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  • receptor
  • In this paper, we will focus on SOCS1, a member of SOCS family, which plays a key role in the negative regulation of both cytokine receptor- and TLR-mediated signaling. (hindawi.com)
  • Kandimalla ER, Zhu FG, Bhagat L, Yu D, Agrawal S. (2003) Toll-like receptor 9: modulation of recognition and cytokine induction by novel synthetic CpG DNAs. (springer.com)
  • proliferation
  • Our analysis showed that comparable CD4 + T cell proliferation and CD4 + memory T cell responses (T CM ) represented by CD62L hi , CCR7 + , and IL-7R + T cell populations were induced with LdCen −/−2W in both asymptomatic and naive animals that received LdCen −/− immunization. (frontiersin.org)
  • induce
  • Carbon tetrachloride (CCl 4 ) is a hepatotoxic chemical that has been widely used to induce experimental liver injury models [ 4 - 6 ]. (hindawi.com)
  • cirrhosis
  • Chronic pancreatitis, alcoholic liver cirrhosis and salivary secretion. (biomedsearch.com)
  • By comparison with control subjects, patients with chronic pancreatitis and alcoholic liver cirrhosis displayed in basal condition a reduction in salivary volume, bicarbonate and an amylase concentration and outputs. (biomedsearch.com)
  • experimental
  • The biological mechanism underlying these relations is not entirely clear, although experimental data in animals indicate that dietary magnesium deficiency may promote an inflammatory response ( 5 ), ultimately leading to endothelial dysfunction and metabolic disease. (diabetesjournals.org)
  • To date, the infusion of MSCs or MSC-conditioned medium has shown encouraging results in the treatment of fulminant hepatic failure and in end-stage liver disease in experimental settings. (hindawi.com)
  • pathologic
  • The results showed that SLE significantly decreased the activities of serum ALT/AST and reduced liver pathologic changes induced by CCl 4 . (hindawi.com)
  • rapidly
  • Directed analysis such as this allows investigators to rapidly compare their chemical responses of interest with a large database of profiles that have been generated on a common microarray platform and consistent protocols. (aspetjournals.org)
  • disease
  • To evaluate the relationship between retinal vascular caliber and cardiovascular disease in non-alcoholic fatty liver disease (NAFLD) patients without diabetes and hypertension. (mdpi.com)
  • Nonalcoholic fatty liver disease (NAFLD) is increasingly recognized as the most common liver disorder in Western countries. (mdpi.com)
  • Before the recent discovery of hepcidin and its function in iron metabolism, anemia of chronic disease was seen as the result of a complex web of inflammatory changes. (wikipedia.org)
  • Schisandra chinensis ( S. chinensis ) is a traditional Chinese herbal medicine widely used for the treatment of liver disease, whose main active components are lignans. (hindawi.com)
  • Actually, the net result of pathogen-host interaction, that is, whether health is maintained or disease develops, relies on the balance between pathogen virulence and the capacity of the individual immune response. (hindawi.com)
  • mechanisms
  • To investigate the transcriptional mechanisms by which testosterone exerts its metabolic and physiological effects on the periphery, we compared gene expression by sex and in response to experimentally elevated testosterone in a well-studied bird species, the dark-eyed junco ( Junco hyemalis ). (biologists.org)
  • therapeutic
  • A better understanding of the involvement of the inflammatory cascade in different envenoming syndromes may have future therapeutic benefits. (scielo.br)
  • bone
  • Inflammatory cytokines also appear to affect other important elements of iron metabolism, including decreasing ferroportin expression, and probably directly blunting erythropoiesis by decreasing the ability of the bone marrow to respond to erythropoietin. (wikipedia.org)
  • extensively
  • Toward developing an effective vaccine, we have reported extensively on the immunogenicity of live attenuated LdCentrin −/− mutants in naive animal models. (frontiersin.org)
  • Humans
  • Recent studies on humans suggest that SOCS1 is involved in the development of various liver disorders in humans. (hindawi.com)
  • cardiac
  • The aim of this study was to measure the central nervous system (CNS) cytokine response following resuscitation from ventricular fibrillation (VF) in a porcine model of cardiac arrest and global hypoxic ischemia. (ahajournals.org)