Liver ppar alpha. Medical search. Frequent questions

Adult rats fed the peroxisome proliferator-activated receptor alpha (PPARalpha) agonist WY14,643 have increased hepatic elongase activity, Elovl-1, Elovl-5, Elovl-6, Delta5, Delta6, and Delta9 desaturase mRNA abundance, and mead acid (20:3,n-9) content. (oregonstate.edu)
Rosiglitazone (0.8, 2.4 and 7.2 mg/kg), a selective PPAR- gamma agonist, was injected intraperitoneally at 1 h before GCIRI. (biomedcentral.com)
Rosiglitazone, a PPAR-gamma agonist, plays a protective role in hippocampal neuron damage of GCIRI rats by inhibiting the oxidative stress response and inflammation. (biomedcentral.com)
Recently, fenofibrate, a peroxisome proliferator-activated receptor alpha (PPARa) agonist has become an off-label therapeutic option for patients with refractory cholestasis. (uri.edu)
This suggests that use of a PPAR-alpha agonist may be beneficial in aiding fat loss . (bodybuilding.com)
An investigational dual PPAR agonist modifies Alzheimer's pathology and shows cognitive benefit in adults with mild-to-moderate disease and high plasma pTau-217 ratio, early data show. (medscape.com)

The research contained in this thesis first sought to improve our current knowledge on the transcriptional regulation by peroxisome proliferator-activated receptors (PPAR)-α activation on human liver in vivo using a novel humanized-liver mouse model. (wur.nl)
Peroxisome proliferator-activated receptors (PPARs, including alpha, beta and gamma subtypes) and their agonists have a protective role in treatment of central nervous system (CNS) diseases. (biomedcentral.com)

PPAR alpha is expressed mainly in skeletal muscle, heart, liver, and kidney and is thought to regulate many genes involved in the beta-oxidation of fatty acids. (thermofisher.com)
Liver, muscle, and intestine tissue samples were taken to measure mRNA expression of key genes involved in glucose, lipid, and protein metabolism. (frontiersin.org)
Gene expression studies performed on PPARα null mice have shed light into a variety of genes regulated by PPARα. (wur.nl)
A comprehensive understanding of the physiological and molecular function of PPARα target genes is needed for the accurate development of therapeutical strategies. (wur.nl)
Then, we pursued to expand our understanding on the physiological and molecular function of two PPARα target genes, Hilpda and Slc25a47. (wur.nl)
The hepatic expression of peroxisome proliferator activated receptor alpha (PPARalpha) target genes involved in fatty acid beta-oxidation was either unchanged or decreased with LA, indicating a different mode of action than for fibrate drugs. (oregonstate.edu)
Moreover, HFD caused steatosis in the liver and abdominal fat and abnormal expression of some genes related to lipid metabolism and tight junction proteins. (bvsalud.org)
Inuit or those living in the arctic have deleted variants in FADS1 & FADS2 (protein coding genes) that essentially means it creates inability to convert plant Omega-3 fatty acids to EPA & DHA, another reason why Inuit consume animal based Omega-3 in high quantities. (selfgrowth.com)
Fasting & ketosis may create too much stress with people having above-mentioned variants in PPAR alpha genes. (selfgrowth.com)
Clofibrate increased or tended to increase liver expression of several PPARalpha target genes involved in fatty acid oxidation (e.g. (oregonstate.edu)

Some feel that PPARbeta/delta may serve as a 'back-up' to PPARalpha or have more specific actions in skeletal muscle than PPARalpha does (Tenenbaum et al. (bodybuilding.com)

ITT, GTT, and MTT showed that CS rats were neither insulin resistant nor glucose intolerant, but mRNA expression of cholecystokinin (CCK) in the duodenum was higher and that of CPT1, PPARα, and PGC1α in liver were lower than in CR rats. (frontiersin.org)
From these results, we make the hypothesis that in CS rats, CCK increased pancreatic secretion, which may favor a quicker absorption of carbohydrates and consequently induces an enhanced inhibition of lipid oxidation in the liver, leading to a progressive accumulation of fat preferentially in visceral deposits. (frontiersin.org)
Five-week-old Zucker Diabetic Fatty (ZDF) rats were fed a diet containing (R)-alpha-lipoic acid (LA, approximately 200mg/kg body weight per day) for 5 weeks. (oregonstate.edu)
Livers from LA-treated rats exhibited elevated glycogen content, suggesting dietary carbohydrates were stored as glycogen rather than becoming lipogenic substrate. (oregonstate.edu)
Overnight starvation and fish oil-enriched diets repressed hepatic elongase activity in livers of adult male rats. (oregonstate.edu)
The present study was designed to investigate the expression changes of PPAR-alpha, -beta, -gamma and NF-kappa B in the hippocampus of rats with global cerebral ischemia/reperfusion injury (GCIRI) after treatment with agonists or antagonists of PPAR-gamma. (biomedcentral.com)
Voss C, Zerban H, Bannasch P, Berger MR. Lifelong exposure to di-(2-ethylhexyl)-phthalate induces tumors in liver and testes of Sprague-Dawley rats. (who.int)

Similarly, in diet-induced NASH mice, HILPDA hepatocyte deficiency modestly yet significantly reduced liver triglyceride accumulation and plasma ALT levels. (wur.nl)
Possible mechanisms for steatosis include reduced synthesis of very low density lipoprotein (VLDL) and increased hepatic triglyceride synthesis (possibly due to decreased oxidation of fatty acids or increased free fatty acids being delivered to the liver). (merckmanuals.com)
These effects may be mediated by AMP kinase-induced fat oxidation, leading to reduced intramyocellular and liver triglyceride content. (diabetesjournals.org)

Our results support the major role of PPARα in regulating hepatic lipid metabolism, highlight the more modest effect of PPARα activation on gene regulation in human liver compared to mouse liver, and indicate that PPARα may have a suppressive effect on DNA synthesis in human liver. (wur.nl)
PPARalpha agonists affect both fatty acid elongation and desaturation pathways leading to changes in hepatic lipid composition. (oregonstate.edu)
Overall, our data indicated that bovine liver responded to clofibrate treatment but not fish oil, although increases in hepatic lipid metabolism were much less than those reported in rodents treated with clofibrate or fish oil. (oregonstate.edu)

Model systems to study PPARα in human liver vary from hepatoma cell lines, human primary hepatocytes, human precision cut liver slices, and mice expressing human PPARα. (wur.nl)
Quantitative PCR indicated that induction of PPARα targets by fenofibrate was less pronounced in the human hepatocytes than in the residual mouse hepatocytes. (wur.nl)
Large eosinophilic hepatocytes (eosinophilic granular cytoplasm represents peroxisome proliferation), biliary hyperplasia (ducts, ductules, oval cells), several mitotic figures, and pigment are present in the liver of this mouse fed a diet containing di-(2-ethylhexyl)-phthalate (DEHP) for 10 months. (nih.gov)
Oxidase immunohistochemical stain showing small oxidase-containing peroxisomes in smaller hepatocytes (on left) in a PPAR alpha null mouse given di(2-ethylhexyl)phthalate as compared with enlarged hepatocytes (on right) with peroxisome proliferation induced by DEHP in a wild type mouse. (nih.gov)
Steatotic liver disease is due to excessive accumulation of lipid in hepatocytes. (merckmanuals.com)
Metabolic dysfunction-associated liver disease (MASLD) includes simple fatty infiltration (a benign condition called steatotic liver disease), whereas metabolic dysfunction-associated steatohepatitis (MASH) is defined as the presence of fat leading to lipotoxicity and inflammatory damage to hepatocytes. (merckmanuals.com)
Fatty liver is excessive accumulation of lipid in hepatocytes. (msdmanuals.com)
Nonalcoholic fatty liver disease (NAFLD) includes simple fatty infiltration (a benign condition called fatty liver), whereas nonalcoholic steatohepatitis (NASH) is defined as the presence of fat leading to lipotoxicity and inflammatory damage to hepatocytes. (msdmanuals.com)

By Western blot, this antibody detects an ~56 kDa protein representing PPAR gamma 2 from NIH-3T3 cell lysate. (thermofisher.com)
Researchers at Rush University discovered that the protein, peroxisome proliferator-activated receptor alpha (PPARalpha), had responsibilities beyond helping the liver metabolize fat in the abdomen. (medicaldaily.com)
The expression changes of PPAR-alpha, -beta and -gamma at mRNA and protein levels were detected by RT-PCR and western blotting. (biomedcentral.com)
The protein levels of phospho-phosphatidylinositol 3-kinase, protein kinase B, phospho-eukaryotic initiation factor 4E binding protein-1 (p-4E-BP1), 4E-BP1 and ribosomal protein S6 kinase 1, in the liver of fish fed the 0.84% diet were higher than those in fish fed the 0.40% diet. (researchsquare.com)
High-density lipoprotein cholesterol (HDL-C), which consists mostly of cholesterol, phospholipid, and protein, is produced and secreted by the liver and intestine. (medscape.com)

They strengthen liver functioning and also have a positive effect on the insulin and glucose metabolism. (ironmagazine.com)
Abnormal lipid metabolism has been associated with a wide range of chronic and infectious diseases including non-alcoholic fatty liver disease, viral hepatitis C infection, atherosclerosis, diabetes, and cancer. (wur.nl)
Peroxisomal proliferator activator receptor alpha (PPARα) is a ligand-activated transcription factor that plays a major role in the regulation of lipid metabolism. (wur.nl)
Ultimately, we sought to identify the physiological function of the liver-specific mitochondrial carrier Slc25a47 in liver lipid metabolism and energy expenditure. (wur.nl)
Comparison with other transcriptomics datasets indicated that hepatocyte humanized livers recapitulate the principal effects of PPARα activation on lipid metabolism as revealed by other model systems of human liver. (wur.nl)
Glucuronidation, a phase II metabolism pathway responsible for BA detoxification, is regulated by PPARα. (uri.edu)
The study showed that optimal methionine levels could enhance the growth of juvenile Megalobrama amblycephala , and the nutrient metabolism response to dietary methionine in the liver and muscle was tissue-specific. (researchsquare.com)
Consequently, drugs that activate any of these xenobiotic sensing receptors can dramatically change the endogenous levels of CYP expression in the liver, potentially impacting the rate of their own metabolism, as well as the metabolism of all other co-administered drugs. (indigobiosciences.com)
PPAR alpha gene plays a major role in fatty acid metabolism, apolipoproteins, HDL, LDL & ketone body production during fasting. (selfgrowth.com)
Effects of the peroxisome proliferator-activated receptor-alpha agonists clofibrate and fish oil on hepatic fatty acid metabolism in weaned dairy calves. (oregonstate.edu)
The objectives of this study were 1) to determine whether partitioning of fatty acid metabolism by liver slices from weaned Holstein calves treated with PPARalpha agonists in vivo is altered compared with partitioning by liver slices from control (untreated) calves, and 2) to measure in vitro metabolism of palmitate and oleate by bovine liver slices and relate these to mRNA abundance for key enzymes. (oregonstate.edu)
Liver slices were incubated for 2, 4, and 8 h to determine in vitro conversion of [1-(14)C] palmitate and [1-(14)C] oleate to CO(2), acid-soluble products, esterified products, and total metabolism. (oregonstate.edu)
In animals, açai supplementation and exercise led to benefits in exercise tolerance and improvements in several hemodynamic parameters, as well as significant improvements in liver markers and glucose metabolism. (bvsalud.org)

Bodybuilding Supplements and Training: Suppversity Excerpt Seabuckthorn Leaves Increase PPAR-Alpha & PPAR-Gamma Expression, Keep the Liver Fat Free and Fatty Oxidation Up. (helpyougetgains.com)
Seabuckthorn Leaves Increase PPAR-Alpha & PPAR-Gamma Expression, Keep the Liver Fat Free and Fatty Oxidation Up. (helpyougetgains.com)
The expression of the "liver cleansing" PPAR-gamma enzymes on the other hand was. (helpyougetgains.com)
And on the endocrine side of things you want to keep an eye on optimal DHEA levels ( read more about its effects on PPAR-gamma), thyroid hormones, testosterone and estrogen (Nemoto. (helpyougetgains.com)
The following product was used in this experiment: PPAR gamma-2 Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA1-824, RRID AB_2166200. (thermofisher.com)
Synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2. (thermofisher.com)
PA1-824 detects peroxisome proliferator activated receptor (PPAR) gamma 2 from human and mouse tissues. (thermofisher.com)
PA1-824 inhibits PPAR gamma 2 DNA binding. (thermofisher.com)
PA1-824 immunogen is a synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2. (thermofisher.com)
This sequence is not conserved in PPAR gamma-1. (thermofisher.com)
PPAR gamma 2, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex. (thermofisher.com)
The activation or antagonism of PPAR-gamma did not affect the expression of PPAR-alpha or -beta, indicating that the three subtypes of PPARs act in independent pathways in the CNS. (biomedcentral.com)
It stimulates mitochondrial biogenesis by activating peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α), a master regulator of mitochondrial biogenesis. (alliedacademies.org)

Peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists increase fatty acid oxidation in liver of nonruminants. (oregonstate.edu)
Applications of PPARalpha agonists may be of interest to increase the rate of hepatic fatty acid oxidation and decrease triacylglycerol accumulation in periparturient dairy cows. (oregonstate.edu)

It is able to inhibit lipid accumulation by stimulating PPAR-alpha, CPT1, and beta-oxidation-related proteins and reducing HMGCR proteins. (naturalnews.com)

HDL-C transports cholesterol from tissues to the liver. (medscape.com)
This process is called reverse cholesterol transport because cholesterol synthesized in peripheral tissues is eventually returned to the liver for its disposal from the body. (medscape.com)

001). Liver enzymes, lipids, glucose profiles, and markers of systemic inflammation were significantly reduced in the elafibranor 120-mg group vs the placebo group. (nih.gov)
Differentiating simple steatosis from MASH can be difficult without a liver biopsy, and elevated liver enzymes are not a sensitive predictor for identifying MASH. (merckmanuals.com)
Application of this platform is to screen chemicals for induction and activity of hepatic drug metabolizing enzymes (DME), which have been linked to Non-Alcoholic Fatty Liver Disease, Steatosis, Cholestasis and other conditions. (indigobiosciences.com)
After Burner causes fat oxidation by augmenting the release of potent thermogenic enzymes through optimized liver function. (fitshop.ca)

PPAR alpha is activated by free fatty acids including linoleic, arachidonic, and oleic acids. (thermofisher.com)
For people living in cold areas & near to mountains, CPT1A mutation increases heat in the body by directing free fatty acids away from liver cells to brown fat. (selfgrowth.com)

The role of PPARα in gene regulation in mouse liver is well characterized. (wur.nl)
LA offset the rise in blood and liver TG by inhibiting liver lipogenic gene expression (e.g. sn-glycerol-3-phosphate acyltransferase-1 and diacylglycerol O-acyltransferase-2), lowering hepatic TG secretion, and stimulating clearance of TG-rich lipoproteins. (oregonstate.edu)
CPT1A gene, found in liver & kidney, is responsible for Ketosis & is a key regulator for importing long chain fatty acids to mitochondria to help maintain energy when carbohydrate is low. (selfgrowth.com)
People living in regions such as Canada & Arctic have homozygous genotypes in the CPT1A gene. (selfgrowth.com)
Like the CPT1A gene, variants in the PPAR alpha gene may cause low Ketone production during fasting. (selfgrowth.com)
Coconut oil (natural saturated fat) does not negatively impact PPAR alpha gene like other forms of saturated fats. (selfgrowth.com)
It would be at best to shift to monounsaturated & polyunsaturated fat in their diet, lower fasting times & consistent intake of foods that stimulate PPAR alpha gene. (selfgrowth.com)
Research is needed to address some gaps, for example which best animal models to use for safety assessment of live microbes, the possibility of antibiotic resistance gene transfer via transformation, and potential impact of probiotic-induced changes in microbiomes, interactions with drugs, and probiotic colonization.What is the impact Probiotics of sufficient quality for patient populations are being developed and should be used accordingly. (cdc.gov)

This in turn reminds me of the effects of fish oil and TTA (a pan PPAR-activator), which - despite their questionable use as a long-term intervention can in fact stimulate intra-hepatic fatty acid oxidation to levels which are so high that oxidation rates in and out of itself could bring about some problems. (helpyougetgains.com)

Activation of rat liver PPAR alpha has been shown to suppress hepatocyte apoptosis. (thermofisher.com)
Moreover, apoptosis in liver tissue was relieved by G-Rh1, according to histological analysis. (bvsalud.org)

Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity. (illumina.com)

Chao HW, Chao SW, Lin H, Ku HC, Cheng CF. Homeostasis of Glucose and Lipid in Non-Alcoholic Fatty Liver Disease . (sinica.edu.tw)

In this research, we performed transcriptomics analysis on the effect of fenofibrate in mice with hepatocyte-humanized livers and compared the results with other relevant transcriptomics datasets. (wur.nl)
In contrast, pathways connected to DNA synthesis were downregulated by fenofibrate in chimeric mice with hepatocyte humanized livers yet upregulated by fenofibrate in normal mouse livers. (wur.nl)

Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion. (oregonstate.edu)
Patients suffering from lipodystrophies experience reduced body fat, severe insulin resistance, hypertriglyceridemia, and hypoleptinemia, and nonalcoholic fatty liver disease. (medscape.com)

Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not heatocarcinogenesis. (who.int)

But now, a new study sheds light on how too much abdominal fat can lead to dementia, as the liver steals proteins associated with memory and learning away from the hippocampus and other parts of the body, in order to help metabolize the fat. (medicaldaily.com)
They found fifty percent less fat [triglycerides] in these cells in the BCAA mice, and much greater activity in the molecules that are involved in fat burning, such as the fat sensor PPAR-alpha, the enzyme COT-1 and the uncoupling proteins 2 and 3. (ironmagazine.com)
Apo-A1 and apo-A2 proteins on HDL-C are derived by direct secretion from the liver. (medscape.com)

Toxaphene-induced mouse liver tumorigenesis is mediated by the constitutive androstane receptor. (proquest.com)

Investigation of the mechanism of triclosan induced liver tumors in mouse. (proquest.com)

Rapidly assess therapeutic candidates' potential for drug-drug interactions and accurately predict xenobiotic-induced liver toxicity. (indigobiosciences.com)
INDIGO's in vitro toxicology platform was developed to meet the increasing demand for more predictive models for liver toxicity due to the fact that hepatotoxicity remains a major reason for drug withdrawal from pharmaceutical development and clinical use. (indigobiosciences.com)
The platform now utilizes upcyte ® human liver cells to assess chemical and drug-induced toxicity. (indigobiosciences.com)
The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha. (who.int)

These ingredients activate the PPAR alpha receptors, which are specifically involved in the burning of fatty acids and the storage of fats. (fitshop.ca)

They are microscopically small and live both on humans and animals. (vetscite.org)

Additionally, in vivo experiments also showed the inhibition of HMGCR, FAS and the stimulation of PPAR-alpha, which were initially observed in vitro. (naturalnews.com)
Such models include in vivo animal models and in vitro models based on human-derived liver cells or transformed cell systems. (indigobiosciences.com)

See also the American Association for the Study of Liver Diseases [AASLD] 2018 practice guidance on the diagnosis and management of MASLD. (merckmanuals.com)
See also the American Association for the Study of Liver Diseases [AASLD] 2018 practice guidance on the diagnosis and management of NAFLD. (msdmanuals.com)

Cholestatic liver diseases are also negatively impacted by hepatic inflammation. (uri.edu)

Takashima K, Ito Y, Gonzalez FJ, Nakajima T. Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar alpha-null mice. (who.int)

Japanese researchers discovered, when doing experiments with mice, that the liver and muscles play a key role in the fat-mass reducing effect of BCAAs. (ironmagazine.com)
A high-cholesterol diet was given to the mice to induce fatty liver. (naturalnews.com)
A recent example of the importance of adipocyte function to have profound systemic effects is provided by the report that mice specifically lacking insulin signaling in adipocytes (FIRKO mouse) are not only lean, leptin sensitive, and obesity resistant ( 1 ), but live almost 20% longer than wild-type control animals ( 2 ). (diabetesjournals.org)
Then the mice were continuously administered with G-Rh1 (5 and 10 mg·kg-1), to explore the protective effects of G-Rh1 against liver injury. (bvsalud.org)

It appears as if the liver is - once again - emerging as a central player in "sick obesity", meaning being fat and sick and not just fat. (helpyougetgains.com)
Elevated blood triacylglycerol (TG) is a significant contributing factor to the current epidemic of obesity-related health disorders, including type-2 diabetes, nonalcoholic fatty liver disease, and cardiovascular disease. (oregonstate.edu)

Additionally, insulin signaling inhibits gluconeogenesis, the process of glucose production from non-carbohydrate sources, in the liver. (alliedacademies.org)

However, less is known about the effect of PPARα activation in human liver in vivo. (wur.nl)
A novel model to study in vivo PPARα activation in human liver is a chimeric mouse carrying human liver cells. (wur.nl)
PPAR-alpha activation increases the expression of lipoprotein lipase and apolipoprotein A-V (apoA-V) while simultaneously decreasing expression of apoC-III in the liver, which decreases VLDL particles and lowering plasma triglycerides in chylomicrons (Staels and Fruchart 2005). (bodybuilding.com)
In addition to the change in plasma fatty acid levels, hepatic apoA-I andapoA-II are increased by PPAR-alpha activation, which improves cholesterol levels by increasing HDL levels (Chinetti et al. (bodybuilding.com)
The mild rise in HDL-C levels from these drugs may be related to inhibition of rho-signaling pathways with activation of peroxisome proliferator-activated receptor (PPAR)-alpha. (medscape.com)

In addition, 1.28% dietary methionine significantly induced fatty acid β-oxidation and lipolysis of the liver and muscle via increased carnitine palmitoyl transferase 1, peroxisome proliferator activated receptor alpha, lipoprotein lipase and lipase expression levels. (researchsquare.com)

Liver disease and diabetes are also possible effects of overweight. (ironmagazine.com)
Data from the groups given the different doses of elafibranor were compared with those from the placebo group using step-down logistic regression, adjusting for baseline nonalcoholic fatty liver disease activity score. (nih.gov)
MASLD includes simple fatty infiltration (a benign condition called steatotic liver disease) and metabolic dysfunction-associated steatohepatitis (MASH), a less common but more important variant. (merckmanuals.com)
Steatotic liver disease develops for many reasons, involves many different biochemical mechanisms, and causes different types of liver damage. (merckmanuals.com)
Role of xenobiotics in the induction and progression of fatty liver disease. (proquest.com)

In October 2010, FibroGen, Inc. initiated phase II clinical study of FG-3019: a human monoclonal antibody against the Connective Tissue Growth Factor (CTGF) to compare the efficacy in reversing the effects of liver fibrosis caused by chronic infection with hepatitis B virus (HBV). (medgadget.com)
Furthermore, growing research collaboration among the key players to develop novel treatment regime combined with regulatory approval of underline drugs for treatment of liver fibrosis is expected to drive the market growth in near future. (medgadget.com)
The global liver fibrosis treatment market is expected to grow at 10.8% CAGR over the forecast period, owing to increasing prevalence of risk factors affecting liver fibrosis, worldwide. (medgadget.com)
Among treatment type, hepatotropic drug accounted for significant market share in liver fibrosis treatment market, as it enables safe and efficient treatment for reducing fibrosis in patients. (medgadget.com)
Among end users, hospitals segment is expected to account for major market share during the forecast period, as hospital offer primary treatment option for patient suffering with liver fibrosis. (medgadget.com)
Hepatic Fibrosis Hepatic fibrosis is overly exuberant wound healing in which excessive connective tissue builds up in the liver. (merckmanuals.com)
Without proper treatment these diseases can progress to fibrosis, cirrhosis, and eventually liver failure. (uri.edu)

The PPAR/RXR dimer then binds to a peroxisome proliferators-response element (Staels and Fruchart 2005), a DNA-specific sequence of which many types exist. (bodybuilding.com)

They had PPARalpha deficiencies in either their hippocampus or in their livers. (medicaldaily.com)
Our study indicates that people may suffer from memory-related problems only when they lose PPARalpha in the hippocampus," Dr. Pahan said in the statement, adding that more research needs to be conducted in order to determine the best way to maintain PPARalpha in the brain. (medicaldaily.com)
The MDA, IL-1, IL-6, IL-10, TNF-alpha content and expression of PPARs increased significantly, but the SOD activity and NF-kappa B expression were weakened in the hippocampus. (biomedcentral.com)

ADP-1 induced an interaction between APPL1 and the small GTPase Rab5 resulting in AMPK phosphorylation, in turn leading to phosphorylation of p38MAP kinase, acetyl coenzyme-A carboxylase, and peroxisome proliferator-activated receptor alpha. (phoenixpeptide.com)

In liver slices incubated for 8 h, conversion of palmitate to CO(2) was greater for calves treated with clofibrate compared with control calves or calves treated with fish oil. (oregonstate.edu)

BCAA affects PPAR-alpha and UCP expression in muscle and liver tissue. (ironmagazine.com)
In conclusion, changes in Elovl-5 expression may account for much of the nutritional and developmental control of fatty acid elongation activity in the rat liver. (oregonstate.edu)
the contents of IL-1, IL-6, IL-10 and TNF-alpha, and the NF- kappa B expression were measured by enzyme-linked immunosorbent assay (ELISA) and immunohistochemical staining. (biomedcentral.com)
After treatment with rosiglitazone or GW9662, no significant change in PPAR-alpha or -beta expression was detected. (biomedcentral.com)

NAFLD includes simple fatty infiltration (a benign condition called fatty liver) and nonalcoholic steatohepatitis (NASH), a less common but more important variant. (msdmanuals.com)

There are two major limitations to the use of human liver cells or their derivatives. (indigobiosciences.com)

Low PPARalpha levels are just one of the many factors that contribute to obesity's contribution to age-related memory loss. (medicaldaily.com)
However, the metabolic polytrophic response in the liver and muscle of juvenile Megalobrama amblycephala to dietary methionine levels is unclear. (researchsquare.com)

The researchers actually found that the supplementation had the greatest effects in the muscle and liver cells rather than in the fat cells. (ironmagazine.com)
The current study was designed to evaluate the ameliorative effects of ginsenoside Rh1 (G-Rh1) on liver injury induced by T2DM. (bvsalud.org)

While PPARalpha deficiency in the brain was related to memory loss and an inability to learn, PPARalpha deficiency in the liver were unaffected. (medicaldaily.com)

Elovl activity is low in fetal liver but increases significantly after birth. (oregonstate.edu)

Anatomy29

Organisms12

Diseases19

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes50

Disciplines and Occupations1

Information Science3

Named Groups1

Health Care1

Agonist6

Peroxisome prolifera2

Genes10

Skeletal muscle1

Rats7

Triglyceride3

Hepatic lipid3

Hepatocytes8

Protein5

Metabolism13

Gamma13

Agonists2

CPT11

Tissues2

Enzymes4

Free fatty2

Gene8

Activator1

Apoptosis2

Inhibit1

Homeostasis1

Fenofibrate2

Hypertriglyceridemia2

Induces1

Proteins3

Constitutive1

Tumors1

Toxicity4

Receptors1

Humans1

Vitro2

20182

Negatively1

Tumorigenesis1

Mice4

Obesity2

Insulin1

Activation5

Lipoprotein lipase1

Disease5

Fibrosis7

Binds1

Hippocampus3

Interaction1

Slices1

Expression4

Nonalcoholic1

Human liver cells1

Levels2

Effects2

Deficiency1

Increases1