs and methylation modifications and clinical features of tumors. (ijbs.com)
Finally, we discuss the potential value of ncRNAs and methylation modifications in clinical diagnosis and therapy. (ijbs.com)
This article will discuss the three main epigenetic signatures (DNA methylation, Histone Modification, and noncoding RNA), how they are regulated, and how their disruption cause diseases. (troscriptions.com)
DNA methylation is one of the key epigenetic modifications that play a role in regulating genes. (troscriptions.com)
DNA methylation in the promoter regions acts as a repressor of gene expression. (troscriptions.com)
We lose methylation capacity as we age, leading to more genes turned on errantly. (troscriptions.com)
The most common PTMs which are well-studied and understood in the context of DNA repair, gene expression, and regulation are acetylation and methylation. (troscriptions.com)
In this review, we highlight the main MMP-13-related changes in OA chondrocytes, including alterations in the activity and expression level of MMP-13 by upstream regulatory factors, DNA methylation, various non-coding RNAs (ncRNAs), and autophagy. (biomedcentral.com)
A member of the argonaut protein family encoded by the Drosophila piwi gene is involved in DNA methylation, transposon silencing, germline development, and fertility [12-14]. (jcimcr.org)

Genomic analysis identified 250 protein-coding genes located near (≤ 10 kb) 194 of the loci encoding testis-specific lincRNAs. (biomedcentral.com)
However in recent years with the development of epigenesis, genomic imprinting and the horizontal transferences of the genes, Lamarck's ideas have resurfaced. (intechopen.com)
With the development of high-throughput sequencing, genome-wide association studies (GWAS) and RNA sequencing (RNA-seq) have been extensively used in recent years to identify genomic regions and candidate genes associated with a variety of pork traits [ 3 - 5 ]. (animbiosci.org)
The Cancer Genome Atlas (TCGA) database has accumulated abundant genomic and gene expression profiles for different diseases in the past decade. (xiahepublishing.com)
In the post-genomic era, the cancer research is focused on the dysregulation of transcriptional dysregulation mediated by epigenetic modifications in the enhancer, SE, and gene promoter regions of key tumor suppressor and tumor-promoting genes [ 5 , 6 ]. (ijbs.com)

Hastings, M. L., Ingle, H. A., Lazar, M. A. & Munroe, S. H. Post-transcriptional regulation of thyroid hormone receptor expression by cis-acting sequences and a naturally occurring antisense RNA. (nature.com)
Gene ontology (GO) analysis showed that these protein-coding genes were enriched for transcriptional regulation-related terms. (biomedcentral.com)
The lab investigates mechanisms of RNA mediated epigenetic gene regulation by employing a combination of biochemistry, cell and molecular biological methods, and genome wide approaches. (lncrnablog.com)
12 ]. Moreover, ncRNAs are also subject to epigenetic regulation and play a role in cancer. (ijbs.com)
RNA-seq performed in humans has determined the molecular regulation mechanisms of fat accumulation between different groups of samples with different genetic backgrounds. (animbiosci.org)
Functional enrichment analysis revealed SNHG4 involvement with regulation of ribosomal RNA synthesis and the RNA processing and surveillance pathway. (xiahepublishing.com)
PE is a multifactorial disease, and while there is a cautious acceptance of links between familial TG003 manufacture concordance and maternal polymorphism in the pathogenesis of the disease [6C13], the placenta is definitely suggested as the main cause TG003 manufacture of PE [14,15], Nonetheless, there is a degree of uncertainty, specifically in regards to the roles of gene expression and regulation within the molecular pathogenesis of the condition. (palomid529.com)
Beyond being the product of gene expression, RNA can also influence the regulation of chromatin. (portlandpress.com)
in some cases, there are clear examples of direct RNA-mediated chromatin regulation mechanisms stemming from these interactions, while others have yet to be determined. (portlandpress.com)
Recent studies have highlighted examples of chromatin regulation via RNA matchmaking, a term we use broadly here to describe intermolecular base-pairing interactions between one RNA molecule and an RNA or DNA match. (portlandpress.com)

9. Zhang Y, Yu F, Bao S, Sun J. Systematic characterization of circular RNA-associated CeRNA network identified novel circRNA biomarkers in Alzheimer's disease. (ac.ir)
In this webinar, Novogene will provide a comprehensive overview of a set of solutions from long non-coding RNA sequencing (lncRNA-seq), small RNA sequencing (sRNA-seq), circular RNA sequencing (circRNA-seq) to whole transcriptome sequencing (WTS) and will discuss their applications in the field of transcriptomics. (novogene.com)

The normal actions and functions of the MIR22HG gene are complex and have not been fully elucidated, but its primary function may be as a tumor suppressor gene. (wikipedia.org)
When overexpressed, it acts as a tumor suppressor gene in many cancer types but in a few cancer types it acts as an oncogene, i.e. a tumor promotor gene: MIR22HG gene's impact on various cancers is strictly dependent on the type of cancer in which it operates. (wikipedia.org)
Thyroid cancer (TC): low levels of MIR22HG lncRNA were found in individuals with large tumor size, lymph node metastases, advanced clinical stage, shorter disease-free survival time, and poor survival times in TC. (wikipedia.org)
Lung adenocarcinoma (LAC): The levels of MIR22HG RNA were lower in LAC tumors than normal lung tissues and lower levels of this lncRNA in LAC tumor tissue were associated with poor patient survival times. (wikipedia.org)
cholangiocarcinoma (CAA): Low levels of MIR22HG lncRNA in CCA tumors were associated with an advanced clinical stage, larger tumor size, lymph node metastasis, and poor survival times. (wikipedia.org)
Low tumor tissue levels of this lncRNA were significantly associated with shorter patient survival times. (wikipedia.org)
They use their complex epigenetic regulatory mechanisms to act as upstream regulators of downstream oncogenes or tumor suppressor genes [ 10 ]. (ijbs.com)
Mammary Tumor-Associated RNAs Impact Tumor Cell Proliferation, Invasion, and Migration. (amaroqtx.com)
This review summarizes current information regarding the reported roles of lncRNA-encoded micropeptides in cancer, and explores the potential clinical value of these micropeptides in the development of anti-cancer drugs and prognostic tumor biomarkers. (biomedcentral.com)
The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were collected to estimate the prognostic value, and the odds ratios (ORs) with 95% CIs were used to evaluate the relationship between lncRNA SNHG6 expression and clinicopathological features, including tumor invasion depth, lymph node metastasis (LNM), distance metastasis (DM), and TNM stage. (researchsquare.com)
Conclusions High lncRNA SNHG6 expression was correlated with tumor invasion depth, LNM, DM, and advanced TNM stage, suggesting that SNHG6 may serve as a promising prognostic biomarker of human cancers. (researchsquare.com)
The multistep transformation of normal cells into malignant cells involves genetic and epigenetic alterations that promote the aberrant expression of critical oncogenes and tumor suppressor genes [ 1 , 2 ]. (ijbs.com)

These studies are important because they established the levels of MIR22HG lncRNA as prognosis indicators and suggest that this lncRNA and the implicated cancerous signaling pathways are therapeutic targets for treating these cancers. (wikipedia.org)
To relate the occurrence of gene fusions to Gleason Grading Groups and disease prognosis, we performed survival analyses using the Kaplan-Meier estimator, log-rank test, and Cox regression. (biomedcentral.com)
We found evidence that the number of gene fusions was associated with the prognosis of PCa. (biomedcentral.com)
Consequently, cancer patients with high lncRNA SNHG6 expression tend to have a poor prognosis. (researchsquare.com)

However, the comparative transcriptome analysis of two spinach accessions with different bolting times identified genome-wide gene expression profiling and large-scale discovery of flowering-related genes from vegetative and reproductive leaves [ 13 ]. (biomedcentral.com)
when the first major genome update was published in 2004, the estimated gene count was revised to 24,000 [ 8 ]. (biomedcentral.com)
Genome-wide association studies (GWAS) attempt to link genetic variants to nearby genes, relying on standard catalogs of human genes. (biomedcentral.com)
They encode the majority of the human genome and regulate gene expression through a variety of mechanisms. (figshare.com)
By mapping each signature to the reference genome, genes associated with the selected SNPs were retrieved. (figshare.com)
The Human Genome Project has revealed that protein-coding genes represent less than 2% of the total genome sequence [ 7 ], and the remaining greater portion of human genomes are regarded as "junk DNAs", for they do not encode any protein. (oncotarget.com)
The majority of the human genome has the capacity to be transcribed and the majority of the non-protein-coding transcripts made by RNA Polymerase II are enriched in the nucleus. (portlandpress.com)
Recent discoveries on RNAs reported that non-coding RNAs contain 98% of the human genome, involving different biological pathological activities [4-6]. (jcimcr.org)

Candidates with research interests in chromatin biology, epigenetics, and non-coding RNAs are encouraged to apply. (lncrnablog.com)

We assembled the sequences from deep RNA sequencing experiments by the Genotype-Tissue Expression (GTEx) project, to create a new catalog of human genes and transcripts, called CHESS. (biomedcentral.com)
These include 224 novel protein-coding genes and 116,156 novel transcripts. (biomedcentral.com)
This gene has 2 transcripts (splice variants). (medchemexpress.cn)
The measured intensities were log -normalized and differentially expressed transcripts/genes were filtered for a fold change (FC) ≥ 2 and an FDR ≤ 0.10. (lncrnablog.com)
While opting for long-read sequencing approaches may intuitively seem like a better option since full-length transcripts are obtained (meaning that no short-read assembly is required), and PCR bias and input RNA fragmentation are avoided, it is important to note that there are also some disadvantages that need to be considered before deciding to deploy this method. (novogene.com)

ncRNA 6, 49-25 (2020). (amaroqtx.com)

Consequently, identifying significant ncRNAs and utilizing them as biomarkers could facilitate the early detection of this cross-talk. (figshare.com)
Sarkar, D. & Diermeier, S. D. Circular RNAs: Potential Applications as Therapeutic Targets and Biomarkers in Breast Cancer. (amaroqtx.com)

MIR22HG (MIR22 host gene), also known as C17orf91, MGC14376, MIRN22, hsa-mir-22, and miR-22 is a human gene that encodes a noncoding RNA (ncRNA).This RNA molecule is not translated into a protein but nonetheless may have important functions. (wikipedia.org)
Antisense Uchl1 function is under the control of stress signalling pathways, as mTORC1 inhibition by rapamycin causes an increase in UCHL1 protein that is associated to the shuttling of antisense Uchl1 RNA from the nucleus to the cytoplasm. (nature.com)
85% of ALK+ ALCLs are associated with a translocation between the NPM (nucleophosmin) gene and the ALK (Anaplastic Lymphoma Kinase) gene resulting in a constitutively activated, oncogenic fusion protein. (crct-inserm.fr)
However, a growing body of evidence suggests that recruitment, stability, and function of epigenetic factors can be mediated by non-protein-coding RNAs. (frontiersin.org)
One surprise at the time was that the protein coding genes identified were far less numerous than expected. (phoenixrising.me)
One reason you may see different figures for this is that even coding regions containing genes are more likely than not to contain 'introns' within genes which are removed before the RNA transcript is spliced together and passed to protein synthesis. (phoenixrising.me)

In this study we analyzed the expression pattern and functional role of ncRNAs from the DLK1-DIO3 locus in epithelial plasticity of the breast. (nih.gov)
We present a schematic that illustrates the role of ncRNAs in pathophysiological changes to ASMCs that may be useful in future research in diagnostic and treatment strategies for patients with asthma. (ersjournals.com)

5%, L). Whole-transcriptome sequencing was performed to explore the differentially expressed (DE) genes between these two groups. (animbiosci.org)
Herein, we screened differentially expressed genes between hepatocytes and untreated BMSCs to identify the genes responsible for the differentiation of BMSCs into hepatocytes. (aging-us.com)

Lucere, K. M., O'Malley, M. M. R. & Diermeier, S. D. Functional Screening Techniques to Identify Long Non-Coding RNAs as Therapeutic Targets in Cancer. (amaroqtx.com)
Mechanistically, RNA immunoprecipitation and RNA pull-down experiment showed that ZFAS1 could simultaneously interact with EZH2 and LSD1/CoREST to repress underlying targets KLF2 and NKD2 transcription. (oncotarget.com)

CIRComa : Deciphering the role of circular RNAs in the pathogenesis and therapeutic resistance of anaplastic large cell lymphomas associated with the oncogenic tyrosine kinase ALK. (crct-inserm.fr)
This project aims to elucidate their role in ALK+ biology including their impact on lncRNA networks and therapeutic resistance. (crct-inserm.fr)

Colorectal cancer (CRC): Low levels of MIR22HG lncRNA were found in CRC tumors compared to normal colorectal tissue. (wikipedia.org)

RNA maps reveal new RNA classes and a possible function for pervasive transcription. (nature.com)
Gene expression, Kaplan-Meier survival, microRNA and transcription factor target analyses were performed with the University of Alabama Cancer (UALCAN) Database, Kaplan-Meier Plotter, LinkedOmics, WebGestalt and gene set enrichment analysis, respectively. (xiahepublishing.com)
The expression of the hub genes in the BMSCs and hepatocytes was verified by reverse transcription-quantitative PCR (RT-qPCR). (aging-us.com)
SEs are defined as large clusters of active enhancers in large clusters that are enriched with high levels of transcription factors (TFs), master co-factors, mediator complexes, RNA polymerase II (RNA pol II), and epigenetic modifications [ 5 , 7 ]. (ijbs.com)

These data reveal another layer of gene expression control at the post-transcriptional level. (nature.com)
However, none of the prognostic models incorporates parameters reflecting the status of chromosomal rearrangements and transcriptional disorganization in a patient sample, even though gene fusions are known to drive PCa development and progression [ 8 ]. (biomedcentral.com)

Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. (amaroqtx.com)
Hub genes were analyzed using the STRING and Cytoscape v 3.8.2, revealing that twenty-four hub genes, play a pivotal role in the differentiation of BMSCs into hepatocytes. (aging-us.com)

Overexpression of the MIR22HG gene in various types of NSCLC cells in culture suppressed cell proliferation and invasion and induced cell cycle arrest (i.e. blocked cell division) apparently by indirectly stimulating the production of p21, an inhibitor of cell replication. (wikipedia.org)

Some of the cancer types that have been associated with the MIR22HG gene and its lncRNA product acting to suppress the cancer are: Non-small-cell lung cancer (NSCLC): The MIR22HG gene was down-regulated (i.e. under-expressed to give low levels of this genes lncRNA) in the NSCLC tumors of individuals who had poorer prognoses. (wikipedia.org)
Hepatocellular carcinoma (HCC): low levels of MIR22HG lncRNA in HCC tumors were associated with short overall survival and poor disease-free survival times. (wikipedia.org)
NcRNAs play a significant role in regulating gene expression in digestive system tumors. (ijbs.com)
Long non-coding RNA small nucleolar RNA host genes (SNHGs) play a critical role in the occurrence and development of tumors. (xiahepublishing.com)
Current studies on lncRNA-encoded peptides in humans have mainly focused on their role in malignant tumors. (biomedcentral.com)

Genes & Development 30, 34-51 (2016). (amaroqtx.com)

Nevertheless, further studies are needed to fully dissect the molecular pathways influenced by non-coding RNAs at the DLK1-DIO3 locus in breast tissue. (nih.gov)

The datasets included transcriptome-wide expression and matched clinical follow-up data to detect and characterize gene fusions in PCa. (biomedcentral.com)
However, a definite conclusion on the clinical value of lncRNA SNHG6 expression in human cancers has not been determined. (researchsquare.com)

Increasing MIR22HG lncRNA levels in cultured NSCLC cells reduced their proliferation and invasiveness. (wikipedia.org)
These are responsible for abnormal gene expression, resulting in increased cancer cell proliferation and escape from immune surveillance, which can speed up the process of development into HCC. (xiahepublishing.com)

For 20 years we have known about RNA interference limiting expression of genes. (phoenixrising.me)

In this study, we investigated gene fusions in PCa, characterized potential novel candidates, and explored their role as prognostic markers for PCa progression. (biomedcentral.com)
LncRNA AGPG has been shown to play a role in esophageal cancer by binding to and stabilizing PFKB3, which increases glycolytic flux and cell cycle progression in esophageal cancer cells. (ijbs.com)
MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression. (amaroqtx.com)

It was discovered that the gene, called an early nodulin 40 (Enod40), previously annotated as transcribed with the formation of lncRNA encodes actually two short peptides (with a length of 12 and 24 amino acid residues) in plants, where they participate in the organogenesis of the root nodules [10, 11]. (fortunepublish.com)

Marked upregulation of ncRNAs from the DLK1-DIO3 locus was seen after EMT induction in two cell line models of EMT. (nih.gov)
We also show that expression of MEG3 is concomitant with the expression of the ncRNAs from the DLK1-DIO3 locus and its expression is therefore likely indicative of activation of all ncRNAs at the locus. (nih.gov)
ENST00000601116.5, a lncRNA in the CEACAM21 locus). (uninsubria.it)

Mechanisms and functions of long non-coding RNAs at multiple regulatory levels. (ac.ir)

In addition, Th2 cells are important mediators of type I allergy, and it has been reported that ncRNA promotes Th2 cell migration to target organs by regulating chemokine gene expression [ 17 ]. (hindawi.com)

Among important regulators of these cellular processes are non-coding RNAs (ncRNAs). (nih.gov)

Here we identify a nuclear-enriched lncRNA antisense to mouse ubiquitin carboxy-terminal hydrolase L1 ( Uchl1 ), a gene involved in brain function and neurodegenerative diseases 11 . (nature.com)
A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition. (nature.com)
More interestingly, a large number of noncoding fragments were found in peripheral blood cells of patients with asthma, including natural antisense chains, pseudogenes, and differential expression of ncRNA between genes [ 14 ]. (hindawi.com)

Part of this can be described as simple interactions between RNA sequences which pair up with single strands of RNA loose in cells, essentially jamming the machinery. (phoenixrising.me)

Small ncRNAs are further divided into myriad subclasses, and each subclass has its own biological and medical importance. (biomedcentral.com)
This study aimed to explore the biological role of long on-coding RNA (lncRNA) CASC9 and its regulatory mechanism in OC. (biomedcentral.com)

We suggest additional function to verify the assignments from the PE linked and exclusive genes, presently not really getting looked into within the molecular pathology of the condition. (palomid529.com)
However, this technique is lately recommended as less delicate for microarray research that look for to take into account variability in gene appearance across test within same course or even to map the molecular pathology of an illness from 'loud' data pieces [23C26]. (palomid529.com)
We further offer proof for putative inter-relationships and contributory tasks of similarly low or higher level indicated genes within the molecular pathology of PE. (palomid529.com)

GSE30419 gene microarray data of BMSCs and GSE72088 gene microarray data of primary hepatocytes were obtained from the Gene Expression Omnibus database. (aging-us.com)
Researchers at the University of Kent have undertaken the first landscape analysis of the lncRNA transcriptome in CHO using a mouse based microarray that also provided for the surveillance of the coding transcriptome. (lncrnablog.com)

These results suggest that the noncoding RNA regulatory network may play a potential role in the development of allergic rhinitis (Figure 1 ). (hindawi.com)
We also discuss the huge potential of the ncRNA regulatory network as the basis for diagnosis and treatment of ASMC dysfunction. (ersjournals.com)

ncRNA 7, 2-17 (2021). (amaroqtx.com)

Many software packages that analyze RNA sequencing (RNA-seq) experiments, which measure gene expression, rely on a database of known genes and cannot measure genes or splice variants unless they are included in the database. (biomedcentral.com)
What was found instead turned out to be hundreds of genes with variants that might increase risk by a few percent. (phoenixrising.me)

Vito D, Smales CM. (2018) The Long Non-Coding RNA Transcriptome Landscape in CHO Cells Under Batch and Fed-Batch Conditions . (lncrnablog.com)

The interaction networks between ncRNA and virus copromote the occurrence of allergic rhinitis. (hindawi.com)

Anatomy2

Organisms1

Diseases1

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes30

Disciplines and Occupations1

Information Science5

LncRNAs46

Nucleotides4

Modulated by the bal1

MiRNAs3

MicroRNAs3

Noncoding RNAs6

Molecules8

MRNA7

Small Nucleolar RNA2

MiRNA4

Proteins8

Methylation11

Genomic5

Regulation10

CircRNA2

Tumor12

Prognosis4

Genome8

Chromatin1

Transcripts5

20201

Biomarkers2

Protein6

Role of ncRNAs2

Differentially expressed2

Targets2

Therapeutic2

Colorectal1

Transcription4

Transcriptional2

Differentiation2

Suppressed cell proliferation and invasion1

Tumors5

20161

Pathways1

Clinical2

Proliferation2

Expression of ge1

Progression3

Encodes1

Locus3

Mechanisms1

Promotes1

Regulators1

Antisense3

Interactions1

Biological2

Molecular3

Microarray2

Regulatory network2

20211

Variants2

20181

Interaction1