• Composition analysis for the ethanol extract (PRExt) was executed by high performance liquid chromatography. (hindawi.com)
  • Recently, we demonstrated that an ethanol extract of Radix Paeoniae Rubra could suppress transcription of the hepatic phosphoenolpyruvate carboxykinase (PEPCK) gene [ 5 ]. (hindawi.com)
  • The ethanol extract of Radix Paeoniae Rubra (PRExt) was prepared as previously described [ 5 ] with some modifications. (hindawi.com)
  • Different doses of propolis ethanol extract were p.o. administered three times per day for three days, after four weeks' alcohol administration. (tmu.edu.tw)
  • It was found that 10 mg/kg of propolis ethanol extract significantly decreased the elevations of serum GOT, GPT, TG and HTG. (tmu.edu.tw)
  • In histopathological examination, 30 mg/kg of propolis ethanol extract also remarkably decreased the hepatocellular fatty degeneration, apparent as vacuolization, induced by chronic alcohol abuse. (tmu.edu.tw)
  • This study aims to study the effect of aqueous extract of L. inermis leaves in acute ethanol induced hepatic damage in adult Wistar rats. (projectreserve.com)
  • Group IV served as the therapeutic group, and received 400 mg/kg of the extract for seven days after receiving 20 ml/kg of 40 % ethanol on the first. (projectreserve.com)
  • The effect of ethanol extract of Dennettia Tripetala on rats exposed to carbon tetrachloride was investigated. (projecttopics.com)
  • Ethanol extract of the plant was prepared using standard procedure. (projecttopics.com)
  • Sets of 30 female wistar albino rats were divided into 6 groups containing five animals each and were treated orally with increasing doses of ethanol extract of Dennettia Tripetala for two weeks. (projecttopics.com)
  • Protective effect of ethanol extract from sweet potato leaves on CCL 4 -induced liver injury in mice. (cabi.org)
  • Objectives: To investigate the protective effect of ethanol extract from sweet potato leaves on liver injury induced by CCI, in mice. (cabi.org)
  • Hepatic steatosis plays a detrimental role in the onset and progression of alcohol-associated liver disease (ALD). (chinaphar.com)
  • We showed that the hepatic MANF expression was markedly upregulated in mouse model of ALD by chronic-plus-single-binge ethanol feeding. (chinaphar.com)
  • Moreover, after chronic-plus-binge ethanol feeding, hepatocyte-specific MANF knockout (HKO) mice displayed more severe hepatic steatosis and liver injury than wild-type (WT) control mice. (chinaphar.com)
  • Ethanol also has direct effects on cardiac muscle, thyroid tissue, and hepatic tissue. (medscape.com)
  • Aetna considers percutaneous ethanol injection (PEI) medically necessary for the treatment of hepatocellular cancers (HCC) without extra-hepatic spread. (aetna.com)
  • Pre-operative hepatic artery chemoembolization followed by orthotopic liver transplantation for HCC. (aetna.com)
  • Aetna considers intra-hepatic chemotherapy (infusion) medically necessary for members with liver metastases from colorectal cancer. (aetna.com)
  • Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
  • Intra-hepatic microspheres for metastases from esophageal cancer, gallbladder cancer, uveal melanom a, liver metastases of pancreatic adenocarcinoma, and other indications not listed above. (aetna.com)
  • After sacrifice, serum transaminases (GOT, GPT), triacylglyceride and hepatic triacylglyceride (HTG) concentration were assayed to observe liver injuries induced by chronic alcohol abuse. (tmu.edu.tw)
  • Because the absence of SOD would confer less resistance to oxidative stress, we determined whether damage to hepatic proteolytic systems was greater in SOD -/- than in SOD +/+ mice after chronic ethanol feeding. (elsevierpure.com)
  • Results: Ethanol-fed SOD -/- mice had 4-fold higher blood ethanol, 2.8-fold higher alanine aminotransferase levels, 20% higher liver weight, a 1.4-fold rise in hepatic protein levels, and 35 to 70% higher levels of lipid peroxides than corresponding wild-type mice. (elsevierpure.com)
  • Cirrhosis is defined histologically as a diffuse hepatic process characterized by fibrosis and conversion of the normal liver architecture into structurally abnormal nodules. (medscape.com)
  • Common signs and symptoms may stem from decreased hepatic synthetic function (eg, coagulopathy), portal hypertension (eg, variceal bleeding), or decreased detoxification capabilities of the liver (eg, hepatic encephalopathy). (medscape.com)
  • Percutaneous ethanol injection is a possible treatment for hepatocellular carcinoma. (wikipedia.org)
  • Hepatocellular carcinoma and bile duct cancer (cholangiocarcinoma) are the main types of adult primary liver cancer. (oncolink.org)
  • We found 187 (74.0%) patients had cirrhotic liver associated with hepatocellular carcinoma. (who.int)
  • Alcohol consumption increases the risk of cancers at seven sites: the oral cavity, pharynx, larynx, oesophagus (squamous cell carcinoma), colorectum, liver (hepatocellular carcinoma), and female breast. (who.int)
  • Type 2 diabetes (T2D) affects more people than does type 1 diabetes and the typical comorbidities are central obesity and fatty liver [ 1 ]. (hindawi.com)
  • In addition, the phenomenon of alcohol induced fatty liver were also observed by histopathological changes. (tmu.edu.tw)
  • While wild-type mice exhibited fatty liver after ethanol administration, SOD -/- mice showed no evidence of ethanol-induced steatosis, although triglyceride levels were elevated in both groups of knockout mice. (elsevierpure.com)
  • Excess ethanol in exhaled breath can be an indicator of intoxication and a biomarker for fatty liver disease. (csircentral.net)
  • Microbiome-derived ethanol in nonalcoholic fatty liver disease. (nih.gov)
  • The pathway of ethanol metabolism. (medscape.com)
  • Background: Ethanol metabolism increases production of reactive oxygen species, including superoxide () in the liver, resulting in significant oxidative stress, which causes cellular damage. (elsevierpure.com)
  • Conclusions: Active oxidants generated during ethanol metabolism increase mitochondrial permeability transition and modulate mitochondrial energy synthesis in hepatocytes. (elsevierpure.com)
  • Clejan, LA, Koop, DR & Cederbaum, AI 1989, ' Sensitivity of the rat liver microsomal oxidation of pyrazole to antibody raised against the ethanol-inducible rabbit liver cytochrome P-450 isozyme ', Drug Metabolism and Disposition , vol. 17, no. 6, pp. 694-698. (elsevierpure.com)
  • Acetaldehyde and the lipid peroxidation-derived aldehyde malondialdehyde (MDA), are reactive compounds that are generated during ethanol metabolism in the liver, and both aldehydes have been shown to be capable of binding to proteins and forming stable adducts. (nebraska.edu)
  • These results indicate that acetaldehyde and MDA can react together in a synergistic manner and generate hybrid adducts (MAA-adducts) and further suggest that MAA adducts may represent a major species of adducts formed in the liver during ethanol metabolism in vivo. (nebraska.edu)
  • The type of alcohol found in alcoholic beverages is ethyl alcohol or ethanol. (howstuffworks.com)
  • The aim of the study was to compere effects of ketoprofen and KLS on the nervous system, kidneys and liver after ethyl alcohol intoxication. (bvsalud.org)
  • The Environmental Protection Agency (EPA) on Friday raised the amount of ethanol permitted for use in cars and light trucks built in 2001 or later. (environmentalleader.com)
  • Blood ethanol levels are also useful in the diagnosis of alcoholism because individuals who habitually use this drug become tolerant. (medscape.com)
  • This diagnosis is suggested when a person can function in a relatively normal capacity (without evidence of intoxication) with a blood ethanol level greater than 150 mg/dL. (medscape.com)
  • These and other atypical responses to ethanol, including the absence of ethanol-induced steatosis and enhanced glutathione levels, appear to be linked to enhanced oxidative stress due to lack of antioxidant enzyme capacity. (elsevierpure.com)
  • Results: Ethanol (50 mmol/l) increased oxidative stress in hepatocytes and subsequently induced an increased mitochondrial permeability transition and a decreased membrane potential. (elsevierpure.com)
  • A continuous infusion of ethanol (50 mmol/l) increased oxidative stress and decreased mitochondrial membrane potential in the pericentral area of isolated perfused rat liver. (elsevierpure.com)
  • Curcumin protects the rat liver from chemically-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. (greenmedinfo.com)
  • Liver tissues were collected for assessment of oxidative stress markers (superoxide dismutase, catalase, reduced glutathione and malondialdehyde), protein concentration, DNA fragmentation, and also for haematoxylin and eosin staining, and acridine orange-ethidium bromide staining. (projectreserve.com)
  • The purpose of the present study was to determine if this weight change was related to oxidative stress subsequent to MWF exposure and also to determine whether ethanol intake influences this effect. (cdc.gov)
  • Hypoglycemia and respiratory depression are the two most immediate life-threatening complications that result from ethanol intoxication in children. (medscape.com)
  • Pediatric ethanol intoxication occurs in patterns that vary with the patient's age. (medscape.com)
  • In infants and children, ethanol intoxication often has an unintentional cause. (medscape.com)
  • 2003). In addition, acute intoxication with CCl4 at high doses, when the hepatocellular necrosis exceeds the regenerative capacity of the liver, fatal liver failure will ensue. (projecttopics.com)
  • Urine ethanol samples are known to be imprecise in estimating BAC and the degree of intoxication. (medscape.com)
  • Curcumin and saikosaponin A inhibit chemical-induced liver inflammation and fibrosis in rats. (greenmedinfo.com)
  • Pyrazole is oxidized to 4-hydroxypyrazole by rat liver microsomes in a cytochrome P-450-dependent reaction and this oxidation can be increased by prior treatment of rats with pyrazole, 4-methylpyrazole, or chronic ethanol feeding. (elsevierpure.com)
  • The anti-3a IgG-sensitive rate of pyrazole oxidation was increased 4- to 5-fold after treatment of rats with pyrazole, 4-methylpyrazole, or ethanol, indicating that the increased oxidation of pyrazole caused by these agents is due to induction of P-450 IIE.1. (elsevierpure.com)
  • A quantitative competitive enzyme- linked immunosorbent assay (ELISA) was developed and detected the presence of MAA-modified proteins in fiver cytosol from ethanol-fed rats but not in pair- fed controls. (nebraska.edu)
  • We also found that MANF supplementation significantly ameliorated ethanol-induced steatosis in vivo and in vitro by activating the AMPK signaling pathway, which was partly ASS1 dependent. (chinaphar.com)
  • It increased ethanol consumption and reduced significantly oil dependence. (scielo.br)
  • Unexpectedly, ethanol feeding significantly elevated total and mitochondrial levels of glutathione in SOD knockout mice compared with wild-type mice. (elsevierpure.com)
  • The ascorbic acid levels in the liver (both sexes) (all groups except 5%, MWF pH 9.7 males) and testes were reduced significantly. (cdc.gov)
  • Malondialdehyde levels in the male liver were significantly increased with topical MWF exposure. (cdc.gov)
  • Glutathione levels were reduced significantly in both male and female liver after 5% MWF (pH 7). (cdc.gov)
  • Alcohol dehydrogenase activity of the male liver increased significantly after MWF (pH 7). (cdc.gov)
  • Liver and kidney mass were significantly lower in group 6 vs group 3,5 and vs group 1,3, respectively. (bvsalud.org)
  • In addition to reducing emissions of particulate matter, running passenger vehicles on fuel blends whose octane source is a higher percentage of ethanol also cuts down on the use of the dirtier- burning benzene, toluene and xylene to boost the octane in gasoline. (governorsbiofuelscoalition.org)
  • It is undeniable that on multiple fronts, burning ethanol results in better overall air quality than when cars burn conventional gasoline. (governorsbiofuelscoalition.org)
  • In the first phase of the program, ethanol was added to gasoline. (scielo.br)
  • Flex-fuel cars can run either on 100% hydrous ethanol or on different blends of ethanol and gasoline. (scielo.br)
  • Furthermore, the use of ethanol blends replaced toxic additives in gasoline, such as tetraethyl lead and oil-derived benzene. (scielo.br)
  • Nowadays, gasoline contains a blending of 27% of anhydrous ethanol. (scielo.br)
  • Going ahead, if India is able to implement 20% ethanol blending in petrol by 2025-26, this is expected to substitute 86 million barrels of gasoline, thereby leading to forex savings of Rs 30,000 crore for India, as well as reducing 10 million tons of carbon emissions. (erpecnewslive.com)
  • Fuel ethanol is a gasoline additive. (scandasia.com)
  • The EPA approved the use of E15, a blend of 85 percent gasoline and 15 percent ethanol. (environmentalleader.com)
  • Widespread use of 15 percent ethanol in gasoline could cause engine failures that could leave consumers stranded, injured or worse, and hit consumers with costly engine repairs. (environmentalleader.com)
  • The US is one of the world's largest ethanol producers but farmers say there is only one winner in the clean fuel versus food debate. (climatechangenews.com)
  • Serious health effects (such as irreparable damage to the liver or kidneys, or birth defects) are not used as a basis for establishing MRLs. (cdc.gov)
  • Side effects of Ketoprofen and ketoprofen lysine salt (KLS) may be inter alia from the central nervous system, kidneys and liver. (bvsalud.org)
  • After euthanasia brains, livers and kidneys were taken to histopathological tests. (bvsalud.org)
  • Assessment of pediatric ethanol toxicity can be complicated by several factors. (medscape.com)
  • These results suggest that MWFs are absorbed through the skin and produce toxicity in the liver of both sexes and in the male gonads. (cdc.gov)
  • Alcohol Toxicity and Withdrawal Alcohol (ethanol) is a central nervous system depressant. (msdmanuals.com)
  • It is equipped with an 0.7-liter ethanol fuel burner that will burn for up to two hours between refills. (screenporchliving.com)
  • A key component of the Grate 36 and many of the Flex firebox inserts, the elongated, stainless steel XL700 ethanol burner has also provided design inspiration for a myriad of custom-made fires - both indoors and out. (ecosmartfire.com)
  • Ethanol is rapidly absorbed, and peak serum concentrations typically occur 30-60 minutes after ingestion. (medscape.com)
  • To convert serum ethanol level to BAC, move the decimal point 3 places to the left. (medscape.com)
  • Example, a 100 mg/dL serum ethanol level is equivalent to a 0.10 (g/dL) BAC, or 0.10% (weight/volume). (medscape.com)
  • The Renewable Fuels Association (RFA) says US ethanol sales in 2020 could fall by more than $10 billion (£8bn) as a result of the global coronavirus lockdown and the resulting collapse in biofuel consumption . (energylivenews.com)
  • The findings by the Harvard team add critical support to the message long conveyed to policy makers by SfL and other biofuel advocates: that ethanol represents a major step in progress towards farm production that is sustainable for the environment and human health. (governorsbiofuelscoalition.org)
  • Moreover, conversion of sugarcane biomass into fermentable sugars for second-generation ethanol production is a promising alternative to meet future demands of biofuel production in the country. (scielo.br)
  • The factory, which will have about four times the capacity of the facility in Crescentino, Italy, will produce two kinds of biofuel: fuel ethanol and mono-ethylene glycol. (scandasia.com)
  • New technologies have also focused on the reduction of vinasse volumes by increasing the ethanol concentrations in wine during fermentation. (scielo.br)
  • Additionally, while ethanol administration induced cytochrome P450 2E1 (CYP2E1) activity in wild-type mice, it caused no such induction in SOD -/- mice. (elsevierpure.com)
  • 3.125 ml of 99.5% alcohol was added to animal's daily diet for four weeks to induce chronic alcohol liver injuries. (tmu.edu.tw)
  • Chronic effects Alcohol (ethanol) is a central nervous system depressant. (msdmanuals.com)
  • With India officially rolling out the retail distribution of E20 fuel, a blend of 20% ethanol and 80% petrol, the industry has mounted brisk efforts to partner the Centre in fulfilling its strong commitment towards achievement of 20% ethanol blending target, advanced to fiscal 2025 from fiscal 2030 and lowering India's emissions to net-zero by 2070. (erpecnewslive.com)
  • In addition, infants and toddlers may be given ethanol orally or percutaneously. (medscape.com)
  • The mechanism by which TCH346 exerts its effect in this liver injury model are independent of GAPDH nuclear levels and aggregation, but involve mitochondrial events. (figshare.com)
  • Ethanol exerts its actions through several mechanisms. (medscape.com)
  • In this study, we investigated the role of MANF in ethanol-induced steatosis and the underlying mechanisms. (chinaphar.com)
  • Roughly half of the ethanol industry is shut down today, as fuel demand has collapsed in response to Covid-19 and it is clear we have a long and bumpy road to recovery ahead of us. (energylivenews.com)
  • Trump's EPA must stop the efforts to scale back the role of ethanol in today's transportation fuels, and must, at the very least, drop efforts to gratuitously hand out to refineries hardship exemptions to the Renewable Fuel Standard that are costing American corn growers and producers of other feedstocks valuable and much needed markets for the renewable fuels that growers generate. (governorsbiofuelscoalition.org)
  • Fuel to fire our amazing range of bio-ethanol fires, supplied as an addition to the fires for convenience. (layzeeliving.co.uk)
  • However, a combination of factors involving oil price drops, reduction of subsidies to producers and rise of sugar prices contributed to fuel shortage that led to a major downturn in the demand for ethanol-run cars. (scielo.br)
  • At the beginning of 21st century, the use of ethanol as fuel was resumed chiefly motivated by high oil prices in the international market and the development of flex-fuel technology. (scielo.br)
  • The government aims to achieve a complete 20% blending of ethanol by 2025-2026 and in line with the phased roadmap, the project has started with E20 fuel being made available at 84 retail outlets of OMCs in 11 states/UTs. (erpecnewslive.com)
  • Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
  • Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
  • Electro-coagulation for the treatment of liver metastases. (aetna.com)
  • One-shot" arterial chemotherapy for members with liver metastases from colorectal cancer. (aetna.com)
  • The RFA has warned economic damage will 'go far beyond the ethanol sector' and warns America's farmers will also be negatively impacted, as ethanol typically provides a market for two out of every five rows of corn and more than one-third of the annual sorghum crop, used for the production of alcoholic beverages. (energylivenews.com)
  • In addition, HKO mice displayed unique urea cycle metabolite patterns in the liver with elevated ammonia accumulation after ethanol feeding. (chinaphar.com)
  • Recent studies have demonstrated that MANF plays an important role in liver diseases. (chinaphar.com)
  • Specific medical therapies may be applied to many liver diseases in an effort to diminish symptoms and to prevent or forestall the development of cirrhosis. (medscape.com)
  • Summary of liver GAPDH changes in response to combined ethanol and APAP exposure and the effects of TCH346 treatment. (figshare.com)
  • The progression of liver injury to cirrhosis may occur over several weeks to years. (medscape.com)
  • Methods: Female wild-type (SOD +/+ ) and Cu/Zn-SOD knockout (SOD -/- ) mice were pair-fed ethanol and control liquid diets for 24 days, after which liver injury was assessed. (elsevierpure.com)
  • Several pharmacological effects of paeoniflorin have been demonstrated, including hypoglycemic, hypolipidemic, and antifatty liver activities [ 5 , 7 , 11 - 14 ]. (hindawi.com)
  • Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. (nature.com)
  • Ethanol administration caused no significant change in proteasome activity, but caused lysosomal leakage in livers of SOD -/- mice but not in wild-type mice. (elsevierpure.com)
  • Alcohol dehydrogenase activity was reduced by 50 to 60% in ethanol-fed SOD -/- mice compared with all other groups. (elsevierpure.com)
  • Curcumin attenuates Concanavalin A-induced liver injury in mice. (greenmedinfo.com)
  • Curcumin protects mice from P. acnes-induced liver injury through reduction of HMGB1 cytoplasmic translocation and expression. (greenmedinfo.com)
  • Our preliminary results, following dermal application of 200 microl of 50% unused (neat) semisynthetic MWF (pH 7 or pH 9.7) to the unshaved backs of 6-wk-old B6C3F1 mice, twice a week for 6 wk, produced significant increase in weights of the liver of both sexes. (cdc.gov)
  • Therefore, 6-mo-old mice of both sexes were exposed to MWFs following the protocol just described, except that the topical application was with 5% MWFs (pH 7 and 9.7, 5 d/wk) with or without adding 5% ethanol to their drinking water (7 d/wk) for 13 wk. (cdc.gov)
  • this P-450 isozyme is recognized by antibody (anti-3a IgG) raised against the ethanol-inducible P-450 in rabbits. (elsevierpure.com)
  • SAIL with the help of the Centre is planning to set up India's first gas to ethanol plant at its ferro alloy plant in Chandrapur in Maharashtra, according to an official. (indiatvnews.com)
  • Background and Aims: The precise pathogenic significance of oxidative injury in the evolution of alcohol-induced liver disease is still obscure. (elsevierpure.com)
  • Curcumin treatment attenuates liver lesions induced by intestinal ischemia/reperfusion. (greenmedinfo.com)
  • In the last 40 years, several scientific and technological advances in microbiology of the fermentation have greatly contributed to evolution of the ethanol industry in Brazil. (scielo.br)
  • In 1980, production of light vehicles that ran on ethanol reached 95% of all fleet produced in Brazil. (scielo.br)
  • Brazil is saying they will share with us technology for ethanol production. (wn.com)
  • Primary liver cancer is a disease in which malignant (cancer) cells form in the tissues of the liver. (oncolink.org)
  • The aim of this work was to investigate the effect of Rheum emodi (MER) on ethanol (EtOH) induced cytotoxicity in human liver cells. (journalcra.com)
  • The present report was designed to investigate whether ethanol alters the production of active oxidants and biological activities of hepatocytes. (elsevierpure.com)
  • Infants usually ingest alcohol as a result of their caregivers giving them over-the-counter cold medications that contain significant amounts of ethanol. (medscape.com)
  • These blood tests measure the amounts of certain substances released into the blood by the liver. (oncolink.org)
  • Large amounts chronically consumed damage the liver. (msdmanuals.com)
  • Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. (nature.com)
  • The drug TCH346, which was previously shown to target GAPDH in the brain, attenuates liver injury in association with EtOH+APAP treatment. (figshare.com)
  • Our findings suggest that MER exert cytoprotective action against EtOH induced liver cell damage. (journalcra.com)
  • There could be a shortage of beer and fizzy drinks in the US as supplies of carbon dioxide from ethanol plants run low, according to a new analysis. (energylivenews.com)
  • Subsequent investigations have confirmed that ethanol was the cause of the fatalities. (vipi.live)
  • In the histopathologic examination of the livers in one animal in group 3 some of the specimens showed perivascular inflammation. (bvsalud.org)
  • The Company will build a dry corn milling plant with an initial annual capacity of 275 million gallons adjacent to the existing ethanol plant in Columbus. (altenergystocks.com)
  • Nowadays, new technologies are available to produce ethanol from sugarcane, corn and other feedstocks, reducing the off-season period. (scielo.br)