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  • cirrhosis
  • The development of liver cirrhosis was verified by histological examination. (phellinus-research.com)
  • Of particular concern is the fact that up to 25% of NASH patients are reported to develop cirrhosis, and nearly 30 to 40% of these patients perish from a liver-related death over a 10-year period ( McCullough, 2006 ). (aspetjournals.org)
  • HCV is a major causative agent for chronic liver diseases such as steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma which are caused by multifactorial processes. (hindawi.com)
  • At present, almost 2% of the world population suffers from chronic infection with HCV.HCV (hepatitis C virus) is a major cause of chronic hepatitis, steatosis, fibrosis, liver cirrhosis, and hepatocellular carcinoma. (hindawi.com)
  • body's
  • Cysteine in sufficient levels will bind with metals-preferentially, the heavy metals lead, mercury, and cadmium bond most strongly-thus, cysteine aids the body's elimination of them. (healthy.net)
  • cystathionine
  • Monensin stimulates the reverse transsulfuration pathway via cystathionine γ-lyase, the biosynthetic enzyme for cysteine, important for redox homeostasis. (pnas.org)
  • One of the genes regulated by ATF4 is the biosynthetic enzyme for cysteine, cystathionine γ-lyase (CSE), which also plays central roles in maintenance of redox homeostasis. (pnas.org)
  • Recently, we demonstrated a major depletion of cystathionine γ-lyase (CSE), the biosynthetic enzyme for cysteine, in HD ( 7 ). (pnas.org)
  • Processes
  • The relevance of ROS for HCV-associated pathogenesis is reviewed with a focus on the interference of elevated ROS levels with processes controlling liver regeneration. (hindawi.com)
  • antioxidant
  • Your body needs Selenium for the production of several important body compounds, including antioxidant enzymes, or catalysts, involved in antioxidant protection and thyroid-hormone metabolism. (cultao.com)
  • It has a role in maintaining the immune system and also acts as an antioxidant for protection of the liver, lungs and brain. (aloe-vera2u.co.uk)
  • Cysteine is becoming even more important as a useful antioxidant-detoxifier-protector with the increasing pollution and toxicity of this industrial age. (healthy.net)
  • arsenic
  • however, NASH liver retained significantly higher levels of the monomethyl arsenic metabolite, whereas dimethyl arsenic was retained significantly less in the kidneys of NASH mice. (aspetjournals.org)
  • atoms
  • The sulphur atoms of these two cysteines are 20 Å apart in the crystal structures of ANT and the optimal spacing of cysteine thiolates for reaction with As (III) is 3-4 Å. (springermedizin.de)
  • In the newer R/S system of designating chirality, based on the atomic numbers of atoms near the asymmetric carbon, cysteine (and selenocysteine) have R chirality, because of the presence of sulfur (resp. (wikipedia.org)
  • mitigate
  • We have harnessed this pathway to mitigate toxicity associated with cysteine deprivation in Huntington's disease (HD). (pnas.org)
  • mice
  • To prove our hypotheses, we employed a diet-induced obesity (DIO) mouse model to evaluate the effects of exogenous H2S on fatty liver of obese mice. (biomedcentral.com)
  • NASH mice had significantly higher levels of the more toxic trivalent form in their urine, whereas the pentavalent form was preferentially retained in the liver of NASH mice. (aspetjournals.org)
  • tissues
  • The MC-LR-Cys can be formed in kidney directly, or transported from liver or other tissues, while the MC-LR-Cys in kidney might be dissociated to MC-LR or excreted. (iwaponline.com)
  • optimal
  • Accordingly, we harnessed the monensin-ATF4-signaling cascade to stimulate CSE expression by preconditioning cells with monensin, which restores cysteine metabolism and an optimal stress response in HD. (pnas.org)
  • redox
  • Huntington's disease (HD), a neurodegenerative disorder, is associated with disrupted cysteine metabolism caused by depletion of CSE leading to abnormal redox balance and stress response. (pnas.org)
  • catabolism
  • Excess levels of Hcy are excreted to the plasma where the liver and kidney are the organs achieving catabolism and excretion of Hcy. (intechopen.com)
  • Kidney
  • MC-LR and MC-LR-Cys were detected in liver, kidney and muscle. (iwaponline.com)
  • The concentration of MC-LR in liver and kidney was 0.052 μg g −1 DW and 0.067 μg g −1 DW, respectively. (iwaponline.com)
  • MC-LR-Cys appeared to be an important metabolite with average contents of 1.104 μg g −1 DW and 0.724 μg g −1 DW in liver and kidney, and the MC-LR-Cys/MC-LR ratio in liver and kidney reaching as high as 21.4 and 10.8. (iwaponline.com)
  • Furthermore, there might be a balance between the accumulation and depuration/metabolism of MC-LR-Cys in kidney. (iwaponline.com)
  • fibrosis
  • However, the molecular mechanism of PLP for the inhibition of liver fibrosis is unclear. (phellinus-research.com)
  • This study aims to investigate the molecular protein signatures involved in the hepatoprotective mechanisms of PLP via a proteomics approach using a thioacetamide (TAA)-induced liver fibrosis rat model. (phellinus-research.com)