Liver tumor suppressor protein. Medical search. Frequent questions

examined 8-oxo-dG levels and also evaluated promoter methylation of 11 tumor suppressor genes (TSGs) in 128 liver biopsy samples. (wikipedia.org)
Their work proposes a novel and paradoxical mechanism of liver tumorigenesis because p53 is one of the most well-known tumor suppressor genes. (revoscience.com)
Lee, E.Y. and Muller, W.J. (2010) Oncogenes and Tumor Suppressor Genes. (scirp.org)
It is believed that the occurrence of leukemia is the result of genetic and epigenetic changes in protooncogene and tumor suppressor genes [ 8 ]. (hindawi.com)
The tumor suppressor genes are inactivated, and the oncogenes are dominant during the formation of the tumor [ 9 ]. (hindawi.com)
Abstract The major tumor suppressor P53 (TP53) acts primarily as a transcription factor by activating or repressing subsets of its numerous target genes, resulting in different cellular outcomes (e.g., cell cycle arrest, apoptosis and senescence). (uni-greifswald.de)
To date, it is well known that lncRNAs participate in chromatin modifications and transcriptional and translational regulation of protein-encoding genes or regulate protein function and activity through specific binding [ 3 - 5 ]. (jcancer.org)
Genes that normally help keep cell division under control or cause cells to die at the right time are known as tumor suppressor genes . (cancer.org)
Researchers don't yet know all of the DNA changes that result in basal or squamous cell skin cancer, but they have found that in many skin cancers the cells have changes in tumor suppressor genes or DNA repair genes. (cancer.org)
Structural genes encode proteins that are not involved in gene regulation. (p450inhibitors.com)
An in vitro assay on HepG2 cells confirmed Cyld and Foxo1, both tumor-suppressor, as miR-182-5p target genes. (univaq.it)
A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. (nottingham.ac.uk)
Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. (nottingham.ac.uk)
We identified ten hub genes in the protein-protein interaction (PPI) network, but only three ( COLEC10, TGFBR3 , and FYN ) appeared closely related to the prognosis. (biomedcentral.com)
As one of the Src family proteins and tumor suppressor genes, FYN has been little researched on liver cancer. (biomedcentral.com)
Meanwhile, synonymous mutations decreasing codon optimality slowed down translation, and were enriched in tumor suppressor genes. (biomedcentral.com)
Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver. (nih.gov)
Protein-coding genes dysregulated by 3 h TCPOBOP exposure were strongly enriched in KEGG pathways of xenobiotic and drug metabolism, with stronger and more extensive gene responses observed in female than male liver. (nih.gov)
Half of the hypermethylated genes overlapped with DNA hypermethylation in IDH1-mutant gliobastomas, suggesting the existence of a common set of genes whose expression may be affected by mutations in IDH1 or IDH2 in different types of tumors. (nih.gov)
The present study examines effects of metallic nickel particles on tumor promoter or suppressor genes and its signal transduction pathways in JB6 cells. (cdc.gov)
From experimentally validated target genes of these 86 miRNAs, pan-sensitive and pan-resistant genes with concordant mRNA and protein expression associated with in-vitro drug response to 19 NCCN-recommended breast cancer drugs were selected. (cdc.gov)

A malfunctioning 'traffic cop' gene apparently plays an important role in the formation of liver cancer, according to researchers from the Duke University Comprehensive Cancer Center and Zeneca Pharmaceuticals of Chesire, United Kingdom. (cancernetwork.com)
A malfunctioning 'traffic cop' gene apparently playsan important role in the formation of liver cancer, accordingto researchers from the Duke University Comprehensive Cancer Centerand Zeneca Pharmaceuticals of Chesire, United Kingdom. (cancernetwork.com)
The discovery that the gene-mannose 6-phosphate/insulin-like growthfactor II receptor (M6P/IGF2r)-acts as a tumor-suppressor genein human liver tumors could help researchers develop an earlydiagnostic test for liver cancer as well as new treatments, theresearchers said. (cancernetwork.com)
The disease is often far advanced at detection,and the 5-year survival rate in the United States is only 4%.A report on this tumor-suppressor gene appears in the December1995 issue of Nature Genetics . (cancernetwork.com)
In research published earlier last year in Oncogene , Jirtle'steam found that liver tumors from 64% of patients studied hadlost one copy of the gene. (cancernetwork.com)
Professor and lead author of the book after the last injection for 10 days at 100mg sAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlgA. (wirelessdesignmag.com)
The CLD liver biopsy samples showed activated p53 was positively correlated with apoptosis levels, SASP, HPC-associated gene expression, and later cancer development. (revoscience.com)
The VHL gene is a tumor suppressor gene, which means it keeps cells from growing and dividing too rapidly or in an uncontrolled way. (medlineplus.gov)
Mutations in this gene prevent production of the VHL protein or lead to the production of an abnormal version of the protein. (medlineplus.gov)
which means that one copy of the altered gene in each cell is sufficient to increase the risk of developing tumors and cysts. (medlineplus.gov)
Unlike most autosomal dominant conditions, in which one altered copy of a gene in each cell is sufficient to cause the disorder, two copies of the VHL gene must be altered to trigger tumor and cyst formation in von Hippel-Lindau syndrome. (medlineplus.gov)
Cells with two altered copies of this gene do not make functional VHL protein, which allows tumors and cysts to develop. (medlineplus.gov)
Cloning and subcellular localization of apr-1--a new gene of tumor specific antigen family]. (nih.gov)
These samples were examined closely to find out if the BAP1 protein was missing and if the p16 gene had certain changes. (survivingmesothelioma.com)
People who have an inherited mutation of this gene produce less of the BAP1 protein. (survivingmesothelioma.com)
research shows that about 90% of the blood system of malignant tumors with at least the height of single gene methylation is closely related since this is a reversible process of genetic modification can be through to handle to restore the normal expression of gene methylation, to achieve the purpose of prevention and treatment of tumor [ 10 ]. (hindawi.com)
The regulatory mechanism included induction of the P53 target gene P21 (CDKN1A) resulting in repression of HELLS via downregulation of the transcription factor Forkhead Box Protein M1 (FOXM1). (uni-greifswald.de)
Kaelin's 1999 study of the tumor-suppressor gene VHL, which helps control HIF, has been crucial for understanding cellular responses to changes in oxygen levels, according to a Harvard Medical School press release . (the-scientist.com)
This gene, often called a tumor suppressor gene, cannot protect cells from becoming cancerous when it isn't working properly. (choa.org)
The genetic changes that cause this syndrome are found in the DICER1 gene, a tumor suppressor gene. (choa.org)
For example, resveratrol, the nutrient found in grape skins (and red wine), has been shown to have a positive effect on heart health, and it may work by activating the SIRT1 gene to make more SIRT1 protein. (foxnews.com)
The female mice with the SIRT6 gene enhancement didn't live longer than regular mice. (foxnews.com)
G to T transversion mutations in codon 249 of the p53 tumour-suppressor gene have been found in human liver tumour from geographic areas with high risk of aflatoxin exposure and in AFB 1 -induced liver toxicity [ 8 ]. (hindawi.com)
All gene expression data of LIHC (liver hepatocellular carcinoma) were obtained from the TCGA database (portal.gdc.cancer.gov/projects/TCGA-LIHC) and GEO database. (biomedcentral.com)
This virtual learning experience will focus on liver cancer and utilize a tumor suppressor gene as a model to interrogate human biology from a computational perspective. (blumberginstitute.org)
In the present study, we identify a mechanism in which the tumor‐suppressor gene, cylindromatosis (CYLD), confers protection from hepatocellular injury and fibrosis. (uni-regensburg.de)
Researchers of Illinois University have found the gene (called as Foxm1b) in animals in vivo that lead to liver cancer . (asiancancer.com)
When the gene has been successfully "removed" from the experimental mice, these animals don't produce tumors. (asiancancer.com)
Robert Costa, the leader of the study as well as professor of biochemistry and molecular genetics, said: "As far as I know, this is the first time for human being to find the gene that directly links to the growth of tumor cells in living animals' bodies. (asiancancer.com)
In the current study, scientists of Costa laboratory use some genetically modified mice to establish the link between the Foxm1b and liver cancer, and this proves that the gene is essential in the process of reproduction of cancer cells. (asiancancer.com)
What's more, Foxm1b has expression in many different types of tumor cells, which convince scientists that besides liver cancer, the gene also plays an important role in other tumor cells' growth. (asiancancer.com)
Data suggest that the gene for MEN-1, called MENIN, is also involved in the pathogenesis of at least one third of sporadic neuroendocrine tumors (NETs), including gastrinomas. (medscape.com)
MEN-1 is due to mutations in the tumor suppressor gene MEN1, located on chromosome 11q13. (medscape.com)
This drug reactivates the P53 tumor-suppressor gene. (medscape.com)
2012) Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers. (who.int)

Furthermore, lncRNA-AK058003 acts as a tumor suppressor, suppressing hepatocellular carcinoma cell proliferation and metastasis in vitro and in vivo . (oncotarget.com)
Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits. (nih.gov)

Of 22 mice fed the diet supplemented with deoxycholate, 20 (91%) developed colonic tumors after 10 months on the diet, and the tumors in 10 of these mice (45% of mice) included an adenocarcinoma (cancer). (wikipedia.org)
The newly discovered 'switch' controls the activity of two proteins - 'deleted in liver cancer-1' ( DLC1 ), a tumour suppressor, and talin. (imperial.ac.uk)
Both proteins control whether or not cancer cells spread to other parts of the body, but the exact mechanisms have remained unclear. (imperial.ac.uk)
It is therefore crucial for the development of hepatocellular carcinoma (HCC) - the most common type of liver cancer. (imperial.ac.uk)
These forces change the shape of talin, which deactivates DLC1 so that it cannot perform its tumour suppressing fuction, leading to cancer. (imperial.ac.uk)
The scientists say their findings in this paper, published in PLOS Biology , help us understand how tumour cells migrate and therefore how to target and prevent cancer spread, particularly in HCC. (medicalxpress.com)
Lung cancer is the first leading diagnosed malignant tumor globally [ 1 ]. (medsci.org)
Liver cancer is one of the most common cancers worldwide,particularly because of its association with viral hepatitis,'said Dr. Randy Jirtle, professor of radiation oncology at DukeUniversity Medical Center and prinicipal investigator of the study.The lack of effective treatments also makes it a particularlydeadly disease, he said. (cancernetwork.com)
Because the receptor is involved both in switching on a growthinhibitor and inactivating a growth factor, the researchers hypothesizedthat losing it might well predispose a cell to cancerous growth.Their past studies showing that the protein was abundantly presentin normal liver cells but nearly absent in cancer cells strengthenedtheir suspicion. (cancernetwork.com)
Osaka, Japan - Researchers observed that constant activation of p53 in liver cells of patients suffering from chronic liver disease (CLD) could actually promote the development of liver cancer. (revoscience.com)
p53 is one of the most important proteins in cancer biology. (revoscience.com)
Tm1 is also a major tumor suppressor in breast cancer. (scirp.org)
Zerradi, M. , Houle, F. and Huot, J. (2015) Regulation of Breast Cancer Progression by Phosphorylation of the Tumor Suppressor Tropomyosin-1 Alpha. (scirp.org)
They are also at an increased risk of developing a type of kidney cancer called clear cell renal cell carcinoma and a type of pancreatic cancer called a pancreatic neuroendocrine tumor. (medlineplus.gov)
HCC tissues derived from chemical-induced rat liver cancer models validated that miR-31 manifestation is significantly down-regulated, and that those cell cycle- and EMT-regulatory proteins are deregulated in rat liver cancer. (nos-nop.org)
Researchers in Italy looked at patients with pleural mesothelioma to see if having a second cancer affected how long they lived. (survivingmesothelioma.com)
The biological role and underlying mechanism of action of zinc-finger protein 326 (ZNF326) in malignant tumors, including breast cancer, are still not clear. (cancerindex.org)
Simple Summary The tumor suppressor protein P53 is a major player in preventing liver cancer development and progression. (uni-greifswald.de)
Our in vitro and in vivo findings indicate an important additional aspect of the tumor suppressive function of P53 in liver cancer linked to epigenetic regulation. (uni-greifswald.de)
Herein, we identified Helicase, lymphoid specific (HELLS), a major epigenetic regulator in liver cancer, as a strong and selective P53 repression target within the SNF2-like helicase family. (uni-greifswald.de)
Our data suggest that functional or mutational inactivation of P53 substantially contributes to overexpression of HELLS in HCC patients and indicates a previously unstudied aspect of P53′s ability to suppress liver cancer formation. (uni-greifswald.de)
SH2 domains of cten and various other tensins bind towards the SIY442DNV site on DLC1 (Deleted in Liver organ Cancer tumor 1) and phosphorylation from the tyrosine is not needed (Liao et al. (researchensemble.com)
In breast cancer, lncRNAs are abnormally expressed and demonstrate differential expression in subtypes of tumors [ 9 , 10 ]. (jcancer.org)
An international team of researchers has discovered a new anti-cancer protein that not only prevents the uncontrolled proliferation of cancer cells in the liver, but also serves as a biomarker for the diagnosis and prognosis of liver cancer. (courtroommail.com)
Anti-cancer proteins, so-called tumor suppressors, prevent uncontrolled cell growth, but are often defective in cancer cells. (courtroommail.com)
They have shown that the loss of LHPP promotes tumor growth and reduces the chance of survival of cancer patients. (courtroommail.com)
With complete loss of the tumour suppressor, cancer patients die on average two years earlier. (courtroommail.com)
This is COOL SCIENCE: Cristae inside mitochondria (purple) align themselves to keep "feeding" certain lung cancer tumors. (cancer.org)
The protein enables cancer cells to live in the low-oxygen conditions found within tumors, and helps the body respond to cardiovascular. (the-scientist.com)
The mutation increases the overall risk for affected children to develop cancer or a number of benign tumors, especially at younger ages. (choa.org)
Not all individuals with a diagnosis of DICER1 syndrome will develop tumors or cancer. (choa.org)
Scientists aren't sure what these proteins do, although there is some evidence suggesting that they might help prevent chronic diseases such as cancer and cardiovascular disease. (foxnews.com)
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and accounts for around 70% of all liver cancers [ 1 ]. (hindawi.com)
Various factors have been implicated as risk factors in the pathogenesis of liver cancer, notably food contaminated with aflatoxins, toxins produced by fungi of the genus Aspergillus sp. (hindawi.com)
AFB 1 acts as a strong hepatotoxicant, mutagen and naturally occurring hepatocarcinogen, which cause liver cancer in a dose-dependent manner [ 5 ]. (hindawi.com)
This ultimately results in membrane damage, fragmentation, or random cross-linking of molecules like DNA, enzymes, and structural proteins and even lead to cell death induced by DNA fragmentation, lipid peroxidation and finally to cancer formation [ 15 ]. (hindawi.com)
More breakthroughs are needed in the clinical practice for liver cancer are needed, and new treatment strategies are required. (biomedcentral.com)
Liver cancer is known for its aggressiveness and high mortality rate. (biomedcentral.com)
Therefore, realizing the early diagnosis of liver cancer is particularly important for treating liver cancer and improving the prognoses [ 4 ]. (biomedcentral.com)
Therefore, we still need to identify additional biomarkers closely related to liver cancer progression to assist in clinical diagnosis and treatment. (biomedcentral.com)
Therefore, we explored the biological functions of FYN in liver cancer cells. (biomedcentral.com)
We fully utilized the transcriptome and translatome of liver cancer and normal tissue from ten patients. (biomedcentral.com)
Synonymous mutations might play a role in liver cancer development by altering codon optimality and translational velocity. (biomedcentral.com)
Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
Likewise, in vivo models of breast cancer have demonstrated that a high-cholesterol diet increases tumor growth by 20%, as well as the likelihood of metastasis. (news-medical.net)
An increased level of apolipoprotein A-I (apoA-I), which is the main protein of HDL, has also been found to increase breast cancer risk. (news-medical.net)
This cholesterol metabolite can act as a tumor suppressor by promoting cellular differentiation and cancer cell death. (news-medical.net)
SMARCA4 oncogenic potential via IRAK1 enhancer to activate Gankyrin and AKR1B10 in liver cancer. (namswlab.com)
2. MicroRNA-221 governs tumor suppressor HDAC6 to potentiate malignant progression of liver cancer. (namswlab.com)
3. MicroRNA-31 functions as a tumor suppressor by regulating cell cycle and epithelial-mesenchymal transition regulatory proteins in liver cancer. (namswlab.com)
Costa and his colleagues are so excited and pleased as they may find a thorough treatment of liver cancer . (asiancancer.com)
3] The HALT-C trial was a multicenter, randomized controlled study that evaluated whether long-term interferon would suppress HCV, prevent progression to cirrhosis, prevent liver cancer, and reduce the need for liver transplantation. (medscape.com)
Many patients are not candidates given the advanced stage of their cancer at diagnosis or their degree of liver disease and, ideally, could be cured by liver transplantation . (medscape.com)
Six miRNAs had concordant expression in both tumors and breast cancer patient blood samples compared with the normal control samples. (cdc.gov)

Hence, SIRT3 may function as a tumor suppressor in HCC. (bvsalud.org)
May function as a tumor suppressor. (lu.se)

They are rare, benign tumors of epithelial origin and occur in less than 0.007-0.012% of the population. (medscape.com)
Mutations in VHL cause von Hippel-Lindau disease, a disorder that results in cysts and benign tumors. (the-scientist.com)

MicroRNAs (miRNAs) act as oncogenes or tumor suppressors in most cancers. (biomedcentral.com)

SIRT3 expression has been discovered to be often downregulated in HCC tissues relative to normal liver tissues. (bvsalud.org)
MAGEH1 expression was downregulated in HCC tumor tissues compared with adjacent normal liver tissues and in samples from patients with tumor recurrence. (nih.gov)
In tumor tissues, lncRNAs are markedly deregulated and pervasively involved in development and progression of cancers [ 6 - 8 ]. (jcancer.org)
A miR-182-5p increase was detected early in livers as NAFLD damage progressed, and in tumors compared to peritumor normal tissues. (univaq.it)
According to miR-182-5p expression, decreased protein levels were observed in tumors compared to peritumor tissues. (univaq.it)
Analysis of miR-182-5p, Cyld and Foxo1 expression levels, based on datasets from human HCC samples, showed results consistent with those from our mouse models, and also highlighted the ability of miR-182-5p to distinguish between normal and tumor tissues (AUC 0.83). (univaq.it)
Overall, this study shows, for the first time, miR-182-5p overexpression and Cyld-Foxo1 downregulation in hepatic tissues and tumors from a diet-induced NAFLD/HCC mouse model. (univaq.it)
Free radicals can cause damage in structural and metabolic components like lipids, proteins, enzymes, carbohydrates and DNA in cells and tissues. (hindawi.com)
Twelve miRNAs showed concordant expression in tumors vs. normal breast tissues and patient survival (n = 1093), with seven as potential tumor suppressors and five as potential oncomiRs. (cdc.gov)

The researchers speculate that, considering how male mice have a higher rate of cancers compared with the females, the SIRT6 could be acting as a tumor suppressor and thus have a larger effect on male life span than female life span. (foxnews.com)
For bats, 3 out of 4 up-regulated miRNA (miR-101-3p, miR-16-5p, miR-143-3p) likely function as tumor suppressors against various kinds of cancers, while one down-regulated miRNA (miR-221-5p) acts as a tumorigenesis promoter in human breast and pancreatic cancers. (biomedcentral.com)

Usinga method to detect mismatches in genetic material, they comparedstrands of DNA from tumor cells and surrounding normal tissue,and discovered mutations in the tumor samples. (cancernetwork.com)

Von Hippel-Lindau syndrome is an inherited disorder characterized by the formation of tumors and fluid-filled sacs (cysts) in many different parts of the body. (medlineplus.gov)
Re-introduction of the genetic information for LHPP by the researchers prevents the formation of tumors and maintains liver function. (courtroommail.com)

reviewed studies indicating that one or more BER proteins also participate(s) in epigenetic alterations involving DNA methylation, demethylation or reactions coupled to histone modification. (wikipedia.org)
Abnormal methylation of Grainyhead-like 2 (GRHL2) is associated with a substantial role in the malignant phenotype of tumor patients. (hindawi.com)
The methylation level of the GRHL2 promoter region in acute leukemia patients and cell lines was significantly higher than the normal control group, and we found the elevated mRNA and protein levels of GRHL2 in acute leukemia cell lines after the use of the demethylation drug arsenic trioxide and 5-azacitidine. (hindawi.com)
MORC2 was found to function in KIRC by downregulating tumor suppressor DAPK1 via DNA methylation. (jci.org)

Mutations in IDH1 or IDH2 were associated with longer overall survival (P=0.028) and were independently associated with a longer time to tumor recurrence after intrahepatic cholangiocarcinoma resection in multivariate analysis (P=0.021). (nih.gov)

These synonymous mutations significantly contributed to the translational changes in tumor samples compared to normal samples. (biomedcentral.com)

The manifestation of miR-31 was normalized to U6 snRNA (*test) (D) The qRT-PCR analysis of miR-31 for hepatocellular carcinoma cell lines (n=7) and liver normal cell lines (n=2) (**test). (nos-nop.org)

GSEA analysis found STARD12 and STARD14 were associated with glycolysis, oxidative phosphorylation and tumor related signaling pathways. (medsci.org)
Background: Tropomyosin 1 alpha chain (Tm1) is an actin-binding protein that regulates the endothelial cell response to oxidative stress following its phosphorylation at Serine 283 (S283). (scirp.org)
In the present study, we investigated the role of phosphorylation of Tm1 in regulating its tumor suppressor properties. (scirp.org)
Conclusion: Phosphorylation of Tm1 at Ser283 contributes to its anti-tumor properties, and this effect results mainly from an increase in cell adhesion associated with a decrease in their migratory and invasive potentials. (scirp.org)
In mouse hepatocytes, p38γ induces proliferation after partial hepatectomy by promoting the phosphorylation of retinoblastoma tumour suppressor protein at known CDK target residues. (nature.com)
non-etheless there are many exceptions like the SH2 domains of SLAM-associated proteins (aka SAP SH2D1A) and cten where the binding needs Temocapril the tyrosine but irrespective of its phosphorylation position. (researchensemble.com)
Mechanistically, we found that lycopene and sorafenib could additively inhibit the mitogen-activated protein kinase (MAPK) pathways, as shown by the protein phosphorylation of ERK1/2, JNK1/2 and p38 were reduced additively. (frontiersin.org)

Collectively, lncRNA-AK058003 can reduce the expression of mRNA stabilizing protein HuR and act as a precursor of miR-15a to suppress γ-synuclein-mediated cell proliferation and the metastasis of hepatocellular carcinoma. (oncotarget.com)
Moreover, we recently reported that lycopene inhibits the metastasis of human liver adenocarcinoma SK-Hep-1 cells by downregulation of the NADPH oxidase 4 (NOX4) proteins ( 18 ). (frontiersin.org)

metastatic potential of HCC cells by selectively regulating epithelial-mesenchymal transition (EMT) regulatory proteins such as N-cadherin, E-cadherin, vimentin and fibronectin. (nos-nop.org)

All taken together, these observations underline the complexity of the mechanisms responsible for the selective destruction of proteins within cells. (cnrs.fr)
Previous studies have shown that p53 is in a constant state of activation in the liver cells of CLD patients. (revoscience.com)
According to researchers, these mice developed liver inflammation with higher amounts of hepatocyte apoptosis and senescence-associated secretory phenotype (SASP), a phenomenon where cells produce signals within the microenvironment that can cause nearby cells to become cancerous. (revoscience.com)
We previously established that an unidentified factor, or factors, present in ovarian tumor ascites fluids reversibly inhibited the activation of T cells by arresting the T-cell signaling cascade. (aacrjournals.org)
The five yr Anisole Methoxybenzene survival rate was significantly decreased in patient with low level of miR-31 manifestation in the tumor cells (Log-rank = 0.0015*) (C) The qRT-PCR analysis for 9 paired HCC cells. (nos-nop.org)
MiR-31 was significantly down-regulated compared to related non-tumor cells. (nos-nop.org)
The fact that and are up-regulated in HCC led us to hypothesize that normal and expressions are balanced by endogenous miR-31, which selectively regulates and mRNA translation in normal hepatic liver cells. (nos-nop.org)
As demonstrated in Fig. ?Fig.2B,2B, knockdown augmented HDAC2 and CDK2 protein expressions in SNU-449 and SKHep-1 cells, whereas co-transfection of miR-31 mimics attenuated knockdown effect on the same cells. (nos-nop.org)
Opdivo helps existing T-cells discover the mesothelioma tumor. (survivingmesothelioma.com)
At the same time, arsenide trioxide and 5-azacitidine are associated with the inhibition of cellular proliferation of acute leukemia cells and also promote the elevated expression of TGF- β signaling pathway-linked proteins, including TGF- β , Smad2, Smad3, and Smad4. (hindawi.com)
Dependence receptors are a group of receptor proteins with shared characteristics of transducing two different signals within cells. (koreascience.kr)
According to a statement released by the University of Basel, liver tumours develop from mutated cells that grow and proliferate uncontrollably. (courtroommail.com)
Any of these types of DNA changes might lead to cells growing out of control and forming a tumor. (cancer.org)
Finally, we explored the function of FYN in HCC cells and xenograft tumor models. (biomedcentral.com)
Scientists have also manufactured a prodrug to block the activation of the Foxm1b, thereby cutting off the supply of the protein produced by Foxm1b transcription to "starve" tumor cells, thereby preventing the proliferation of tumor cells. (asiancancer.com)
The hematoxylin and eosin (H&E) stain below depicts "ground-glass" cells seen in approximately 50-75% of livers affected by chronic HBV infection. (medscape.com)
Ground-glass cells are present in 50% to 75% of livers with chronic HBV infection. (medscape.com)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
Tumor-associated antigens (TAAs) are relatively restricted to tumor cells. (msdmanuals.com)
Tumor-specific antigens (TSAs) are unique to tumor cells. (msdmanuals.com)
However, several antigens with selective expression on the surface of tumor cells are not associated with the major histocompatibility complex and may be candidates for therapeutic targeting. (msdmanuals.com)
References Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)

Animals treated with ArtinM had fewer pre-neoplastic foci and hepatic tumors than the animals that receiving mycotoxin alone, as well as showing greater hepatic expression of tumor suppressor proteins. (usp.br)
The hepatic artery supplies 30% of the blood flow to the normal liver parenchyma but greater than 90% to hepatic tumors, including both HCC and metastatic lesions. (medscape.com)

Disclaimer: Operation is effective to early solid tumors, but it's not suitable for most middle or advanced tumors. (asiancancer.com)
Researchers anticipate enrolling 130 participants with one of several solid tumors. (medscape.com)

MEN-1 is known to cause multiple tumors within the pancreas, pituitary, parathyroid, and adrenal glands through an autosomal dominant pattern of inheritance. (medscape.com)

MicroRNA-495-3p functions as a tumour suppressor by regulating multiple epigenetic modifiers in gastric carcinogenesis. (namswlab.com)

However, oxidative stress has emerged as a key player in the development and the progression of liver cirrhosis [ 4 ] which is known to be a precursor of HCC. (hindawi.com)
Conclusions: Our findings highlight a novel link between CYLD and HDAC7, offering mechanistic insight into the contribution of these proteins to progression of liver disease. (uni-regensburg.de)

The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex 1 . (nature.com)
The protein interaction landscape of the human CMGC kinase group. (nature.com)
Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. (nature.com)
C1: proteins kinase C conserved locations. (researchensemble.com)

For example, 8-oxo-dG was increased 10-fold in the livers of mice subjected to ionizing radiation, but the excess 8-oxo-dG was removed with a half-life of 11 minutes. (wikipedia.org)
In fact, mice with p53 accumulation did have increased liver tumor development. (revoscience.com)
When the HPCs were isolated, grown in culture, and then injected under the skin of lab mice, these animals developed tumors. (revoscience.com)
In males, ACOT1 deficiency increased mitochondrial uncoupling protein-2 (UCP2) protein abundance while reducing 4-hydroxynonenal, a marker of oxidative stress, in white adipose tissue and liver of HFD-fed mice. (jci.org)
Researchers have found that a long-suspected anti-aging protein called sirtuin can make male mice live about 16 percent longer than average, the first such advance for mammals in a field that has thus far only offered the blessings of extended life span to yeast , nematodes and fruit flies. (foxnews.com)
Although the Israeli scientists cannot explain why female mice didn't also live longer like the males, an accompanying commentary describes the findings as bringing the field of anti-aging research to a new level of maturity. (foxnews.com)
The team's previous work revealed that mice genetically bred to have lots of SIRT6 could get fat on rich diets yet show no signs of heart disease, fatty liver disease and other diseases associated with obesity. (foxnews.com)
Previous research by other groups showed that mice genetically bred to have little SIRT6 don't live very long. (foxnews.com)
So, this time the Israeli team simply decided to let the SIRT6 mice live a natural life. (foxnews.com)
These male mice lived longer , about 16 percent longer on average, than regular mice kept in the same conditions. (foxnews.com)
They note that measuring life spans in longer-lived and more complex animals can be tricky, because, for example, life spans can vary by many months for genetically similar mice in similar environments with similar feed. (foxnews.com)
Likewise, 27-hydroxycholesterol, an endogenous oxysterol, increases estrogen receptor- and liver X receptor-dependent tumor growth in mice. (news-medical.net)
Exogenous application of HGF rescued the liver injury phenotype of CYLD−/− mice. (uni-regensburg.de)
Even use some experimental techniques to artificially create a number of factors inducing tumor in the laboratory, these mice won't produce tumors. (asiancancer.com)

The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. (nih.gov)
The xenograft model showed that overexpression of FYN could significantly inhibit malignant tumor behaviors and promote tumor cell apoptosis. (biomedcentral.com)

The underlying regulatory mechanism involved P53-dependent induction of P21 (CDKN1A), leading to repression of Forkhead Box Protein M1 (FOXM1) that in turn resulted in downregulation of HELLS expression. (uni-greifswald.de)
Additionally, NUDT21 was confirmed to act as a tumor suppressor mainly depending on downregulation of MORC2. (jci.org)

H19 may play as an oncogene or suppressor depending on tumor types [ 13 ]. (jcancer.org)

The incidence of pre-neoplastic lesions and liver tumors was measured 3 and 12 months after the start of treatments, respectively. (usp.br)
Patients with MEN-1 may also have an increased risk of skin lesions and carcinoid and smooth muscle tumors. (medscape.com)

When unchecked, fibroblasts can produce scar tissue in the liver, which leads to cirrhosis and HCC. (imperial.ac.uk)
The pathogenesis and clinical manifestations of hepatitis B are due to the interaction of the virus and the host immune system, which lead to liver injury and, potentially, cirrhosis and hepatocellular carcinoma. (medscape.com)
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. (medscape.com)
Whereas in the past, HCC generally presented at an advanced stage with right-upper-quadrant pain, weight loss, and signs of decompensated liver disease, it is now increasingly recognized at a much earlier stage as a consequence of the routine screening of patients with known cirrhosis , using cross-sectional imaging studies and serum alpha-fetoprotein (AFP) measurements. (medscape.com)
There is also a growing problem with cirrhosis, which develops in the setting of nonalcoholic fatty liver disease (NAFLD), or nonalcoholic steatohepatitis (NASH). (medscape.com)
The hepatitis B virus (HBV) and hepatitis D virus (HDV) infections cause liver disease, including hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). (cdc.gov)

Overall, we suggest that miR-31 functions like a tumor suppressor by selectively regulating cell cycle and EMT regulatory proteins in human being hepatocarcinogenesis providing a novel target FANCG for the molecular treatment of liver malignancies. (nos-nop.org)

Gastrinomas are neuroendocrine tumors that are usually found in the duodenum wall (approximately 50%) or in the pancreas. (medscape.com)
Gastrinomas are the second most common neuroendocrine tumors in the overall population, after insulinomas and before vasoactive intestinal polypeptide tumors (VIPomas) and glucagonomas. (medscape.com)

Only 1.5% of nucleic acids in human genome are used for protein encoding, but other 98.5% of the genome does not encode proteins. (jcancer.org)

It is striking that LHPP is present in healthy tissue and completely absent in tumor tissue," says first author Sravanth Hindupur. (courtroommail.com)
Significant exposure to Aflatoxin B 1 (AFB 1 ), a potent hepatotoxic and hepatocarcinogenic mycotoxin, plays a major role in liver carcinogenesis through oxidative tissue damage and p53 mutation. (hindawi.com)
AFB 1 -administered HCC-bearing rats (Group II) showed increased levels of lipid peroxides (LPOs), thiobarbituric acid substances (TBARs), and protein carbonyls (PCOs) and decreased levels of enzymic and nonenzymic antioxidants when compared to control animals (Group I). Administration of TD orally (300 mg/kg body weight/day) for 45 days to HCC-bearing animals (Group III) significantly reduced the tissue damage accompanied by restoration of the levels of antioxidants. (hindawi.com)
The mechanisms tipping the balance from restoration to progressive liver tissue scarring are not well understood. (uni-regensburg.de)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)

2011 This relationship recruits DLC1 a tumor suppressor to focal adhesions (Liao et al. (researchensemble.com)

Additionally, DBC1 knockdown eliminated the up-regulation of MMP7, EMT-related proteins, and cell cycle-related proteins as well as the enhanced proliferation and invasiveness induced by ZNF326. (cancerindex.org)

The receptor also works insidethe cell as a shuttle craft, moving proteolytic enzymes to thelysosomes, a part of the cellular digestive system that breaksdown proteins into simpler compounds. (cancernetwork.com)

ATP + a protein = ADP + a phosphoprotein. (lu.se)

The results showed that lycopene reduced the number of metastatic tumors in the lungs, which was further suppressed by the combined treatment with sorafenib. (frontiersin.org)

both E2F1 and c-Myc are stimulating factors of H19 expression, and the H19 lncRNA functions as a downstream effector of c-Myc and E2F1 in tumor development and progression [ 11 ]. (jcancer.org)

Because p53 is such a vital part of how the human body prevents tumor formation, its role in CLD became even more intriguing. (revoscience.com)
The identification of immunosuppressive factors within human tumor microenvironments, and the ability to block these factors, would be expected to enhance patients' antitumor immune responses. (aacrjournals.org)
In LPS/D-GalN hepatitis a dose titration of twice, a quarter and a twentieth of the human equivalent dose resulted in improvement of liver hemorrhage and necrosis, reduction in liver HIF-1 α and Pro-IL-1 β transcripts as well as the proteins of IL-1 β, HIF-1 α, pro-IL-1 β and cleaved (P10) caspase-1. (p450inhibitors.com)
The cover image displays normal human skin stained to highlight proteins critical for epidermal integrity, including the desmosomal cadherin desmoglein 1 (yellow), which is linked to the keratin 10 cytoskeleton (magenta). (jci.org)
To elucidate the molecular mechanisms that may underlie their unusual longevity, we have deep sequenced 246.5 million small RNA reads from whole blood of the long-lived greater mouse-eared bats, Myotis myotis , and conducted a series of genome-wide comparative analyses between bat and non-bat mammals (human, pig and cow) in both blood miRNomes and transcriptomes, for the first time. (biomedcentral.com)

START domain-containing proteins (STARDs) are responsible for lipid metabolism. (medsci.org)
SIRT3 belongs to the Sirtuin family of proteins, a collection of NAD+-dependent enzymes that play a role in controlling several cellular functions, including metabolism, aging, and stress response. (bvsalud.org)

Activator protein-1 (AP-1) and nuclear factor-kB (NF-kB) have been shown to play pivotal roles in tumor initiation, promotion, and progression. (cdc.gov)

Are there multiple proteolytic pathways contributing to c-Fos, c-Jun and p53 protein degradation in vivo? (cnrs.fr)
Growing tumors exist in metabolically compromised environments that require activation of multiple pathways to scavenge nutrients to support accelerated rates of growth. (jci.org)

Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. (nottingham.ac.uk)
Host Response to Tumors The immune response to foreign antigens consists of Humoral mechanisms (eg, antibodies) Cellular mechanisms (See also Tumor Antigens. (msdmanuals.com)

The incidence of HCC is highest in Asia and Africa, where the endemic high prevalence of hepatitis B and hepatitis C strongly predisposes to the development of chronic liver disease and subsequent development of HCC. (medscape.com)

Lundberg, A. S. & Weinberg, R. A. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. (nature.com)

These biopsies were taken from patients with chronic hepatitis C, a condition causing oxidative damages in the liver. (wikipedia.org)
We then compared samples from 182 CLD patients with 23 healthy liver samples," says Dr. Makino. (revoscience.com)
The authors say that constitutively activated p53 in hepatocytes of CLD patients can create a microenvironment that is supportive of tumor formation from HPCs. (revoscience.com)
Liver biopsy, percutaneous or laparoscopic, is the standard procedure to assess the severity of disease in patients with features of chronic active liver disease (ie, abnormal aminotransferase levels and detectable levels of HBV DNA). (medscape.com)
[ 3 ] Thus, developing effective and efficient care for patients with end-stage liver disease and HCC must become a significant focus. (medscape.com)

Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. (nature.com)

lncRNA-AK058003 can reduce mRNA stabilizing protein HuR, which results in the inhibition of the expression of γ-synuclein. (oncotarget.com)
Secondly, we employed qRT-PCR and Western blotting to detect the mRNA and protein levels of GRHL2 in leukemia cell lines. (hindawi.com)
Then we investigated the demethylating effect of arsenic trioxide and 5-azacitidine on the mRNA and protein expression levels of GRHL2 in cell lines of acute leukemia. (hindawi.com)

Studies have also shown that AA women tend to develop estrogen receptor (ER) negative tumors at an earlier age, and EA women are more likely to develop ER positive tumors at later ages [3-8]. (cdc.gov)

Synonymous mutations do not change the protein sequences. (biomedcentral.com)

Shukla V, Cuenin C, Dubey N, Herceg Z. (2011) Loss of histone acetyltransferase cofactor transformation/transcription domain-associated protein impairs liver regeneration after toxic injury. (who.int)

The deletion of one copy, or allele,means that a mutation in the remaining copy can limit or destroya cell's ability to produce functional protein. (cancernetwork.com)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)

Thus, through regulation of HGF level, CYLD ameliorates hepatocellular damage and liver fibrogenesis. (uni-regensburg.de)

Anatomy19

Organisms8

Diseases37

Chemicals and Drugs91

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes68

Disciplines and Occupations1

Information Science3

Health Care1

Genes21

Gene35

Acts as a tumor suppressor2

Cancer54

Function as a tumor suppressor2

Benign tumors2

Oncogenes or tumor1

Tissues9

Cancers2

Mutations in the tumor1

Formation of tumors2

Methylation4

Recurrence1

Changes in tumor1

Hepatocellular carcinoma cell1

Phosphorylation7

Metastasis2

Epithelial-mesenchyma1

Cells24

Hepatic tumors2

Solid tumors2

Multiple tumors1

Epigenetic1

Progression of liver2

Kinase4

Mice14

Apoptosis2

Downregulation2

Oncogene1

Lesions2

Cirrhosis6

Regulatory proteins1

Neuroendocrine2

Encode proteins1

Tissue5

DLC11

Additionally1

Digestive system1

Phosphoprotein1

Metastatic1

Development and progression1

Human5

Metabolism2

Initiation1

Pathways2

Mechanisms2

Chronic liver d1

Inactivation1

Patients5

Cell Cycle1

MRNA3

Estrogen receptor1

Sequences1

Impairs1

Functional2

Cyld1