Treatment with BMP6 increased hepcidin expression in human liver-derived cells but not in bovine liver-derived cells. (bvsalud.org)
Regulation5
Regulation of hepcidin expression by iron status has been proposed on the basis of evidence mainly from rodents and humans. (bvsalud.org)
We revealed the unique regulation of bovine hepcidin expression and the characteristic TGF-ß family signaling mediated by bovine Smad4. (bvsalud.org)
Two hepcidin genes were identified in the X. tropicalis frog but only tHEP2 was responsive to iron loading, indicating a possible role of tHEP2 in the regulation of ironhomeostasis. (auburn.edu)
These preliminary data suggested that X. tropicalis could be a promising animal model which allows us to separate some features of the regulation of hepcidin expression at the transcriptional level. (auburn.edu)
2017). Hepcidin- (in)dependent mechanisms of iron metabolism regulation during infection by Listeria and Salmonella . (up.pt)
Phenotypes1
Ubiquitin-like modifier activating enzyme 1 as a novel diagnostic and prognostic indicator that correlates with ferroptosis and the malignant phenotypes of liver cancer cells. (biotrend.com)
Cytokines1
Inflammatory cytokines stimulate the liver to produce the iron metabolism regulator protein hepcidin, that reduces available iron. (wikipedia.org)
Receptor2
The phylogenetic study revealed the co-evolution of hepcidin and its receptor ferroportin. (auburn.edu)
Androgen receptor splice variant 7 (AR-V7) is an important oncogenic driver and an early diagnostic and prognostic marker, as well as a therapeutic target in hormone-resistant CRPC. (bjbms.org)
Regulates2
Hepcidin negatively regulates systemic iron levels by inhibiting iron entry into the circulation. (bvsalud.org)
Our previous work demonstrated that life-long intake of 2% of total energy from TFA (an intake typical of the American diet [ 9 ]) in senescence-accelerated mice (SAMP8 strain) was associated with increases in plasma triglyceride and total cholesterol, suggesting an effect of TFA on the liver - an organ that regulates plasma fat and cholesterol [ 10 ]. (biomedcentral.com)
Regulator2
AIM: The aim of the study was to investigate the respective roles of iron excess and hepcidin, the systemic iron regulator, in the development of iron-related osteoporosis. (bvsalud.org)
Hepcidin, originally identified as a 25 amino acid (aa) antimicrobial peptide made in the liver, is a small peptide hormone that has been shown to be the long-sought regulator of iron metabolism in humans and mice. (auburn.edu)
Serum3
In naturally occurring anemic fish, the concentration of serum iron, total iron binding capacity, and liveriron content were half of that in healthy controls. (auburn.edu)
Serum samples have been analyzed with ELISA for ferritin, hepcidin and IL-6. (iisinai.org)
and elevated ranges of serum hepcidin in AD and DS. (iisinai.org)
Concentrations2
We evaluated the effect of iron administration on plasma hepcidin concentrations in calves and the expression of bovine hepcidin by the BMP pathway in a cell culture study. (bvsalud.org)
Although intramuscular administration of iron increased iron-related parameters, plasma hepcidin concentrations were unaffected. (bvsalud.org)
Antimicrobial1
The liver-derived hormone hepcidin, a member of the defensin household of antimicrobial peptides, performs an vital position in host protection and innate immunity as a result of its broad antibacterial and antiviral properties. (iisinai.org)
Oxidative stress6
Our goal was to assess the effects of the diet on protein markers of inflammation and oxidative stress in the liver. (biomedcentral.com)
At the indicated ages, livers were harvested and evaluated for markers of inflammation and oxidative stress, as well as for enzymes of fat metabolism via immunoblotting. (biomedcentral.com)
Our results suggest sexually dimorphic protein expression in the liver, with female mice demonstrating lower inflammation and increased oxidative stress defenses. (biomedcentral.com)
In another study, aged mice (20-month-old) fed a high-fat diet for 4 months demonstrated increased inflammation, oxidative stress, and fibrosis in the liver, compared to aged mice on the control diet [ 7 ]. (biomedcentral.com)
Furthermore, diets high in TFA are associated with an increase in oxidative stress in the liver [ 5 ]. (biomedcentral.com)
Therefore, the effects of long-term, moderate TFA intake on inflammation and oxidative stress in the liver with aging are unclear. (biomedcentral.com)
Mice2
MATERIAL AND METHODS: We used mice models with genetic iron overload (GIO) related to hepcidin deficiency (Hfe-/- and Bmp6-/- ) and secondary iron overload (SIO) exhibiting a hepcidin increase secondary to iron excess. (bvsalud.org)
In this study, we investigated the effects of a trans -fatty acid (TFA) diet on the liver in adult (25 wk) and old (60 wk) senescence-accelerated mice (SAMP8 strain) of both sexes. (biomedcentral.com)
Expression4
The lower expression levels of bovine Smad4 were responsible for the lower activity of the hepcidin reporter, which might be due to the instability of bovine Smad4 mRNA. (bvsalud.org)
The present study suggests that knowledge of the regulatory expression of hepcidin as well as TGF-ß family signaling obtained in murine and human cells is not always applicable to bovine cells. (bvsalud.org)
Hepcidin supplementation of cells had a rescue effect on the collagen 1 and alkaline phosphatase expression level decrease. (bvsalud.org)
However, augmented hepcidin expression in the gut and olfactory sac was detected only at 48 h post infection. (auburn.edu)
Protein2
Hepcidin production is increased in response to an increase in systemic iron via the activation of the bone morphogenetic protein (BMP) pathway. (bvsalud.org)
Hepcidin protein was seen within the epithelial cells of choroid plexus, meningeal macrophages and within the astrocytes near the endothelium of blood vessels. (iisinai.org)
Iron7
The osteoblastic MC3T3 murine cells that are able to mineralize were exposed to iron and/or hepcidin. (bvsalud.org)
CONCLUSION: Together, these data suggest that iron in excess alone is not sufficient to induce osteoporosis and that low hepcidin levels also contribute to the development of osteoporosis. (bvsalud.org)
In order to supply adequate iron during pregnancy, the levels of the iron regulatory hormone hepcidin in the maternal circulation are suppressed, thereby increasing dietary iron absorption and storage iron release. (bvsalud.org)
Although closely related hepcidin genes and peptides have been identified in other mammals, amphibians and various fish species, it is still largely unknown whether hepcidin can regulate iron metabolism in fish and amphibians. (auburn.edu)
In Xenopus tropicalis study, we demonstrated for the first time that hepcidin may regulate iron metabolism in amphibians. (auburn.edu)
A Prospective, Randomized, Interventional Study of Oral Iron Supplementation Comparing Daily Dose with Alternate Day Regimen Using Hepcidin as a Biomarker in Iron Deficiency Anemia. (mcmaster.ca)
Inflammation1
If hepcidin levels increase because of non-bacterial sources of inflammation, like viral infection, cancer, auto-immune diseases or other chronic diseases, then the anemia of chronic disease may result. (wikipedia.org)
Levels3
Alterations in bone microarchitecture in the Bmp6-/- model were positively correlated with hepcidin levels (BV/TV (ρ = +.481, p (bvsalud.org)
In the current study, it was found that in channel catfish hepcidin transcript levels in the liver were increased by 4, 19, and 22 fold at 4, 24, and 48 hours post Edwardsiella ictaluri challenge, respectively. (auburn.edu)
The levels of hepcidin transcript in the livers of catfish affected by anemia were only 14% of that of healthy catfish. (auburn.edu)
Dietary2
However, less attention has focused on the effects of a dietary intervention on the liver in a model of aging. (biomedcentral.com)
Since the number of individuals aged 80 and older in the world increases steadily, and the risk for liver pathology increases with aging [ 8 ], determining the effects of dietary manipulations on the potential for age-related pathologies is an important area of investigation. (biomedcentral.com)
Function1
Studies on influence of sex steroid hormone on the immune system and function of the common pigeon columba livia. (publiguia.net)
Analysis2
Multiple Sequence Analysis (MSA) demonstrated that charged residues (E, D, H, K, and R) within external segments (ESs) are most likely involved in the hepcidin-ferroportin interaction. (auburn.edu)
Characterization and transcriptional analysis of hupSLW in Gloeothece sp. (up.pt)
Study2
The study on the promoter areas of the two hepcidin genes supports such notions. (auburn.edu)
In this study, highly conserved external segments (ES1-4, and ES6) were predicted to play a critical role during the binding between hepcidin and ferroportin. (auburn.edu)
Content1
Right here, cytokine content material and related transcriptional modifications have been measured in rat pores and skin for 3 hours instantly following induction of a scald-type (60°C, 2 minutes) burn damage mannequin. (iisinai.org)
Lower1
The reporter activity of hepcidin was lower in the cells transfected with bovine Smad4 than in those transfected with murine Smad4. (bvsalud.org)
Blood1
Hepcidin might be transported through macrophages and nearly all of the vesicular hepcidin enters the mind through a compromised blood mind barrier (BBB). (iisinai.org)
Responsible1
On the other hand, the most variable external segment ES5 was proposed to be responsible for the endurance of ferroportin to hepcidin variation. (auburn.edu)