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  • coagulopathy
  • Acute liver failure is an uncommon condition in which rapid deterioration of liver function results in coagulopathy, usually with an international normalized ratio (INR) of greater than 1.5, and alteration in the mental status (encephalopathy) of a previously healthy individual. (medscape.com)
  • 1993
  • The 1993 classification defines hyperacute as within 1 week, acute as 8-28 days, and subacute as 4-12 weeks. (wikipedia.org)
  • kidney failure
  • Other health problems , such as kidney failure, hypoglycemia (decreased blood sugar level), and pancreatitis may occur. (drugs.com)
  • Kidney failure is common, present in more than 50% of ALF patients, either due to original insult such as paracetamol resulting in acute tubular necrosis or from hyperdynamic circulation leading to hepatorenal syndrome or functional kidney failure. (wikipedia.org)
  • transplants
  • found that LDLT accounts for less than 5% of liver transplants in the U.S. and Europe compared to more than 90% in Asia excluding mainland China. (medindia.net)
  • coma
  • It was worse or no better than placebo for all encephalopathy grades, all levels of organ failure, and all maximum coma grades. (medpagetoday.com)
  • centers
  • Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States," Annals of Internal Medicine , vol. 137, no. 12, pp. 947-954, 2002. (hindawi.com)
  • occur
  • Bleeding problems may occur because your liver does not produce enough clotting factors. (drugs.com)
  • Infections, such as respiratory and urinary tract infections, may occur with acute liver failure. (drugs.com)
  • It has become evident that liver cell death can occur via distinct biochemical pathways and morphological alterations, including apoptosis, autophagic cell death, and necrosis. (frontiersin.org)
  • subacute
  • The 1993 classification defines hyperacute as within 1 week, acute as 8-28 days, and subacute as 4-12 weeks. (wikipedia.org)
  • metabolic
  • Necrosis is typically the consequence of acute metabolic perturbation with ATP depletion, whereas apoptosis represents an ATP-dependent cell death program. (frontiersin.org)
  • injury
  • An ultrasound or CT may show signs of liver injury. (drugs.com)
  • The serum transaminases reflect both the acuity as well as the extent of liver injury. (renalandurologynews.com)
  • Acetaminophen is the most widely used pain reliever in the United States--36 percent of Americans ingest it at least once a month--but taking more than the recommended dose can lead to fatal liver injury. (medicalnewstoday.com)
  • Mouse models of acute liver injury revealed that liver-resident macrophages, Kupffer cells, sense hepatocyte-mediated release of alarmins, which results in Kupffer cell activation and cytokine release. (bmj.com)
  • 3 4 However, there is ample experimental evidence that monocyte-derived macrophages change their phenotype in the liver, if injury has terminated, towards repair-promoting phagocytes. (bmj.com)
  • The objective of this thesis was to investigate definitions, prognostic indicators and their association with adverse events, mainly mortality for acute liver failure (ALF), acute-on-chronic liver failure (ACLF) and acute kidney injury (AKI). (uva.nl)