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  • pathways
  • It provokes a series of downstream signaling pathways upon binding with IL-22R complex which protects liver damage through STAT3 activation. (hindawi.com)
  • Until our study, the molecular and cellular pathways that would initiate and maintain liver regeneration were not known," says Dr. Bi-Sen Ding, the study's first author and a senior postdoctoral fellow in Dr. Rafii's lab. (healthcanal.com)
  • About 70% of those differentially expressed genes involved in glycolysis and fatty acid synthesis pathways failed to induce during liver regeneration due to PPARβ deficiency. (ku.edu)
  • Thus, multiple pathways are currently considered to be involved in the initiation of liver regeneration. (spandidos-publications.com)
  • cirrhosis
  • A new study, appearing in the April 13 issue of The Journal of Biological Chemistry, provides new information on the inner workings of cells from regenerating livers that could significantly affect the way physicians make livers regrow in patients with liver diseases such as cirrhosis, hepatitis, or cancer. (eurekalert.org)
  • Liver cirrhosis on the basis of a chronic hepatitis B or C, autoimmune hepatitis, chronic alcohol abuse, primary sclerosing cholangitis, and primary biliary cirrhosis are only a few possible reasons for functional liver insufficiency. (hindawi.com)
  • organ regeneration
  • Although organ regeneration has been observed in many animals, the details of how it happens at the cellular level are still not completely understood. (eurekalert.org)
  • Many of the proteins that induce organ regeneration have been identified and scientists are now trying to make organs regrow by stimulating these proteins. (eurekalert.org)
  • The results of their study are published today in the online edition of the journal Nature, with a companion study in the Oct. 24 issue of Nature Cell Biology describing how endothelial cells are activated to initiate organ regeneration. (healthcanal.com)
  • Tumors
  • Tumors in TG livers showed up-regulation of beta-catenin, cyclin-D1, and unique genetic aberrations, whereas other canonical targets were unremarkable. (nih.gov)
  • An interesting clinical observation after IRE treatment of liver tumors is that the liver tissue assumes its normal structure much more quickly than following thermal ablation, as assessed by imaging methods. (peerj.com)
  • gene
  • The ALR gene and gene product were subsequently described, but little is known about the cellular/subcellular sites of ALR synthesis in the liver, or about the release and dissemination of the peptide. (pubmedcentralcanada.ca)
  • Gene expression of auxiliary mitogens in mouse liver was compared to patients after ALPPS or PVL. (sigmaaldrich.com)
  • Genes
  • Conclusion: Our data suggest that miRNA changes are regulated by negative feedback loops between miRNAs and their regulatory genes that may play an important role in the steady‐state regulation of liver regeneration. (umich.edu)
  • growth
  • Liver Cancer is the uncontrolled growth of cells in the liver. (medindia.net)
  • Quickly stimulating the growth of the remaining portion of their liver could be their only chance of survival. (eurekalert.org)
  • beta-Catenin overexpression offers growth advantage during liver regeneration. (nih.gov)
  • In the latest study, which involved collaboration between the University Department of Surgery at the MedUni Vienna led by Patrick Starlinger and the Institute of Physiology led by Alice Assinger, scientists were able to demonstrate that the specific release of growth factors from the α granules was associated with post-operative liver regeneration. (healthcanal.com)
  • The microenvironment comprises the extracellular matrix, epithelial and nonepithelial resident liver cells, and recruited inflammatory cells, as well as a variety of growth-modulating molecules [ 3 , 6 ]. (hindawi.com)
  • fibrosis
  • Its level was found to be positively correlated with the severity of liver damage and fibrosis. (hindawi.com)
  • Irrespective of the cause of a chronic liver damage fibrosis is the ultimate endpoint. (hindawi.com)
  • Significance of the Balance between Regulatory T (Treg) and T Helper 17 (Th17) Cells during Hepatitis B Virus Related Liver Fibrosis. (ebscohost.com)
  • Background: Hepatitis B virus-related liver fibrosis (HBV-LF) always progresses from inflammation to fibrosis. (ebscohost.com)
  • Signaling
  • Similarly, miR-33 targets key enzymes involved in the regulation of fatty acid oxidation including CROT, CPT1A, HADHB, SIRT6 and AMPKα, likewise, IRS2, an essential component of the insulin- signaling pathway in the liver. (hu-berlin.de)
  • proteins
  • IRI results in part from the deposition of immune proteins called complement on the surface of liver cells, causing them to die and thus impairing liver regeneration. (medindia.net)
  • Complement inhibitors effectively dampen IRI, but the benefits of this approach come at a cost, as certain complement proteins are also required for liver tissue to regrow. (medindia.net)
  • The novel inhibitor limited the deposition of complement proteins and promoted the division of new liver cells. (medindia.net)
  • To investigate how the liver regenerates, Karp and his colleagues set out to determine which proteins are involved in the regenerating cells. (eurekalert.org)
  • Instead, proteins that help cells proliferate were active in both the developing and regenerating livers. (eurekalert.org)
  • Since the transcription factors were not present in regenerating livers, it might be easier to stimulate liver regeneration by only activating the other identified proteins. (eurekalert.org)
  • Not only did we discover that the number of proteins involved in liver regeneration is relatively low, but they don't include transcription factors, so we may be closer to being able to stimulate liver regeneration than we thought. (eurekalert.org)
  • The liver is a central organ involved in inflammatory processes, including the elaboration of acute-phase proteins. (springer.com)
  • We provide direct evidence that levels of an inhibitory factor control the rate of liver regeneration, and we identify Tob1 as a crucial check point molecule that modulates the expression and activity of cell cycle proteins. (unl.edu)
  • stem cells
  • Studies have shown that adult stem cells are involved in the repair of many organs, but in the case of the liver, the cells repairing it through regeneration may simply be regular cells, not stem cells. (eurekalert.org)
  • In the light of the persisting lack of donor organs and the risks of allotransplantations, the possibility of liver regeneration with autologous stem cells from adipose tissue (ADSC) is an intriguing alternative. (hindawi.com)
  • healing damaged
  • Further, the researchers believe that in the coming years it will be possible to facilitate healing damaged livers by transplanting certain types of endothelial cells with liver cells. (healthcanal.com)
  • whereas
  • From these observations, we postulated that selective up‐regulation of miRNAs in the early phase after PH was involved in the priming and commitment to liver regeneration, whereas the subsequent genomewide down‐regulation of miRNAs was required for efficient recovery of liver cell mass. (umich.edu)
  • populations
  • However, in studies published in recent years, the Weill Cornell researchers have demonstrated that endothelial cells actively influence the self-renewal of certain stem cell populations and the regeneration of tissue. (healthcanal.com)
  • ethanol
  • It may be therefore possible to raise a hypothesis that ethanol-induccd apoptosis in SECs may cause impaired angiogenesis in liver, thus contributing to delay of liver regeneration. (nii.ac.jp)
  • cell
  • Instead, regeneration could actually be only due to an increase in cells that multiply through regular cell divisions, a process called hyperplasia. (eurekalert.org)
  • This finding will open the door for designing new therapies to treat damaged livers," says the study's senior author, Dr. Shahin Rafii, who is the Arthur B. Belfer Professor in Genetic Medicine and co-director of the Ansary Stem Cell Institute at Weill Cornell Medical College and a Howard Hughes Medical Institute investigator. (healthcanal.com)
  • The activities of most, but not of all, aminoacyl-tRNA synthetases in cell sap of regenerating liver tend to be greater than normal. (biochemj.org)
  • Sedimentation analysis of cell sap in sucrose density gradients shows a shift of prolyl-tRNA synthetase activity toward the high-Mr form in regenerating liver. (biochemj.org)
  • remnant
  • All vertebrate livers, for example, can make up for tissue mass loss (via surgical excision of a portion of the liver) by replication of their differentiated cells within the remnant lobes. (upenn.edu)
  • RESULTS: After portal vein occlusion, the ratio of the future liver remnant volume to total parenchymal liver volume (FLR%) was reduced in patients receiving neoadjuvant chemotherapy (27 +/- 1% vs 32 +/- 1%, p = 0.03). (lu.se)
  • A smaller future liver remnant before portal vein occlusion resulted in a greater degree of hypertrophy (r(2) = 0.18, p. (lu.se)