• Nasopharyngeal carcinoma (NPC) is a distinctive type of head and neck cancer with special racial and geographic distributions. (biomedcentral.com)
  • The present invention relates to compositions and methods for treating cancerous tumors, including naïve, metastatic and recurrent cancers. (justia.com)
  • Targeted therapies specifically target cancer cells while sparing healthy cells, leading to fewer side effects and improved patient outcomes. (patentpc.com)
  • Immunotherapies harness the body's immune system to recognize and destroy cancer cells, offering a novel and effective treatment option. (patentpc.com)
  • The following text points out several possibilities and chemical pathways in which "Intume" chlorine dioxide intervention can destroy tumors and prevent proliferation of cancer cells. (justia.com)
  • Cancer cells are rich in polyamines which is necessary for survival and growth of tumors. (justia.com)
  • ix Capacity of cancer tissue to produce abundant PA likely contributes to cancer cell's higher growth rates.ix ,x High concentrations of PA enhance cancer cells to invade, and is associated with less apoptosis and increased expression of the genes affecting metastasis.ix ,xi The association of increased polyamine synthesis and cancer was first reported in the late 1960s. (justia.com)
  • We speculate that precancerous stem cells (pCSCs) arise during the evolution of carcinomas based on long-term experimental findings, published literature, and the cancer stem cell (CSC) theory, wherein pCSCs exist in precancerous lesions and have characteristics of both CSCs and normal stem cells. (biomedcentral.com)
  • Therefore, investigations on testing and maintaining the integrity of genomic DNA within precancerous stem cells (pCSCs), which are within the framework of the cancer stem cell (CSC) hypothesis, are necessary. (biomedcentral.com)
  • Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)
  • Mechanistically, stemness is induced in non-stem cancer cells upon their direct contact with macrophages via Notch-Jagged signaling. (nature.com)
  • In breast cancers from patients, the density of TMEM doorways correlates with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites. (nature.com)
  • At the apex of the hierarchy are the cancer stem cells (CSCs). (nature.com)
  • Cancer stem cells (CSCs) are considered to be critically involved in the recurrence and metastasis of NB and are isolated as NB spheres. (oncotarget.com)
  • Accumulating evidence has shown that cancer stem cells (CSCs) are a small subpopulation of tumor cells that exhibit the properties of self-renewal, differentiation into various tumor cell types, tumorigenicity, and chemo/irradiation resistance [ 1 ]. (oncotarget.com)
  • Therefore, CSCs have become promising target cancer cells for preventing cancer relapse and improving the prognosis of tumor patients [ 3 ]. (oncotarget.com)
  • Using this model, we evaluated the cytoprotective effects of two dietary flavonoids including cannflavins A and B against RCSs and erastin-induced cytotoxicity in HaCaT cells. (bvsalud.org)
  • In their meta-analysis, Kinkel et al compared US, CT, MRI, and fluorodeoxyglucose (FDG) imaging in the detection of liver metastases from colorectal, gastric, and esophageal cancers and concluded that, with an equivalent specificity, FDG positron emission tomography (PET) is the most sensitive noninvasive imaging modality for the diagnosis of liver metastases. (medscape.com)
  • The observation that one inch of cancerous liver tissue can have more than 100 000 000 mutations and an identical mutation can result in different phenotypes, depending on the environment surrounding that mutation, makes it very unlikely that mutations by themselves are causative of most cancers. (4open-sciences.org)
  • The blood supply of the liver is exceeded only by that of the lung, in terms of blood flow per minute. (medscape.com)
  • According to the American Cancer Society (ACS), the 5-year relative survival rate differs significantly according to cancer type with higher rates ≥90% for prostate cancer, melanoma, skin and female breast cancer compared to lower rates ≤18% in liver, lung, and pancreatic cancer [ 1 ]. (4open-sciences.org)
  • The antibodies can be used to target carcinomas in the brain, skin and bone, as well as cancers of the lungs, esophagus or stomach, liver, gallbladder, pancreas. (patentpc.com)
  • The market for compositions for the treatment and detection of cancer has witnessed significant growth in recent years. (patentpc.com)
  • Compositions for the treatment and detection of cancer play a crucial role in improving patient outcomes and saving lives. (patentpc.com)
  • As a result, there is a pressing need for advanced compositions that can effectively treat and detect cancer at an early stage. (patentpc.com)
  • Compositions such as targeted therapies, immunotherapies, and precision medicine have emerged as promising approaches in the fight against cancer. (patentpc.com)
  • The market for compositions for the treatment and detection of cancer is also driven by increased research and development activities. (patentpc.com)
  • Pharmaceutical and biotechnology companies are investing heavily in developing innovative compositions that can effectively target and treat various types of cancer. (patentpc.com)
  • Compositions such as liquid biopsies, molecular diagnostics, and imaging techniques have shown great promise in detecting cancer at its earliest stages, enabling timely intervention and treatment. (patentpc.com)
  • The market for compositions for the treatment and detection of cancer is highly competitive, with numerous players vying for market share. (patentpc.com)
  • These companies are constantly striving to develop innovative compositions that can address the unmet needs of cancer patients. (patentpc.com)
  • In conclusion, the market for compositions for the treatment and detection of cancer is witnessing significant growth due to the rising incidence of cancer, advancements in technology, increased research and development activities, and the growing importance of early cancer detection. (patentpc.com)
  • As the global burden of cancer continues to increase, the demand for effective and innovative compositions will only continue to rise. (patentpc.com)
  • Accurate assessment of the carcinogenic potential of oral mucosal diseases can significantly reduce the prevalence of oral cancer. (biomedcentral.com)
  • While more advanced cancer stages reveal significantly lower survival rates [ 1 ] they may just represent clinical empiricism [ 4 , 5 ] and do not explain the origin of cancer. (4open-sciences.org)
  • A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
  • Thus, a better understanding of the in vivo mechanisms that regulate CSCs is essential for the development of more effective anti-cancer therapies. (nature.com)
  • With the increasing prevalence of cancer worldwide, there is a growing need for innovative and effective solutions to combat this deadly disease. (patentpc.com)
  • The increasing prevalence of risk factors such as tobacco use, unhealthy diets, physical inactivity, and exposure to carcinogens has contributed to the growing burden of cancer. (patentpc.com)
  • The prognosis for GBM is poor despite the availability of many treatments including surgery, radiotherapy, and chemotherapy. (patentpc.com)
  • Interest in targeting polyamine metabolism as a potential strategy for cancer chemotherapy was stimulated in the early 1970s. (justia.com)
  • Here, we employ high-resolution intravital microscopy using a CSC biosensor to directly observe CSCs in live mice with mammary tumors. (nature.com)
  • Selective hepatic angiography may demonstrate hypervascular liver metastases by showing capillary blush in involved areas, highlighting the potential response of tumors to embolization. (medscape.com)
  • Macrophages are emerging as major cellular factors in the tumor ecosystem that can influence the stem phenotype and cancer progression. (nature.com)
  • Notch signaling has been implicated in many microenvironmental processes associated with cancer progression such as vascular remodeling, immunosuppression, epithelial to mesenchymal transition (EMT), as well as maintenance of the CSC pool 21 . (nature.com)
  • There is a kind of zeitgeist that findings in genetics, namely somatic mutations, are reflexively viewed as being causative for carcinogenesis, although some 80% of all cancers are presently termed "sporadic" (i.e., with no proven cause). (4open-sciences.org)
  • The methods of use are not limited to cancer diagnostics and therapies. (patentpc.com)
  • However, evidence supporting the use of MRI in the evaluation of liver metastases is accumulating because MRI allows the effective localization of hepatic and vascular invasion. (medscape.com)
  • For detection and characterization of small lesions and to evaluate the liver with background fatty liver changes, MRI may be superior to multidector CT and positron emission tomography (PET). (medscape.com)
  • Contrast-enhanced US in the liver-specific phase of contrast enhancement improves the detection of hepatic metastases, relative to nonenhanced conventional US. (medscape.com)
  • Advancements in technology have revolutionized the field of cancer treatment and detection. (patentpc.com)
  • Early detection plays a crucial role in improving survival rates and reducing the burden of cancer. (patentpc.com)
  • From a "birds-eye" view, it may appear that we have made little progress in eradicating cancer and that outcomes are largely based on the merits, or lack thereof, of any selected therapy " meaning to reach the proposed vision " Imagine a world without cancer " [ 6 ], we need to work much harder to understand the as yet unanswered questions that surround the origins of most cancers. (4open-sciences.org)
  • CT permits better evaluation of the involvement of extrahepatic tissues, including the bones, bowel, lymph nodes, and mesentery. (medscape.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • The liver provides a fertile soil in which metastases may become established, not only because of its rich, dual blood supply but also because of humoral factors that promote cell growth. (medscape.com)
  • The antibodies disclosed herein can bind certain cancer cell surface. (patentpc.com)
  • We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. (mdpi.com)
  • 90% of cancer-related deaths, is a multi-step process involving cancer cell intravasation into the bloodstream, dissemination to distant sites, and seeding in new organs 1 . (nature.com)
  • This preference is largely attributable to the effects of the dual blood supply on the enhancement characteristics of metastases, as compared with normal liver parenchyma. (medscape.com)
  • Presently, the likelihood of an oral potentially malignant disorder (OPMD) progressing to oral cancer is determined according to histopathological findings, which are susceptible to inadequate and/or subjective qualitative interpretations [ 5 ]. (biomedcentral.com)
  • Despite success in some cancer survival rates, these numbers differ by race, ethnicity, socioeconomics, health policy, geography, and age so the overall survival numbers ignore the large variations within any given group. (4open-sciences.org)
  • Human Cripto-1, also known as teratocarcinoma-derived growth factor-1 (TDGF-1), is a member of the Epidermal growth factor-cripto FRL1 cryptic (EGF-CFC) family (Cripto in humans, FRL1 in Xenopus, and Cryptic in mice), which is indispensable for early embryonic development[ 4 ]. (biomedcentral.com)
  • Epidemiologically, cancer is an age-related disease which will be a major burden to healthcare worldwide along with neurologic, cardiovascular diseases, and diabetes [ 3 ]. (4open-sciences.org)
  • Additionally, a data-independent acquisition approach was used to characterize RCSs' and erastin's molecular network including genes, canonical pathways, and upstream regulators. (bvsalud.org)
  • Plain chest radiographs are routinely obtained in patients who are suspected of having cancer and are also used in the staging of cancer, but plain abdominal radiography has a limited role in the investigation of liver metastases. (medscape.com)
  • Mechanistic studies supported that the cytoprotective effects of cannflavins A and B are associated with their antioxidant activities including free radical scavenging capacity and an inhibitory effect on glycation. (bvsalud.org)
  • Epidemiologic evidence indicates that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer and that vitamin D supplementation is associated with decreased cancer mortality. (mdpi.com)
  • In general, the imaging appearances of liver metastases are nonspecific, and biopsy specimens are required for histologic diagnosis. (medscape.com)
  • The vast majority of anticancer strategies are symptomatic but in order to achieve some tangible progress, we need to identify the cause(s) of the majority of cancers. (4open-sciences.org)
  • Late-phase pulse-inversion harmonic imaging is a useful technique for characterizing hepatic lesions and for demonstrating both greater numbers of liver metastases and smaller liver metastases. (medscape.com)
  • The left image shows metastases in both lobes of the liver and, thus, inoperable. (medscape.com)
  • No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. (mdpi.com)