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  • ischemic
  • Deficiency of adenosine deaminase 2 (DADA2) is caused by biallelic deleterious mutations in CECR1 DADA2 results in variable autoinflammation and vasculopathy (recurrent fevers, livedo reticularis, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency and bone marrow failure. (readbyqxmd.com)
  • Symptoms
  • Mottling is more common in the forearms, thighs and lowerabdomen.Livedo reticularis occurs primarily on the legs, arms, and trunk with symptoms becomingmore pronounced in cold weather. (medigoo.com)
  • The patient should be queried regarding amelioratingand exacerbating factors of their livedo (eg, effect of temperature andleg elevation) and whether or not any associated symptoms exist. (medigoo.com)
  • treatment
  • i've had livedo reticularis for many years before my infant onset lupus was rediagnosed & treatment began 4 years ago, but it's never been quite as vivid as it has been since last feb when i stopped hydroxy. (healthunlocked.com)
  • known
  • A detailed history forpotentially causative or exacerbating medications is essential (amantadine,vasoconstrictors, interferons) and one should investigate for coexistent systemicdiseases (autoimmune, hematologic, infectious, neurologic diseases)or interventional procedures (catheterization) known to be associated withlivedo reticularis. (medigoo.com)
  • appearance
  • The rash in livedo reticularis is described as a reticular or lacy, net-likepurplish coloration surrounding a pale central area.The mottled appearance is related to spasms that occurin the dilated vessels. (medigoo.com)