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  • 2016
  • The oldest known organ donor was a 107-year-old Scottish woman, whose corneas were donated after her death in 2016. (wikipedia.org)
  • 2017
  • a short A BBB video appeal was published in early 2017 The laws of different countries allow potential donors to permit or refuse donation, or give this choice to relatives. (wikipedia.org)
  • Hepatic
  • INTRODUCTION: Liver stiffness measurements (LSMs) using transient elastography (TE) provide a noninvasive means to assess liver fibrosis that correlate with hepatic cholestasis. (yonsei.ac.kr)
  • Liver resection with a knife and reconstruction of the IVC and the hepatic veins were completed without blood loss. (nii.ac.jp)
  • New device for harvesting the hepatic graft from the living donor. (nii.ac.jp)
  • Hepatic mitochondrial redox potensial and nutrirional support in liver insufficiency. (nii.ac.jp)
  • Effect of repeat Kasai hepatic portoenterostomy on pediatric live-donor liver graft for biliary atresia. (nih.gov)
  • A sudden onset of life-threatening hepatic insufficiency is known as acute liver failure (ALF). (wikipedia.org)
  • On the other hand, a patient with a chronic hepatic disease can suffer an acute decompensation of liver function following a precipitating event such as variceal bleeding, sepsis and excessive alcohol intake among others that can lead to a condition referred to as acute-on-chronic liver failure (ACLF). (wikipedia.org)
  • Both types of hepatic insufficiency, ALF and ACLF, can potentially be reversible and liver functionality can return to a level similar to that prior to the insult or precipitating event. (wikipedia.org)
  • Bio-artificial liver (BAL) Hepatassist 2000 uses porcine hepatocytes11 whereas ELAD system employs hepatocytes derived from human hepatoblastoma C3A cell lines.9, Both techniques can produce, in fulminant hepatic failure (FHF), an improvement of hepatic encephalopathy grade and biochemical parameters. (wikipedia.org)
  • Other biological hepatic systems are Bioartificial Liver Support (BLSS)12 and Radial Flow Bioreactor (RFB).15 Detoxification capacity of these systems is poor and therefore they must be used combined with other systems to mitigate this deficiency. (wikipedia.org)
  • Liver transplantation or hepatic transplantation is the replacement of a diseased liver with the healthy liver from another person (allograft). (wikipedia.org)
  • for example, Staudacher reported "arterialization" of the donor portal vein via the recipient hepatic artery, and use of cholecystostomy for biliary drainage. (wikipedia.org)
  • The hepatectomy involves division of all ligamentous attachments to the liver, as well as the common bile duct, hepatic artery, hepatic vein and portal vein. (wikipedia.org)
  • Allografts
  • The limited supply of liver allografts from non-living donors relative to the number of potential recipients spurred the development of living donor liver transplantation. (wikipedia.org)
  • citation needed]Bone autograft is generally preferred by surgeons because, as well as eliminating the risks associated with allografts, bone autograft contains native bone-forming cells (osteoblasts), so the graft itself forms new bone (osteoinductive), as well as acting as a matrix or scaffold to new bone growing from the bones being bridged (osteoconductive). (wikipedia.org)
  • Furthermore, certain processing practices have been shown to also retain the acid-stable osteoinductive proteins in cortical bone grafts, so that many bone allografts can be considered both osteoconductive and osteoinductive. (wikipedia.org)
  • transfusion
  • Balanced Blood Product Transfusion during Liver Transplantation. (amedeo.com)
  • Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare complication of blood transfusion, in which the donor T lymphocytes mount an immune response against the recipient's lymphoid tissue. (wikipedia.org)
  • In developing countries the donor is sometimes specifically recruited by or for the recipient, typically a family member, and the donation occurs immediately before the transfusion. (wikipedia.org)
  • brain-dead donor
  • A method for rapid, non-invasive assessment of liver function in a brain-dead donor, prior to procurement is presented. (patents.com)
  • She underwent a 15-hour operation in November 2005 in which surgeons transplanted the nose, lips and chin from a brain-dead donor at a hospital in Amiens. (wikipedia.org)
  • disease
  • The variables analyzed were gender, age, etiology of liver disease, Child-Pugh classification, model of end-stage liver disease (MELD score), pretransplantation serum sodium level, and graft weight-to-recipient body weight (GRBW) ratio. (scielo.br)
  • RESULTS: Pretransplantation serum total bilirubin, international normalized ratio, and Model for End-stage Liver Disease scores of recipients were significantly higher in group H than group L. Regarding the pretransplantation donor characteristics, the graft-recipient weight ratio was significantly smaller among those in group H (P = .039). (yonsei.ac.kr)
  • Extracorporeal photopheresis (ECP) is used to treat chronic graft-versus-host disease (cGVHD)-a complication of bone marrow or stem cell transplant that occurs when donor cells attack the recipient. (medicalxpress.com)
  • A new priority policy for patients with hepatocellular carcinoma awaiting liver transplantation within the model for end-stage liver disease system. (nih.gov)
  • The Effects of Gestational Alloimmune Liver Disease on Fetal and Infant Morbidity and Mortality. (amedeo.com)
  • Association of Pretransplant Opioid Use with Graft Loss or Death in Liver Transplantation Patients with Model of End Stage Liver Disease Exceptions. (amedeo.com)
  • While intestinal failure can oftentimes be treated with alternative therapies such as parenteral nutrition (PN), complications such as PN-associated liver disease and short bowel syndrome may make transplantation the only viable option. (wikipedia.org)
  • Over long periods of time, PN can lead to numerous health conditions, including severe dehydration, catheter-related infections, and liver disease. (wikipedia.org)
  • This can result in graft-versus-host disease. (wikipedia.org)
  • The experimental use of everolimus in refractory chronic graft-versus-host disease was reported in 2012. (wikipedia.org)
  • mortality
  • A high portal venous pressure gradient increases gut-related bacteremia and consequent early mortality after living donor liver transplantation. (amedeo.com)
  • KPD is also being used to find better donor-recipient matches for compatible pairs who want a lower lifetime mortality and longer lasting transplant. (wikipedia.org)
  • Mortality is higher in TA-GvHD than in GvHD associated with bone marrow transplantation, where the engrafted lymphoid cells in the bone marrow are of donor origin and therefore the immune reaction is not directed against them. (wikipedia.org)
  • fibrosis
  • CONCLUSIONS: This pilot study suggested that a high LSM after LDLT suggests intrahepatic cholestasis and portal hypercirculation in the graft, irrespective of liver fibrosis, outflow obstruction, or biliary obstruction. (yonsei.ac.kr)
  • transplantable
  • In 2010, a team led by Uygun in the Center for Engineering in Medicine at Massachusetts General Hospital developed a technique that someday may allow growth of transplantable replacement livers. (wikipedia.org)
  • Uygun's technique developed functional, transplantable rat liver grafts. (wikipedia.org)
  • bone
  • For complex injuries and other situations requiring bone grafts, the best available technique involves autologous bone harvesting and re-implantation at the site of regrowth. (medicalxpress.com)
  • citation needed] It can be done in several ways: A bone graft can be created between the two bones using a bone from elsewhere in the person's body (autograft) or using donor bone (allograft) from a bone bank. (wikipedia.org)
  • however, the treatment process the bone goes through following harvest, which usually involves deep-freezing and may also involve demineralization, irradiation and/or freeze-drying, kills living bone or bone marrow cells. (wikipedia.org)
  • antibody
  • Overall, 22% developed anti-HLA antibodies, of which 6% were donor-specific antibodies, and 6% developed anti-MICA antibody. (stanford.edu)
  • Long-term lamivudine monotherapy prevents development of hepatitis B virus infection in hepatitis B surface-antigen negative liver transplant recipients from hepatitis B core-antibody-positive donors. (nih.gov)
  • Risk of de novo hepatitis in liver recipients from hepatitis-B core antibody-positive grafts - a systematic analysis. (nih.gov)
  • More than one-third of potential living kidney donors who want to donate their kidney to a friend or family member cannot donate due to blood type or antibody incompatibility. (wikipedia.org)
  • METHODS
  • Objective To investigate the significance of cell signaling pathwaysof acute phase injury, tumor cell invasion/migration and angiogene-sis on tumor recurrence in small-for-size liver grafts after LDLT.Patients and Methods 87 LDLT and 34 DDLT were included inthis study. (hku.hk)
  • METHODS: Sixty-three biopsy-matched urine samples (41 stable and 22 allograft injury) were analyzed from female recipients of male donors for chromosome Y (donor)-specific dd-cfDNA. (stanford.edu)
  • The grafts are obtained in one or both of the two primary methods of surgical extraction, follicular unit transplantation, colloquially referred to as "strip harvesting", or Follicular Unit Extraction (FUE), in which follicles are transplanted individually. (wikipedia.org)
  • Injury
  • Intragraft mRNA levels of Egr-1, RhoA, FAK andVEGF was significantly higher in Group 1.Conclusion Significant activation of signaling pathways of acutephase injury and angiogenesis, cell invasion and migration in small-for-size liver grafts after LDLT might contribute to the higher inci-dence of liver tumor recurrence/metastases. (hku.hk)
  • He did general surgery training at the Tulane University School of Medicine in New Orleans, also spending a year in the Liver Transplant Lab at The Mount Sinai Medical Center in New York City, where he investigated the effects of hypernatremia in brain death and ischemia/reperfusion injury in liver transplantation. (wikipedia.org)
  • lungs
  • Livers and lungs for transplant can only be taken from controlled donors, and are still somewhat experimental as they have only been performed successfully in relatively few centres. (wikipedia.org)