• The protective effects of polysaccharide peptide (PSP) of Trametes versicolor on hepatotoxicity were investigated using carbon tetrachloride (CCl 4 )-induced and paracetamol (APAP)-induced liver injury in the rat as the chemical hepatitis models. (begellhouse.com)
  • Though phallotoxins are highly toxic to liver cells, they have since been found to have little input into the destroying angel's toxicity as they are not absorbed through the gut. (morelmushroomhunting.com)
  • The available trials in patients with toxic (e.g. solvents) or iatrogenic (e.g. antispychotic or tacrine) liver diseases, which are mostly outdated and underpowered, do not enable any valid conclusions to be drawn on the value of silymarin. (springer.com)
  • That can be a real problem - it's what happens with acetaminophen/paracetamol overdose, which sends that compound past the usual glucuronidation pathway and into oxidative metabolism, producing a toxic metabolite that then causes liver damage. (sciencemag.org)
  • For example, If β-amanitin comes in contact with skin, it may cause irritation, burns, redness, severe pain, and could be absorbed through the skin, causing similar effects to exposure via inhalation and ingestion. (wikipedia.org)
  • symptoms of jaundice , diarrhea, delirium , seizures , and coma may follow with death from liver failure 6-16 days post ingestion. (bionity.com)
  • Although there were no clinical end-points in the four trials considered in patients with alcoholic liver disease, histological findings were reported as improved in two out of two trials, improvement of prothrombin time was significant (two trials pooled) and liver transaminase levels were consistently lower in the silymarin-treated groups. (springer.com)
  • Most commonly that measurement of clotting time becomes prolonged in amanitin poisoning when the damaged liver produces less prothrombin. (mykoweb.com)
  • The authors concluded that patients whose thromboplastin time and creatinine were in the possibly fatal range should be transferred to liver transplant centers for further evaluation and possible surgery. (mykoweb.com)
  • At high doses and over long periods, aflatoxin is known to cause acute and chronic liver injury and cause liver cancer. (cdc.gov)
  • Jang SH, Cho SW, Yoon HM, Jang KJ, Song CH, Kim CH. Hepatoprotective Evaluation of Ganoderma lucidum Pharmacopuncture: In vivo Studies of Ethanol-induced Acute Liver Injury. (shaklee.com)
  • Moreover, the liver is going to be trying to deal with the onslaught, too - caffeine is metabolized by various N-demethylations, and the CYP1A2 enzyme in particular will be slammed trying to deal with things. (sciencemag.org)
  • Moldenhauer, who has many years of experience in developing therapeutic antibodies, already has plans for amanitin-conjugated guided missiles against other cancers. (dkfz.de)
  • PSP probably acts to prevent the fall of hepatic reduced glutathione (GSH) through some GSH-dependent enzymes and preserve the structural integrity of the cellular membrane of hepatocytes, or probably protect paracetamol-induced liver injury through their antioxidant properties acting as a scavenger of free radicals even at low levels of GSH. (begellhouse.com)
  • The high prevalence of liver diseases such as chronic hepatitis and cirrhosis underscores the need for efficient and cost-effective treatments. (springer.com)
  • This is not the case, though, as liver failure is developing, and can become irreversible if it isn't caught and aggressively treated. (cathealth.com)
  • Analysis was performed on five trials with a total of 602 patients with liver cirrhosis. (springer.com)
  • The potential benefit of silymarin (extracted from the seeds of Silybum marianum or milk thistle) in the treatment of liver diseases remains a controversial issue. (springer.com)
  • Luper S. A review of plants used in the treatment of liver disease: part 1. (springer.com)