• PET imaging greatly assists in treatment planning and assessment of response in a large number of different tumor types affecting the liver in patients receiving radioembolization. (diagnosticimaging.com)
  • The way radioembolization is performed is continuously evolving, pushed by technical innovations, the current availability of three different types of microspheres and increasing insight into the need for patient-specific dosimetry. (cirse.org)
  • In this ESIR course, "Radioembolization of liver tumours", organised by Dr. Maarten Smits, Dr. Arthur Braat and Prof. Marnix Lam, attendees will learn about the fundamentals, latest evidence and techniques for performing radioembolization. (cirse.org)
  • Radioembolization with 90 yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies. (thieme-connect.com)
  • 9 d'Abadie P, Hesse M, Louppe A, Lhommel R, Walrand S, Jamar F. Microspheres used in liver radioembolization: from conception to clinical effects. (thieme-connect.com)
  • 11 Lee EJ, Chung HW, Jo JH, So Y. Radioembolization for the treatment of primary and metastatic liver cancers. (thieme-connect.com)
  • Liver surgery after selective internal Radioembolization (SIRT) has been scarcely reported.It has been claimed that (open) liver surgery after right lobe SIRT can be technically demanding due to possible firm adhesions between the right liver and the diaphragm /caval vein. (sages.org)
  • Yttrium-90 radioembolization (RE) is a widely used transcatheter intraarterial therapy for patients with unresectable liver cancer. (unav.edu)
  • Patients with cancer in the liver are sometimes treated with internal radiotherapy (radioembolization). (noviotechcampus.com)
  • Embolization procedure uses various types of embolization particles such as radioembolization spheres, microspheres, drug eluting beads, PVA particles, gelfoam particles, and other particles. (coherentmarketinsights.com)
  • Arterially directed therapies - Bland transarterial embolization (TAE), transarterial chemoembolization (TACE), TACE with drug-eluting beads (DEB-TACE), and radioembolization (RE) with yttrium-90 microspheres. (medscape.com)
  • This patient, who presented with right uveal cancer (A) and synchronous liver metastases (B), had a complete response within six months of microsphere treatment in the liver (C), which contained persistent cancer despite 13 prior transcatheter arterial chemoembolization procedures. (diagnosticimaging.com)
  • Aetna considers intra-hepatic chemotherapy (infusion) medically necessary for members with liver metastases from colorectal cancer. (aetna.com)
  • Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
  • Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
  • Electro-coagulation for the treatment of liver metastases. (aetna.com)
  • Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
  • Intra-hepatic microspheres for metastases from esophageal cancer, gallbladder cancer, uveal melanom a, liver metastases of pancreatic adenocarcinoma, and other indications not listed above. (aetna.com)
  • One-shot" arterial chemotherapy for members with liver metastases from colorectal cancer. (aetna.com)
  • Transarterial chemoembolisation (TACE) using irinotecan-eluting beads is an additional treatment option for colorectal cancer liver metastases (CRLM) patients that are not eligible for curative treatment approaches. (springer.com)
  • Transarterial chemoembolisation (TACE) using irinotecan-eluting beads is part of the loco-regional treatments toolbox to control colorectal cancer liver metastases (CRLM) in the 80% of patients that are not eligible for the only proven curative treatment options, surgery and thermal ablation [ 1 , 2 ]. (springer.com)
  • Eligible patients were ≥ 18 years with histologically confirmed colorectal adenocarcinoma with liver-only or liver-dominant metastases, and treatment with LP-irinotecan TACE (LifePearl™ microspheres, Terumo Europe N.V., Leuven, Belgium) decided in a multi-disciplinary tumour board. (springer.com)
  • Hepatic arterial infusion in the treatment of liver metastases with PEG liposomes in combination with degradable starch microspheres (DSM) increases tumor 5-FU concentration. (mdc-berlin.de)
  • The regional application of cytostatics in liver metastases leads to increased concentrations in the tumor tissue. (mdc-berlin.de)
  • LifePearl™ microspheres are indicated for embolization of blood vessels supplying primary hypervascular tumours or metastases in the liver. (terumo-europe.com)
  • Our findings do require further validation and, subject to this, may support considering earlier use of SIRT for mCRC patients with liver-only or liver-dominant metastases from right-sided primary tumours. (salesandmarketingnetwork.com)
  • Y-90 radiolabelled resin and glass microspheres have been used for decades to treat primary hepatic carcinoma and liver metastases. (psi.ch)
  • Selective internal radiation therapy with 90Y microspheres for colorectal liver metastases: single-centre experience with 100 patients. (kanker-actueel.nl)
  • BACKGROUND: Many patients with colorectal liver metastases die from liver-only disease. (kanker-actueel.nl)
  • METHODS: One hundred patients with advanced colorectal liver metastases were treated with SIRT. (kanker-actueel.nl)
  • For instance, in 2017, Sirtex introduced SIR-Spheres Y-90 resin microspheres, which serves as first-line treatment for patients with liver metastases from right-sided primary colon cancer. (coherentmarketinsights.com)
  • An intestinal carcinoid does not usually cause carcinoid syndrome unless hepatic metastases have occurred because metabolic products released by the tumor are rapidly destroyed by blood and liver enzymes in the portal circulation (eg, serotonin by hepatic monoamine oxidase). (msdmanuals.com)
  • With more than 6000 patients treated in the U.S. alone in the past three years, a significant body of peer-reviewed literature has been published to aid in understanding how and in which patient population to use this treatment, particularly yttrium-90 microspheres. (diagnosticimaging.com)
  • Internal radiotherapy with yttrium-90 microspheres has demonstrated consistent and useful tumor reductions. (diagnosticimaging.com)
  • Carcinoid tumor in the liver treated with microspheres has demonstrated excellent response and reversal of clinical symptoms. (diagnosticimaging.com)
  • This is due to a combination of parenchymal retraction during fibrotic healing and hypertrophy of unirradiated healthy liver immediately adjacent to the tumor deposits. (diagnosticimaging.com)
  • The patient experienced 70% reduction in his serum tumor marker value and significant reduction in carcinoid symptoms after a single microsphere treatment. (diagnosticimaging.com)
  • Six months after, the tumor size was 4,5×3,5 cm with atrophy of the right liver and left side hypertrophy to 1128,4 ml (70% of the liver volume). (sages.org)
  • As a result, it is possible that not as many microspheres as planned flow to a tumor, causing a too low radiation dose, and the desired tumor-shrinking effect is not achieved. (noviotechcampus.com)
  • Radioactive microsphere therapy is gaining in popularity among specialists who deal with both primary and metastatic solid tumors in the liver. (diagnosticimaging.com)
  • radioactive microspheres containing Yittrium-90, can tolerate a 150 Gy single dose or 268 Gy repeated dose without risk of radiation-induced liver disease. (news-medical.net)
  • Patients who suffer from liver tumours that cannot be surgically removed nor respond to chemotherapy, may benefit from a local treatment with radioactive particles. (bronkhorst.com)
  • Quirem Medical manufactures polylactic acid microspheres containing radioactive holmium, suitable for such treatment. (bronkhorst.com)
  • The radioactive microspheres will lodge within the small blood vessels near the liver tumour where they deliver their radiation locally, with the aim to kill the tumour cells. (bronkhorst.com)
  • Quirem Medical manufactures the non-radioactive microspheres. (bronkhorst.com)
  • It is very important that the physician use multiple medical imaging techniques in order to map out the structures of the blood vessels to ensure that the radioactive spheres will be deposited into the liver tumour, and not into healthy liver tissues or into areas where they can bypass the liver and travel to other parts of the body (e.g. the lungs). (raremetalblog.com)
  • This can be done by injecting small radioactive microspheres into the liver artery. (noviotechcampus.com)
  • Nijsen and colleagues have, however, developed a therapy based on radioactive holmium microspheres. (noviotechcampus.com)
  • Transarterial chemoembolization with drug-eluting microspheres (DEM-TACE) is recommended for patients with BCLC stage B hepatocellular carcinoma (HCC) and stage 0-A unsuitable for curative treatments (i.e. surgery or ablation). (terumo-europe.com)
  • The B-TACE procedures ( n = 96 patients) were compared with a control group of non-B-TACE treatments ( n = 434 pts), performed with conventional (cTACE) or drug-eluting microspheres TACE (DEM-TACE). (springer.com)
  • From July´2007 -July´2015, 40 patients with liver tumors treated with SIRT underwent R0 resections in our center: 30 resections and 10 liver transplants. (sages.org)
  • Laparoscopic liver resection after SIRT is feasible and safe, even in major hepatectomies. (sages.org)
  • In alle studies werd SIRT gevolgd door TACE en/of LITT . (kanker-actueel.nl)
  • Selective internal radiation therapy (SIRT) is an evolving method suitable for treating patients with non-resectable metastatic liver disease. (kanker-actueel.nl)
  • Edward Kim, MD, discusses the FDA approval of TheraSphere™ Yttrium-90 Glass Microspheres in hepatocellular carcinoma. (onclive.com)
  • Edward Kim, MD, director, Interventional Oncology, assistant professor of radiology and surgery, Division of Vascular and Interventional Radiology, Mount Sinai Medical Center, discusses the FDA approval of TheraSphere™ Yttrium-90 (Y-90) Glass Microspheres in hepatocellular carcinoma (HCC). (onclive.com)
  • Liver cancer includes two major types: hepatocellular carcinoma (HCC) and intrahepatic bile duct cancer. (oncolink.org)
  • For more information, see Liver (Hepatocellular) Cancer Prevention. (oncolink.org)
  • Liver cancer - in particular, hepatocellular carcinoma (HCC) - is a complex disease, often detected in later stages, which leads to poorer patient outcomes. (siemens-healthineers.com)
  • Non-alcoholic fatty liver disease (NAFLD) is a spectrum of conditions that range from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis, and hepatocellular carcinoma (HCC). (siemens-healthineers.com)
  • Hepatocellular carcinoma (HCC) is the most frequent type of liver cancer, accounting for 90% of all liver cancers [ 2 ]. (biomedcentral.com)
  • Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. (medscape.com)
  • The next step in the development of this innovative therapy is to find out whether the distribution of holmium microspheres can also be adjusted during the procedure, as a result of decision making based on the MRI images. (noviotechcampus.com)
  • In conclusion, this thesis describes the application of novel biodegradable microspheres made from a hydrophilic polyester, poly(D,L-lactide-co-hydroxymethyl glycolide) (PLHMGA) for controlled delivery of peptide and protein pharmaceuticals. (uu.nl)
  • A minimally invasive, image-guided procedure that blocks small vessels in the knee with the help of biodegradable microspheres relieves symptoms of knee osteoarthritis (OA), a small study found. (medscape.com)
  • This striking and essentially unexpected finding may bring new hope to mCRC patients with liver-only or liver-dominant tumours that have spread from the right side of the bowel or colon. (salesandmarketingnetwork.com)
  • Currently, Y-90 radiotherapy is generally restricted to liver tumours and it requires a significant amount of pre-planning by the physician. (raremetalblog.com)
  • The role of radiotherapy and chemoradiation in the management of primary liver tumours. (cancercentrum.se)
  • In total, 50 patients ≥ 18 years diagnosed with CRLM and decided to be treated with irinotecan-eluting LifePearl™ microspheres TACE (LP-irinotecan TACE) by a multidisciplinary tumour board. (springer.com)
  • The CIrse REgistry for LifePearl™ microspheres (CIREL) was designed to prospectively capture data of CRLM patients decided to be treated with TACE using irinotecan-eluting LifePearl™ microspheres (LP-irinotecan TACE). (springer.com)
  • The second terminal artery, called the "isolated artery", penetrates the liver parenchyma unaccompanied by the bile duct, creating extrahepatic and intersegmental collaterals after repeated TACE procedures, which can feed a residual tumour. (springer.com)
  • Chinese kruiden worden gebruikt naast TACE en LITT. (kanker-actueel.nl)
  • ook melatonine die voor een significant beter effect en langere overlevingstijd zorgen naast TACE en LITT. (kanker-actueel.nl)
  • Intra-arterial transcatheter embolotherapies are recommended for non-surgical patients in the intermediate HCC stage, while sorafenib is the standard systemic herapy for patients with advanced HCC and well-preserved liver function and those with intermediate-stage HCC who progress following trans-arterial chemoembolization (TACE). (biomedcentral.com)
  • In 2016, UK National Institute for Health and Care Excellence (NICE) issued a new update stating that National Health Service (NHS) doctors and commissioners may consider Sirtex's SIR-Spheres Y-90 resin microspheres as an alternative to standard therapy with trans-arterial chemoembolization (TACE) or sorafenib in the treatment of patients with inoperable primary liver cancer. (coherentmarketinsights.com)
  • A study in February's Journal of Vascular and Interventional Radiology found that patients undergoing liver cancer treatment with Theraspheres? (news-medical.net)
  • Get comprehensive information about liver cancer and treatment options in this clinician summary. (oncolink.org)
  • For more information about other, less common types of liver cancer, see the Cellular Classification of Primary Liver Cancer section. (oncolink.org)
  • Their larger size causes the microspheres to become lodged in these blood vessels where they can deliver a strong dose of radiation to the cancer and work to cut off its blood supply. (raremetalblog.com)
  • As your partner in liver cancer management, Siemens Healthineers helps you accelerate the path from risk stratification, diagnosis, therapy and survivorship. (siemens-healthineers.com)
  • In the video interview, they discuss how imaging can address the challenges in liver cancer diagnosis and treatment today. (siemens-healthineers.com)
  • Liver cancer is one of the most frequent cancers in the world, with a 5-year prevalence of 633,000 cases, 782,000 new diagnoses in 2012, causing more than 700,000 deaths globally per annum [ 1 ]. (biomedcentral.com)
  • The BCLC (Barcelona-Clinic Liver Cancer) classification is considered the standard system by the American Association of for the Study of Liver Disease (AASLD) [ 3 ] and European Association for the Study of the Liver [ 4 ]. (biomedcentral.com)
  • These particles are used in different procedures such as liver cancer, metastatic cancer in the liver, kidney cancer, neuroendocrine tumors, uterine fibroids, and aneurysms. (coherentmarketinsights.com)
  • Many patients are not candidates given the advanced stage of their cancer at diagnosis or their degree of liver disease and, ideally, could be cured by liver transplantation . (medscape.com)
  • To evaluate the efficacy and safety of EqualSpheres microspheres loaded with vinorelbine in the treatment of patients with non-small cell lung cancer and obstructive lesions who have failed standard treatments. (who.int)
  • He ultimately died of distant metastatic disease but did not experience liver dysfunction over his 2.5-year survival after radiation. (diagnosticimaging.com)
  • Metastasis occurs most frequently in the liver but may also occur in the lymph nodes, lungs, or kidneys. (medscape.com)
  • Three patients underwent laparoscopic right hepatectomy after previous right hemiliver radiation lobectomy: two cirrhotic patients with HCC and one with CCR liver metastasis. (sages.org)
  • Fifty milliliters of cell suspension was then introduced into a rotating wall vessel with 10 mg/mL of porous Cytodex-3 microcarrier beads (collagen type I-coated porous microspheres, average diameter 175 μm (Sigma, Dorset, UK and Zwijndrecht, the Netherlands) and incubated at 37°C in 5% CO 2 . (cdc.gov)
  • None of this research or treatment application would be possible without a multidisciplinary approach that incorporates the latest in imaging technology to localize tumors, evaluate extent of disease, assess the safety of future microsphere treatment, and confirm treatment success. (diagnosticimaging.com)
  • Researchers at the Third Annual Symposium on Liver-Directed Microsphere Therapy presented compelling pretreatment and post-treatment PET scans of patients who received internal radiotherapy for unresectable and chemorefractory tumors from breast, colon, bile duct, pancreatic, esophageal, neuroendocrine, and melanoma cancers. (diagnosticimaging.com)
  • For treatment of neuroendocrine cancers (i.e., carcinoid tumors and pancreatic endocrine tumors) involving the liver. (aetna.com)
  • This opens the way to a more personalized approach to treatment of liver tumors. (noviotechcampus.com)
  • This means that the tumors are not irradiated from outside the body, but from inside the liver itself. (noviotechcampus.com)
  • These microspheres are carried along by the blood and get stuck in the very small blood vessels, especially around the tumors. (noviotechcampus.com)
  • We can follow the injection of the microspheres live based on the MRI images and, in addition, measure how many spheres have lodged in the tumors and the healthy liver. (noviotechcampus.com)
  • This interim analysis focuses on feasibility of the planned statistical analysis regarding data distribution and completeness, treatment intention, safety and health-related quality of life (HRQOL) of the first 50 patients prospectively enrolled in the CIrse REgistry for LifePearl™ microspheres (CIREL), an observational multicentre study conducted across Europe. (springer.com)
  • Note: LifePearl™ microspheres can be loaded with chemotherapeutic drugs. (terumo-europe.com)
  • LifePearl™ microspheres are compatible with doxorubicin, epirubicin idarubicin and irinotecan. (terumo-europe.com)
  • The following pictorial demonstrates how imaging is used in microsphere therapy. (diagnosticimaging.com)
  • Chemotherapy is ineffective, and the disease is typically spread throughout the liver, excluding surgical removal or external-beam radiation therapy. (diagnosticimaging.com)
  • Transarterially administered gene therapy for primary and secondary liver malignancies. (aetna.com)
  • In addition, special considerations include bridge therapy for patients awaiting liver transplantation, and combination therapies. (medscape.com)
  • The effects of internal radiotherapy are apparent in these images, with overall liver healing accompanied by a change in contour and volume of segments. (diagnosticimaging.com)
  • TARE may compete with systemic chemotherapy, sorafenib, in intermediate stage patients with prior chemoembolization failure or advanced patients with tumoral macrovascular invasion with no extra-hepatic spread and good liver function. (biomedcentral.com)
  • In its current application, Y-90 is encapsulated in microspheres (particles with size of 20-30 mm, one mm is a millionth of a meter) that are then directly injected into the blood vessels feeding a tumour using a catheter. (raremetalblog.com)
  • Topics for hands-on workshops are performing dosimetry, handling of the administration systems for the three types of microspheres, working with innovative catheter-designs and imaging techniques. (cirse.org)
  • These results provide mechanisms and protein mediators of LR that might prove useful for the follow-up of the regenerative process in the liver after PH as well as preventing the occurrence of complications associated with liver resection. (bvsalud.org)
  • They reported that these magnetic biopolymer microspheres could exhibit significant effect on magnetic contrast capability suitable for MRI application, demonstrating that the microspheres could be suitable also as drug delivery vehicles, in addition, such PHBV/SPION microspheres exhibited biocompatibility towards human T-lymphoma suspension cells and adherent colon carcinoma HT-29 cells. (nature.com)
  • The first section of this study involves the modification of SPIONs to obtain adequate stability of SPIONs in suspension and suitable interaction between hydrophobic PHBV solution and the surfaces of SPIONs during preparation of magnetic microspheres, which is presented in the second part of the study. (nature.com)
  • Certain measurements are used to determine the amount of liver cells indirectly by measuring metabolic function or drug clearance as a substitute for quantitative liver function. (hindawi.com)
  • Pre-operative use as a bridge to orthotopic liver transplantation for HCC. (aetna.com)
  • Liver transplantation may offer an alternative for curative treatment. (medscape.com)
  • Liver transplantation is generally considered a first choice for patients with early-stage HCC and moderate-severe cirrhosis (Child-Pugh class B and C), and to patients with unresectable disease. (medscape.com)
  • he was treated with chemoembolization of liver masses multiple times and finally succumbed to disease 20 years after initial surgical treatment. (medscape.com)
  • Liver disease is a substantial contributor to the development of end-stage renal disease (ESRD). (hindawi.com)
  • In patients with cirrhosis, liver disease, or other risk factors for HCC, and with lesions greater than 1 cm, triple-phase, contrast-enhanced studies (dynamic computed tomography [CT] or magnetic resonance imaging [MRI]) can be used to establish a diagnosis of HCC. (oncolink.org)
  • Most patients with HCC have signs of advanced fibrosis, which is caused by chronic liver diseases, such as nonalcoholic fatty liver disease, alcoholic liver disease or viral hepatitis. (siemens-healthineers.com)
  • Although viral hepatitis is still the leading risk factor for HCC, it is expected that soon non-alcoholic fat liver disease (NAFLD) will become the leading cause for HCC 2 . (siemens-healthineers.com)
  • Often called a silent killer, liver disease has become more prevalent in recent years. (siemens-healthineers.com)
  • Studies have shown an increase in stiffness due to liver disease, as measured with Ultrasound Elastography, to be rapid, reliable, and reproducible. (siemens-healthineers.com)
  • Multidisciplinary management of HCC with comprehensive review of radiological and pathological findings helps to tackle the complexity of liver disease 9 . (siemens-healthineers.com)
  • This exceptional property represents a therapeutic opportunity for severe liver disease patients. (bvsalud.org)
  • The incidence of HCC is highest in Asia and Africa, where the endemic high prevalence of hepatitis B and hepatitis C strongly predisposes to the development of chronic liver disease and subsequent development of HCC. (medscape.com)
  • Whereas in the past, HCC generally presented at an advanced stage with right-upper-quadrant pain, weight loss, and signs of decompensated liver disease, it is now increasingly recognized at a much earlier stage as a consequence of the routine screening of patients with known cirrhosis , using cross-sectional imaging studies and serum alpha-fetoprotein (AFP) measurements. (medscape.com)
  • There is also a growing problem with cirrhosis, which develops in the setting of nonalcoholic fatty liver disease (NAFLD), or nonalcoholic steatohepatitis (NASH). (medscape.com)
  • [ 3 ] Thus, developing effective and efficient care for patients with end-stage liver disease and HCC must become a significant focus. (medscape.com)
  • To evaporate the solvent in the microsphere synthesis, classic type EL-FLOW mass flow controllers are used. (bronkhorst.com)
  • The release of biopharmaceuticals and degradation of the microspheres could be successfully tailored by synthesis of copolymers differing in copolymer composition. (uu.nl)
  • Y-90 is an emitter of beta radiation, which is capable of damaging and killing living cells. (raremetalblog.com)
  • Since beta radiation only travels a few millimeters inside the body, radiation damage to the surrounding healthy liver tissue is generally minimized. (raremetalblog.com)
  • Foodborne transmission of hepatitis E virus (HEV) to humans from consumption of undercooked pig liver and deer meat has been reported in Japan ( 1 - 3 ). (cdc.gov)
  • It was revealed that the magnetic PHBV microspheres were non-toxic when assessed with mouse embryotic fibroblast cells (MEF) at different concentrations of microspheres. (nature.com)
  • Chronic exposure to PM10, NO2 and living near a major road might increase the risk of developing COPD and can have a detrimental effect on lung function. (nih.gov)
  • In this work, the solid-in-oil-in-water (S/O/W) emulsion-solvent extraction/evaporation method was utilized to fabricate magnetic polymer microspheres incorporating SPIONs in PHBV. (nature.com)
  • This was also proven via magnetic susceptibility measurement as a higher value of this magnetic property was detected for PHBV/SPIONs Lauric microspheres. (nature.com)
  • These results confirmed that the fabricated magnetic PHBV microspheres are potential candidates for use in biomedical applications. (nature.com)
  • PCR-amplified mycobacterial genes are sequence-specifically captured on microspheres, labeled by magnetic nanoprobes, and detected by nuclear magnetic resonance. (cdc.gov)
  • The method is based on a magnetic barcoding strategy: PCR-amplified target MTB genes are captured and magnetically labeled by a pair of complementary oligonucleotides conjugated to microspheres and magnetic nanoprobes. (cdc.gov)
  • They then block small capillaries in the synovium with 75- to 100-µm microspheres used in the treatment of multiple conditions, including uterine fibroids . (medscape.com)
  • The liver is in the upper abdomen near the stomach, intestines, gallbladder, and pancreas. (oncolink.org)
  • In this study, the production of PHBV microspheres with modified SPIONs was chosen via emulsion-solvent extraction/evaporation method. (nature.com)
  • Microspheres can be successfully made from PLHMGA, by the double emulsion extraction-evaporation method. (uu.nl)
  • One of the major challenges with PLGA microspheres is prevention of the drop of pH inside degrading microspheres which is detrimental for the integrity of acid labile molecules such as peptides and proteins. (uu.nl)
  • Na het overlijden van Gerda najaar 2017 is de website opereren zonder snijden off line geweest en fucntioneerde niet meer. (kanker-actueel.nl)