• Although the molecular mechanisms that regulate autophagy are not fully understood, recent work indicates that dysfunctional/impaired autophagic functions are associated with the development and progression of nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), and hepatocellular carcinoma (HCC). (hindawi.com)
  • In this review, we summarize how impaired autophagy affects liver function and contributes to NAFLD, AFLD, and HCC progression. (hindawi.com)
  • In general, autophagy degrades long-lived damaged intracellular proteins, in contrast to the ubiquitin-proteasome system, which controls the degradation of short-lived proteins [ 2 ]. (hindawi.com)
  • These potent effects are driven by curcumin's ability to induce G2/M cell cycle arrest, induce autophagy, activate apoptosis, disrupt molecular signaling, inhibit invasion and metastasis, and increase the efficacy of current chemotherapeutics. (hindawi.com)
  • Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
  • Here we will review Dox-induced cardiotoxicity and cell death in the broad context of the autophagy and mitophagy processes. (oncotarget.com)
  • Treatment with E/PCF-NPs under irradiation induced 4T1 cell apoptosis in approximately 93.6% cells. (dovepress.com)
  • The efficiency of blackberry loaded AgNPs, AuNPs and Ag@AuNPs mediated pectin in the treatment of cisplatin-induced cardiotoxicity. (greenmedinfo.com)
  • However, cardiotoxicity is the adverse reaction of drug dose cumulative toxicity, but the mechanism is still unclear. (frontiersin.org)
  • A rise in serum biomarkers (ALT, AST, ALP, total protein, and albumin), which are indicators of toxicity alongside anomalous oxidative stress indices (lipid peroxidation (LPO), glutathione (GSH), superoxide dismutase (SOD) and catalase), was detected. (bvsalud.org)
  • Due to its high antioxidant content, GSE can help prevent disease and protect against oxidative stress, tissue damage, and inflammation. (healthline.com)
  • It is worth noting that we have found the key upstream target of DOX-induced HF, PTP1B, which inhibits the expression of HIF-1α by inhibiting the phosphorylation of IRS, leading to disorders of fatty acid metabolism and glycolysis, which together with the decrease of Nrf2, SOD, Cytc, and AK4 proteins lead to oxidative stress. (frontiersin.org)
  • Anwer, T. et al: Protective effect of Withania somnifera against oxidative stress and pancreatic beta-cell damage in type 2 diabetic rats. (natur-wiki.de)
  • The present study investigated the effect of Saponin on sperm oxidative stress and testicular structure in streptozotocin-induced diabetic mice. (iranjournals.ir)
  • Considering the severe toxicities reported with anti-inflammatory and disease-modifying agents, there is a clear need to develop new treatments that are specific in their effect while not being associated with significant toxicities. (bvsalud.org)
  • Uncommon side effects that have been reported include severe rash, liver damage, and severe allergic reactions. (webmd.com)
  • however, severe neurological toxicity has been reported rarely following treatment with standard cladribine dosing regimens. (nih.gov)
  • The clinical application of gambogic acid, a natural component with promising antitumor activity, is limited due to its extremely poor aqueous solubility, short half-life in blood, and severe systemic toxicity. (dovepress.com)
  • The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue - Evid Based Complement Alternat Med. (qualitycounts.com)
  • Lipoic acid displays striking benefits in components of metabolic syndrome, including inducing weight loss, improving insulin resistance, and lowering blood pressure. (lifeextension.com)
  • Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. (upm.edu.my)
  • An alcohol-free fermented blueberry and blackberry beverage extract attenuates diet-induced obesity and blood glucose in mice. (greenmedinfo.com)
  • Kaur, T. und Kaur, G.: Withania somnifera as a potential candidate to ameliorate high fat diet-induced anxiety and neuroinflammation. (natur-wiki.de)
  • The present findings suggested that NP exhibits potent antioxidant and anti-inflammatory activities that can protect rats' livers against Cyp-induced liver damage through hepatoprotective activities. (bvsalud.org)
  • Therefore, GSE likely protected against further heart damage. (healthline.com)
  • The antioxidant role of Saponin improves sperm parameters and diabetes-induced testicular oxidative damage. (iranjournals.ir)
  • Dox is a mitochondrial toxin, and mitochondrial damage is central to Dox-induced cardiac dysfunction and cell death [ 8 ]. (oncotarget.com)
  • Lipoic acid increases the abundance of other protective antioxidants while improving mitochondrial function and preventing glycation-induced damage in the kidney and blood vessels of those with diabetes-thus defending against diabetic kidney disease, vision loss, and vascular dysfunction. (lifeextension.com)
  • In this study, proteomics and metabonomics techniques were used to analyze the tissue and plasma of DOX-induced heart failure (HF) in rats and to clarify the molecular mechanism of the harmful effects of DOX on cardiac metabolism and function in rats from a new point of view. (frontiersin.org)
  • Based on the above studies, when anthracycline is used as a chemotherapeutic agent, cardiac toxicity has become the main limiting factor, and the discovery, prevention, and treatment of it will be an important issue. (frontiersin.org)
  • Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. (jci.org)
  • Therefore, we think that PTP1B may play an important role in the development of heart failure induced by doxorubicin and can be used as a potential target for the treatment of heart failure. (frontiersin.org)
  • Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. (oncotarget.com)
  • The temperature elevation and thermal toxicity of nanoparticles were studied. (dovepress.com)
  • Interleukin (IL) -6, IL-1β, tumor necrosis factor alpha (TNF-α), nitric-oxide (NO) in serum blood and superoxide dismutase (SOD), catalase (CAT) malondialdehyde, (MDA) and myeloperoxidase (MPO) in liver and spleen homogenates were measured. (iranjournals.ir)
  • The measurement of blood serum nitric-oxide and survival of all groups of rats were also performed. (iranjournals.ir)
  • Nitric oxide synthase (NOS) and nicotinamide adenine dinucleotide phosphate-oxidase (NOX) enzymes play an important role in Dox-induced production of ROS [ 15 ]. (oncotarget.com)
  • Following the cecal ligation and puncture (CLP) procedure, intravenous dosing of AVR-25 (10 mg/kg, 6-12 h post-CLP) alone and in combination with antibiotic imipenem protected both young adult (10-12 week old) and aged (16-18 month old) mice against polymicrobial infection, organ dysfunction, and death. (nature.com)
  • Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
  • Dox-induced over-production of reactive oxygen and nitrogen species (ROS and RNS) such as superoxide, hydrogen peroxide, hydroxyl radical and peroxynitrite has been proposed to be the main cause of Dox-induced acute cardiomyocyte toxicity and cell death by damaging various molecular constituents and organelles [ 9 - 12 ]. (oncotarget.com)
  • Both chemotherapy and radiation therapy have from the onset been focused on killing cancer cells, in one case by using highly toxic chemicals and in the other case by using focused radiation. (anti-agingfirewalls.com)
  • Noninfectious hemorrhagic cystitis most commonly occurs in patients who have undergone pelvic radiation (see the image below), chemotherapy, or both. (medscape.com)
  • Certain circumstances seem to predispose to urinary tract infections and cause signs and symptoms disproportionate to the amount of pathogen growth, especially in hemorrhagic cystitis due to radiation treatment or chemotherapy. (medscape.com)
  • Correlation analysis showed that DOX-induced HF mainly affected phenylalanine, tyrosine, and tryptophan biosynthesis, D-glutamine and D-glutamate metabolism, phenylalanine metabolism, biosynthesis of unsaturated fatty acids, and other metabolic pathways, suggesting abnormal amino acid metabolism, fatty acid metabolism, and glycerol phospholipid metabolism. (frontiersin.org)
  • Here, we used ultra-high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) to analyze DOX-induced HF in rats, to explain the toxicological pathways of DOX to the heart, especially the combined proteomic technology, to provide more information for the study of its pathogenesis. (frontiersin.org)
  • A detailed description of the pathways by which Dox induces production of ROS and RNS can be found in references [ 13 , 14 ]. (oncotarget.com)
  • Cypermethrin (Cyp) is a pyrethroid that has been associated with the toxicity of various organs. (bvsalud.org)
  • As proof of the importance of Vitamin C for brain health, the brain retains Vitamin C at the expense of other tissues during chronic states of deficiency and can uphold concentrations 100-fold higher than other organs, e.g. liver and kidney [ 6 , 7 ]. (selfhacked.com)
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
  • Patients with malignancies and those undergoing chemotherapy are often immunocompromised and are at high risk of acquiring bacterial and viral infections that can cause hemorrhagic cystitis. (medscape.com)
  • Liver function test abnormalities related to the primary process may be found but are generally not related to the hemorrhagic cystitis. (medscape.com)
  • The amount of antioxidant enzymes in the spleen and liver, and finally cell viability and rats' survival were investigated. (iranjournals.ir)
  • Cell viability and rats' survival were significantly improved in rats that received ANO and pioglitazone compared to rats with CLP group. (iranjournals.ir)
  • Compared to chemotherapy or photothermal treatment alone, the combined treatment in vitro significantly inhibited the survival rate of 4T1 cells to 17.7%, induced ROS generation, and reduced NAD + /NADH significantly. (dovepress.com)
  • This nutrient protects vital cellular energy and shields against diabetes, obesity, cardiovascular disease, and neurodegeneration. (lifeextension.com)
  • E/PCF-NPs show enhanced anti-cancer effects due to synergistic effects of chemotherapy with photothermal therapy and may be potential therapeutic agents for cancer treatment. (dovepress.com)
  • Aetna considers laboratory testing for manganese medically necessary for persons with specific signs and symptoms of manganese toxicity (dyscoordination, loss of balance, confusion) who have a history of likely exposure to high levels of manganese (e.g., occupational exposures to manganese aerosols or dust in the welding or steel industries, exposure to high levels of manganese in contaminated drinking water, suspected manganese toxicity in persons on chronic total parenteral nutrition). (aetna.com)
  • Given that protein aggregates in liver cells are closely linked to alcoholic liver disease, these findings suggest that quercetin could be a useful treatment for patients with this condition. (qualitycounts.com)
  • Tetracycline resistance is often due to the acquisition of new genes, which code for energy-dependent efflux of tetracyclines or for a protein that protects bacterial ribosomes from the action of tetracyclines. (wikipedia.org)
  • Several physiological stresses including nutrient starvation, hypoxia, reactive oxygen species (ROS) production, pathogenic infections, and chemotherapy can trigger phagophore formation. (hindawi.com)
  • Recently, treatment outcomes have been improved in conjunction with a reduction in toxicity through technological innovations such as intensity modulated radiotherapy or stereotactic body radiotherapy. (springer.com)
  • The white blood cell (WBC) count may be elevated because of a concurrent infection or because of the treatment (eg, chemotherapy) of the underlying malignancy. (medscape.com)
  • Metabolomics approach to investigate the ergogenic effect of Morinda citrifolia L. leaf extract on obese Sprague Dawley rats. (upm.edu.my)
  • The aim of our study was to evaluate the hepatoprotective and antioxidant activities of nano-piperine (NP) against Cyp toxicity. (bvsalud.org)
  • Moreover, the ketolides are associated with a low potential for inducing resistance, making them promising first-line agents for respiratory tract infections. (cdc.gov)
  • Obtaining vitamin B6 through diet may help to reduce the risk of certain cancers, but using B6 supplements does not prevent cancer or reduce chemotherapy side effects. (mskcc.org)
  • Getting B6 through diet along with other nutrients is associated with cancer-preventive effects, but it cannot reduce side effects from chemotherapy. (mskcc.org)
  • Serious neurological toxicity (including irreversible paraparesis and quadraparesis) has been reported in patients who received LEUSTATIN Injection by continuous infusion at high doses (4 to 9 times the recommended dose for Hairy Cell Leukemia). (nih.gov)
  • Managing Focal Nodular Hyperplasia of the Liver: Surgery or Minimally-invasive Approaches? (iiarjournals.org)
  • Sometimes these approaches have worked and have saved lives. (anti-agingfirewalls.com)
  • L-dopa is now rarely used by itself, but rather in combination with carbidopa (Sinemet) or benserazide (Madopar) that protects it from breaking down before it reaches the brain tissue. (digitalnaturopath.com)
  • Today, it constitutes the standard of care for many cancer patients, along with surgery and chemotherapy. (springer.com)
  • Aetna considers the dimercaptosuccinic acid (DMSA) or ethylenediaminetetraacetic (EDTA) provocative chelation/mobilization test experimental and investigational as a means of diagnosing lead toxicity because of insufficient evidence of its effectiveness. (aetna.com)
  • 5 - 10 Unfortunately, gambogic acid has poor solubility (less than 0.5 μg/mL), a short half-life (less than 1 hour in dogs and less than 20 minutes in rats), and low bioavailability, which limits its application. (dovepress.com)
  • However, the administration of NP dramatically reversed all of the Cyp-induced alterations, inducing reductions in serum marker levels, stress level, the production of cytokines, and caspase expression. (bvsalud.org)
  • melphalan decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
  • 2Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Spain. (faksignaling.com)
  • The diabetes was induced by the administration of 150 mg kg-1 streptozotocin via a single intraperitoneal injection. (iranjournals.ir)
  • The spontaneously hypertensive rat (SHR) is the most widely studied animal model of essential hypertension. (jci.org)
  • These findings demonstrate that BP regulatory gene(s) exist within the differential chromosome segment trapped in the SHR-Lx congenic strain and that this region of chromosome 8 plays a major role in the hypertension of SHR vs. BN-Lx rats. (jci.org)
  • Two standard methods of preventing cyclophosphamide-related bladder toxicity are hyperhydration and mesna administration. (medscape.com)
  • To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. (nih.gov)
  • and 3) persons who live with or care for persons at high risk (e.g., health-care workers and household contacts who have frequent contact with persons at high risk and who can transmit influenza to those persons at high risk). (cdc.gov)
  • A weblog on the sciences and practices of living healthily very long - perhaps hundreds of years. (anti-agingfirewalls.com)
  • That knowledge will help guide the development of public health use cases and thus the evidence base for public health action and enable CDC and other organizations to translate lessons learned into public health practices that maximize health and save lives. (cdc.gov)
  • Footnotes *Testing of whole blood lead level is the most sensitive and specific means in assessing lead toxicity. (aetna.com)
  • If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected] . (selfhacked.com)
  • The selective toxicity of 2-chloro-2΄-deoxy-β-D-adenosine towards certain normal and malignant lymphocyte and monocyte populations is based on the relative activities of deoxycytidine kinase and deoxynucleotidase. (nih.gov)
  • They were randomly divided to four groups (n = 10) including Group A: as control group receiving normal saline, Group B: the rats with CLP as surgical control group, Group C: the rats receiving ANO, and Group D: the rats receiving pioglitazone. (iranjournals.ir)